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Heart block

MedGen UID:
42363
•Concept ID:
C0018794
•
Disease or Syndrome; Finding
Synonyms: Block, Heart; Blocks, Heart; Heart Block; Heart Blocks
SNOMED CT: Heart block (233916004); HB - Heart block (233916004)
 
HPO: HP:0012722

Definition

Impaired conduction of cardiac impulse occurring anywhere along the conduction pathway. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHeart block

Conditions with this feature

Meier-Gorlin syndrome 7
MedGen UID:
934705
•Concept ID:
C4310738
•
Disease or Syndrome
Any Meier-Gorlin syndrome in which the cause of the disease is a mutation in the CDC45 gene.
See: Condition Record
Meier-Gorlin syndrome 7

Professional guidelines

PubMed

Fetal Arrhythmia Diagnosis and Pharmacologic Management.
Strasburger JF, Eckstein G, Butler M, Noffke P, Wacker-Gussmann A
J Clin Pharmacol 2022 Sep;62 Suppl 1(Suppl 1):S53-S66. doi: 10.1002/jcph.2129. PMID: 36106782Free PMC Article
2018 ACC/AHA/HRS Guideline on the Evaluation and Management of Patients With Bradycardia and Cardiac Conduction Delay: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society.
Kusumoto FM, Schoenfeld MH, Barrett C, Edgerton JR, Ellenbogen KA, Gold MR, Goldschlager NF, Hamilton RM, Joglar JA, Kim RJ, Lee R, Marine JE, McLeod CJ, Oken KR, Patton KK, Pellegrini CN, Selzman KA, Thompson A, Varosy PD
Circulation 2019 Aug 20;140(8):e382-e482. Epub 2018 Nov 6 doi: 10.1161/CIR.0000000000000628. PMID: 30586772
HRS expert consensus statement on the diagnosis and management of arrhythmias associated with cardiac sarcoidosis.
Birnie DH, Sauer WH, Bogun F, Cooper JM, Culver DA, Duvernoy CS, Judson MA, Kron J, Mehta D, Cosedis Nielsen J, Patel AR, Ohe T, Raatikainen P, Soejima K
Heart Rhythm 2014 Jul;11(7):1305-23. Epub 2014 May 9 doi: 10.1016/j.hrthm.2014.03.043. PMID: 24819193

Recent clinical studies

Etiology

Congenital Heart Block.
Steinberg L
Cardiol Clin 2023 Aug;41(3):399-410. doi: 10.1016/j.ccl.2023.03.002. PMID: 37321690
Congenital Heart Block.
Steinberg L
Card Electrophysiol Clin 2021 Dec;13(4):691-702. doi: 10.1016/j.ccep.2021.07.006. PMID: 34689896
Fetal dysrhythmias.
Carvalho JS
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:28-41. Epub 2019 Jan 9 doi: 10.1016/j.bpobgyn.2019.01.002. PMID: 30738635
Cardiac manifestations of systemic lupus erythematosus.
Miner JJ, Kim AH
Rheum Dis Clin North Am 2014 Feb;40(1):51-60. doi: 10.1016/j.rdc.2013.10.003. PMID: 24268009
Pregnancy in lupus.
Meng C, Lockshin M
Curr Opin Rheumatol 1999 Sep;11(5):348-51. doi: 10.1097/00002281-199909000-00004. PMID: 10503653

Diagnosis

Systemic Diseases and Heart Block.
Sabzwari SRA, Tzou WS
Rheum Dis Clin North Am 2024 Aug;50(3):381-408. doi: 10.1016/j.rdc.2024.03.008. PMID: 38942576
Congenital Heart Block.
Steinberg L
Cardiol Clin 2023 Aug;41(3):399-410. doi: 10.1016/j.ccl.2023.03.002. PMID: 37321690
Congenital Heart Block.
Steinberg L
Card Electrophysiol Clin 2021 Dec;13(4):691-702. doi: 10.1016/j.ccep.2021.07.006. PMID: 34689896
Neonatal congenital heart block.
Yildirim A, Tunaoolu FS, Karaaoac AT
Indian Pediatr 2013 May 8;50(5):483-8. doi: 10.1007/s13312-013-0156-3. PMID: 23778728
Atrioventricular block revisited.
Barold SS
Compr Ther 2002 Spring;28(1):74-8. doi: 10.1007/s12019-002-0044-6. PMID: 11894446

Therapy

Electrocautery-Induced Complete Heart Block.
Alghanem H, Patoli D, Greenberg SB, Szokol JW, Silk VL
J Cardiothorac Vasc Anesth 2021 Jul;35(7):2230-2232. Epub 2020 Nov 10 doi: 10.1053/j.jvca.2020.11.018. PMID: 33268040
Beta-blockers for congestive heart failure in children.
Alabed S, Sabouni A, Al Dakhoul S, Bdaiwi Y
Cochrane Database Syst Rev 2020 Jul 23;7(7):CD007037. doi: 10.1002/14651858.CD007037.pub4. PMID: 32700759Free PMC Article
Hydroxychloroquine to Prevent Recurrent Congenital Heart Block in Fetuses of Anti-SSA/Ro-Positive Mothers.
Izmirly P, Kim M, Friedman DM, Costedoat-Chalumeau N, Clancy R, Copel JA, Phoon CKL, Cuneo BF, Cohen RE, Robins K, Masson M, Wainwright BJ, Zahr N, Saxena A, Buyon JP
J Am Coll Cardiol 2020 Jul 21;76(3):292-302. doi: 10.1016/j.jacc.2020.05.045. PMID: 32674792Free PMC Article
Fetal dysrhythmias.
Carvalho JS
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:28-41. Epub 2019 Jan 9 doi: 10.1016/j.bpobgyn.2019.01.002. PMID: 30738635
Should we treat congenital heart block with fluorinated corticosteroids?
Brucato A, Tincani A, Fredi M, Breda S, Ramoni V, Morel N, Costedoat-Chalumeau N
Autoimmun Rev 2017 Nov;16(11):1115-1118. Epub 2017 Sep 9 doi: 10.1016/j.autrev.2017.09.005. PMID: 28899797

