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Coronary heart disease, susceptibility to, 7(CHDS7)

MedGen UID:
370260
Concept ID:
C1970441
Finding
Synonym: Coronary heart disease 7
 
Gene (location): CD36 (7q21.11)
 
Monarch Initiative: MONDO:0012585
OMIM®: 610938

Definition

Any coronary artery disease in which the cause of the disease is a mutation in the CD36 gene. [from MONDO]

Professional guidelines

PubMed

Damluji AA, Forman DE, Wang TY, Chikwe J, Kunadian V, Rich MW, Young BA, Page RL 2nd, DeVon HA, Alexander KP; American Heart Association Cardiovascular Disease in Older Populations Committee of the Council on Clinical Cardiology and Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Radiology and Intervention; and Council on Lifestyle and Cardiometabolic Health
Circulation 2023 Jan 17;147(3):e32-e62. Epub 2022 Dec 12 doi: 10.1161/CIR.0000000000001112. PMID: 36503287Free PMC Article
Gornik HL, Persu A, Adlam D, Aparicio LS, Azizi M, Boulanger M, Bruno RM, de Leeuw P, Fendrikova-Mahlay N, Froehlich J, Ganesh SK, Gray BH, Jamison C, Januszewicz A, Jeunemaitre X, Kadian-Dodov D, Kim ES, Kovacic JC, Mace P, Morganti A, Sharma A, Southerland AM, Touzé E, van der Niepen P, Wang J, Weinberg I, Wilson S, Olin JW, Plouin PF
Vasc Med 2019 Apr;24(2):164-189. Epub 2019 Jan 16 doi: 10.1177/1358863X18821816. PMID: 30648921
Nou E, Lo J, Hadigan C, Grinspoon SK
Lancet Diabetes Endocrinol 2016 Jul;4(7):598-610. Epub 2016 Feb 10 doi: 10.1016/S2213-8587(15)00388-5. PMID: 26873066Free PMC Article

Recent clinical studies

Etiology

Gan T, Hu J, Liu W, Li C, Xu Q, Wang Y, Lu S, Aledan AKO, Wang Y, Wang Z
J Am Heart Assoc 2023 Jun 20;12(12):e029689. Epub 2023 Jun 10 doi: 10.1161/JAHA.123.029689. PMID: 37301769Free PMC Article
Luo J, le Cessie S, van Heemst D, Noordam R
J Am Coll Cardiol 2021 Jan 5;77(1):45-54. doi: 10.1016/j.jacc.2020.10.048. PMID: 33413940
Fan M, Sun D, Zhou T, Heianza Y, Lv J, Li L, Qi L
Eur Heart J 2020 Mar 14;41(11):1182-1189. doi: 10.1093/eurheartj/ehz849. PMID: 31848595Free PMC Article
Jaiswal S, Natarajan P, Silver AJ, Gibson CJ, Bick AG, Shvartz E, McConkey M, Gupta N, Gabriel S, Ardissino D, Baber U, Mehran R, Fuster V, Danesh J, Frossard P, Saleheen D, Melander O, Sukhova GK, Neuberg D, Libby P, Kathiresan S, Ebert BL
N Engl J Med 2017 Jul 13;377(2):111-121. Epub 2017 Jun 21 doi: 10.1056/NEJMoa1701719. PMID: 28636844Free PMC Article
Khera AV, Emdin CA, Drake I, Natarajan P, Bick AG, Cook NR, Chasman DI, Baber U, Mehran R, Rader DJ, Fuster V, Boerwinkle E, Melander O, Orho-Melander M, Ridker PM, Kathiresan S
N Engl J Med 2016 Dec 15;375(24):2349-2358. Epub 2016 Nov 13 doi: 10.1056/NEJMoa1605086. PMID: 27959714Free PMC Article

