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Childhood-onset schizophrenia

MedGen UID:
48576
Concept ID:
C0036346
Mental or Behavioral Dysfunction
Synonym: Childhood schizophrenia
SNOMED CT: Very early-onset schizophrenia (1335862003); VEOS - very early-onset schizophrenia (1335862003); Childhood-onset schizophrenia (1335862003); COS - childhood-onset schizophrenia (1335862003)
 
Monarch Initiative: MONDO:0957430

Definition

A rare neurologic disease with psychiatric involvement with characteristics of prominent pre-psychotic developmental disabilities (cognitive, language, motor), socio-communicative disturbances, auditory hallucinations (visual and tactile hallucinations are rarer) preceding psychotic symptoms, presenting before 13 years of age. Co-occurrence of neurodevelopmental disorders (e.g. autism spectrum disorders, attention deficit hyperactivity disorder) is frequent. Disease course is more severe than adult-onset form of the disease, with major neurodevelopmental impact. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Professional guidelines

PubMed

Correll CU, Arango C, Fagerlund B, Galderisi S, Kas MJ, Leucht S
Eur Neuropsychopharmacol 2024 May;82:57-71. Epub 2024 Mar 15 doi: 10.1016/j.euroneuro.2024.02.005. PMID: 38492329
Adnan M, Motiwala F, Trivedi C, Sultana T, Mansuri Z, Jain S
J Child Adolesc Psychopharmacol 2022 Feb;32(1):2-11. Epub 2022 Jan 28 doi: 10.1089/cap.2021.0092. PMID: 35099269
Lachman A
J Child Adolesc Ment Health 2014;26(2):109-24. doi: 10.2989/17280583.2014.924416. PMID: 25391710

Recent clinical studies

Etiology

Correll CU, Arango C, Fagerlund B, Galderisi S, Kas MJ, Leucht S
Eur Neuropsychopharmacol 2024 May;82:57-71. Epub 2024 Mar 15 doi: 10.1016/j.euroneuro.2024.02.005. PMID: 38492329
Driver DI, Thomas S, Gogtay N, Rapoport JL
Child Adolesc Psychiatr Clin N Am 2020 Jan;29(1):71-90. doi: 10.1016/j.chc.2019.08.017. PMID: 31708054
Forsyth JK, Asarnow RF
Child Adolesc Psychiatr Clin N Am 2020 Jan;29(1):157-170. Epub 2019 Oct 17 doi: 10.1016/j.chc.2019.08.007. PMID: 31708045Free PMC Article
Hoffmann A, Ziller M, Spengler D
Int J Mol Sci 2018 Nov 30;19(12) doi: 10.3390/ijms19123829. PMID: 30513688Free PMC Article
Ordóñez AE, Luscher ZI, Gogtay N
Schizophr Res 2016 Jun;173(3):124-131. Epub 2015 Mar 26 doi: 10.1016/j.schres.2015.03.003. PMID: 25819937Free PMC Article

Diagnosis

Correll CU, Arango C, Fagerlund B, Galderisi S, Kas MJ, Leucht S
Eur Neuropsychopharmacol 2024 May;82:57-71. Epub 2024 Mar 15 doi: 10.1016/j.euroneuro.2024.02.005. PMID: 38492329
Driver DI, Thomas S, Gogtay N, Rapoport JL
Child Adolesc Psychiatr Clin N Am 2020 Jan;29(1):71-90. doi: 10.1016/j.chc.2019.08.017. PMID: 31708054
Hoffmann A, Ziller M, Spengler D
Int J Mol Sci 2018 Nov 30;19(12) doi: 10.3390/ijms19123829. PMID: 30513688Free PMC Article
Asarnow RF, Forsyth JK
Child Adolesc Psychiatr Clin N Am 2013 Oct;22(4):675-87. Epub 2013 Jul 23 doi: 10.1016/j.chc.2013.06.004. PMID: 24012080Free PMC Article
Remschmidt H, Theisen F
Neuropsychobiology 2012;66(1):63-9. Epub 2012 Jul 13 doi: 10.1159/000338548. PMID: 22797279

