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Aortic dilatation

MedGen UID:
78118
•Concept ID:
C0265004
•
Finding; Pathologic Function
Synonyms: Aortic dilation; Aortic ectasia
SNOMED CT: Dilatation of aorta (26660001)

Definition

A pathologic widening of the aortic lumen. It is often associated with hypertensive vascular disease and may progress to dissection and rupture. [from NCI]

Professional guidelines

PubMed

Diagnosis and management of acute aortic syndromes in the emergency department.
Morello F, Santoro M, Fargion AT, Grifoni S, Nazerian P
Intern Emerg Med 2021 Jan;16(1):171-181. Epub 2020 May 1 doi: 10.1007/s11739-020-02354-8. PMID: 32358680
Update in the management of type B aortic dissection.
Nauta FJ, Trimarchi S, Kamman AV, Moll FL, van Herwaarden JA, Patel HJ, Figueroa CA, Eagle KA, Froehlich JB
Vasc Med 2016 Jun;21(3):251-63. Epub 2016 Apr 11 doi: 10.1177/1358863X16642318. PMID: 27067136
Aortopathies: etiologies, genetics, differential diagnosis, prognosis and management.
Paterick TE, Humphries JA, Ammar KA, Jan MF, Loberg R, Bush M, Khandheria BK, Tajik AJ
Am J Med 2013 Aug;126(8):670-8. Epub 2013 Jun 22 doi: 10.1016/j.amjmed.2013.01.029. PMID: 23800581

Recent clinical studies

Etiology

Expanding the phenotypic spectrum of Chromosome 16p13.11 microduplication: A multicentric analysis of 206 patients.
Hamad A, Sherlaw-Sturrock CA, Glover K, Salmon R, Low K, Nair R, Sansbury FH, Rawlins L, Carmichael J, Horton R, Wedderburn S, Edgerley K, Irving R, Callaghan M, Mercer C, McGowan R, Robert L, Titheradge H, Naik S
Eur J Med Genet 2023 Apr;66(4):104714. Epub 2023 Jan 29 doi: 10.1016/j.ejmg.2023.104714. PMID: 36724812
Abdominal Aortic Aneurysm.
Haque K, Bhargava P
Am Fam Physician 2022 Aug;106(2):165-172. PMID: 35977132
Diagnosis and management of acute aortic syndromes in the emergency department.
Morello F, Santoro M, Fargion AT, Grifoni S, Nazerian P
Intern Emerg Med 2021 Jan;16(1):171-181. Epub 2020 May 1 doi: 10.1007/s11739-020-02354-8. PMID: 32358680
Aortic surgery in pregnancy.
Lansman SL, Goldberg JB, Kai M, Tang GH, Malekan R, Spielvogel D
J Thorac Cardiovasc Surg 2017 Feb;153(2):S44-S48. Epub 2016 Jun 24 doi: 10.1016/j.jtcvs.2016.06.015. PMID: 27431443
Aortic disease and pregnancy.
Bons LR, Roos-Hesselink JW
Curr Opin Cardiol 2016 Nov;31(6):611-617. doi: 10.1097/HCO.0000000000000336. PMID: 27652809

Diagnosis

Expanding the phenotypic spectrum of Chromosome 16p13.11 microduplication: A multicentric analysis of 206 patients.
Hamad A, Sherlaw-Sturrock CA, Glover K, Salmon R, Low K, Nair R, Sansbury FH, Rawlins L, Carmichael J, Horton R, Wedderburn S, Edgerley K, Irving R, Callaghan M, Mercer C, McGowan R, Robert L, Titheradge H, Naik S
Eur J Med Genet 2023 Apr;66(4):104714. Epub 2023 Jan 29 doi: 10.1016/j.ejmg.2023.104714. PMID: 36724812
Abdominal Aortic Aneurysm.
Haque K, Bhargava P
Am Fam Physician 2022 Aug;106(2):165-172. PMID: 35977132
Heart and Turner syndrome.
Donadille B, Christin-Maitre S
Ann Endocrinol (Paris) 2021 Jun;82(3-4):135-140. Epub 2020 Dec 8 doi: 10.1016/j.ando.2020.12.004. PMID: 33307001
Diagnosis and management of acute aortic syndromes in the emergency department.
Morello F, Santoro M, Fargion AT, Grifoni S, Nazerian P
Intern Emerg Med 2021 Jan;16(1):171-181. Epub 2020 May 1 doi: 10.1007/s11739-020-02354-8. PMID: 32358680
PET in vasculitis.
Blockmans D
Ann N Y Acad Sci 2011 Jun;1228:64-70. doi: 10.1111/j.1749-6632.2011.06021.x. PMID: 21718324

Therapy

Fluoroquinolones increase susceptibility to aortic aneurysm and aortic dissection: Molecular mechanism and clinical evidence.
Xuan X, Li Y, Cao G, Zhang R, Hu J, Jin H, Dong H
Vasc Med 2023 Dec;28(6):604-613. Epub 2023 Sep 27 doi: 10.1177/1358863X231198055. PMID: 37756313
Update in the management of type B aortic dissection.
Nauta FJ, Trimarchi S, Kamman AV, Moll FL, van Herwaarden JA, Patel HJ, Figueroa CA, Eagle KA, Froehlich JB
Vasc Med 2016 Jun;21(3):251-63. Epub 2016 Apr 11 doi: 10.1177/1358863X16642318. PMID: 27067136
Aortic dilatation and aortopathy in congenital heart diseases.
Zanjani KS, Niwa K
J Cardiol 2013 Jan;61(1):16-21. Epub 2012 Nov 21 doi: 10.1016/j.jjcc.2012.08.018. PMID: 23177793
Diagnostic and therapeutic strategies for small abdominal aortic aneurysms.
Klink A, Hyafil F, Rudd J, Faries P, Fuster V, Mallat Z, Meilhac O, Mulder WJ, Michel JB, Ramirez F, Storm G, Thompson R, Turnbull IC, Egido J, Martín-Ventura JL, Zaragoza C, Letourneur D, Fayad ZA
Nat Rev Cardiol 2011 Jun;8(6):338-47. Epub 2011 Feb 8 doi: 10.1038/nrcardio.2011.1. PMID: 21304473
Post-stenotic aortic dilatation.
Wilton E, Jahangiri M
J Cardiothorac Surg 2006 Mar 3;1:7. doi: 10.1186/1749-8090-1-7. PMID: 16722611Free PMC Article

