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Schizophrenia 6(SCZD6)

MedGen UID:: 350380
•Concept ID:: C1864275
•: Disease or Syndrome

Synonyms:	SCHIZOPHRENIA SUSCEPTIBILITY LOCUS, CHROMOSOME 8p-RELATED; SCZD6

Gene (location): Gene(s) directly associated with this condition or phenotype.	NRG1 (8p12)

Monarch Initiative:	MONDO:0011280
OMIM®:	603013

Definition

A schizophrenia that has material basis in an autosomal dominant mutation of SCZD6 on chromosome 8p21. [from MONDO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVSchizophrenia
- CROGVChromosome 2p16.3 deletion syndrome
- CROGVSchizophrenia 1
- CROGVSchizophrenia 2
- CROGVSchizophrenia 3
- CROGVSchizophrenia 4
- CROGVSchizophrenia 5
- CROGVSchizophrenia 6
- CROGVSchizophrenia 7
- CROGVSchizophrenia 8
- CROGVSchizophrenia 9
- CROGVSchizophrenia 10
- CROGVSchizophrenia 11
- CROGVSchizophrenia 12
- CROGVSchizophrenia 13
- CROGVSchizophrenia 14
- CROGVSchizophrenia 15
- CROGVSchizophrenia 16
- CROGVSchizophrenia 18
- CROGVSchizophrenia 19

Abnormality of the nervous system
- Abnormal nervous system physiology
  - Abnormality of mental function
    - Atypical behavior
      - Diagnostic behavioral phenotype
        Schizophrenia
        Schizophrenia 6

Professional guidelines

PubMed

Augmentation of clozapine with amisulpride: an effective therapeutic strategy for violent treatment-resistant schizophrenia patients in a UK high-security hospital.

Hotham JE, Simpson PJ, Brooman-White RS, Basu A, Ross CC, Humphreys SA, Larkin F, Gupta N, Das M
CNS Spectr 2014 Oct;19(5):403-10. Epub 2013 Nov 28 doi: 10.1017/S1092852913000874. PMID: 24284256

Effectiveness of antipsychotic treatment for schizophrenia: 6-month results of the Pan-European Schizophrenia Outpatient Health Outcomes (SOHO) study.

Haro JM, Edgell ET, Novick D, Alonso J, Kennedy L, Jones PB, Ratcliffe M, Breier A; SOHO advisory board
Acta Psychiatr Scand 2005 Mar;111(3):220-31. doi: 10.1111/j.1600-0447.2004.00450.x. PMID: 15701107

The key-lock principle in the diagnosis and treatment of nonorganic insomnia related to psychiatric disorders: sleep laboratory investigations.

Saletu-Zyhlarz GM, Arnold O, Saletu B, Anderer P
Methods Find Exp Clin Pharmacol 2002;24 Suppl D:37-49. PMID: 12575467

See all (3)

Recent clinical studies

Etiology

Medial Frontal Cortex GABA Concentrations in Psychosis Spectrum and Mood Disorders: A Meta-analysis of Proton Magnetic Resonance Spectroscopy Studies.

Simmonite M, Steeby CJ, Taylor SF
Biol Psychiatry 2023 Jan 15;93(2):125-136. Epub 2022 Aug 17 doi: 10.1016/j.biopsych.2022.08.004. PMID: 36335069 Free PMC Article

Assessment of Quality of Life 8-Dimension (AQoL-8D): translation, validation, and application in two Dutch trials in patients with epilepsy and schizophrenia.

Chan HY, Wijnen BFM, Hiligsmann M, Smit F, Leenen LAM, Majoie MHJM, Evers SMAA
Expert Rev Pharmacoecon Outcomes Res 2022 Jul;22(5):795-803. Epub 2021 Sep 26 doi: 10.1080/14737167.2021.1981861. PMID: 34553651 Free PMC Article

Durable Cognitive Gains and Symptom Improvement Are Observed in Individuals With Recent-Onset Schizophrenia 6 Months After a Randomized Trial of Auditory Training Completed Remotely.

