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Gallbladder disease 4(GBD4)

MedGen UID:
370601
•Concept ID:
C1969115
•
Disease or Syndrome
Synonym: GBD4
 
Gene (location): ABCG8 (2p21)
 
OMIM®: 611465

Clinical features

From HPO
Cholelithiasis
MedGen UID:
3039
•Concept ID:
C0008350
•
Disease or Syndrome
Hard, pebble-like deposits that form within the gallbladder.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Evidence-based clinical practice guidelines for cholelithiasis 2021.
Fujita N, Yasuda I, Endo I, Isayama H, Iwashita T, Ueki T, Uemura K, Umezawa A, Katanuma A, Katayose Y, Suzuki Y, Shoda J, Tsuyuguchi T, Wakai T, Inui K, Unno M, Takeyama Y, Itoi T, Koike K, Mochida S
J Gastroenterol 2023 Sep;58(9):801-833. Epub 2023 Jul 15 doi: 10.1007/s00535-023-02014-6. PMID: 37452855Free PMC Article
Management and follow-up of gallbladder polyps: updated joint guidelines between the ESGAR, EAES, EFISDS and ESGE.
Foley KG, Lahaye MJ, Thoeni RF, Soltes M, Dewhurst C, Barbu ST, Vashist YK, Rafaelsen SR, Arvanitakis M, Perinel J, Wiles R, Roberts SA
Eur Radiol 2022 May;32(5):3358-3368. Epub 2021 Dec 17 doi: 10.1007/s00330-021-08384-w. PMID: 34918177Free PMC Article
Tokyo Guidelines 2018: surgical management of acute cholecystitis: safe steps in laparoscopic cholecystectomy for acute cholecystitis (with videos).
Wakabayashi G, Iwashita Y, Hibi T, Takada T, Strasberg SM, Asbun HJ, Endo I, Umezawa A, Asai K, Suzuki K, Mori Y, Okamoto K, Pitt HA, Han HS, Hwang TL, Yoon YS, Yoon DS, Choi IS, Huang WS, Giménez ME, Garden OJ, Gouma DJ, Belli G, Dervenis C, Jagannath P, Chan ACW, Lau WY, Liu KH, Su CH, Misawa T, Nakamura M, Horiguchi A, Tagaya N, Fujioka S, Higuchi R, Shikata S, Noguchi Y, Ukai T, Yokoe M, Cherqui D, Honda G, Sugioka A, de Santibañes E, Supe AN, Tokumura H, Kimura T, Yoshida M, Mayumi T, Kitano S, Inomata M, Hirata K, Sumiyama Y, Inui K, Yamamoto M
J Hepatobiliary Pancreat Sci 2018 Jan;25(1):73-86. Epub 2018 Jan 10 doi: 10.1002/jhbp.517. PMID: 29095575

Recent clinical studies

Etiology

Surgical Infection Society Guidelines for Antibiotic Use in Patients Undergoing Cholecystectomy for Gallbladder Disease.
Colling KP, Besshoff KE, Forrester JD, Kendrick D, Mercier P, Huston JM
Surg Infect (Larchmt) 2022 May;23(4):339-350. Epub 2022 Mar 31 doi: 10.1089/sur.2021.207. PMID: 35363086
Acute acalculous cholecystitis in children.
Poddighe D, Sazonov V
World J Gastroenterol 2018 Nov 21;24(43):4870-4879. doi: 10.3748/wjg.v24.i43.4870. PMID: 30487697Free PMC Article
Gallbladder Dysfunction: Cholecystitis, Choledocholithiasis, Cholangitis, and Biliary Dyskinesia.
Wilkins T, Agabin E, Varghese J, Talukder A
Prim Care 2017 Dec;44(4):575-597. Epub 2017 Oct 5 doi: 10.1016/j.pop.2017.07.002. PMID: 29132521
Porcelain gallbladder.
Ansari S
Indian J Gastroenterol 2014 Jul;33(4):399. doi: 10.1007/s12664-013-0362-x. PMID: 23982704
The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis.
Guh DP, Zhang W, Bansback N, Amarsi Z, Birmingham CL, Anis AH
BMC Public Health 2009 Mar 25;9:88. doi: 10.1186/1471-2458-9-88. PMID: 19320986Free PMC Article

