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Asthma, aspirin-induced, susceptibility to

MedGen UID:
362637
•Concept ID:
C1876174
•
Finding
Synonym: ASTHMA, ASPIRIN-INDUCED, SUSCEPTIBILITY TO
 
Monarch Initiative: MONDO:0800415
OMIM®: 176804; 208550; 604895

Professional guidelines

PubMed

Bax-gene transfer enhances apoptosis by steroid treatment in human nasal fibroblasts.
Kimura Y, Sugimoto C, Takabayashi T, Tanaka T, Kojima A, Narita N, Fujieda S
Eur Arch Otorhinolaryngol 2010 Jan;267(1):61-6. doi: 10.1007/s00405-009-1053-1. PMID: 19636580
Update on recent advances in the management of aspirin exacerbated respiratory disease.
Palikhe NS, Kim JH, Park HS
Yonsei Med J 2009 Dec 31;50(6):744-50. Epub 2009 Dec 18 doi: 10.3349/ymj.2009.50.6.744. PMID: 20046412Free PMC Article

Recent clinical studies

Etiology

Single nucleotide polymorphisms in TNF are associated with susceptibility to aspirin-exacerbated respiratory disease but not to cytokine levels: a study in Mexican mestizo population.
Pavón-Romero GF, Reséndiz-Hernández JM, Ramírez-Jiménez F, Pérez-Rubio G, Camarena Á, Terán LM, Falfán-Valencia R
Biomark Med 2017 Dec;11(12):1047-1055. Epub 2017 Nov 27 doi: 10.2217/bmm-2017-0164. PMID: 29172674
Association of TRPM3 Polymorphism (rs10780946) and Aspirin-Exacerbated Respiratory Disease (AERD).
Narayanankutty A, Palma-Lara I, Pavón-Romero G, Pérez-Rubio G, Camarena Á, Teran LM, Falfán-Valencia R
Lung 2016 Apr;194(2):273-9. Epub 2016 Feb 18 doi: 10.1007/s00408-016-9852-9. PMID: 26891941
Aspirin or other nonsteroidal inflammatory agent exacerbated asthma.
Ledford DK, Wenzel SE, Lockey RF
J Allergy Clin Immunol Pract 2014 Nov-Dec;2(6):653-7. Epub 2014 Nov 6 doi: 10.1016/j.jaip.2014.09.009. PMID: 25439353
Associations of functional NLRP3 polymorphisms with susceptibility to food-induced anaphylaxis and aspirin-induced asthma.
Hitomi Y, Ebisawa M, Tomikawa M, Imai T, Komata T, Hirota T, Harada M, Sakashita M, Suzuki Y, Shimojo N, Kohno Y, Fujita K, Miyatake A, Doi S, Enomoto T, Taniguchi M, Higashi N, Nakamura Y, Tamari M
J Allergy Clin Immunol 2009 Oct;124(4):779-85.e6. Epub 2009 Sep 19 doi: 10.1016/j.jaci.2009.07.044. PMID: 19767079
Pathogenesis of nonsteroidal antiinflammatory drug-induced asthma.
Kim SH, Park HS
Curr Opin Allergy Clin Immunol 2006 Feb;6(1):17-22. doi: 10.1097/01.all.0000199794.79551.ec. PMID: 16505607

Diagnosis

Aspirin Sensitivity in Patients with Moderate to Severe Asthma.
Arshi S, Eslami N, Nabavi M, Bemanian MH, Fallahpour M, Shokri S, Ahmadian J, Molatefi R, Darabi K, Sedighi GR, Moinfar Z, Darougar S
Iran J Allergy Asthma Immunol 2020 Aug 25;19(4):447-451. doi: 10.18502/ijaai.v19i4.4120. PMID: 33463111
Upper airways in aspirin-exacerbated respiratory disease.
Choi JH, Kim JH, Park HS
Curr Opin Allergy Clin Immunol 2015 Feb;15(1):21-6. doi: 10.1097/ACI.0000000000000122. PMID: 25546326
Aspirin or other nonsteroidal inflammatory agent exacerbated asthma.
Ledford DK, Wenzel SE, Lockey RF
J Allergy Clin Immunol Pract 2014 Nov-Dec;2(6):653-7. Epub 2014 Nov 6 doi: 10.1016/j.jaip.2014.09.009. PMID: 25439353
HLA and asthma phenotypes/endotypes: a review.
Kontakioti E, Domvri K, Papakosta D, Daniilidis M
Hum Immunol 2014 Aug;75(8):930-9. Epub 2014 Jun 30 doi: 10.1016/j.humimm.2014.06.022. PMID: 24994462
Genetic markers for differentiating aspirin-hypersensitivity.
Kim SH, Park HS
Yonsei Med J 2006 Feb 28;47(1):15-21. doi: 10.3349/ymj.2006.47.1.15. PMID: 16502481Free PMC Article

