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Drug- or toxin-induced pulmonary arterial hypertension

MedGen UID:
573792
Concept ID:
C0340544
Disease or Syndrome
Synonyms: Drug- or toxin-induced PAH; drug- or toxin-induced PAH; drug- or toxin-induced pulmonary arterial hypertension; Drug-induced pulmonary hypertension; Pulmonary arterial hypertension caused by drug; Pulmonary arterial hypertension induced by drug; Pulmonary hypertension caused by drug
SNOMED CT: Pulmonary arterial hypertension induced by drug (233945002); Pulmonary arterial hypertension caused by drug (233945002); Pulmonary hypertension caused by drug (233945002); Drug-induced pulmonary hypertension (233945002)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
Concept ID:
C0600599
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
 
Monarch Initiative: MONDO:0017149
Orphanet: ORPHA275786

Definition

Drug- or toxin-induced pulmonary arterial hypertension (PAH) is a form of pulmonary arterial hypertension (PAH, see this term) secondary to the exposition to drugs. Drug- or toxin-induced PAH is characterized by elevated pulmonary arterial resistance leading to right heart failure. Drug or toxin induced PAH is progressive and potentially fatal. [from ORDO]

Professional guidelines

PubMed

Samson SL, Vellanki P, Blonde L, Christofides EA, Galindo RJ, Hirsch IB, Isaacs SD, Izuora KE, Low Wang CC, Twining CL, Umpierrez GE, Valencia WM
Endocr Pract 2023 May;29(5):305-340. doi: 10.1016/j.eprac.2023.02.001. PMID: 37150579
Wainwright TW, Gill M, McDonald DA, Middleton RG, Reed M, Sahota O, Yates P, Ljungqvist O
Acta Orthop 2020 Feb;91(1):3-19. Epub 2019 Oct 30 doi: 10.1080/17453674.2019.1683790. PMID: 31663402Free PMC Article
Funder JW, Carey RM, Mantero F, Murad MH, Reincke M, Shibata H, Stowasser M, Young WF Jr
J Clin Endocrinol Metab 2016 May;101(5):1889-916. Epub 2016 Mar 2 doi: 10.1210/jc.2015-4061. PMID: 26934393

Recent clinical studies

Etiology

Możdżeń K, Kaleta K, Murawska A, Pośpiech J, Panek P, Lorkowska-Zawicka B, Bujak-Giżycka B
Folia Med Cracov 2023 Jul 30;63(2):107-134. doi: 10.24425/fmc.2023.145917. PMID: 37903383
Wilkerson RG
Emerg Med Clin North Am 2022 Feb;40(1):39-55. Epub 2021 Oct 29 doi: 10.1016/j.emc.2021.09.001. PMID: 34782090
Roessler HI, Knoers NVAM, van Haelst MM, van Haaften G
Trends Pharmacol Sci 2021 Apr;42(4):255-267. Epub 2021 Feb 6 doi: 10.1016/j.tips.2021.01.003. PMID: 33563480
Olgen S
Curr Med Chem 2019;26(28):5338-5339. doi: 10.2174/092986732628191025094454. PMID: 31721690
Pushpakom S, Iorio F, Eyers PA, Escott KJ, Hopper S, Wells A, Doig A, Guilliams T, Latimer J, McNamee C, Norris A, Sanseau P, Cavalla D, Pirmohamed M
Nat Rev Drug Discov 2019 Jan;18(1):41-58. Epub 2018 Oct 12 doi: 10.1038/nrd.2018.168. PMID: 30310233

Diagnosis

Mesraoua B, Brigo F, Lattanzi S, Abou-Khalil B, Al Hail H, Asadi-Pooya AA
J Neurol Sci 2023 Sep 15;452:120766. Epub 2023 Aug 14 doi: 10.1016/j.jns.2023.120766. PMID: 37597343
Plana D, Palmer AC, Sorger PK
Cancer Discov 2022 Mar 1;12(3):606-624. doi: 10.1158/2159-8290.CD-21-0212. PMID: 34983746Free PMC Article
Ramien M, Goldman JL
F1000Res 2020;9 Epub 2020 Aug 13 doi: 10.12688/f1000research.20419.1. PMID: 32850118Free PMC Article
Coleman JJ, Pontefract SK
Clin Med (Lond) 2016 Oct;16(5):481-485. doi: 10.7861/clinmedicine.16-5-481. PMID: 27697815Free PMC Article
Demoly P, Adkinson NF, Brockow K, Castells M, Chiriac AM, Greenberger PA, Khan DA, Lang DM, Park HS, Pichler W, Sanchez-Borges M, Shiohara T, Thong BY
Allergy 2014 Apr;69(4):420-37. doi: 10.1111/all.12350. PMID: 24697291

