U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Juvenile nasopharyngeal angiofibroma

MedGen UID:
237137
•Concept ID:
C1367536
•
Neoplastic Process
Synonyms: JNA; Juvenile angiofibroma of nasopharynx; juvenile nasopharyngeal angiofibroma; juvenile nasopharyngeal angiofibroma (disease); Nasopharyngeal Angiofibroma; nasopharyngeal angiofibroma; nasopharyngeal juvenile angiofibroma; Sinonasal Angiofibroma; Sinonasal Tract Angiofibroma
SNOMED CT: Juvenile angiofibroma of nasopharynx (716590006); Juvenile nasopharyngeal angiofibroma (716590006)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
HPO: HP:0030429
Monarch Initiative: MONDO:0017340
Orphanet: ORPHA289596

Definition

A benign but highly vascular nasopharyngeal neoplasm. The tumor originates from the sphenopalatine foramen and involves both the pterygopalatine fossa and the posterior nasal cavity. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVJuvenile nasopharyngeal angiofibroma

Professional guidelines

PubMed

Juvenile nasopharyngeal angiofibroma-20 years of experience in endoscopic treatment.
Szyfter W, Balcerowiak A, Gawęcki W, Juszkat R, Wierzbicka M
Otolaryngol Pol 2021 Feb 16;75(2):9-14. doi: 10.5604/01.3001.0014.5220. PMID: 33949314
Nasal juvenile angiofibroma: Current perspectives with emphasis on management.
López F, Triantafyllou A, Snyderman CH, Hunt JL, Suárez C, Lund VJ, Strojan P, Saba NF, Nixon IJ, Devaney KO, Alobid I, Bernal-Sprekelsen M, Hanna EY, Rinaldo A, Ferlito A
Head Neck 2017 May;39(5):1033-1045. Epub 2017 Feb 15 doi: 10.1002/hed.24696. PMID: 28199045
Imaging Evaluation and Treatment of Vascular Lesions at the Skull Base.
Jindal G, Miller T, Raghavan P, Gandhi D
Radiol Clin North Am 2017 Jan;55(1):151-166. Epub 2016 Oct 25 doi: 10.1016/j.rcl.2016.08.003. PMID: 27890183

Recent clinical studies

Etiology

Embolization in Juvenile Nasopharyngeal Angiofibroma Surgery: A Systematic Review and Meta-Analysis.
Diaz A, Wang E, Bujnowski D, Arimoto R, Armstrong M, Cyberski T, Nordgren R, Seal SM, Kass-Hout T, Roxbury C
Laryngoscope 2023 Jul;133(7):1529-1539. Epub 2023 Feb 15 doi: 10.1002/lary.30616. PMID: 36789781
Preoperative emobilisation of juvenile nasopharyngeal angiofibroma.
Meher R, Kathuria S, Wadhwa V, Ali MR, Shah B, Bansal A, Goel P
Am J Otolaryngol 2022 Sep-Oct;43(5):103532. Epub 2022 Jun 11 doi: 10.1016/j.amjoto.2022.103532. PMID: 35714497
Juvenile nasopharyngeal angiofibroma surgical treatment in paediatric patients.
Oré Acevedo JF, La Torre Caballero LM, Urteaga Quiroga RJ
Acta Otorrinolaringol Esp (Engl Ed) 2019 Sep-Oct;70(5):279-285. Epub 2018 Aug 6 doi: 10.1016/j.otorri.2018.06.003. PMID: 30093086
Transnasal microscopic approach for juvenile nasopharyngeal angiofibroma.
Gołąbek W, Szymańska A, Morshed K
Otolaryngol Pol 2018 Aug 6;72(5):31-36. doi: 10.5604/01.3001.0012.2303. PMID: 30460914
Juvenile nasopharyngeal angiofibroma.
Tewfik TL, Tan AK, al Noury K, Chowdhury K, Tampieri D, Raymond J, Vuong T
J Otolaryngol 1999 Jun;28(3):145-51. PMID: 10410346

