U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hemoglobin, high altitude adaptation(HALAH)

MedGen UID:
322997
Concept ID:
C1836778
Finding
Synonym: HALAH
 
Gene (location): EGLN1 (1q42.2)
 
OMIM®: 609070

Definition

Individuals with high altitude adaptation hemoglobin can survive in extremely hypoxic conditions without an increase in hematocrit or the development of erythrocytosis or polycythemia vera (summary by Lorenzo et al., 2014). [from OMIM]

Professional guidelines

PubMed

Jiang C, Chen J, Liu F, Luo Y, Xu G, Shen HY, Gao Y, Gao W
BMC Public Health 2014 Jul 9;14:701. doi: 10.1186/1471-2458-14-701. PMID: 25007716Free PMC Article

Recent clinical studies

Etiology

Ge RL, Simonson TS, Gordeuk V, Prchal JT, McClain DA
Exp Physiol 2015 Nov;100(11):1247-55. Epub 2015 Jul 14 doi: 10.1113/EP085292. PMID: 26053282Free PMC Article
Bonne TC, Lundby C, Jørgensen S, Johansen L, Mrgan M, Bech SR, Sander M, Papoti M, Nordsborg NB
Eur J Appl Physiol 2014;114(7):1439-49. Epub 2014 Mar 27 doi: 10.1007/s00421-014-2863-4. PMID: 24668421
Huicho L
Respir Physiol Neurobiol 2007 Sep 30;158(2-3):190-203. Epub 2007 May 10 doi: 10.1016/j.resp.2007.05.004. PMID: 17573246
Wu T, Kayser B
High Alt Med Biol 2006 Fall;7(3):193-208. doi: 10.1089/ham.2006.7.193. PMID: 16978132
Berglund B
Sports Med 1992 Nov;14(5):289-303. doi: 10.2165/00007256-199214050-00002. PMID: 1439397

Diagnosis

Getu A
Biomed Res Int 2022;2022:5749382. Epub 2022 Apr 15 doi: 10.1155/2022/5749382. PMID: 35463974Free PMC Article
Mairbäurl H, Gassmann M, Muckenthaler MU
J Appl Physiol (1985) 2020 Dec 1;129(6):1451-1459. Epub 2020 Oct 1 doi: 10.1152/japplphysiol.00025.2020. PMID: 33002380
Ge RL, Simonson TS, Gordeuk V, Prchal JT, McClain DA
Exp Physiol 2015 Nov;100(11):1247-55. Epub 2015 Jul 14 doi: 10.1113/EP085292. PMID: 26053282Free PMC Article
Mairbäurl H, Weber RE
Compr Physiol 2012 Apr;2(2):1463-89. doi: 10.1002/cphy.c080113. PMID: 23798307
Wagner PD
High Alt Med Biol 2010 Summer;11(2):111-9. doi: 10.1089/ham.2009.1084. PMID: 20586595Free PMC Article

Therapy

Brocherie F, Millet GP, Hauser A, Steiner T, Rysman J, Wehrlin JP, Girard O
Med Sci Sports Exerc 2015 Oct;47(10):2140-9. doi: 10.1249/MSS.0000000000000630. PMID: 25668402
Gore CJ, Sharpe K, Garvican-Lewis LA, Saunders PU, Humberstone CE, Robertson EY, Wachsmuth NB, Clark SA, McLean BD, Friedmann-Bette B, Neya M, Pottgiesser T, Schumacher YO, Schmidt WF
Br J Sports Med 2013 Dec;47 Suppl 1(Suppl 1):i31-9. doi: 10.1136/bjsports-2013-092840. PMID: 24282204Free PMC Article
He B, Wang J, Qian G, Hu M, Qu X, Wei Z, Li J, Chen Y, Chen H, Zhou Q, Wang G
PLoS One 2013;8(5):e62072. Epub 2013 May 1 doi: 10.1371/journal.pone.0062072. PMID: 23650508Free PMC Article
Agostoni P, Swenson ER, Bussotti M, Revera M, Meriggi P, Faini A, Lombardi C, Bilo G, Giuliano A, Bonacina D, Modesti PA, Mancia G, Parati G; HIGHCARE Investigators
J Appl Physiol (1985) 2011 Jun;110(6):1564-71. Epub 2011 Mar 24 doi: 10.1152/japplphysiol.01167.2010. PMID: 21436463
Hsia CC
Am J Med Sci 1994 Jun;307(6):448-64. doi: 10.1097/00000441-199406000-00013. PMID: 8198153

Prognosis

Sharma D, Amgain K, Panta PP, Pokhrel B
BMC Pregnancy Childbirth 2020 Mar 23;20(1):182. doi: 10.1186/s12884-020-02870-7. PMID: 32204701Free PMC Article
Gore CJ, Sharpe K, Garvican-Lewis LA, Saunders PU, Humberstone CE, Robertson EY, Wachsmuth NB, Clark SA, McLean BD, Friedmann-Bette B, Neya M, Pottgiesser T, Schumacher YO, Schmidt WF
Br J Sports Med 2013 Dec;47 Suppl 1(Suppl 1):i31-9. doi: 10.1136/bjsports-2013-092840. PMID: 24282204Free PMC Article
Wagner PD
High Alt Med Biol 2010 Summer;11(2):111-9. doi: 10.1089/ham.2009.1084. PMID: 20586595Free PMC Article
Schmidt W
High Alt Med Biol 2002 Summer;3(2):167-76. doi: 10.1089/15270290260131902. PMID: 12162861
Hahn AG, Gore CJ
Sports Med 2001;31(7):533-57. doi: 10.2165/00007256-200131070-00008. PMID: 11428690

Clinical prediction guides

Sharma V, Varshney R, Sethy NK
Hum Genomics 2022 Jul 15;16(1):21. doi: 10.1186/s40246-022-00395-y. PMID: 35841113Free PMC Article
Storz JF, Bautista NM
Mol Aspects Med 2022 Apr;84:101052. Epub 2021 Dec 5 doi: 10.1016/j.mam.2021.101052. PMID: 34879970Free PMC Article
Storz JF
Mol Biol Evol 2021 Jun 25;38(7):2677-2691. doi: 10.1093/molbev/msab064. PMID: 33751123Free PMC Article
Wilber RL, Pitsiladis YP
Int J Sports Physiol Perform 2012 Jun;7(2):92-102. doi: 10.1123/ijspp.7.2.92. PMID: 22634972
Yi X, Liang Y, Huerta-Sanchez E, Jin X, Cuo ZX, Pool JE, Xu X, Jiang H, Vinckenbosch N, Korneliussen TS, Zheng H, Liu T, He W, Li K, Luo R, Nie X, Wu H, Zhao M, Cao H, Zou J, Shan Y, Li S, Yang Q, Asan, Ni P, Tian G, Xu J, Liu X, Jiang T, Wu R, Zhou G, Tang M, Qin J, Wang T, Feng S, Li G, Huasang, Luosang J, Wang W, Chen F, Wang Y, Zheng X, Li Z, Bianba Z, Yang G, Wang X, Tang S, Gao G, Chen Y, Luo Z, Gusang L, Cao Z, Zhang Q, Ouyang W, Ren X, Liang H, Zheng H, Huang Y, Li J, Bolund L, Kristiansen K, Li Y, Zhang Y, Zhang X, Li R, Li S, Yang H, Nielsen R, Wang J, Wang J
Science 2010 Jul 2;329(5987):75-8. doi: 10.1126/science.1190371. PMID: 20595611Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...