Diagnosis

Acute acalculous cholecystitis in children.
Poddighe D, Sazonov V
World J Gastroenterol 2018 Nov 21;24(43):4870-4879. doi: 10.3748/wjg.v24.i43.4870. PMID: 30487697Free PMC Article
Gallbladder Dysfunction: Cholecystitis, Choledocholithiasis, Cholangitis, and Biliary Dyskinesia.
Wilkins T, Agabin E, Varghese J, Talukder A
Prim Care 2017 Dec;44(4):575-597. Epub 2017 Oct 5 doi: 10.1016/j.pop.2017.07.002. PMID: 29132521
Gallbladder disease in children.
Rothstein DH, Harmon CM
Semin Pediatr Surg 2016 Aug;25(4):225-31. Epub 2016 May 11 doi: 10.1053/j.sempedsurg.2016.05.005. PMID: 27521713
Preface.
St Peter SD, Snyder CL
Semin Pediatr Surg 2016 Aug;25(4):197. Epub 2016 May 24 doi: 10.1053/j.sempedsurg.2016.05.008. PMID: 27521707
Intraoperative ultrasound.
Machi J, Oishi AJ, Furumoto NL, Oishi RH
Surg Clin North Am 2004 Aug;84(4):1085-111, vi-i. doi: 10.1016/j.suc.2004.04.001. PMID: 15261754

Therapy

Surgical Infection Society Guidelines for Antibiotic Use in Patients Undergoing Cholecystectomy for Gallbladder Disease.
Colling KP, Besshoff KE, Forrester JD, Kendrick D, Mercier P, Huston JM
Surg Infect (Larchmt) 2022 May;23(4):339-350. Epub 2022 Mar 31 doi: 10.1089/sur.2021.207. PMID: 35363086
Acute Cholecystitis: A Review.
Gallaher JR, Charles A
JAMA 2022 Mar 8;327(10):965-975. doi: 10.1001/jama.2022.2350. PMID: 35258527
Single-cell RNA-sequencing atlas reveals an MDK-dependent immunosuppressive environment in ErbB pathway-mutated gallbladder cancer.
Zhang Y, Zuo C, Liu L, Hu Y, Yang B, Qiu S, Li Y, Cao D, Ju Z, Ge J, Wang Q, Wang T, Bai L, Yang Y, Li G, Shao Z, Gao Y, Li Y, Bian R, Miao H, Li L, Li X, Jiang C, Yan S, Wang Z, Wang Z, Cui X, Huang W, Xiang D, Wang C, Li Q, Wu X, Gong W, Liu Y, Shao R, Liu F, Li M, Chen L, Liu Y
J Hepatol 2021 Nov;75(5):1128-1141. Epub 2021 Jun 23 doi: 10.1016/j.jhep.2021.06.023. PMID: 34171432
Acute acalculous cholecystitis in children.
Poddighe D, Sazonov V
World J Gastroenterol 2018 Nov 21;24(43):4870-4879. doi: 10.3748/wjg.v24.i43.4870. PMID: 30487697Free PMC Article
Management of gallstones.
Bellows CF, Berger DH, Crass RA
Am Fam Physician 2005 Aug 15;72(4):637-42. PMID: 16127953

