Idiopathic scoliosis, an abnormality of the vertebral column in which patients develop lateral curvature of the spine of at least 10 degrees, affects approximately 2 to 3% of the worldwide population and has a heritable component (summary by Bashiardes et al., 2004).
For a discussion of genetic heterogeneity of isolated scoliosis, see IS1 (181800). [from
OMIM]