Therapy

Inheritance of NSAID-Exacerbated Respiratory Disease.
Suikkila A, Lyly A, Hafrén L, Saarinen R, Klockars T
Otolaryngol Head Neck Surg 2023 Mar;168(3):540-543. Epub 2023 Jan 29 doi: 10.1177/01945998221102085. PMID: 35639475
Aspirin Sensitivity in Patients with Moderate to Severe Asthma.
Arshi S, Eslami N, Nabavi M, Bemanian MH, Fallahpour M, Shokri S, Ahmadian J, Molatefi R, Darabi K, Sedighi GR, Moinfar Z, Darougar S
Iran J Allergy Asthma Immunol 2020 Aug 25;19(4):447-451. doi: 10.18502/ijaai.v19i4.4120. PMID: 33463111
Aspirin or other nonsteroidal inflammatory agent exacerbated asthma.
Ledford DK, Wenzel SE, Lockey RF
J Allergy Clin Immunol Pract 2014 Nov-Dec;2(6):653-7. Epub 2014 Nov 6 doi: 10.1016/j.jaip.2014.09.009. PMID: 25439353
Genetic markers for differentiating aspirin-hypersensitivity.
Kim SH, Park HS
Yonsei Med J 2006 Feb 28;47(1):15-21. doi: 10.3349/ymj.2006.47.1.15. PMID: 16502481Free PMC Article
The broken balance in aspirin hypersensitivity.
Szczeklik A, Sanak M
Eur J Pharmacol 2006 Mar 8;533(1-3):145-55. Epub 2006 Feb 7 doi: 10.1016/j.ejphar.2005.12.053. PMID: 16457808

Prognosis

Physiopathology and genetics in aspirin-exacerbated respiratory disease.
Pavón-Romero GF, Ramírez-Jiménez F, Roldán-Alvarez MA, Terán LM, Falfán-Valencia R
Exp Lung Res 2017 Oct;43(8):327-335. Epub 2017 Oct 16 doi: 10.1080/01902148.2017.1358776. PMID: 29035123
Upper airways in aspirin-exacerbated respiratory disease.
Choi JH, Kim JH, Park HS
Curr Opin Allergy Clin Immunol 2015 Feb;15(1):21-6. doi: 10.1097/ACI.0000000000000122. PMID: 25546326
Exonic variants associated with development of aspirin exacerbated respiratory diseases.
Shin SW, Park BL, Chang H, Park JS, Bae DJ, Song HJ, Choi IS, Kim MK, Park HS, Kim LH, Namgoong S, Kim JO, Shin HD, Park CS
PLoS One 2014;9(11):e111887. Epub 2014 Nov 5 doi: 10.1371/journal.pone.0111887. PMID: 25372592Free PMC Article
Natural history of aspirin-induced asthma. AIANE Investigators. European Network on Aspirin-Induced Asthma.
Szczeklik A, Nizankowska E, Duplaga M
Eur Respir J 2000 Sep;16(3):432-6. doi: 10.1034/j.1399-3003.2000.016003432.x. PMID: 11028656
LTC4 synthase. Enzymology, biochemistry, and molecular characterization.
Penrose JF
Clin Rev Allergy Immunol 1999 Spring-Summer;17(1-2):133-52. doi: 10.1007/BF02737601. PMID: 10436863

Clinical prediction guides

Aspirin Sensitivity in Patients with Moderate to Severe Asthma.
Arshi S, Eslami N, Nabavi M, Bemanian MH, Fallahpour M, Shokri S, Ahmadian J, Molatefi R, Darabi K, Sedighi GR, Moinfar Z, Darougar S
Iran J Allergy Asthma Immunol 2020 Aug 25;19(4):447-451. doi: 10.18502/ijaai.v19i4.4120. PMID: 33463111
Physiopathology and genetics in aspirin-exacerbated respiratory disease.
Pavón-Romero GF, Ramírez-Jiménez F, Roldán-Alvarez MA, Terán LM, Falfán-Valencia R
Exp Lung Res 2017 Oct;43(8):327-335. Epub 2017 Oct 16 doi: 10.1080/01902148.2017.1358776. PMID: 29035123
Upper airways in aspirin-exacerbated respiratory disease.
Choi JH, Kim JH, Park HS
Curr Opin Allergy Clin Immunol 2015 Feb;15(1):21-6. doi: 10.1097/ACI.0000000000000122. PMID: 25546326
Exonic variants associated with development of aspirin exacerbated respiratory diseases.
Shin SW, Park BL, Chang H, Park JS, Bae DJ, Song HJ, Choi IS, Kim MK, Park HS, Kim LH, Namgoong S, Kim JO, Shin HD, Park CS
PLoS One 2014;9(11):e111887. Epub 2014 Nov 5 doi: 10.1371/journal.pone.0111887. PMID: 25372592Free PMC Article
Potential association between ANXA4 polymorphisms and aspirin-exacerbated respiratory disease.
Park TJ, Kim JH, Bae JS, Park BL, Cheong HS, Pasaje CF, Park JS, Uh ST, Kim MK, Choi IS, Park CS, Shin HD
Diagn Mol Pathol 2012 Sep;21(3):164-71. doi: 10.1097/PDM.0b013e3182461d0d. PMID: 22847161

Recent systematic reviews

Safety risks for patients with aspirin-exacerbated respiratory disease after acute exposure to selective nonsteroidal anti-inflammatory drugs and COX-2 inhibitors: Meta-analysis of controlled clinical trials.
Morales DR, Lipworth BJ, Guthrie B, Jackson C, Donnan PT, Santiago VH
J Allergy Clin Immunol 2014 Jul;134(1):40-5. Epub 2013 Dec 31 doi: 10.1016/j.jaci.2013.10.057. PMID: 24388008

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