Diagnosis

Gan T, Hu J, Liu W, Li C, Xu Q, Wang Y, Lu S, Aledan AKO, Wang Y, Wang Z
J Am Heart Assoc 2023 Jun 20;12(12):e029689. Epub 2023 Jun 10 doi: 10.1161/JAHA.123.029689. PMID: 37301769Free PMC Article
Li X, Ma H, Wang X, Feng H, Qi L
Arterioscler Thromb Vasc Biol 2023 Jul;43(7):1324-1333. Epub 2023 May 18 doi: 10.1161/ATVBAHA.123.319290. PMID: 37199161Free PMC Article
Damluji AA, Forman DE, Wang TY, Chikwe J, Kunadian V, Rich MW, Young BA, Page RL 2nd, DeVon HA, Alexander KP; American Heart Association Cardiovascular Disease in Older Populations Committee of the Council on Clinical Cardiology and Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Radiology and Intervention; and Council on Lifestyle and Cardiometabolic Health
Circulation 2023 Jan 17;147(3):e32-e62. Epub 2022 Dec 12 doi: 10.1161/CIR.0000000000001112. PMID: 36503287Free PMC Article
Welsh P, Preiss D, Hayward C, Shah ASV, McAllister D, Briggs A, Boachie C, McConnachie A, Padmanabhan S, Welsh C, Woodward M, Campbell A, Porteous D, Mills NL, Sattar N
Circulation 2019 Jun 11;139(24):2754-2764. Epub 2019 Apr 24 doi: 10.1161/CIRCULATIONAHA.118.038529. PMID: 31014085Free PMC Article
Gornik HL, Persu A, Adlam D, Aparicio LS, Azizi M, Boulanger M, Bruno RM, de Leeuw P, Fendrikova-Mahlay N, Froehlich J, Ganesh SK, Gray BH, Jamison C, Januszewicz A, Jeunemaitre X, Kadian-Dodov D, Kim ES, Kovacic JC, Mace P, Morganti A, Sharma A, Southerland AM, Touzé E, van der Niepen P, Wang J, Weinberg I, Wilson S, Olin JW, Plouin PF
Vasc Med 2019 Apr;24(2):164-189. Epub 2019 Jan 16 doi: 10.1177/1358863X18821816. PMID: 30648921

Therapy

Gan T, Hu J, Liu W, Li C, Xu Q, Wang Y, Lu S, Aledan AKO, Wang Y, Wang Z
J Am Heart Assoc 2023 Jun 20;12(12):e029689. Epub 2023 Jun 10 doi: 10.1161/JAHA.123.029689. PMID: 37301769Free PMC Article
Yu Chen H, Dina C, Small AM, Shaffer CM, Levinson RT, Helgadóttir A, Capoulade R, Munter HM, Martinsson A, Cairns BJ, Trudsø LC, Hoekstra M, Burr HA, Marsh TW, Damrauer SM, Dufresne L, Le Scouarnec S, Messika-Zeitoun D, Ranatunga DK, Whitmer RA, Bonnefond A, Sveinbjornsson G, Daníelsen R, Arnar DO, Thorgeirsson G, Thorsteinsdottir U, Gudbjartsson DF, Hólm H, Ghouse J, Olesen MS, Christensen AH, Mikkelsen S, Jacobsen RL, Dowsett J, Pedersen OBV, Erikstrup C, Ostrowski SR; Regeneron Genetics Center, O'Donnell CJ, Budoff MJ, Gudnason V, Post WS, Rotter JI, Lathrop M, Bundgaard H, Johansson B, Ljungberg J, Näslund U, Le Tourneau T, Smith JG, Wells QS, Söderberg S, Stefánsson K, Schott JJ, Rader DJ, Clarke R, Engert JC, Thanassoulis G
Eur Heart J 2023 Jun 1;44(21):1927-1939. doi: 10.1093/eurheartj/ehad142. PMID: 37038246Free PMC Article
Luo J, le Cessie S, van Heemst D, Noordam R
J Am Coll Cardiol 2021 Jan 5;77(1):45-54. doi: 10.1016/j.jacc.2020.10.048. PMID: 33413940
Vujkovic M, Keaton JM, Lynch JA, Miller DR, Zhou J, Tcheandjieu C, Huffman JE, Assimes TL, Lorenz K, Zhu X, Hilliard AT, Judy RL, Huang J, Lee KM, Klarin D, Pyarajan S, Danesh J, Melander O, Rasheed A, Mallick NH, Hameed S, Qureshi IH, Afzal MN, Malik U, Jalal A, Abbas S, Sheng X, Gao L, Kaestner KH, Susztak K, Sun YV, DuVall SL, Cho K, Lee JS, Gaziano JM, Phillips LS, Meigs JB, Reaven PD, Wilson PW, Edwards TL, Rader DJ, Damrauer SM, O'Donnell CJ, Tsao PS; HPAP Consortium; Regeneron Genetics Center; VA Million Veteran Program, Chang KM, Voight BF, Saleheen D
Nat Genet 2020 Jul;52(7):680-691. Epub 2020 Jun 15 doi: 10.1038/s41588-020-0637-y. PMID: 32541925Free PMC Article
Gornik HL, Persu A, Adlam D, Aparicio LS, Azizi M, Boulanger M, Bruno RM, de Leeuw P, Fendrikova-Mahlay N, Froehlich J, Ganesh SK, Gray BH, Jamison C, Januszewicz A, Jeunemaitre X, Kadian-Dodov D, Kim ES, Kovacic JC, Mace P, Morganti A, Sharma A, Southerland AM, Touzé E, van der Niepen P, Wang J, Weinberg I, Wilson S, Olin JW, Plouin PF
Vasc Med 2019 Apr;24(2):164-189. Epub 2019 Jan 16 doi: 10.1177/1358863X18821816. PMID: 30648921

