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Vascular dementia

MedGen UID:: 41447
•Concept ID:: C0011269
•: Disease or Syndrome

Synonyms:	Dementia, Vascular; Dementias, Vascular; Vascular Dementia; Vascular Dementias
SNOMED CT:	Vascular dementia (429998004)

Monarch Initiative:	MONDO:0004648

Definition

A degenerative vascular disorder affecting the brain. It is caused by the blockage of the blood supply to the brain. It is manifested with decline of memory and cognitive functions. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

Vascular dementia

Disease
- Disorder by Site
  - Disorder of nervous system
    - Disorder of the central nervous system
      - Brain disorder
        Cerebrovascular disorder
        Vascular dementia
        Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
        CARASIL syndrome
        Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1
        Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2
        Multi-infarct dementia

Professional guidelines

PubMed

Dementia Prevention and Treatment: A Narrative Review.

Reuben DB, Kremen S, Maust DT
JAMA Intern Med 2024 May 1;184(5):563-572. doi: 10.1001/jamainternmed.2023.8522. PMID: 38436963

Cognitive Impairment in Older Adults: Epidemiology, Diagnosis, and Treatment.

Pérez Palmer N, Trejo Ortega B, Joshi P
Psychiatr Clin North Am 2022 Dec;45(4):639-661. Epub 2022 Oct 14 doi: 10.1016/j.psc.2022.07.010. PMID: 36396270

Cannabinoids for the treatment of dementia.

Bosnjak Kuharic D, Markovic D, Brkovic T, Jeric Kegalj M, Rubic Z, Vuica Vukasovic A, Jeroncic A, Puljak L
Cochrane Database Syst Rev 2021 Sep 17;9(9):CD012820. doi: 10.1002/14651858.CD012820.pub2. PMID: 34532852 Free PMC Article

See all (386)

Recent clinical studies

Etiology

Vascular Cognitive Impairment and Dementia.

Chang Wong E, Chang Chui H
Continuum (Minneap Minn) 2022 Jun 1;28(3):750-780. doi: 10.1212/CON.0000000000001124. PMID: 35678401 Free PMC Article

Behavioral and psychological symptoms in Alzheimer's dementia and vascular dementia.

Deardorff WJ, Grossberg GT
Handb Clin Neurol 2019;165:5-32. doi: 10.1016/B978-0-444-64012-3.00002-2. PMID: 31727229

Epidemiology of Vascular Dementia.

Wolters FJ, Ikram MA
Arterioscler Thromb Vasc Biol 2019 Aug;39(8):1542-1549. Epub 2019 Jul 11 doi: 10.1161/ATVBAHA.119.311908. PMID: 31294622

Sleep disturbances increase the risk of dementia: A systematic review and meta-analysis.

Shi L, Chen SJ, Ma MY, Bao YP, Han Y, Wang YM, Shi J, Vitiello MV, Lu L
Sleep Med Rev 2018 Aug;40:4-16. Epub 2017 Jul 6 doi: 10.1016/j.smrv.2017.06.010. PMID: 28890168

Vascular dementia.

O'Brien JT, Thomas A
Lancet 2015 Oct 24;386(10004):1698-706. doi: 10.1016/S0140-6736(15)00463-8. PMID: 26595643

See all (4468)

Diagnosis

Vascular Cognitive Impairment and Dementia.

Chang Wong E, Chang Chui H
Continuum (Minneap Minn) 2022 Jun 1;28(3):750-780. doi: 10.1212/CON.0000000000001124. PMID: 35678401 Free PMC Article

Behavioral and psychological symptoms in Alzheimer's dementia and vascular dementia.

Deardorff WJ, Grossberg GT
Handb Clin Neurol 2019;165:5-32. doi: 10.1016/B978-0-444-64012-3.00002-2. PMID: 31727229

Magnetic resonance imaging in dementia.

