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Trichomegaly(TCMGLY)

MedGen UID:
163139
•Concept ID:
C0854699
•
Finding
Synonym: TCMGLY
 
Gene (location): FGF5 (4q21.21)
 
Monarch Initiative: MONDO:0008593
OMIM®: 190330

Definition

Trichomegaly (TCMGLY), or excessively long eyelashes, is a rare familial trait (Higgins et al., 2014). [from OMIM]

Clinical features

From HPO
Long eyelashes
MedGen UID:
342955
•Concept ID:
C1853738
•
Finding
Mid upper eyelash length >10 mm or increased length of the eyelashes (subjective).
See: Feature record | Search on this feature
Cataract
MedGen UID:
39462
•Concept ID:
C0086543
•
Disease or Syndrome
A cataract is an opacity or clouding that develops in the crystalline lens of the eye or in its capsule.
See: Feature record | Search on this feature
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Professional guidelines

PubMed

Skin Toxicities During Colorectal Cancer Chemotherapy: Incidence and Pearls of Treatment in Our Experience.
Panariello L, Donnarumma M, Iaffaioli RV, Chiodini P, Annunziata MC, Peduto T, Fabbrocini G
Clin Colorectal Cancer 2020 Dec;19(4):e235-e242. Epub 2020 May 29 doi: 10.1016/j.clcc.2020.05.006. PMID: 32665093
Taiwanese Dermatological Association consensus for the prevention and management of epidermal growth factor receptor tyrosine kinase inhibitor-related skin toxicities.
Chu CY, Chen KY, Wen-Cheng Chang J, Wei YF, Lee CH, Wang WM
J Formos Med Assoc 2017 Jun;116(6):413-423. Epub 2017 Mar 27 doi: 10.1016/j.jfma.2017.03.001. PMID: 28351555
Ocular toxicities of epidermal growth factor receptor inhibitors and their management.
Basti S
Cancer Nurs 2007 Jul-Aug;30(4 Suppl 1):S10-6. doi: 10.1097/01.NCC.0000281759.23823.82. PMID: 17666986

Recent clinical studies

Etiology

Eyelash trichomegaly: a systematic review of acquired and congenital aetiologies of lengthened lashes.
Hutchison DM, Duffens A, Yale K, Park A, Cardenas K, Mesinkovska NA
J Eur Acad Dermatol Venereol 2022 Apr;36(4):536-546. Epub 2021 Dec 31 doi: 10.1111/jdv.17877. PMID: 34919300
Alopecia and Hair Damage Induced by Oncological Therapy.
Jedličková H, Vokurka S, Vojtíšek R, Malečková A
Klin Onkol 2019 Fall;32(5):353-359. doi: 10.14735/amko2019353. PMID: 31610668
Madarosis, milphosis, eyelash trichomegaly, and dermatochalasis.
Vij A, Bergfeld WF
Clin Dermatol 2015 Mar-Apr;33(2):217-26. doi: 10.1016/j.clindermatol.2014.10.013. PMID: 25704941
Ocular side effects and trichomegaly of eyelashes induced by erlotinib: a case report and review of the literature.
Celik T, Kosker M
Cont Lens Anterior Eye 2015 Feb;38(1):59-60. Epub 2014 Sep 22 doi: 10.1016/j.clae.2014.08.005. PMID: 25249292
Progressive trichomegaly.
Vano-Galvan S, Moreno-Martin P, Jaén P
Neth J Med 2009 Jan;67(1):35-6. PMID: 19155549

Diagnosis

Madarosis, milphosis, eyelash trichomegaly, and dermatochalasis.
Vij A, Bergfeld WF
Clin Dermatol 2015 Mar-Apr;33(2):217-26. doi: 10.1016/j.clindermatol.2014.10.013. PMID: 25704941
Ocular side effects and trichomegaly of eyelashes induced by erlotinib: a case report and review of the literature.
Celik T, Kosker M
Cont Lens Anterior Eye 2015 Feb;38(1):59-60. Epub 2014 Sep 22 doi: 10.1016/j.clae.2014.08.005. PMID: 25249292
Hair disorders associated with autoimmune connective tissue diseases.
Cassano N, Amerio P, D'Ovidio R, Vena GA
G Ital Dermatol Venereol 2014 Oct;149(5):555-65. Epub 2014 Jun 30 PMID: 24975949
Essential trichomegaly: case report.
Rossetto JD, Nascimento H, Muccioli C, Belfort R Jr
Arq Bras Oftalmol 2013 Jan-Feb;76(1):50-1. doi: 10.1590/s0004-27492013000100015. PMID: 23812530
Erlotinib-associated trichomegaly.
Lane K, Goldstein SM
Ophthalmic Plast Reconstr Surg 2007 Jan-Feb;23(1):65-6. doi: 10.1097/IOP.0b013e31802d9802. PMID: 17237698