Therapy

Correll CU, Arango C, Fagerlund B, Galderisi S, Kas MJ, Leucht S
Eur Neuropsychopharmacol 2024 May;82:57-71. Epub 2024 Mar 15 doi: 10.1016/j.euroneuro.2024.02.005. PMID: 38492329
Adnan M, Motiwala F, Trivedi C, Sultana T, Mansuri Z, Jain S
J Child Adolesc Psychopharmacol 2022 Feb;32(1):2-11. Epub 2022 Jan 28 doi: 10.1089/cap.2021.0092. PMID: 35099269
Driver DI, Thomas S, Gogtay N, Rapoport JL
Child Adolesc Psychiatr Clin N Am 2020 Jan;29(1):71-90. doi: 10.1016/j.chc.2019.08.017. PMID: 31708054
Remschmidt H, Theisen F
Neuropsychobiology 2012;66(1):63-9. Epub 2012 Jul 13 doi: 10.1159/000338548. PMID: 22797279
Gordon CT
New Dir Ment Health Serv 1992 Summer;(54):71-5. doi: 10.1002/yd.23319925414. PMID: 1352624

Prognosis

Driver DI, Thomas S, Gogtay N, Rapoport JL
Child Adolesc Psychiatr Clin N Am 2020 Jan;29(1):71-90. doi: 10.1016/j.chc.2019.08.017. PMID: 31708054
Hoffmann A, Ziller M, Spengler D
Int J Mol Sci 2018 Nov 30;19(12) doi: 10.3390/ijms19123829. PMID: 30513688Free PMC Article
Ordóñez AE, Sastry NV, Gogtay N
CNS Spectr 2015 Aug;20(4):442-50. doi: 10.1017/S1092852915000437. PMID: 26234702
Driver DI, Gogtay N, Rapoport JL
Child Adolesc Psychiatr Clin N Am 2013 Oct;22(4):539-55. Epub 2013 Jun 18 doi: 10.1016/j.chc.2013.04.001. PMID: 24012072Free PMC Article
Remschmidt H, Theisen F
Neuropsychobiology 2012;66(1):63-9. Epub 2012 Jul 13 doi: 10.1159/000338548. PMID: 22797279

Clinical prediction guides

Adnan M, Motiwala F, Trivedi C, Sultana T, Mansuri Z, Jain S
J Child Adolesc Psychopharmacol 2022 Feb;32(1):2-11. Epub 2022 Jan 28 doi: 10.1089/cap.2021.0092. PMID: 35099269
Craddock KES, Zhou X, Liu S, Gochman P, Dickinson D, Rapoport JL
Schizophr Res 2018 Jul;197:71-77. Epub 2017 Nov 13 doi: 10.1016/j.schres.2017.10.045. PMID: 29146021Free PMC Article
Ahn K, An SS, Shugart YY, Rapoport JL
Mol Psychiatry 2016 Jan;21(1):94-6. Epub 2014 Dec 16 doi: 10.1038/mp.2014.158. PMID: 25510512
Asarnow JR, Tompson MC, McGrath EP
J Child Psychol Psychiatry 2004 Feb;45(2):180-94. doi: 10.1111/j.1469-7610.2004.00213.x. PMID: 14982235
Russell AT
Schizophr Bull 1994;20(4):631-46. doi: 10.1093/schbul/20.4.631. PMID: 7701273

Recent systematic reviews

Adnan M, Motiwala F, Trivedi C, Sultana T, Mansuri Z, Jain S
J Child Adolesc Psychopharmacol 2022 Feb;32(1):2-11. Epub 2022 Jan 28 doi: 10.1089/cap.2021.0092. PMID: 35099269
Kennedy E, Kumar A, Datta SS
Cochrane Database Syst Rev 2007 Jul 18;2007(3):CD004027. doi: 10.1002/14651858.CD004027.pub2. PMID: 17636744Free PMC Article

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