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HAIR MORPHOLOGY 1(HRM1)

MedGen UID:
390803
•Concept ID:
C2675460
•
Finding
Synonyms: HAIR THICKNESS, VARIATION IN; HRM1
 
Gene (location): EDAR (2q13)
 
OMIM®: 612630

Professional guidelines

PubMed

Energy-based devices for the treatment of Acne Scars: 2022 International consensus recommendations.
Salameh F, Shumaker PR, Goodman GJ, Spring LK, Seago M, Alam M, Al-Niaimi F, Cassuto D, Chan HH, Dierickx C, Donelan M, Gauglitz GG, Haedersdal M, Krakowski AC, Manuskiatti W, Norbury WB, Ogawa R, Ozog DM, Paasch U, Victor Ross E, Clementoni MT, Waibel J, Bayat A, Goo BL, Artzi O
Lasers Surg Med 2022 Jan;54(1):10-26. Epub 2021 Oct 31 doi: 10.1002/lsm.23484. PMID: 34719045
Female Androgenetic Alopecia: An Update on Diagnosis and Management.
Starace M, Orlando G, Alessandrini A, Piraccini BM
Am J Clin Dermatol 2020 Feb;21(1):69-84. doi: 10.1007/s40257-019-00479-x. PMID: 31677111
AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS, AMERICAN COLLEGE OF ENDOCRINOLOGY, AND ANDROGEN EXCESS AND PCOS SOCIETY DISEASE STATE CLINICAL REVIEW: GUIDE TO THE BEST PRACTICES IN THE EVALUATION AND TREATMENT OF POLYCYSTIC OVARY SYNDROME--PART 1.
Goodman NF, Cobin RH, Futterweit W, Glueck JS, Legro RS, Carmina E; American Association of Clinical Endocrinologists (AACE); American College of Endocrinology (ACE); Androgen Excess and PCOS Society (AES)
Endocr Pract 2015 Nov;21(11):1291-300. doi: 10.4158/EP15748.DSC. PMID: 26509855

Recent clinical studies

Etiology

The Alopecia Areata Consensus of Experts (ACE) study part II: Results of an international expert opinion on diagnosis and laboratory evaluation for alopecia areata.
Meah N, Wall D, York K, Bhoyrul B, Bokhari L, Asz-Sigall D, Bergfeld WF, Betz RC, Blume-Peytavi U, Callender V, Chitreddy V, Combalia A, Cotsarelis G, Craiglow B, Donovan J, Eisman S, Farrant P, Green J, Grimalt R, Harries M, Hordinsky M, Irvine AD, Itami S, Jolliffe V, King B, Lee WS, McMichael A, Messenger A, Mirmirani P, Olsen E, Orlow SJ, Piraccini BM, Rakowska A, Reygagne P, Roberts JL, Rudnicka L, Shapiro J, Sharma P, Tosti A, Vogt A, Wade M, Yip L, Zlotogorski A, Sinclair RD
J Am Acad Dermatol 2021 Jun;84(6):1594-1601. Epub 2020 Sep 12 doi: 10.1016/j.jaad.2020.09.028. PMID: 32926985
The Genetics of Human Skin and Hair Pigmentation.
Pavan WJ, Sturm RA
Annu Rev Genomics Hum Genet 2019 Aug 31;20:41-72. Epub 2019 May 17 doi: 10.1146/annurev-genom-083118-015230. PMID: 31100995
Effect of a nutritional supplement on hair loss in women.
Le Floc'h C, Cheniti A, Connétable S, Piccardi N, Vincenzi C, Tosti A
J Cosmet Dermatol 2015 Mar;14(1):76-82. Epub 2015 Jan 8 doi: 10.1111/jocd.12127. PMID: 25573272
Progressive trichomegaly.
Vano-Galvan S, Moreno-Martin P, Jaén P
Neth J Med 2009 Jan;67(1):35-6. PMID: 19155549
Molecular insights into the hair follicle and its pathology: a review of recent developments.
Stenn KS
Int J Dermatol 2003 Jan;42(1):40-3. doi: 10.1046/j.1365-4362.2003.01726.x. PMID: 12581142