Prognosis

Damluji AA, Forman DE, Wang TY, Chikwe J, Kunadian V, Rich MW, Young BA, Page RL 2nd, DeVon HA, Alexander KP; American Heart Association Cardiovascular Disease in Older Populations Committee of the Council on Clinical Cardiology and Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Radiology and Intervention; and Council on Lifestyle and Cardiometabolic Health
Circulation 2023 Jan 17;147(3):e32-e62. Epub 2022 Dec 12 doi: 10.1161/CIR.0000000000001112. PMID: 36503287Free PMC Article
Fan M, Sun D, Zhou T, Heianza Y, Lv J, Li L, Qi L
Eur Heart J 2020 Mar 14;41(11):1182-1189. doi: 10.1093/eurheartj/ehz849. PMID: 31848595Free PMC Article
Gornik HL, Persu A, Adlam D, Aparicio LS, Azizi M, Boulanger M, Bruno RM, de Leeuw P, Fendrikova-Mahlay N, Froehlich J, Ganesh SK, Gray BH, Jamison C, Januszewicz A, Jeunemaitre X, Kadian-Dodov D, Kim ES, Kovacic JC, Mace P, Morganti A, Sharma A, Southerland AM, Touzé E, van der Niepen P, Wang J, Weinberg I, Wilson S, Olin JW, Plouin PF
Vasc Med 2019 Apr;24(2):164-189. Epub 2019 Jan 16 doi: 10.1177/1358863X18821816. PMID: 30648921
Said MA, Verweij N, van der Harst P
JAMA Cardiol 2018 Aug 1;3(8):693-702. doi: 10.1001/jamacardio.2018.1717. PMID: 29955826Free PMC Article
Khera AV, Emdin CA, Drake I, Natarajan P, Bick AG, Cook NR, Chasman DI, Baber U, Mehran R, Rader DJ, Fuster V, Boerwinkle E, Melander O, Orho-Melander M, Ridker PM, Kathiresan S
N Engl J Med 2016 Dec 15;375(24):2349-2358. Epub 2016 Nov 13 doi: 10.1056/NEJMoa1605086. PMID: 27959714Free PMC Article

