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Pervasive developmental disorder

MedGen UID:
99336
•Concept ID:
C0524528
•
Mental or Behavioral Dysfunction
Synonym: Rare pervasive developmental disorder
SNOMED CT: Autism spectrum disorder (35919005); Autism (35919005); Pervasive developmental disorder (35919005)
 
Monarch Initiative: MONDO:0000594
Orphanet: ORPHA168778

Definition

A category of developmental disorders characterized by impaired communication and socialization skills. The impairments are incongruent with the individual''s developmental level or mental age. These disorders can be associated with general medical or genetic conditions. [from NCI]

Professional guidelines

PubMed

Practitioner Review: Pharmacological treatment of attention-deficit/hyperactivity disorder symptoms in children and youth with autism spectrum disorder: a systematic review and meta-analysis.
Rodrigues R, Lai MC, Beswick A, Gorman DA, Anagnostou E, Szatmari P, Anderson KK, Ameis SH
J Child Psychol Psychiatry 2021 Jun;62(6):680-700. Epub 2020 Aug 26 doi: 10.1111/jcpp.13305. PMID: 32845025
Autism Spectrum Disorders - Diagnosis and Management.
Mukherjee SB
Indian J Pediatr 2017 Apr;84(4):307-314. Epub 2017 Jan 19 doi: 10.1007/s12098-016-2272-2. PMID: 28101829
Autism Spectrum Disorder: Primary Care Principles.
Sanchack KE, Thomas CA
Am Fam Physician 2016 Dec 15;94(12):972-979. PMID: 28075089

Recent clinical studies

Etiology

Autism Spectrum Disorder: Classification, diagnosis and therapy.
Sharma SR, Gonda X, Tarazi FI
Pharmacol Ther 2018 Oct;190:91-104. Epub 2018 May 12 doi: 10.1016/j.pharmthera.2018.05.007. PMID: 29763648
Autism Spectrum Disorders - Diagnosis and Management.
Mukherjee SB
Indian J Pediatr 2017 Apr;84(4):307-314. Epub 2017 Jan 19 doi: 10.1007/s12098-016-2272-2. PMID: 28101829
Autism and related disorders.
McPartland J, Volkmar FR
Handb Clin Neurol 2012;106:407-18. doi: 10.1016/B978-0-444-52002-9.00023-1. PMID: 22608634Free PMC Article
Randomized, controlled trial of an intervention for toddlers with autism: the Early Start Denver Model.
Dawson G, Rogers S, Munson J, Smith M, Winter J, Greenson J, Donaldson A, Varley J
Pediatrics 2010 Jan;125(1):e17-23. Epub 2009 Nov 30 doi: 10.1542/peds.2009-0958. PMID: 19948568Free PMC Article
Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children.
Wakefield AJ, Murch SH, Anthony A, Linnell J, Casson DM, Malik M, Berelowitz M, Dhillon AP, Thomson MA, Harvey P, Valentine A, Davies SE, Walker-Smith JA
Lancet 1998 Feb 28;351(9103):637-41. doi: 10.1016/s0140-6736(97)11096-0. PMID: 9500320

Diagnosis

Autism Spectrum Disorder: Classification, diagnosis and therapy.
Sharma SR, Gonda X, Tarazi FI
Pharmacol Ther 2018 Oct;190:91-104. Epub 2018 May 12 doi: 10.1016/j.pharmthera.2018.05.007. PMID: 29763648
Autism Spectrum Disorders - Diagnosis and Management.
Mukherjee SB
Indian J Pediatr 2017 Apr;84(4):307-314. Epub 2017 Jan 19 doi: 10.1007/s12098-016-2272-2. PMID: 28101829
Autism Spectrum Disorder: Primary Care Principles.
Sanchack KE, Thomas CA
Am Fam Physician 2016 Dec 15;94(12):972-979. PMID: 28075089
Autism and related disorders.
McPartland J, Volkmar FR
Handb Clin Neurol 2012;106:407-18. doi: 10.1016/B978-0-444-52002-9.00023-1. PMID: 22608634Free PMC Article
Asperger's syndrome.
McPartland J, Klin A
Adolesc Med Clin 2006 Oct;17(3):771-88; abstract xiii. doi: 10.1016/j.admecli.2006.06.010. PMID: 17030291

Therapy

Autism Spectrum Disorder: Classification, diagnosis and therapy.
Sharma SR, Gonda X, Tarazi FI
Pharmacol Ther 2018 Oct;190:91-104. Epub 2018 May 12 doi: 10.1016/j.pharmthera.2018.05.007. PMID: 29763648
Autism Spectrum Disorders - Diagnosis and Management.
Mukherjee SB
Indian J Pediatr 2017 Apr;84(4):307-314. Epub 2017 Jan 19 doi: 10.1007/s12098-016-2272-2. PMID: 28101829
Autism Spectrum Disorder: Primary Care Principles.
Sanchack KE, Thomas CA
Am Fam Physician 2016 Dec 15;94(12):972-979. PMID: 28075089
Randomized, controlled trial of an intervention for toddlers with autism: the Early Start Denver Model.
Dawson G, Rogers S, Munson J, Smith M, Winter J, Greenson J, Donaldson A, Varley J
Pediatrics 2010 Jan;125(1):e17-23. Epub 2009 Nov 30 doi: 10.1542/peds.2009-0958. PMID: 19948568Free PMC Article
Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children.
Wakefield AJ, Murch SH, Anthony A, Linnell J, Casson DM, Malik M, Berelowitz M, Dhillon AP, Thomson MA, Harvey P, Valentine A, Davies SE, Walker-Smith JA
Lancet 1998 Feb 28;351(9103):637-41. doi: 10.1016/s0140-6736(97)11096-0. PMID: 9500320