Therapy

Ramirez RL 3rd, Pienkos SM, de Jesus Perez V, Zamanian RT
Clin Chest Med 2021 Mar;42(1):19-38. doi: 10.1016/j.ccm.2020.11.008. PMID: 33541612
Weimer K, Enck P
Handb Exp Pharmacol 2014;225:237-72. doi: 10.1007/978-3-662-44519-8_14. PMID: 25304536
Giacinti L, Lopez M, Giordano A
Front Biosci 2006 Sep 1;11:2918-23. doi: 10.2741/2020. PMID: 16720363
Rubinstein LV
Hematol Oncol Clin North Am 2000 Aug;14(4):849-76, ix. doi: 10.1016/s0889-8588(05)70315-4. PMID: 10949777
Br Med J 1979 Feb 3;1(6159):288-9. PMID: 369658Free PMC Article

Prognosis

Sebastian SA, Co EL, Mehendale M, Sudan S, Manchanda K, Khan S
Curr Probl Cardiol 2022 Sep;47(9):101267. Epub 2022 May 28 doi: 10.1016/j.cpcardiol.2022.101267. PMID: 35636519
Rhee C, Dantes R, Epstein L, Murphy DJ, Seymour CW, Iwashyna TJ, Kadri SS, Angus DC, Danner RL, Fiore AE, Jernigan JA, Martin GS, Septimus E, Warren DK, Karcz A, Chan C, Menchaca JT, Wang R, Gruber S, Klompas M; CDC Prevention Epicenter Program
JAMA 2017 Oct 3;318(13):1241-1249. doi: 10.1001/jama.2017.13836. PMID: 28903154Free PMC Article
Freyer DR, Chen L, Krailo MD, Knight K, Villaluna D, Bliss B, Pollock BH, Ramdas J, Lange B, Van Hoff D, VanSoelen ML, Wiernikowski J, Neuwelt EA, Sung L
Lancet Oncol 2017 Jan;18(1):63-74. Epub 2016 Dec 1 doi: 10.1016/S1470-2045(16)30625-8. PMID: 27914822Free PMC Article
Chamberlain MC
J Clin Oncol 2005 May 20;23(15):3605-13. doi: 10.1200/JCO.2005.01.131. PMID: 15908671
JAMA 1991 Jun 26;265(24):3255-64. PMID: 2046107

Clinical prediction guides

Jiang M, Li CL, Luo XM, Chuan ZR, Lv WZ, Li X, Cui XW, Dietrich CF
Eur J Cancer 2021 Apr;147:95-105. Epub 2021 Feb 24 doi: 10.1016/j.ejca.2021.01.028. PMID: 33639324
Salto-Tellez M, Cree IA
Eur J Cancer 2019 Jul;115:57-60. Epub 2019 May 17 doi: 10.1016/j.ejca.2019.03.026. PMID: 31108243
Gillam LD, Leipsic J, Weissman NJ
JACC Cardiovasc Imaging 2017 Mar;10(3):296-303. doi: 10.1016/j.jcmg.2016.12.003. PMID: 28279377
Gagne JJ, Glynn RJ, Avorn J, Levin R, Schneeweiss S
J Clin Epidemiol 2011 Jul;64(7):749-59. Epub 2011 Jan 5 doi: 10.1016/j.jclinepi.2010.10.004. PMID: 21208778Free PMC Article
Olson H, Betton G, Robinson D, Thomas K, Monro A, Kolaja G, Lilly P, Sanders J, Sipes G, Bracken W, Dorato M, Van Deun K, Smith P, Berger B, Heller A
Regul Toxicol Pharmacol 2000 Aug;32(1):56-67. doi: 10.1006/rtph.2000.1399. PMID: 11029269

Recent systematic reviews

Salari N, Kanjoori AH, Hosseinian-Far A, Hasheminezhad R, Mansouri K, Mohammadi M
Infect Dis Poverty 2023 May 25;12(1):57. doi: 10.1186/s40249-023-01107-x. PMID: 37231463Free PMC Article
Lin Y, Zhang Y, Wang D, Yang B, Shen YQ
Phytomedicine 2022 Dec;107:154481. Epub 2022 Oct 1 doi: 10.1016/j.phymed.2022.154481. PMID: 36215788
Salas M, Petracek J, Yalamanchili P, Aimer O, Kasthuril D, Dhingra S, Junaid T, Bostic T
Pharmaceut Med 2022 Oct;36(5):295-306. Epub 2022 Jul 29 doi: 10.1007/s40290-022-00441-z. PMID: 35904529
Verheyden MJ, Bilgic A, Murrell DF
Acta Derm Venereol 2020 Aug 17;100(15):adv00224. doi: 10.2340/00015555-3457. PMID: 32176310Free PMC Article
Tan MG, Worley B, Kim WB, Ten Hove M, Beecker J
Am J Clin Dermatol 2020 Apr;21(2):163-172. doi: 10.1007/s40257-019-00485-z. PMID: 31741184

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