U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mycobacterium tuberculosis, protection against

MedGen UID:
370720
Concept ID:
C1969665
Finding
Synonym: MYCOBACTERIUM TUBERCULOSIS, PROTECTION AGAINST
 
OMIM®: 107470; 147570; 606252; 607948

Professional guidelines

PubMed

Ganchua SK, Maiello P, Chao M, Hopkins F, Mugahid D, Lin PL, Fortune SM, Flynn JL
Infect Immun 2024 Apr 9;92(4):e0053523. Epub 2024 Mar 22 doi: 10.1128/iai.00535-23. PMID: 38514467Free PMC Article
Piñeros AR, Campos LW, Fonseca DM, Bertolini TB, Gembre AF, Prado RQ, Alves-Filho JC, Ramos SG, Russo M, Bonato VL
Sci Rep 2017 Jan 27;7:41240. doi: 10.1038/srep41240. PMID: 28128217Free PMC Article

Recent clinical studies

Etiology

Motta I, Boeree M, Chesov D, Dheda K, Günther G, Horsburgh CR Jr, Kherabi Y, Lange C, Lienhardt C, McIlleron HM, Paton NI, Stagg HR, Thwaites G, Udwadia Z, Van Crevel R, Velásquez GE, Wilkinson RJ, Guglielmetti L; Study group on Mycobacteria (ESGMYC) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID)
Clin Microbiol Infect 2024 Sep;30(9):1107-1114. Epub 2023 Jul 22 doi: 10.1016/j.cmi.2023.07.013. PMID: 37482332
Martinez L, Cords O, Liu Q, Acuna-Villaorduna C, Bonnet M, Fox GJ, Carvalho ACC, Chan PC, Croda J, Hill PC, Lopez-Varela E, Donkor S, Fielding K, Graham SM, Espinal MA, Kampmann B, Reingold A, Huerga H, Villalba JA, Grandjean L, Sotgiu G, Egere U, Singh S, Zhu L, Lienhardt C, Denholm JT, Seddon JA, Whalen CC, García-Basteiro AL, Triasih R, Chen C, Singh J, Huang LM, Sharma S, Hannoun D, Del Corral H, Mandalakas AM, Malone LL, Ling DL, Kritski A, Stein CM, Vashishtha R, Boulahbal F, Fang CT, Boom WH, Netto EM, Lemos AC, Hesseling AC, Kay A, Jones-López EC, Horsburgh CR, Lange C, Andrews JR
Lancet Glob Health 2022 Sep;10(9):e1307-e1316. doi: 10.1016/S2214-109X(22)00283-2. PMID: 35961354Free PMC Article
Kohli M, Schiller I, Dendukuri N, Yao M, Dheda K, Denkinger CM, Schumacher SG, Steingart KR
Cochrane Database Syst Rev 2021 Jan 15;1(1):CD012768. doi: 10.1002/14651858.CD012768.pub3. PMID: 33448348Free PMC Article
Basu Roy R, Whittaker E, Seddon JA, Kampmann B
Lancet Infect Dis 2019 Mar;19(3):e96-e108. Epub 2018 Oct 12 doi: 10.1016/S1473-3099(18)30157-9. PMID: 30322790Free PMC Article
Nemes E, Geldenhuys H, Rozot V, Rutkowski KT, Ratangee F, Bilek N, Mabwe S, Makhethe L, Erasmus M, Toefy A, Mulenga H, Hanekom WA, Self SG, Bekker LG, Ryall R, Gurunathan S, DiazGranados CA, Andersen P, Kromann I, Evans T, Ellis RD, Landry B, Hokey DA, Hopkins R, Ginsberg AM, Scriba TJ, Hatherill M; C-040-404 Study Team
N Engl J Med 2018 Jul 12;379(2):138-149. doi: 10.1056/NEJMoa1714021. PMID: 29996082Free PMC Article