Prognosis

Autism Spectrum Disorders - Diagnosis and Management.
Mukherjee SB
Indian J Pediatr 2017 Apr;84(4):307-314. Epub 2017 Jan 19 doi: 10.1007/s12098-016-2272-2. PMID: 28101829
Autism Spectrum Disorder: Primary Care Principles.
Sanchack KE, Thomas CA
Am Fam Physician 2016 Dec 15;94(12):972-979. PMID: 28075089
microRNA and Autism.
Anitha A, Thanseem I
Adv Exp Med Biol 2015;888:71-83. doi: 10.1007/978-3-319-22671-2_5. PMID: 26663179
Autism, oxytocin and interoception.
Quattrocki E, Friston K
Neurosci Biobehav Rev 2014 Nov;47:410-30. Epub 2014 Sep 30 doi: 10.1016/j.neubiorev.2014.09.012. PMID: 25277283Free PMC Article
Randomized, controlled trial of an intervention for toddlers with autism: the Early Start Denver Model.
Dawson G, Rogers S, Munson J, Smith M, Winter J, Greenson J, Donaldson A, Varley J
Pediatrics 2010 Jan;125(1):e17-23. Epub 2009 Nov 30 doi: 10.1542/peds.2009-0958. PMID: 19948568Free PMC Article

Clinical prediction guides

Autism Spectrum Disorder: Classification, diagnosis and therapy.
Sharma SR, Gonda X, Tarazi FI
Pharmacol Ther 2018 Oct;190:91-104. Epub 2018 May 12 doi: 10.1016/j.pharmthera.2018.05.007. PMID: 29763648
Prevalence of Autism Spectrum Disorder Among Children Aged 8 Years - Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2014.
Baio J, Wiggins L, Christensen DL, Maenner MJ, Daniels J, Warren Z, Kurzius-Spencer M, Zahorodny W, Robinson Rosenberg C, White T, Durkin MS, Imm P, Nikolaou L, Yeargin-Allsopp M, Lee LC, Harrington R, Lopez M, Fitzgerald RT, Hewitt A, Pettygrove S, Constantino JN, Vehorn A, Shenouda J, Hall-Lande J, Van Naarden Braun K, Dowling NF
MMWR Surveill Summ 2018 Apr 27;67(6):1-23. doi: 10.15585/mmwr.ss6706a1. PMID: 29701730Free PMC Article
Autism Spectrum Disorders - Diagnosis and Management.
Mukherjee SB
Indian J Pediatr 2017 Apr;84(4):307-314. Epub 2017 Jan 19 doi: 10.1007/s12098-016-2272-2. PMID: 28101829
Pesticide exposure in children.
Roberts JR, Karr CJ; Council On Environmental Health
Pediatrics 2012 Dec;130(6):e1765-88. Epub 2012 Nov 26 doi: 10.1542/peds.2012-2758. PMID: 23184105Free PMC Article
Randomized, controlled trial of an intervention for toddlers with autism: the Early Start Denver Model.
Dawson G, Rogers S, Munson J, Smith M, Winter J, Greenson J, Donaldson A, Varley J
Pediatrics 2010 Jan;125(1):e17-23. Epub 2009 Nov 30 doi: 10.1542/peds.2009-0958. PMID: 19948568Free PMC Article

Recent systematic reviews

Efficacy and Safety of Alpha-2 Agonists in Autism Spectrum Disorder: A Systematic Review.
Kaye AD, Green AM, Claude JT 2nd, Daniel CP, Cooley JF, Sala KR, Potharaju P, Rieger R, Patil S, Ahmadzadeh S, Shekoohi S
Adv Ther 2024 Nov;41(11):4299-4311. Epub 2024 Sep 13 doi: 10.1007/s12325-024-02980-0. PMID: 39269569
Practitioner Review: Pharmacological treatment of attention-deficit/hyperactivity disorder symptoms in children and youth with autism spectrum disorder: a systematic review and meta-analysis.
Rodrigues R, Lai MC, Beswick A, Gorman DA, Anagnostou E, Szatmari P, Anderson KK, Ameis SH
J Child Psychol Psychiatry 2021 Jun;62(6):680-700. Epub 2020 Aug 26 doi: 10.1111/jcpp.13305. PMID: 32845025
Mitochondrial Aspartate/Glutamate Carrier SLC25A12 and Autism Spectrum Disorder: a Meta-Analysis.
Aoki Y, Cortese S
Mol Neurobiol 2016 Apr;53(3):1579-1588. Epub 2015 Feb 10 doi: 10.1007/s12035-015-9116-3. PMID: 25663199
Comorbidity in pediatric bipolar disorder: prevalence, clinical impact, etiology and treatment.
Frías Á, Palma C, Farriols N
J Affect Disord 2015 Mar 15;174:378-89. Epub 2014 Dec 12 doi: 10.1016/j.jad.2014.12.008. PMID: 25545605
How will DSM-5 affect autism diagnosis? A systematic literature review and meta-analysis.
Kulage KM, Smaldone AM, Cohn EG
J Autism Dev Disord 2014 Aug;44(8):1918-32. doi: 10.1007/s10803-014-2065-2. PMID: 24531932

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