Raposo Rodríguez L, Tovar Salazar DJ, Fernández García N, Pastor Hernández L, Fernández Guinea Ó
Radiologia (Engl Ed) 2018 Nov-Dec;60(6):476-484. Epub 2018 Jun 11 doi: 10.1016/j.rx.2018.04.003. PMID: 29903629

The pathology and pathophysiology of vascular dementia.

Kalaria RN
Neuropharmacology 2018 May 15;134(Pt B):226-239. Epub 2017 Dec 19 doi: 10.1016/j.neuropharm.2017.12.030. PMID: 29273521

Vascular dementia.

O'Brien JT, Thomas A
Lancet 2015 Oct 24;386(10004):1698-706. doi: 10.1016/S0140-6736(15)00463-8. PMID: 26595643

See all (3806)

Therapy

Dementia Prevention and Treatment: A Narrative Review.

Reuben DB, Kremen S, Maust DT
JAMA Intern Med 2024 May 1;184(5):563-572. doi: 10.1001/jamainternmed.2023.8522. PMID: 38436963

Pharmacological Management of Apathy in Dementia.

Azhar L, Kusumo RW, Marotta G, Lanctôt KL, Herrmann N
CNS Drugs 2022 Feb;36(2):143-165. Epub 2022 Jan 10 doi: 10.1007/s40263-021-00883-0. PMID: 35006557

Antipsychotics for agitation and psychosis in people with Alzheimer's disease and vascular dementia.

Mühlbauer V, Möhler R, Dichter MN, Zuidema SU, Köpke S, Luijendijk HJ
Cochrane Database Syst Rev 2021 Dec 17;12(12):CD013304. doi: 10.1002/14651858.CD013304.pub2. PMID: 34918337 Free PMC Article

Cadasil.

Chabriat H, Joutel A, Dichgans M, Tournier-Lasserve E, Bousser MG
Lancet Neurol 2009 Jul;8(7):643-53. doi: 10.1016/S1474-4422(09)70127-9. PMID: 19539236

Ginkgo biloba.

Sierpina VS, Wollschlaeger B, Blumenthal M
Am Fam Physician 2003 Sep 1;68(5):923-6. PMID: 13678141

See all (1815)

Prognosis

A potential association between COVID-19 vaccination and development of Alzheimer's disease.

Roh JH, Jung I, Suh Y, Kim MH
QJM 2024 Oct 1;117(10):709-716. doi: 10.1093/qjmed/hcae103. PMID: 38806183

Age at Diagnosis of Atrial Fibrillation and Incident Dementia.

Zhang W, Liang J, Li C, Gao D, Ma Q, Pan Y, Wang Y, Xie W, Zheng F
JAMA Netw Open 2023 Nov 1;6(11):e2342744. doi: 10.1001/jamanetworkopen.2023.42744. PMID: 37938842 Free PMC Article

Handgrip strength and all-cause dementia incidence and mortality: findings from the UK Biobank prospective cohort study.

Esteban-Cornejo I, Ho FK, Petermann-Rocha F, Lyall DM, Martinez-Gomez D, Cabanas-Sánchez V, Ortega FB, Hillman CH, Gill JMR, Quinn TJ, Sattar N, Pell JP, Gray SR, Celis-Morales C
J Cachexia Sarcopenia Muscle 2022 Jun;13(3):1514-1525. Epub 2022 Apr 21 doi: 10.1002/jcsm.12857. PMID: 35445560 Free PMC Article

The Alzheimer's Disease Amyloid-Beta Hypothesis in Cardiovascular Aging and Disease: JACC Focus Seminar.

Stakos DA, Stamatelopoulos K, Bampatsias D, Sachse M, Zormpas E, Vlachogiannis NI, Tual-Chalot S, Stellos K
J Am Coll Cardiol 2020 Mar 3;75(8):952-967. doi: 10.1016/j.jacc.2019.12.033. PMID: 32130931 Free PMC Article

MIND not Mediterranean diet related to 12-year incidence of cognitive impairment in an Australian longitudinal cohort study.