Diagnosis

Martinez L, Cords O, Liu Q, Acuna-Villaorduna C, Bonnet M, Fox GJ, Carvalho ACC, Chan PC, Croda J, Hill PC, Lopez-Varela E, Donkor S, Fielding K, Graham SM, Espinal MA, Kampmann B, Reingold A, Huerga H, Villalba JA, Grandjean L, Sotgiu G, Egere U, Singh S, Zhu L, Lienhardt C, Denholm JT, Seddon JA, Whalen CC, García-Basteiro AL, Triasih R, Chen C, Singh J, Huang LM, Sharma S, Hannoun D, Del Corral H, Mandalakas AM, Malone LL, Ling DL, Kritski A, Stein CM, Vashishtha R, Boulahbal F, Fang CT, Boom WH, Netto EM, Lemos AC, Hesseling AC, Kay A, Jones-López EC, Horsburgh CR, Lange C, Andrews JR
Lancet Glob Health 2022 Sep;10(9):e1307-e1316. doi: 10.1016/S2214-109X(22)00283-2. PMID: 35961354Free PMC Article
Kohli M, Schiller I, Dendukuri N, Yao M, Dheda K, Denkinger CM, Schumacher SG, Steingart KR
Cochrane Database Syst Rev 2021 Jan 15;1(1):CD012768. doi: 10.1002/14651858.CD012768.pub3. PMID: 33448348Free PMC Article
Nemes E, Geldenhuys H, Rozot V, Rutkowski KT, Ratangee F, Bilek N, Mabwe S, Makhethe L, Erasmus M, Toefy A, Mulenga H, Hanekom WA, Self SG, Bekker LG, Ryall R, Gurunathan S, DiazGranados CA, Andersen P, Kromann I, Evans T, Ellis RD, Landry B, Hokey DA, Hopkins R, Ginsberg AM, Scriba TJ, Hatherill M; C-040-404 Study Team
N Engl J Med 2018 Jul 12;379(2):138-149. doi: 10.1056/NEJMoa1714021. PMID: 29996082Free PMC Article
Lange C, Chesov D, Heyckendorf J, Leung CC, Udwadia Z, Dheda K
Respirology 2018 Jul;23(7):656-673. Epub 2018 Apr 11 doi: 10.1111/resp.13304. PMID: 29641838
Lu J, Holmgren A
Free Radic Biol Med 2014 Jan;66:75-87. Epub 2013 Jul 27 doi: 10.1016/j.freeradbiomed.2013.07.036. PMID: 23899494

Therapy

Motta I, Boeree M, Chesov D, Dheda K, Günther G, Horsburgh CR Jr, Kherabi Y, Lange C, Lienhardt C, McIlleron HM, Paton NI, Stagg HR, Thwaites G, Udwadia Z, Van Crevel R, Velásquez GE, Wilkinson RJ, Guglielmetti L; Study group on Mycobacteria (ESGMYC) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID)
Clin Microbiol Infect 2024 Sep;30(9):1107-1114. Epub 2023 Jul 22 doi: 10.1016/j.cmi.2023.07.013. PMID: 37482332
Lange C, Aaby P, Behr MA, Donald PR, Kaufmann SHE, Netea MG, Mandalakas AM
Lancet Infect Dis 2022 Jan;22(1):e2-e12. Epub 2021 Sep 7 doi: 10.1016/S1473-3099(21)00403-5. PMID: 34506734
Moorlag SJCFM, Khan N, Novakovic B, Kaufmann E, Jansen T, van Crevel R, Divangahi M, Netea MG
Cell Rep 2020 May 19;31(7):107634. doi: 10.1016/j.celrep.2020.107634. PMID: 32433977Free PMC Article
Fatima S, Kumari A, Das G, Dwivedi VP
Life Sci 2020 Jul 1;252:117594. Epub 2020 Apr 16 doi: 10.1016/j.lfs.2020.117594. PMID: 32305522
Mascola JR, Fauci AS
Nat Rev Immunol 2020 Feb;20(2):87-88. doi: 10.1038/s41577-019-0243-3. PMID: 31712767Free PMC Article

Prognosis

Martinez L, Cords O, Liu Q, Acuna-Villaorduna C, Bonnet M, Fox GJ, Carvalho ACC, Chan PC, Croda J, Hill PC, Lopez-Varela E, Donkor S, Fielding K, Graham SM, Espinal MA, Kampmann B, Reingold A, Huerga H, Villalba JA, Grandjean L, Sotgiu G, Egere U, Singh S, Zhu L, Lienhardt C, Denholm JT, Seddon JA, Whalen CC, García-Basteiro AL, Triasih R, Chen C, Singh J, Huang LM, Sharma S, Hannoun D, Del Corral H, Mandalakas AM, Malone LL, Ling DL, Kritski A, Stein CM, Vashishtha R, Boulahbal F, Fang CT, Boom WH, Netto EM, Lemos AC, Hesseling AC, Kay A, Jones-López EC, Horsburgh CR, Lange C, Andrews JR
Lancet Glob Health 2022 Sep;10(9):e1307-e1316. doi: 10.1016/S2214-109X(22)00283-2. PMID: 35961354Free PMC Article
Fatima S, Kumari A, Das G, Dwivedi VP
Life Sci 2020 Jul 1;252:117594. Epub 2020 Apr 16 doi: 10.1016/j.lfs.2020.117594. PMID: 32305522
Tait DR, Hatherill M, Van Der Meeren O, Ginsberg AM, Van Brakel E, Salaun B, Scriba TJ, Akite EJ, Ayles HM, Bollaerts A, Demoitié MA, Diacon A, Evans TG, Gillard P, Hellström E, Innes JC, Lempicki M, Malahleha M, Martinson N, Mesia Vela D, Muyoyeta M, Nduba V, Pascal TG, Tameris M, Thienemann F, Wilkinson RJ, Roman F
N Engl J Med 2019 Dec 19;381(25):2429-2439. Epub 2019 Oct 29 doi: 10.1056/NEJMoa1909953. PMID: 31661198
Lange C, Chesov D, Heyckendorf J, Leung CC, Udwadia Z, Dheda K
Respirology 2018 Jul;23(7):656-673. Epub 2018 Apr 11 doi: 10.1111/resp.13304. PMID: 29641838
Jacobs AJ, Mongkolsapaya J, Screaton GR, McShane H, Wilkinson RJ
Tuberculosis (Edinb) 2016 Dec;101:102-113. Epub 2016 Aug 26 doi: 10.1016/j.tube.2016.08.001. PMID: 27865379Free PMC Article