Prognosis

Proximal aorta dilatation in hypertension.
Zuo X, Liu L, Liu K, Zhang X, Ye R, Yang C, Ma J, Jia S, Yang X, Liu X, Sun L, Huo X, Chen X
J Hypertens 2023 Oct 1;41(10):1511-1520. Epub 2023 Aug 2 doi: 10.1097/HJH.0000000000003518. PMID: 37642588
Dynamic Aortic Aneurism Risk Factors.
Metsker O, Kopanitsa G, Irtyuga O, Uspenskiy V
Stud Health Technol Inform 2021 Oct 27;285:130-135. doi: 10.3233/SHTI210585. PMID: 34734863
PET in vasculitis.
Blockmans D
Ann N Y Acad Sci 2011 Jun;1228:64-70. doi: 10.1111/j.1749-6632.2011.06021.x. PMID: 21718324
Biomarkers in aortic dissection.
Wen D, Zhou XL, Li JJ, Hui RT
Clin Chim Acta 2011 Apr 11;412(9-10):688-95. Epub 2011 Jan 13 doi: 10.1016/j.cca.2010.12.039. PMID: 21237193
Identification of the minimal combination of clinical features in probands for efficient mutation detection in the FBN1 gene.
Stheneur C, Collod-Béroud G, Faivre L, Buyck JF, Gouya L, Le Parc JM, Moura B, Muti C, Grandchamp B, Sultan G, Claustres M, Aegerter P, Chevallier B, Jondeau G, Boileau C
Eur J Hum Genet 2009 Sep;17(9):1121-8. Epub 2009 Mar 18 doi: 10.1038/ejhg.2009.36. PMID: 19293843Free PMC Article

Clinical prediction guides

Proximal aorta dilatation in hypertension.
Zuo X, Liu L, Liu K, Zhang X, Ye R, Yang C, Ma J, Jia S, Yang X, Liu X, Sun L, Huo X, Chen X
J Hypertens 2023 Oct 1;41(10):1511-1520. Epub 2023 Aug 2 doi: 10.1097/HJH.0000000000003518. PMID: 37642588
Dynamic Aortic Aneurism Risk Factors.
Metsker O, Kopanitsa G, Irtyuga O, Uspenskiy V
Stud Health Technol Inform 2021 Oct 27;285:130-135. doi: 10.3233/SHTI210585. PMID: 34734863
Imaging in systemic vasculitis.
Prieto-González S, Arguis P, Cid MC
Curr Opin Rheumatol 2015 Jan;27(1):53-62. doi: 10.1097/BOR.0000000000000130. PMID: 25405825
PET in vasculitis.
Blockmans D
Ann N Y Acad Sci 2011 Jun;1228:64-70. doi: 10.1111/j.1749-6632.2011.06021.x. PMID: 21718324
Biomarkers in aortic dissection.
Wen D, Zhou XL, Li JJ, Hui RT
Clin Chim Acta 2011 Apr 11;412(9-10):688-95. Epub 2011 Jan 13 doi: 10.1016/j.cca.2010.12.039. PMID: 21237193

Recent systematic reviews

Family screening for bicuspid aortic valve and aortic dilatation: a meta-analysis.
Bray JJH, Freer R, Pitcher A, Kharbanda R
Eur Heart J 2023 Sep 1;44(33):3152-3164. doi: 10.1093/eurheartj/ehad320. PMID: 37288540Free PMC Article
Surgical valvotomy versus balloon dilatation for children with severe aortic valve stenosis: a systematic review.
Elhedai H, S Mohamed SS, Idriss H, Bhattacharya P, Y Mohamedahmed AY
Future Cardiol 2022 Nov;18(11):901-913. Epub 2022 Sep 5 doi: 10.2217/fca-2022-0053. PMID: 36062928
Cardiac and Aortic Modifications After Endovascular Repair for Blunt Thoracic Aortic Injury: A Systematic Review.
Mandigers TJ, Bissacco D, Domanin M, D'Alessio I, Tolva VS, Piffaretti G, van Herwaarden JA, Trimarchi S
Eur J Vasc Endovasc Surg 2022 Aug-Sep;64(2-3):176-187. Epub 2022 May 7 doi: 10.1016/j.ejvs.2022.05.004. PMID: 35537638
Contemporary natural history of bicuspid aortic valve disease: a systematic review.
Masri A, Svensson LG, Griffin BP, Desai MY
Heart 2017 Sep;103(17):1323-1330. Epub 2017 May 10 doi: 10.1136/heartjnl-2016-309916. PMID: 28490615
Endovascular treatment for type B dissection in Marfan syndrome: is it worthwhile?
Pacini D, Parolari A, Berretta P, Di Bartolomeo R, Alamanni F, Bavaria J
Ann Thorac Surg 2013 Feb;95(2):737-49. Epub 2012 Dec 28 doi: 10.1016/j.athoracsur.2012.09.059. PMID: 23273625

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