Diagnosis

Nasal Septal Angiofibroma.
Thobejane O, Maharaj S
Ear Nose Throat J 2023 Oct;102(10):NP483-NP484. Epub 2021 Jun 16 doi: 10.1177/01455613211026517. PMID: 34134540
Juvenile nasopharyngeal angiofibroma: National practice patterns and resource utilization via HCUP KID.
Pool C, Gates CJ, Patel VA, Carr MM
Int J Pediatr Otorhinolaryngol 2021 Oct;149:110871. Epub 2021 Aug 5 doi: 10.1016/j.ijporl.2021.110871. PMID: 34385042
Acquired Vascular Tumors of the Head and Neck.
Persky M, Tran T
Otolaryngol Clin North Am 2018 Feb;51(1):255-274. Epub 2017 Oct 27 doi: 10.1016/j.otc.2017.09.015. PMID: 29106888
Nasal juvenile angiofibroma: Current perspectives with emphasis on management.
López F, Triantafyllou A, Snyderman CH, Hunt JL, Suárez C, Lund VJ, Strojan P, Saba NF, Nixon IJ, Devaney KO, Alobid I, Bernal-Sprekelsen M, Hanna EY, Rinaldo A, Ferlito A
Head Neck 2017 May;39(5):1033-1045. Epub 2017 Feb 15 doi: 10.1002/hed.24696. PMID: 28199045
Juvenile nasopharyngeal angiofibroma.
Zito J, Fitzpatrick P, Amedee R
J La State Med Soc 2001 Aug;153(8):395-8. PMID: 11565634

Therapy

Embolization in Juvenile Nasopharyngeal Angiofibroma Surgery: A Systematic Review and Meta-Analysis.
Diaz A, Wang E, Bujnowski D, Arimoto R, Armstrong M, Cyberski T, Nordgren R, Seal SM, Kass-Hout T, Roxbury C
Laryngoscope 2023 Jul;133(7):1529-1539. Epub 2023 Feb 15 doi: 10.1002/lary.30616. PMID: 36789781
Emergency Department care of childhood epistaxis.
Béquignon E, Teissier N, Gauthier A, Brugel L, De Kermadec H, Coste A, Prulière-Escabasse V
Emerg Med J 2017 Aug;34(8):543-548. Epub 2016 Aug 19 doi: 10.1136/emermed-2015-205528. PMID: 27542804
Managing Vascular Tumors-Open Approaches.
Schmalbach CE, Gourin C
Otolaryngol Clin North Am 2016 Jun;49(3):777-90. doi: 10.1016/j.otc.2016.03.001. PMID: 27267025
Juvenile nasopharyngeal angiofibroma.
Blount A, Riley KO, Woodworth BA
Otolaryngol Clin North Am 2011 Aug;44(4):989-1004, ix. doi: 10.1016/j.otc.2011.06.003. PMID: 21819885
Juvenile nasopharyngeal angiofibroma.
Wilson WR, Miller D, Lee KJ, Yules RB
Laryngoscope 1972 Jun;82(6):985-97. doi: 10.1288/00005537-197206000-00006. PMID: 4338568

Prognosis

Electron microscopy of juvenile nasopharyngeal angiofibroma: clinical and histopathological correlates.
Hage A, Singhai A, Mishra A, Mishra SC
Eur Arch Otorhinolaryngol 2022 Jan;279(1):233-247. Epub 2021 Apr 29 doi: 10.1007/s00405-021-06815-4. PMID: 33912996
Juvenile nasopharyngeal angiofibroma staging: An overview.
Alshaikh NA, Eleftheriadou A
Ear Nose Throat J 2015 Jun;94(6):E12-22. doi: 10.1177/014556131509400615. PMID: 26053985
Treatment and prognosis of nasopharyngeal angiofibroma involving the eye and optic nerve.
Xu Y, Lin G, Lin C, Fang Z, Li Z, Zhou A, Lan S, Xu G, Yi Z
J Laryngol Otol 2012 Nov;126(11):1108-13. Epub 2012 Sep 4 doi: 10.1017/S0022215112001831. PMID: 22947339
Juvenile nasopharyngeal angiofibroma.
Zito J, Fitzpatrick P, Amedee R
J La State Med Soc 2001 Aug;153(8):395-8. PMID: 11565634
Juvenile nasopharyngeal angiofibroma.
Tewfik TL, Tan AK, al Noury K, Chowdhury K, Tampieri D, Raymond J, Vuong T
J Otolaryngol 1999 Jun;28(3):145-51. PMID: 10410346

