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Diastolic dysfunction

MedGen UID:
105464
Concept ID:
C0520863
Pathologic Function
Synonym: Diastolic Dysfunction
SNOMED CT: Diastolic dysfunction (3545003)

Definition

Impairment in the filling of the ventricles during diastole. Causes include hypertrophic and restrictive cardiomyopathies, coronary artery disease, chronic high blood pressure, aortic stenosis, and aging. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Diastolic dysfunction

Professional guidelines

PubMed

Ommen SR, Ho CY, Asif IM, Balaji S, Burke MA, Day SM, Dearani JA, Epps KC, Evanovich L, Ferrari VA, Joglar JA, Khan SS, Kim JJ, Kittleson MM, Krittanawong C, Martinez MW, Mital S, Naidu SS, Saberi S, Semsarian C, Times S, Waldman CB
Circulation 2024 Jun 4;149(23):e1239-e1311. Epub 2024 May 8 doi: 10.1161/CIR.0000000000001250. PMID: 38718139
Ommen SR, Mital S, Burke MA, Day SM, Deswal A, Elliott P, Evanovich LL, Hung J, Joglar JA, Kantor P, Kimmelstiel C, Kittleson M, Link MS, Maron MS, Martinez MW, Miyake CY, Schaff HV, Semsarian C, Sorajja P
Circulation 2020 Dec 22;142(25):e533-e557. Epub 2020 Nov 20 doi: 10.1161/CIR.0000000000000938. PMID: 33215938
Ommen SR, Mital S, Burke MA, Day SM, Deswal A, Elliott P, Evanovich LL, Hung J, Joglar JA, Kantor P, Kimmelstiel C, Kittleson M, Link MS, Maron MS, Martinez MW, Miyake CY, Schaff HV, Semsarian C, Sorajja P
Circulation 2020 Dec 22;142(25):e558-e631. Epub 2020 Nov 20 doi: 10.1161/CIR.0000000000000937. PMID: 33215931

Recent clinical studies

Etiology

Reichart D, Magnussen C, Zeller T, Blankenberg S
J Intern Med 2019 Oct;286(4):362-372. Epub 2019 Jul 29 doi: 10.1111/joim.12944. PMID: 31132311
Nadruz W, Shah AM, Solomon SD
Med Clin North Am 2017 Jan;101(1):7-17. doi: 10.1016/j.mcna.2016.08.013. PMID: 27884237
Ruiz-del-Árbol L, Serradilla R
World J Gastroenterol 2015 Nov 7;21(41):11502-21. doi: 10.3748/wjg.v21.i41.11502. PMID: 26556983Free PMC Article
Wan SH, Vogel MW, Chen HH
J Am Coll Cardiol 2014 Feb 11;63(5):407-16. Epub 2013 Nov 27 doi: 10.1016/j.jacc.2013.10.063. PMID: 24291270Free PMC Article
Ewy GA
J Insur Med 2004;36(4):292-7. PMID: 15683207

Diagnosis

Lima MR, Silva D
Rev Port Cardiol 2023 May;42(5):471-481. Epub 2023 Mar 7 doi: 10.1016/j.repc.2021.05.020. PMID: 36893835
Reichart D, Magnussen C, Zeller T, Blankenberg S
J Intern Med 2019 Oct;286(4):362-372. Epub 2019 Jul 29 doi: 10.1111/joim.12944. PMID: 31132311
Paolillo S, Marsico F, Prastaro M, Renga F, Esposito L, De Martino F, Di Napoli P, Esposito I, Ambrosio A, Ianniruberto M, Mennella R, Paolillo R, Gargiulo P
Heart Fail Clin 2019 Jul;15(3):341-347. Epub 2019 Apr 5 doi: 10.1016/j.hfc.2019.02.003. PMID: 31079692
Jeong EM, Dudley SC Jr
Circ J 2015;79(3):470-7. Epub 2015 Feb 5 doi: 10.1253/circj.CJ-15-0064. PMID: 25746522Free PMC Article
Wan SH, Vogel MW, Chen HH
J Am Coll Cardiol 2014 Feb 11;63(5):407-16. Epub 2013 Nov 27 doi: 10.1016/j.jacc.2013.10.063. PMID: 24291270Free PMC Article

Therapy

Rubinstein J, Sanford D
Cardiol Clin 2019 Aug;37(3):267-273. Epub 2019 May 15 doi: 10.1016/j.ccl.2019.04.002. PMID: 31279420
Santos Mateo JJ, Sabater Molina M, Gimeno Blanes JR
Med Clin (Barc) 2018 Jun 8;150(11):434-442. Epub 2017 Nov 14 doi: 10.1016/j.medcli.2017.09.013. PMID: 29150126
Jeong EM, Dudley SC Jr
Circ J 2015;79(3):470-7. Epub 2015 Feb 5 doi: 10.1253/circj.CJ-15-0064. PMID: 25746522Free PMC Article
Cleland JG, Tendera M, Adamus J, Freemantle N, Polonski L, Taylor J; PEP-CHF Investigators
Eur Heart J 2006 Oct;27(19):2338-45. Epub 2006 Sep 8 doi: 10.1093/eurheartj/ehl250. PMID: 16963472
Flachskampf FA, Lethen H, Hoffmann R, Hanrath P
Eur Heart J 1997 Jun;18 Suppl D:D37-42. doi: 10.1093/eurheartj/18.suppl_d.37. PMID: 9183609