Prognosis

Transcatheter aortic valve replacement and cardiac conduction.
Shreenivas S, Schloss E, Choo J, Sarembock I, Lilly S, Kereiakes D
Expert Rev Cardiovasc Ther 2019 Apr;17(4):293-304. doi: 10.1080/14779072.2019.1598264. PMID: 30912984
Congenitally corrected transposition.
Wallis GA, Debich-Spicer D, Anderson RH
Orphanet J Rare Dis 2011 May 14;6:22. doi: 10.1186/1750-1172-6-22. PMID: 21569592Free PMC Article
Pacemaker therapies in cardiology.
Toogood G
Aust Fam Physician 2007 Jul;36(7):518-9, 521-4. PMID: 17619666
Neonatal lupus erythematosus.
Lee LA
J Invest Dermatol 1993 Jan;100(1):9S-13S. doi: 10.1111/1523-1747.ep12355173. PMID: 8423406
Second degree atrioventricular block.
Bexton RS, Camm AJ
Eur Heart J 1984 Mar;5 Suppl A:111-4. doi: 10.1093/eurheartj/5.suppl_a.111. PMID: 6373268

Clinical prediction guides

Autoimmune-mediated congenital heart block.
Wainwright B, Bhan R, Trad C, Cohen R, Saxena A, Buyon J, Izmirly P
Best Pract Res Clin Obstet Gynaecol 2020 Apr;64:41-51. Epub 2019 Oct 8 doi: 10.1016/j.bpobgyn.2019.09.001. PMID: 31685414
Cardiac manifestations of systemic lupus erythematosus.
Miner JJ, Kim AH
Rheum Dis Clin North Am 2014 Feb;40(1):51-60. doi: 10.1016/j.rdc.2013.10.003. PMID: 24268009
Syncope diagnostic scores.
Sheldon R
Prog Cardiovasc Dis 2013 Jan-Feb;55(4):390-5. doi: 10.1016/j.pcad.2012.10.011. PMID: 23472776
Historical criteria that distinguish syncope from seizures.
Sheldon R, Rose S, Ritchie D, Connolly SJ, Koshman ML, Lee MA, Frenneaux M, Fisher M, Murphy W
J Am Coll Cardiol 2002 Jul 3;40(1):142-8. doi: 10.1016/s0735-1097(02)01940-x. PMID: 12103268
Pregnancy in lupus.
Meng C, Lockshin M
Curr Opin Rheumatol 1999 Sep;11(5):348-51. doi: 10.1097/00002281-199909000-00004. PMID: 10503653

Recent systematic reviews

Maternal and infant outcomes of pregnancy associated with anti-SSA/RO antibodies: a systematic review and meta-analysis.
Sheng X, Song X, Xiong Y, Ren T, Chang X, Wu J, Cao J, Cheng T, Wang M
Pediatr Rheumatol Online J 2023 Mar 4;21(1):22. doi: 10.1186/s12969-023-00803-0. PMID: 36870970Free PMC Article
Beta-blockers for congestive heart failure in children.
Alabed S, Sabouni A, Al Dakhoul S, Bdaiwi Y
Cochrane Database Syst Rev 2020 Jul 23;7(7):CD007037. doi: 10.1002/14651858.CD007037.pub4. PMID: 32700759Free PMC Article
Clinical and electrocardiographic features of complete heart block after blunt cardiac injury: A systematic review of the literature.
Ali H, Furlanello F, Lupo P, Foresti S, De Ambroggi G, Epicoco G, Semprini L, Fundaliotis A, Cappato R
Heart Rhythm 2017 Oct;14(10):1561-1569. Epub 2017 Jun 3 doi: 10.1016/j.hrthm.2017.05.040. PMID: 28583850
Prolonged PR interval, first-degree heart block and adverse cardiovascular outcomes: a systematic review and meta-analysis.
Kwok CS, Rashid M, Beynon R, Barker D, Patwala A, Morley-Davies A, Satchithananda D, Nolan J, Myint PK, Buchan I, Loke YK, Mamas MA
Heart 2016 May;102(9):672-80. Epub 2016 Feb 15 doi: 10.1136/heartjnl-2015-308956. PMID: 26879241
Third-degree heart block associated with lyme carditis: review of published cases.
Forrester JD, Mead P
Clin Infect Dis 2014 Oct;59(7):996-1000. Epub 2014 May 30 doi: 10.1093/cid/ciu411. PMID: 24879781

Supplemental Content

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    Related information

    • ClinVar
      Related medical variations
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
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      Related Medical Subject Headings
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