Clinical prediction guides

Musvosvi M, Huang H, Wang C, Xia Q, Rozot V, Krishnan A, Acs P, Cheruku A, Obermoser G, Leslie A, Behar SM, Hanekom WA, Bilek N, Fisher M, Kaufmann SHE, Walzl G, Hatherill M, Davis MM, Scriba TJ; Adolescent Cohort Study team; GC6-74 Consortium
Nat Med 2023 Jan;29(1):258-269. Epub 2023 Jan 5 doi: 10.1038/s41591-022-02110-9. PMID: 36604540Free PMC Article
Kohli M, Schiller I, Dendukuri N, Yao M, Dheda K, Denkinger CM, Schumacher SG, Steingart KR
Cochrane Database Syst Rev 2021 Jan 15;1(1):CD012768. doi: 10.1002/14651858.CD012768.pub3. PMID: 33448348Free PMC Article
Nemes E, Geldenhuys H, Rozot V, Rutkowski KT, Ratangee F, Bilek N, Mabwe S, Makhethe L, Erasmus M, Toefy A, Mulenga H, Hanekom WA, Self SG, Bekker LG, Ryall R, Gurunathan S, DiazGranados CA, Andersen P, Kromann I, Evans T, Ellis RD, Landry B, Hokey DA, Hopkins R, Ginsberg AM, Scriba TJ, Hatherill M; C-040-404 Study Team
N Engl J Med 2018 Jul 12;379(2):138-149. doi: 10.1056/NEJMoa1714021. PMID: 29996082Free PMC Article
Lange C, Chesov D, Heyckendorf J, Leung CC, Udwadia Z, Dheda K
Respirology 2018 Jul;23(7):656-673. Epub 2018 Apr 11 doi: 10.1111/resp.13304. PMID: 29641838
Bañuls AL, Sanou A, Van Anh NT, Godreuil S
J Med Microbiol 2015 Nov;64(11):1261-1269. Epub 2015 Jan 11 doi: 10.1099/jmm.0.000171. PMID: 26385049

Recent systematic reviews

Martinez L, Cords O, Liu Q, Acuna-Villaorduna C, Bonnet M, Fox GJ, Carvalho ACC, Chan PC, Croda J, Hill PC, Lopez-Varela E, Donkor S, Fielding K, Graham SM, Espinal MA, Kampmann B, Reingold A, Huerga H, Villalba JA, Grandjean L, Sotgiu G, Egere U, Singh S, Zhu L, Lienhardt C, Denholm JT, Seddon JA, Whalen CC, García-Basteiro AL, Triasih R, Chen C, Singh J, Huang LM, Sharma S, Hannoun D, Del Corral H, Mandalakas AM, Malone LL, Ling DL, Kritski A, Stein CM, Vashishtha R, Boulahbal F, Fang CT, Boom WH, Netto EM, Lemos AC, Hesseling AC, Kay A, Jones-López EC, Horsburgh CR, Lange C, Andrews JR
Lancet Glob Health 2022 Sep;10(9):e1307-e1316. doi: 10.1016/S2214-109X(22)00283-2. PMID: 35961354Free PMC Article
Kohli M, Schiller I, Dendukuri N, Yao M, Dheda K, Denkinger CM, Schumacher SG, Steingart KR
Cochrane Database Syst Rev 2021 Jan 15;1(1):CD012768. doi: 10.1002/14651858.CD012768.pub3. PMID: 33448348Free PMC Article
Kohli M, Schiller I, Dendukuri N, Dheda K, Denkinger CM, Schumacher SG, Steingart KR
Cochrane Database Syst Rev 2018 Aug 27;8(8):CD012768. doi: 10.1002/14651858.CD012768.pub2. PMID: 30148542Free PMC Article
Roy A, Eisenhut M, Harris RJ, Rodrigues LC, Sridhar S, Habermann S, Snell L, Mangtani P, Adetifa I, Lalvani A, Abubakar I
BMJ 2014 Aug 5;349:g4643. doi: 10.1136/bmj.g4643. PMID: 25097193Free PMC Article
Mangtani P, Abubakar I, Ariti C, Beynon R, Pimpin L, Fine PE, Rodrigues LC, Smith PG, Lipman M, Whiting PF, Sterne JA
Clin Infect Dis 2014 Feb;58(4):470-80. Epub 2013 Dec 13 doi: 10.1093/cid/cit790. PMID: 24336911

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...