Loewy R, Fisher M, Ma S, Carter C, Ragland JD, Niendam TA, Stuart B, Schlosser D, Amirfathi F, Yohannes S, Vinogradov S
Schizophr Bull 2022 Jan 21;48(1):262-272. doi: 10.1093/schbul/sbab102. PMID: 34510196 Free PMC Article

Clinical staging in severe mental disorders; bipolar disorder, depression and schizophrenia.

de la Fuente-Tomas L, Sánchez-Autet M, García-Álvarez L, González-Blanco L, Velasco Á, Sáiz Martínez PA, Garcia-Portilla MP, Bobes J
Rev Psiquiatr Salud Ment (Engl Ed) 2019 Apr-Jun;12(2):106-115. Epub 2018 Oct 9 doi: 10.1016/j.rpsm.2018.08.002. PMID: 30314812

Efficacy and safety of second-generation antipsychotics in children and adolescents with psychotic and bipolar spectrum disorders: comprehensive review of prospective head-to-head and placebo-controlled comparisons.

Fraguas D, Correll CU, Merchán-Naranjo J, Rapado-Castro M, Parellada M, Moreno C, Arango C
Eur Neuropsychopharmacol 2011 Aug;21(8):621-45. Epub 2010 Aug 10 doi: 10.1016/j.euroneuro.2010.07.002. PMID: 20702068

See all (29)

Diagnosis

Stability of schizophrenia diagnosis in a 10-year longitudinal study on first episode of non-affective psychosis: Conclusions from the PAFIP cohort.

Suárez-Pinilla P, Suárez-Pinilla M, Setién-Suero E, Ortiz-García de la Foz V, Mayoral-Van Son J, Vázquez-Bourgon J, Gómez-Revuelta M, Juncal-Ruíz M, Ayesa-Arriola R, Crespo-Facorro B
Acta Psychiatr Scand 2021 Oct;144(4):342-357. Epub 2021 Jul 21 doi: 10.1111/acps.13344. PMID: 34228812

Schizophrenia is a later-onset feature of PCDH19 Girls Clustering Epilepsy.

Vlaskamp DRM, Bassett AS, Sullivan JE, Robblee J, Sadleir LG, Scheffer IE, Andrade DM
Epilepsia 2019 Mar;60(3):429-440. Epub 2019 Mar 3 doi: 10.1111/epi.14678. PMID: 30828795

Clinical staging in severe mental disorders; bipolar disorder, depression and schizophrenia.

Follow-up of subjects with suspected pre-psychotic state in Taiwan.

Liu CC, Lai MC, Liu CM, Chiu YN, Hsieh MH, Hwang TJ, Chien YL, Chen WJ, Hua MS, Hsiung PC, Huang YC, Hwu HG
Schizophr Res 2011 Mar;126(1-3):65-70. Epub 2010 Nov 26 doi: 10.1016/j.schres.2010.10.028. PMID: 21112187

The Roscommon Family Study. I. Methods, diagnosis of probands, and risk of schizophrenia in relatives.

Kendler KS, McGuire M, Gruenberg AM, O'Hare A, Spellman M, Walsh D
Arch Gen Psychiatry 1993 Jul;50(7):527-40. doi: 10.1001/archpsyc.1993.01820190029004. PMID: 8317947

See all (23)

Therapy

The potential use of folate and its derivatives in treating psychiatric disorders: A systematic review.

Lam NSK, Long XX, Li X, Saad M, Lim F, Doery JC, Griffin RC, Galletly C
Biomed Pharmacother 2022 Feb;146:112541. Epub 2021 Dec 22 doi: 10.1016/j.biopha.2021.112541. PMID: 34953391

Assessment of Quality of Life 8-Dimension (AQoL-8D): translation, validation, and application in two Dutch trials in patients with epilepsy and schizophrenia.

Durable Cognitive Gains and Symptom Improvement Are Observed in Individuals With Recent-Onset Schizophrenia 6 Months After a Randomized Trial of Auditory Training Completed Remotely.