Hosking DE, Eramudugolla R, Cherbuin N, Anstey KJ
Alzheimers Dement 2019 Apr;15(4):581-589. Epub 2019 Feb 28 doi: 10.1016/j.jalz.2018.12.011. PMID: 30826160

See all (1742)

Clinical prediction guides

Vascular Function in Alzheimer's Disease and Vascular Dementia.

Tachibana H, Washida K, Kowa H, Kanda F, Toda T
Am J Alzheimers Dis Other Demen 2016 Aug;31(5):437-42. Epub 2016 Jun 9 doi: 10.1177/1533317516653820. PMID: 27284205 Free PMC Article

Poor Gait Performance and Prediction of Dementia: Results From a Meta-Analysis.

Beauchet O, Annweiler C, Callisaya ML, De Cock AM, Helbostad JL, Kressig RW, Srikanth V, Steinmetz JP, Blumen HM, Verghese J, Allali G
J Am Med Dir Assoc 2016 Jun 1;17(6):482-90. Epub 2016 Feb 4 doi: 10.1016/j.jamda.2015.12.092. PMID: 26852960 Free PMC Article

Clinical diagnosis of vascular dementia.

Nagata K, Saito H, Ueno T, Sato M, Nakase T, Maeda T, Satoh Y, Komatsu H, Suzuki M, Kondoh Y
J Neurol Sci 2007 Jun 15;257(1-2):44-8. Epub 2007 Apr 19 doi: 10.1016/j.jns.2007.01.049. PMID: 17445833

Donepezil: in vascular dementia.

Goldsmith DR, Scott LJ
Drugs Aging 2003;20(15):1127-36. doi: 10.2165/00002512-200320150-00005. PMID: 14651435

Elements of mobility as predictors of survival in elderly patients with dementia: findings from the Canadian Study of Health and Aging.

Koutsavlis AT, Wolfson C
Chronic Dis Can 2000;21(3):93-103. PMID: 11082345

See all (2634)

Recent systematic reviews

Physical activity as a protective factor for dementia and Alzheimer's disease: systematic review, meta-analysis and quality assessment of cohort and case-control studies.

Iso-Markku P, Kujala UM, Knittle K, Polet J, Vuoksimaa E, Waller K
Br J Sports Med 2022 Jun;56(12):701-709. Epub 2022 Mar 17 doi: 10.1136/bjsports-2021-104981. PMID: 35301183 Free PMC Article

Antipsychotics for agitation and psychosis in people with Alzheimer's disease and vascular dementia.

Mühlbauer V, Möhler R, Dichter MN, Zuidema SU, Köpke S, Luijendijk HJ
Cochrane Database Syst Rev 2021 Dec 17;12(12):CD013304. doi: 10.1002/14651858.CD013304.pub2. PMID: 34918337 Free PMC Article

The Prevalence of Dementia: A Systematic Review and Meta-Analysis.

Cao Q, Tan CC, Xu W, Hu H, Cao XP, Dong Q, Tan L, Yu JT
J Alzheimers Dis 2020;73(3):1157-1166. doi: 10.3233/JAD-191092. PMID: 31884487

Alcohol use and dementia: a systematic scoping review.

Rehm J, Hasan OSM, Black SE, Shield KD, Schwarzinger M
Alzheimers Res Ther 2019 Jan 5;11(1):1. doi: 10.1186/s13195-018-0453-0. PMID: 30611304 Free PMC Article

Sleep disturbances increase the risk of dementia: A systematic review and meta-analysis.

Shi L, Chen SJ, Ma MY, Bao YP, Han Y, Wang YM, Shi J, Vitiello MV, Lu L
Sleep Med Rev 2018 Aug;40:4-16. Epub 2017 Jul 6 doi: 10.1016/j.smrv.2017.06.010. PMID: 28890168

See all (285)

MedGen

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Vascular dementia

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

Related information

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