Prognosis

Differences in the incidence and mortality of digestive cancer between Global Cancer Observatory 2020 and Global Burden of Disease 2019.
Yu Z, Bai X, Zhou R, Ruan G, Guo M, Han W, Jiang S, Yang H
Int J Cancer 2024 Feb 15;154(4):615-625. Epub 2023 Sep 26 doi: 10.1002/ijc.34740. PMID: 37750191
Acute acalculous cholecystitis in children.
Poddighe D, Sazonov V
World J Gastroenterol 2018 Nov 21;24(43):4870-4879. doi: 10.3748/wjg.v24.i43.4870. PMID: 30487697Free PMC Article
Gallstone ileus.
Willekens I, Verdries D, Ceulemans G, Vandenbroucke F, Delvaux G, de Mey J
JBR-BTR 2010 Jan-Feb;93(1):4-6. doi: 10.5334/jbr-btr.24. PMID: 20397425
The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis.
Guh DP, Zhang W, Bansback N, Amarsi Z, Birmingham CL, Anis AH
BMC Public Health 2009 Mar 25;9:88. doi: 10.1186/1471-2458-9-88. PMID: 19320986Free PMC Article
Primary carcinoma of the gallbladder.
Paraskevopoulos JA, Dennison AR, Johnson AG
HPB Surg 1991;4(4):277-89. doi: 10.1155/1991/92731. PMID: 1810370Free PMC Article

Clinical prediction guides

Increasing gallstone disease prevalence and associations with gallbladder and biliary tract mortality in the US.
Unalp-Arida A, Ruhl CE
Hepatology 2023 Jun 1;77(6):1882-1895. Epub 2023 Jan 13 doi: 10.1097/HEP.0000000000000264. PMID: 36631004
Acute Cholecystitis: A Review.
Gallaher JR, Charles A
JAMA 2022 Mar 8;327(10):965-975. doi: 10.1001/jama.2022.2350. PMID: 35258527
Acute acalculous cholecystitis in children.
Poddighe D, Sazonov V
World J Gastroenterol 2018 Nov 21;24(43):4870-4879. doi: 10.3748/wjg.v24.i43.4870. PMID: 30487697Free PMC Article
The Parkland grading scale for cholecystitis.
Madni TD, Leshikar DE, Minshall CT, Nakonezny PA, Cornelius CC, Imran JB, Clark AT, Williams BH, Eastman AL, Minei JP, Phelan HA, Cripps MW
Am J Surg 2018 Apr;215(4):625-630. Epub 2017 Jun 6 doi: 10.1016/j.amjsurg.2017.05.017. PMID: 28619262
Imaging of cholecystitis.
O'Connor OJ, Maher MM
AJR Am J Roentgenol 2011 Apr;196(4):W367-74. doi: 10.2214/AJR.10.4340. PMID: 21427298

Recent systematic reviews

Role of semaglutide in the treatment of nonalcoholic fatty liver disease or non-alcoholic steatohepatitis: A systematic review and meta-analysis.
Bandyopadhyay S, Das S, Samajdar SS, Joshi SR
Diabetes Metab Syndr 2023 Oct;17(10):102849. Epub 2023 Sep 13 doi: 10.1016/j.dsx.2023.102849. PMID: 37717295
Long-term hormone therapy for perimenopausal and postmenopausal women.
Marjoribanks J, Farquhar C, Roberts H, Lethaby A, Lee J
Cochrane Database Syst Rev 2017 Jan 17;1(1):CD004143. doi: 10.1002/14651858.CD004143.pub5. PMID: 28093732Free PMC Article
Open versus laparoscopic cholecystectomy in acute cholecystitis. Systematic review and meta-analysis.
Coccolini F, Catena F, Pisano M, Gheza F, Fagiuoli S, Di Saverio S, Leandro G, Montori G, Ceresoli M, Corbella D, Sartelli M, Sugrue M, Ansaloni L
Int J Surg 2015 Jun;18:196-204. Epub 2015 May 6 doi: 10.1016/j.ijsu.2015.04.083. PMID: 25958296
Subtotal cholecystectomy for "difficult gallbladders": systematic review and meta-analysis.
Elshaer M, Gravante G, Thomas K, Sorge R, Al-Hamali S, Ebdewi H
JAMA Surg 2015 Feb;150(2):159-68. doi: 10.1001/jamasurg.2014.1219. PMID: 25548894
The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis.
Guh DP, Zhang W, Bansback N, Amarsi Z, Birmingham CL, Anis AH
BMC Public Health 2009 Mar 25;9:88. doi: 10.1186/1471-2458-9-88. PMID: 19320986Free PMC Article

Supplemental Content

Table of contents

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      OMIM records containing genes associated with phenotypes registered in MedGen
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