Prognosis

Nair N
Rev Cardiovasc Med 2020 Dec 30;21(4):531-540. doi: 10.31083/j.rcm.2020.04.154. PMID: 33387998
Povar-Echeverría M, Auquilla-Clavijo PE, Povar-Marco BJ, Moreno-Esteban EM, Figueras-Villalba MP
Arch Cardiol Mex 2020;90(3):259-265. doi: 10.24875/ACM.19000238. PMID: 32952176
Reichart D, Magnussen C, Zeller T, Blankenberg S
J Intern Med 2019 Oct;286(4):362-372. Epub 2019 Jul 29 doi: 10.1111/joim.12944. PMID: 31132311
Ryan TD, Chin C
Semin Pediatr Surg 2017 Aug;26(4):206-212. Epub 2017 Jul 26 doi: 10.1053/j.sempedsurg.2017.07.012. PMID: 28964475
Zangwill S, Hamilton R
Pacing Clin Electrophysiol 2009 Jul;32 Suppl 2:S41-3. doi: 10.1111/j.1540-8159.2009.02383.x. PMID: 19602161

Clinical prediction guides

Ommen SR, Mital S, Burke MA, Day SM, Deswal A, Elliott P, Evanovich LL, Hung J, Joglar JA, Kantor P, Kimmelstiel C, Kittleson M, Link MS, Maron MS, Martinez MW, Miyake CY, Schaff HV, Semsarian C, Sorajja P
Circulation 2020 Dec 22;142(25):e533-e557. Epub 2020 Nov 20 doi: 10.1161/CIR.0000000000000938. PMID: 33215938
Ommen SR, Mital S, Burke MA, Day SM, Deswal A, Elliott P, Evanovich LL, Hung J, Joglar JA, Kantor P, Kimmelstiel C, Kittleson M, Link MS, Maron MS, Martinez MW, Miyake CY, Schaff HV, Semsarian C, Sorajja P
Circulation 2020 Dec 22;142(25):e558-e631. Epub 2020 Nov 20 doi: 10.1161/CIR.0000000000000937. PMID: 33215931
Obokata M, Reddy YNV, Borlaug BA
JACC Cardiovasc Imaging 2020 Jan;13(1 Pt 2):245-257. Epub 2019 Jun 12 doi: 10.1016/j.jcmg.2018.12.034. PMID: 31202759Free PMC Article
Nagueh SF
JACC Cardiovasc Imaging 2020 Jan;13(1 Pt 2):228-244. Epub 2019 Apr 12 doi: 10.1016/j.jcmg.2018.10.038. PMID: 30982669
Muchtar E, Blauwet LA, Gertz MA
Circ Res 2017 Sep 15;121(7):819-837. doi: 10.1161/CIRCRESAHA.117.310982. PMID: 28912185

Recent systematic reviews

Kaddoura R, Madurasinghe V, Chapra A, Abushanab D, Al-Badriyeh D, Patel A
Curr Probl Cardiol 2024 Mar;49(3):102376. Epub 2024 Jan 5 doi: 10.1016/j.cpcardiol.2024.102376. PMID: 38184132
Zhuang C, Luo X, Wang Q, Wang W, Sun R, Zhang X, Yu J
Kardiol Pol 2021;79(10):1107-1115. Epub 2021 Sep 2 doi: 10.33963/KP.a2021.0101. PMID: 34472077
Depla AL, De Wit L, Steenhuis TJ, Slieker MG, Voormolen DN, Scheffer PG, De Heus R, Van Rijn BB, Bekker MN
Ultrasound Obstet Gynecol 2021 Apr;57(4):539-550. doi: 10.1002/uog.22163. PMID: 32730637Free PMC Article
van Riet EE, Hoes AW, Wagenaar KP, Limburg A, Landman MA, Rutten FH
Eur J Heart Fail 2016 Mar;18(3):242-52. Epub 2016 Jan 4 doi: 10.1002/ejhf.483. PMID: 26727047
Sanfilippo F, Corredor C, Fletcher N, Landesberg G, Benedetto U, Foex P, Cecconi M
Intensive Care Med 2015 Jun;41(6):1004-13. Epub 2015 Mar 24 doi: 10.1007/s00134-015-3748-7. PMID: 25800584

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