Clinical prediction guides

Electron microscopy of juvenile nasopharyngeal angiofibroma: clinical and histopathological correlates.
Hage A, Singhai A, Mishra A, Mishra SC
Eur Arch Otorhinolaryngol 2022 Jan;279(1):233-247. Epub 2021 Apr 29 doi: 10.1007/s00405-021-06815-4. PMID: 33912996
Endoscopic Endonasal and Transmaxillary Resection of a Nasopharyngeal Angiofibroma.
Singh R, Thorwarth R, Bendok BR, Lal D
World Neurosurg 2021 Nov;155:180. Epub 2021 Aug 25 doi: 10.1016/j.wneu.2021.08.064. PMID: 34450322
Molecular interactions in juvenile nasopharyngeal angiofibroma: preliminary signature and relevant review.
Mishra A, Jaiswal R, Amita P, Mishra SC
Eur Arch Otorhinolaryngol 2019 Jan;276(1):93-100. Epub 2018 Nov 1 doi: 10.1007/s00405-018-5178-y. PMID: 30387011
Current status and clinical association of beta-catenin with juvenile nasopharyngeal angiofibroma.
Mishra A, Singh V, Verma V, Pandey S, Trivedi R, Singh HP, Kumar S, Dwivedi RC, Mishra SC
J Laryngol Otol 2016 Oct;130(10):907-913. Epub 2016 Aug 30 doi: 10.1017/S0022215116008690. PMID: 27572281
Juvenile nasopharyngeal angiofibroma staging: An overview.
Alshaikh NA, Eleftheriadou A
Ear Nose Throat J 2015 Jun;94(6):E12-22. doi: 10.1177/014556131509400615. PMID: 26053985

Recent systematic reviews

Early-onset juvenile nasopharyngeal angiofibroma (JNA): a systematic review.
Newman M, Nguyen TBV, McHugh T, Reddy K, Sommer DD
J Otolaryngol Head Neck Surg 2023 Dec 19;52(1):85. doi: 10.1186/s40463-023-00687-w. PMID: 38115030Free PMC Article
MRI features of sinonasal tract angiofibroma/juvenile nasopharyngeal angiofibroma: Case series and systematic review.
Baba A, Kurokawa R, Kurokawa M, Srinivasan A
J Neuroimaging 2023 Sep-Oct;33(5):675-687. Epub 2023 May 10 doi: 10.1111/jon.13116. PMID: 37164909
Embolization in Juvenile Nasopharyngeal Angiofibroma Surgery: A Systematic Review and Meta-Analysis.
Diaz A, Wang E, Bujnowski D, Arimoto R, Armstrong M, Cyberski T, Nordgren R, Seal SM, Kass-Hout T, Roxbury C
Laryngoscope 2023 Jul;133(7):1529-1539. Epub 2023 Feb 15 doi: 10.1002/lary.30616. PMID: 36789781
Exclusive endoscopic resection of juvenile nasopharyngeal angiofibroma: a systematic review of the literature.
Khoueir N, Nicolas N, Rohayem Z, Haddad A, Abou Hamad W
Otolaryngol Head Neck Surg 2014 Mar;150(3):350-8. Epub 2013 Dec 31 doi: 10.1177/0194599813516605. PMID: 24381014
A systematic review of surgical outcomes for advanced juvenile nasopharyngeal angiofibroma with intracranial involvement.
Leong SC
Laryngoscope 2013 May;123(5):1125-31. Epub 2013 Apr 2 doi: 10.1002/lary.23760. PMID: 23553370

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...