Clinical prediction guides

Fan M, Sun D, Zhou T, Heianza Y, Lv J, Li L, Qi L
Eur Heart J 2020 Mar 14;41(11):1182-1189. doi: 10.1093/eurheartj/ehz849. PMID: 31848595Free PMC Article
Gornik HL, Persu A, Adlam D, Aparicio LS, Azizi M, Boulanger M, Bruno RM, de Leeuw P, Fendrikova-Mahlay N, Froehlich J, Ganesh SK, Gray BH, Jamison C, Januszewicz A, Jeunemaitre X, Kadian-Dodov D, Kim ES, Kovacic JC, Mace P, Morganti A, Sharma A, Southerland AM, Touzé E, van der Niepen P, Wang J, Weinberg I, Wilson S, Olin JW, Plouin PF
Vasc Med 2019 Apr;24(2):164-189. Epub 2019 Jan 16 doi: 10.1177/1358863X18821816. PMID: 30648921
Said MA, Verweij N, van der Harst P
JAMA Cardiol 2018 Aug 1;3(8):693-702. doi: 10.1001/jamacardio.2018.1717. PMID: 29955826Free PMC Article
Khera AV, Emdin CA, Drake I, Natarajan P, Bick AG, Cook NR, Chasman DI, Baber U, Mehran R, Rader DJ, Fuster V, Boerwinkle E, Melander O, Orho-Melander M, Ridker PM, Kathiresan S
N Engl J Med 2016 Dec 15;375(24):2349-2358. Epub 2016 Nov 13 doi: 10.1056/NEJMoa1605086. PMID: 27959714Free PMC Article
Nikpay M, Goel A, Won HH, Hall LM, Willenborg C, Kanoni S, Saleheen D, Kyriakou T, Nelson CP, Hopewell JC, Webb TR, Zeng L, Dehghan A, Alver M, Armasu SM, Auro K, Bjonnes A, Chasman DI, Chen S, Ford I, Franceschini N, Gieger C, Grace C, Gustafsson S, Huang J, Hwang SJ, Kim YK, Kleber ME, Lau KW, Lu X, Lu Y, Lyytikäinen LP, Mihailov E, Morrison AC, Pervjakova N, Qu L, Rose LM, Salfati E, Saxena R, Scholz M, Smith AV, Tikkanen E, Uitterlinden A, Yang X, Zhang W, Zhao W, de Andrade M, de Vries PS, van Zuydam NR, Anand SS, Bertram L, Beutner F, Dedoussis G, Frossard P, Gauguier D, Goodall AH, Gottesman O, Haber M, Han BG, Huang J, Jalilzadeh S, Kessler T, König IR, Lannfelt L, Lieb W, Lind L, Lindgren CM, Lokki ML, Magnusson PK, Mallick NH, Mehra N, Meitinger T, Memon FU, Morris AP, Nieminen MS, Pedersen NL, Peters A, Rallidis LS, Rasheed A, Samuel M, Shah SH, Sinisalo J, Stirrups KE, Trompet S, Wang L, Zaman KS, Ardissino D, Boerwinkle E, Borecki IB, Bottinger EP, Buring JE, Chambers JC, Collins R, Cupples LA, Danesh J, Demuth I, Elosua R, Epstein SE, Esko T, Feitosa MF, Franco OH, Franzosi MG, Granger CB, Gu D, Gudnason V, Hall AS, Hamsten A, Harris TB, Hazen SL, Hengstenberg C, Hofman A, Ingelsson E, Iribarren C, Jukema JW, Karhunen PJ, Kim BJ, Kooner JS, Kullo IJ, Lehtimäki T, Loos RJF, Melander O, Metspalu A, März W, Palmer CN, Perola M, Quertermous T, Rader DJ, Ridker PM, Ripatti S, Roberts R, Salomaa V, Sanghera DK, Schwartz SM, Seedorf U, Stewart AF, Stott DJ, Thiery J, Zalloua PA, O'Donnell CJ, Reilly MP, Assimes TL, Thompson JR, Erdmann J, Clarke R, Watkins H, Kathiresan S, McPherson R, Deloukas P, Schunkert H, Samani NJ, Farrall M
Nat Genet 2015 Oct;47(10):1121-1130. Epub 2015 Sep 7 doi: 10.1038/ng.3396. PMID: 26343387Free PMC Article

Recent systematic reviews

Gill D, Cameron AC, Burgess S, Li X, Doherty DJ, Karhunen V, Abdul-Rahim AH, Taylor-Rowan M, Zuber V, Tsao PS, Klarin D; VA Million Veteran Program, Evangelou E, Elliott P, Damrauer SM, Quinn TJ, Dehghan A, Theodoratou E, Dawson J, Tzoulaki I
Hypertension 2021 Feb;77(2):383-392. Epub 2020 Dec 28 doi: 10.1161/HYPERTENSIONAHA.120.16547. PMID: 33356394Free PMC Article
Song C, Burgess S, Eicher JD, O'Donnell CJ, Johnson AD
J Am Heart Assoc 2017 May 26;6(6) doi: 10.1161/JAHA.116.004918. PMID: 28550093Free PMC Article
Pulido-Gómez K, Hernández-Díaz Y, Tovilla-Zárate CA, Juárez-Rojop IE, González-Castro TB, López-Narváez ML, Alpuin-Reyes M
Arch Med Res 2016 Oct;47(7):557-572. doi: 10.1016/j.arcmed.2016.11.006. PMID: 28262198
Lu Y, Boer JM, Barsova RM, Favorova O, Goel A, Müller M, Feskens EJ; PROCARDIS CARDIoGRAM Consortium
BMC Med Genet 2012 May 18;13:39. doi: 10.1186/1471-2350-13-39. PMID: 22607024Free PMC Article
Zhang HF, Xie SL, Wang JF, Chen YX, Wang Y, Huang TC
Thromb Res 2011 May;127(5):400-5. Epub 2011 Feb 5 doi: 10.1016/j.thromres.2010.12.018. PMID: 21296384

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