Diagnosis

Female Androgenetic Alopecia: An Update on Diagnosis and Management.
Starace M, Orlando G, Alessandrini A, Piraccini BM
Am J Clin Dermatol 2020 Feb;21(1):69-84. doi: 10.1007/s40257-019-00479-x. PMID: 31677111
Lichen planopilaris.
Farah RS, Ferguson NN, Swick BL
Cutis 2013 Jul;92(1):11, 17-8. PMID: 23961528
Alopecia in adolescents.
Tackett BN, Hrismalos EN
Adolesc Med State Art Rev 2011 Apr;22(1):16-34. PMID: 21815442
Scurvy.
Ghorbani AJ, Eichler C
J Am Acad Dermatol 1994 May;30(5 Pt 2):881-3. doi: 10.1016/s0190-9622(94)70105-9. PMID: 8169268
Trichilemmoma.
Chan P, White SW, Pierson DL, Rodman OG
J Dermatol Surg Oncol 1979 Jan;5(1):58-9. doi: 10.1111/j.1524-4725.1979.tb00605.x. PMID: 759462

Therapy

Alopecia Areata: Current Treatments and New Directions.
Dahabreh D, Jung S, Renert-Yuval Y, Bar J, Del Duca E, Guttman-Yassky E
Am J Clin Dermatol 2023 Nov;24(6):895-912. Epub 2023 Aug 22 doi: 10.1007/s40257-023-00808-1. PMID: 37606849
Clascoterone: First Approval.
Dhillon S
Drugs 2020 Nov;80(16):1745-1750. doi: 10.1007/s40265-020-01417-6. PMID: 33030710
Female Androgenetic Alopecia: An Update on Diagnosis and Management.
Starace M, Orlando G, Alessandrini A, Piraccini BM
Am J Clin Dermatol 2020 Feb;21(1):69-84. doi: 10.1007/s40257-019-00479-x. PMID: 31677111
Alopecia areata: A multifactorial autoimmune condition.
Simakou T, Butcher JP, Reid S, Henriquez FL
J Autoimmun 2019 Mar;98:74-85. Epub 2018 Dec 15 doi: 10.1016/j.jaut.2018.12.001. PMID: 30558963
Androgenetic alopecia.
Piraccini BM, Alessandrini A
G Ital Dermatol Venereol 2014 Feb;149(1):15-24. PMID: 24566563

Prognosis

The Alopecia Areata Consensus of Experts (ACE) study part II: Results of an international expert opinion on diagnosis and laboratory evaluation for alopecia areata.
Meah N, Wall D, York K, Bhoyrul B, Bokhari L, Asz-Sigall D, Bergfeld WF, Betz RC, Blume-Peytavi U, Callender V, Chitreddy V, Combalia A, Cotsarelis G, Craiglow B, Donovan J, Eisman S, Farrant P, Green J, Grimalt R, Harries M, Hordinsky M, Irvine AD, Itami S, Jolliffe V, King B, Lee WS, McMichael A, Messenger A, Mirmirani P, Olsen E, Orlow SJ, Piraccini BM, Rakowska A, Reygagne P, Roberts JL, Rudnicka L, Shapiro J, Sharma P, Tosti A, Vogt A, Wade M, Yip L, Zlotogorski A, Sinclair RD
J Am Acad Dermatol 2021 Jun;84(6):1594-1601. Epub 2020 Sep 12 doi: 10.1016/j.jaad.2020.09.028. PMID: 32926985
Dermatological Toxicities of Bruton's Tyrosine Kinase Inhibitors.
Sibaud V, Beylot-Barry M, Protin C, Vigarios E, Recher C, Ysebaert L
Am J Clin Dermatol 2020 Dec;21(6):799-812. doi: 10.1007/s40257-020-00535-x. PMID: 32613545
Alopecia areata: Disease characteristics, clinical evaluation, and new perspectives on pathogenesis.
Strazzulla LC, Wang EHC, Avila L, Lo Sicco K, Brinster N, Christiano AM, Shapiro J
J Am Acad Dermatol 2018 Jan;78(1):1-12. doi: 10.1016/j.jaad.2017.04.1141. PMID: 29241771
Congenital lesions of epithelial origin.
Hills SE, Maddalozzo J
Otolaryngol Clin North Am 2015 Feb;48(1):209-23. doi: 10.1016/j.otc.2014.09.014. PMID: 25439555
Androgenetic alopecia.
Piraccini BM, Alessandrini A
G Ital Dermatol Venereol 2014 Feb;149(1):15-24. PMID: 24566563

