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CYP2C19-related poor drug metabolism

MedGen UID:
322801
•Concept ID:
C1836023
•
Disease or Syndrome
Synonym: Drug Metabolism, Poor, CYP2C19-Related
 
Gene (location): CYP2C19 (10q23.33)
 
OMIM®: 609535

Professional guidelines

PubMed

CYP2C19 genotype-phenotype discordance in patients with multiple myeloma leads to an acquired loss of drug-metabolising activity.
Burns KE, Goldthorpe MA, Porteus F, Browett P, Helsby NA
Cancer Chemother Pharmacol 2014 Mar;73(3):651-5. Epub 2014 Feb 12 doi: 10.1007/s00280-014-2409-9. PMID: 24519754

Recent clinical studies

Etiology

Pharmacodynamic effects and kinetic disposition of rabeprazole in relation to CYP2C19 genotypes.
Horai Y, Kimura M, Furuie H, Matsuguma K, Irie S, Koga Y, Nagahama T, Murakami M, Matsui T, Yao T, Urae A, Ishizaki T
Aliment Pharmacol Ther 2001 Jun;15(6):793-803. doi: 10.1046/j.1365-2036.2001.00980.x. PMID: 11380317
Steady-state plasma concentrations of imipramine and desipramine in relation to S-mephenytoin 4'-hydroxylation status in Japanese depressive patients.
Koyama E, Tanaka T, Chiba K, Kawakatsu S, Morinobu S, Totsuka S, Ishizaki T
J Clin Psychopharmacol 1996 Aug;16(4):286-93. doi: 10.1097/00004714-199608000-00003. PMID: 8835703

Therapy

CYP2C19 genotype-phenotype discordance in patients with multiple myeloma leads to an acquired loss of drug-metabolising activity.
Burns KE, Goldthorpe MA, Porteus F, Browett P, Helsby NA
Cancer Chemother Pharmacol 2014 Mar;73(3):651-5. Epub 2014 Feb 12 doi: 10.1007/s00280-014-2409-9. PMID: 24519754
Pharmacodynamic effects and kinetic disposition of rabeprazole in relation to CYP2C19 genotypes.
Horai Y, Kimura M, Furuie H, Matsuguma K, Irie S, Koga Y, Nagahama T, Murakami M, Matsui T, Yao T, Urae A, Ishizaki T
Aliment Pharmacol Ther 2001 Jun;15(6):793-803. doi: 10.1046/j.1365-2036.2001.00980.x. PMID: 11380317
Proguanil disposition and toxicity in malaria patients from Vanuatu with high frequencies of CYP2C19 mutations.
Kaneko A, Bergqvist Y, Taleo G, Kobayakawa T, Ishizaki T, Björkman A
Pharmacogenetics 1999 Jun;9(3):317-26. PMID: 10471063
Intrinsic efficacy of proguanil against falciparum and vivax malaria independent of the metabolite cycloguanil.
Kaneko A, Bergqvist Y, Takechi M, Kalkoa M, Kaneko O, Kobayakawa T, Ishizaki T, Björkman A
J Infect Dis 1999 Apr;179(4):974-9. doi: 10.1086/314683. PMID: 10068594
Steady-state plasma concentrations of imipramine and desipramine in relation to S-mephenytoin 4'-hydroxylation status in Japanese depressive patients.
Koyama E, Tanaka T, Chiba K, Kawakatsu S, Morinobu S, Totsuka S, Ishizaki T
J Clin Psychopharmacol 1996 Aug;16(4):286-93. doi: 10.1097/00004714-199608000-00003. PMID: 8835703

Prognosis

Clinical validity: Combinatorial pharmacogenomics predicts antidepressant responses and healthcare utilizations better than single gene phenotypes.
Altar CA, Carhart JM, Allen JD, Hall-Flavin DK, Dechairo BM, Winner JG
Pharmacogenomics J 2015 Oct;15(5):443-51. Epub 2015 Feb 17 doi: 10.1038/tpj.2014.85. PMID: 25686762
CYP2C19 genotype-phenotype discordance in patients with multiple myeloma leads to an acquired loss of drug-metabolising activity.
Burns KE, Goldthorpe MA, Porteus F, Browett P, Helsby NA
Cancer Chemother Pharmacol 2014 Mar;73(3):651-5. Epub 2014 Feb 12 doi: 10.1007/s00280-014-2409-9. PMID: 24519754
High and variable frequencies of CYP2C19 mutations: medical consequences of poor drug metabolism in Vanuatu and other Pacific islands.
Kaneko A, Lum JK, Yaviong L, Takahashi N, Ishizaki T, Bertilsson L, Kobayakawa T, Björkman A
Pharmacogenetics 1999 Oct;9(5):581-90. PMID: 10591538

Clinical prediction guides

Clinical validity: Combinatorial pharmacogenomics predicts antidepressant responses and healthcare utilizations better than single gene phenotypes.
Altar CA, Carhart JM, Allen JD, Hall-Flavin DK, Dechairo BM, Winner JG
Pharmacogenomics J 2015 Oct;15(5):443-51. Epub 2015 Feb 17 doi: 10.1038/tpj.2014.85. PMID: 25686762
The CYP2C19*17 variant is not independently associated with clopidogrel response.
Lewis JP, Stephens SH, Horenstein RB, O'Connell JR, Ryan K, Peer CJ, Figg WD, Spencer SD, Pacanowski MA, Mitchell BD, Shuldiner AR
J Thromb Haemost 2013 Sep;11(9):1640-6. doi: 10.1111/jth.12342. PMID: 23809542Free PMC Article
Pharmacodynamic effects and kinetic disposition of rabeprazole in relation to CYP2C19 genotypes.
Horai Y, Kimura M, Furuie H, Matsuguma K, Irie S, Koga Y, Nagahama T, Murakami M, Matsui T, Yao T, Urae A, Ishizaki T
Aliment Pharmacol Ther 2001 Jun;15(6):793-803. doi: 10.1046/j.1365-2036.2001.00980.x. PMID: 11380317
High and variable frequencies of CYP2C19 mutations: medical consequences of poor drug metabolism in Vanuatu and other Pacific islands.
Kaneko A, Lum JK, Yaviong L, Takahashi N, Ishizaki T, Bertilsson L, Kobayakawa T, Björkman A
Pharmacogenetics 1999 Oct;9(5):581-90. PMID: 10591538
Intrinsic efficacy of proguanil against falciparum and vivax malaria independent of the metabolite cycloguanil.
Kaneko A, Bergqvist Y, Takechi M, Kalkoa M, Kaneko O, Kobayakawa T, Ishizaki T, Björkman A
J Infect Dis 1999 Apr;179(4):974-9. doi: 10.1086/314683. PMID: 10068594

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