Therapy

Trichomegaly and Trichiasis Associated with Pemigatinib.
Campagna GA, Liu ST, Tsui E
Ophthalmology 2021 Sep;128(9):1364. doi: 10.1016/j.ophtha.2021.02.022. PMID: 34420597
Panitumumab-induced trichomegaly.
Sütcüoğlu O, Özet A
Curr Probl Cancer 2021 Dec;45(6):100748. Epub 2021 Apr 23 doi: 10.1016/j.currproblcancer.2021.100748. PMID: 33933278
Alopecia and Hair Damage Induced by Oncological Therapy.
Jedličková H, Vokurka S, Vojtíšek R, Malečková A
Klin Onkol 2019 Fall;32(5):353-359. doi: 10.14735/amko2019353. PMID: 31610668
Hair disorders in patients with cancer.
Freites-Martinez A, Shapiro J, Goldfarb S, Nangia J, Jimenez JJ, Paus R, Lacouture ME
J Am Acad Dermatol 2019 May;80(5):1179-1196. Epub 2018 Apr 14 doi: 10.1016/j.jaad.2018.03.055. PMID: 29660422Free PMC Article
Trichomegaly Induced by Cetuximab: Case Series and Review the Literature.
Koksal UI, Pilanci KN, Ordu C, Okutur K, Saglam S, Demir G
Am J Ther 2016 Sep-Oct;23(5):e1226-9. doi: 10.1097/MJT.0000000000000189. PMID: 26079631

Prognosis

Oliver McFarlane syndrome: two new cases and a review of the literature.
Lisbjerg K, Andersen MKG, Bertelsen M, Brost AG, Buchvald FF, Jensen RB, Bisgaard AM, Rosenberg T, Tümer Z, Kessel L
Ophthalmic Genet 2021 Aug;42(4):464-473. Epub 2021 Apr 5 doi: 10.1080/13816810.2021.1904419. PMID: 33818269
Trichomegaly Associated with Panitumumab.
Goyal A, Blaes A
N Engl J Med 2020 Oct 15;383(16):e94. doi: 10.1056/NEJMicm2003622. PMID: 33053288
Alopecia and Hair Damage Induced by Oncological Therapy.
Jedličková H, Vokurka S, Vojtíšek R, Malečková A
Klin Onkol 2019 Fall;32(5):353-359. doi: 10.14735/amko2019353. PMID: 31610668
Madarosis, milphosis, eyelash trichomegaly, and dermatochalasis.
Vij A, Bergfeld WF
Clin Dermatol 2015 Mar-Apr;33(2):217-26. doi: 10.1016/j.clindermatol.2014.10.013. PMID: 25704941
Hair disorders associated with autoimmune connective tissue diseases.
Cassano N, Amerio P, D'Ovidio R, Vena GA
G Ital Dermatol Venereol 2014 Oct;149(5):555-65. Epub 2014 Jun 30 PMID: 24975949

Clinical prediction guides

Prostaglandin-Associated Periorbitopathy in Children and Young Adults with Glaucoma.
Kim JS, Blizzard S, Woodward JA, Leyngold IM, Liss J, Freedman SF
Ophthalmol Glaucoma 2020 Jul-Aug;3(4):288-294. Epub 2020 Apr 3 doi: 10.1016/j.ogla.2020.03.009. PMID: 33008561
Hypertrichosis, trichomegaly, and androgenic alopecia related to cetuximab treatment.
Turker S, Cilbir E, Karacin C, Altinbas M
J Cancer Res Ther 2020 Apr-Jun;16(3):690-692. doi: 10.4103/jcrt.JCRT_343_17. PMID: 32719294
Oliver McFarlane syndrome and choroidal neovascularisation: a case report.
Makuloluwa AK, Dodeja R, Georgiou M, Gonzalez-Martin J, Hagan R, Madhusudhan S, Michaelides M
Ophthalmic Genet 2020 Oct;41(5):451-456. Epub 2020 Jun 25 doi: 10.1080/13816810.2020.1783689. PMID: 32586184
Alopecia and Hair Damage Induced by Oncological Therapy.
Jedličková H, Vokurka S, Vojtíšek R, Malečková A
Klin Onkol 2019 Fall;32(5):353-359. doi: 10.14735/amko2019353. PMID: 31610668
Hair disorders associated with autoimmune connective tissue diseases.
Cassano N, Amerio P, D'Ovidio R, Vena GA
G Ital Dermatol Venereol 2014 Oct;149(5):555-65. Epub 2014 Jun 30 PMID: 24975949

Recent systematic reviews

Ophthalmologic and facial abnormalities of Nicolaides-Baraitser syndrome.
Simmers R, Goodwin A, Al Saif H, Couser N
Ophthalmic Genet 2022 Oct;43(5):699-702. Epub 2022 Jun 27 doi: 10.1080/13816810.2022.2089358. PMID: 35762114
Eyelash trichomegaly: a systematic review of acquired and congenital aetiologies of lengthened lashes.
Hutchison DM, Duffens A, Yale K, Park A, Cardenas K, Mesinkovska NA
J Eur Acad Dermatol Venereol 2022 Apr;36(4):536-546. Epub 2021 Dec 31 doi: 10.1111/jdv.17877. PMID: 34919300

Supplemental Content

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    Related information

    • ClinVar
      Related medical variations
    • Gene
      Related information in NCBI Gene
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • OMIM
      Related records in OMIM
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
    • PMC Articles
      Related information in PubMed Central Links
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      Related literature resources in PubMed
    • PubMed (OMIM)
      Related literature resources in PubMed

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