Clinical prediction guides

Hair-bearing human skin generated entirely from pluripotent stem cells.
Lee J, Rabbani CC, Gao H, Steinhart MR, Woodruff BM, Pflum ZE, Kim A, Heller S, Liu Y, Shipchandler TZ, Koehler KR
Nature 2020 Jun;582(7812):399-404. Epub 2020 Jun 3 doi: 10.1038/s41586-020-2352-3. PMID: 32494013Free PMC Article
Digit ratio and hair color relationships with coronary atherosclerotic markers.
Nafakhi H, Al-Mosawi AA, Mudhafar MM, Al-Nafakh HA, Alsaady R
Asian Cardiovasc Thorac Ann 2019 Jun;27(5):362-368. Epub 2019 Apr 24 doi: 10.1177/0218492319847379. PMID: 31018656
Visually scoring hirsutism.
Yildiz BO, Bolour S, Woods K, Moore A, Azziz R
Hum Reprod Update 2010 Jan-Feb;16(1):51-64. doi: 10.1093/humupd/dmp024. PMID: 19567450Free PMC Article
Giant solitary trichoepithelioma.
Jemec B, Løvgreen Nielsen P, Jemec GB, Balsev E
Dermatol Online J 1999 May;5(1):1. PMID: 10673444
Alopecia: histologic changes.
Bergfeld WF
Adv Dermatol 1989;4:301-20; discussion 321. PMID: 2701796

Recent systematic reviews

Frontal fibrosing alopecia and personal care product use: a systematic review and meta-analysis.
Kam O, Na S, Guo W, Tejeda CI, Kaufmann T
Arch Dermatol Res 2023 Oct;315(8):2313-2331. Epub 2023 Apr 4 doi: 10.1007/s00403-023-02604-7. PMID: 37014396
Female Genital Hair-Thread Tourniquet Syndrome: A Case Report and Literature Systematic Review.
De Vitis LA, Barba M, Lazzarin S, Molinari S, Spinelli M, Arosio E, Manodoro S, Frigerio M
J Pediatr Adolesc Gynecol 2021 Feb;34(1):65-70. Epub 2020 Jul 18 doi: 10.1016/j.jpag.2020.07.007. PMID: 32693024
Reference values for skin microanatomy: A systematic review and meta-analysis of ex vivo studies.
Xu H, Fonseca M, Wolner Z, Chung E, Wu X, Geller S, Dusza SW, DeRosa AP, Marghoob AA, Busam KJ, Halpern AC, Marchetti MA
J Am Acad Dermatol 2017 Dec;77(6):1133-1144.e4. Epub 2017 Jul 14 doi: 10.1016/j.jaad.2017.06.009. PMID: 28716435Free PMC Article
Injections of platelet-rich plasma for androgenic alopecia: A systematic review.
Picard F, Hersant B, Niddam J, Meningaud JP
J Stomatol Oral Maxillofac Surg 2017 Oct;118(5):291-297. Epub 2017 Jul 1 doi: 10.1016/j.jormas.2017.06.011. PMID: 28676455
Topical medication instillation techniques for glaucoma.
Xu L, Wang X, Wu M
Cochrane Database Syst Rev 2017 Feb 20;2(2):CD010520. doi: 10.1002/14651858.CD010520.pub2. PMID: 28218404Free PMC Article

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      OMIM records containing genes associated with phenotypes registered in MedGen
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