Neurocognitive enhancement therapy with work therapy in schizophrenia: 6-month follow-up of neuropsychological performance.

Bell M, Fiszdon J, Greig T, Wexler B, Bryson G
J Rehabil Res Dev 2007;44(5):761-70. doi: 10.1682/jrrd.2007.02.0032. PMID: 17943687

See all (18)

Prognosis

Durable Cognitive Gains and Symptom Improvement Are Observed in Individuals With Recent-Onset Schizophrenia 6 Months After a Randomized Trial of Auditory Training Completed Remotely.

Stability of schizophrenia diagnosis in a 10-year longitudinal study on first episode of non-affective psychosis: Conclusions from the PAFIP cohort.

The 15q11.2 BP1-BP2 Microdeletion (Burnside-Butler) Syndrome: In Silico Analyses of the Four Coding Genes Reveal Functional Associations with Neurodevelopmental Phenotypes.

Rafi SK, Butler MG
Int J Mol Sci 2020 May 6;21(9) doi: 10.3390/ijms21093296. PMID: 32384786 Free PMC Article

Clinical staging in severe mental disorders; bipolar disorder, depression and schizophrenia.

Neurocognitive enhancement therapy with work therapy in schizophrenia: 6-month follow-up of neuropsychological performance.

Bell M, Fiszdon J, Greig T, Wexler B, Bryson G
J Rehabil Res Dev 2007;44(5):761-70. doi: 10.1682/jrrd.2007.02.0032. PMID: 17943687

See all (14)

Clinical prediction guides

Durable Cognitive Gains and Symptom Improvement Are Observed in Individuals With Recent-Onset Schizophrenia 6 Months After a Randomized Trial of Auditory Training Completed Remotely.

The 15q11.2 BP1-BP2 Microdeletion (Burnside-Butler) Syndrome: In Silico Analyses of the Four Coding Genes Reveal Functional Associations with Neurodevelopmental Phenotypes.

Rafi SK, Butler MG
Int J Mol Sci 2020 May 6;21(9) doi: 10.3390/ijms21093296. PMID: 32384786 Free PMC Article

Follow-up of subjects with suspected pre-psychotic state in Taiwan.

Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory.

Cannon TD, Hennah W, van Erp TG, Thompson PM, Lonnqvist J, Huttunen M, Gasperoni T, Tuulio-Henriksson A, Pirkola T, Toga AW, Kaprio J, Mazziotta J, Peltonen L
Arch Gen Psychiatry 2005 Nov;62(11):1205-13. doi: 10.1001/archpsyc.62.11.1205. PMID: 16275808

Efficacy of loxapine in the treatment of paranoid schizophrenia.

Bishop MP, Simpson GM, Dunnett CW, Kiltie H
Psychopharmacology (Berl) 1977 Jan 31;51(2):107-15. doi: 10.1007/BF00431725. PMID: 14350

See all (19)

Recent systematic reviews

The potential use of folate and its derivatives in treating psychiatric disorders: A systematic review.

Lam NSK, Long XX, Li X, Saad M, Lim F, Doery JC, Griffin RC, Galletly C
Biomed Pharmacother 2022 Feb;146:112541. Epub 2021 Dec 22 doi: 10.1016/j.biopha.2021.112541. PMID: 34953391

The vicious circle of social exclusion and psychopathology: a systematic review of experimental ostracism research in psychiatric disorders.

Reinhard MA, Dewald-Kaufmann J, Wüstenberg T, Musil R, Barton BB, Jobst A, Padberg F
Eur Arch Psychiatry Clin Neurosci 2020 Aug;270(5):521-532. Epub 2019 Oct 4 doi: 10.1007/s00406-019-01074-1. PMID: 31586242

See all (2)

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Schizophrenia 6(SCZD6)

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Genetic Testing Registry

Clinical resources

Practice guidelines

Molecular resources

Consumer resources

Reviews

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