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Benign neoplasm of rectum

MedGen UID:
99222
•Concept ID:
C0496867
•
Neoplastic Process
Synonyms: Benign Neoplasm of Rectum; benign neoplasm of rectum; Benign Neoplasm of the Rectum; benign neoplasm of the rectum; Benign Rectal Neoplasm; benign rectal neoplasm; Benign Rectal Neoplasms; benign rectal neoplasms; Benign Rectal Tumor; benign rectal tumor; Benign Rectal Tumors; benign rectal tumors; benign rectal tumour; benign rectal tumours; Benign tumor of rectum; Benign Tumor of Rectum; benign tumor of rectum; Benign Tumor of the Rectum; benign tumor of the rectum; benign tumour of rectum; benign tumour of the rectum; Rectal Neoplasms, Benign; rectal neoplasms, benign; Rectal Tumors, Benign; rectal tumors, benign; rectum benign neoplasm
SNOMED CT: Benign tumor of rectum (92318000); Benign neoplasm of rectum (92318000)
 
Monarch Initiative: MONDO:0021462

Definition

A neoplasm that arises from the rectum and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Colon Cancer.
Vogel JD, Felder SI, Bhama AR, Hawkins AT, Langenfeld SJ, Shaffer VO, Thorsen AJ, Weiser MR, Chang GJ, Lightner AL, Feingold DL, Paquette IM
Dis Colon Rectum 2022 Feb 1;65(2):148-177. doi: 10.1097/DCR.0000000000002323. PMID: 34775402
Colorectal Cancer Screening Methods and Molecular Markers for Early Detection.
Wu Z, Li Y, Zhang Y, Hu H, Wu T, Liu S, Chen W, Xie S, Lu Z
Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820980426. doi: 10.1177/1533033820980426. PMID: 33353503Free PMC Article
MRI of Rectal Cancer: Tumor Staging, Imaging Techniques, and Management.
Horvat N, Carlos Tavares Rocha C, Clemente Oliveira B, Petkovska I, Gollub MJ
Radiographics 2019 Mar-Apr;39(2):367-387. Epub 2019 Feb 15 doi: 10.1148/rg.2019180114. PMID: 30768361Free PMC Article

Recent clinical studies

Etiology

Development and Validation of a Post-Radiotherapy Prediction Model for Bowel Dysfunction After Rectal Cancer Resection.
Qin Q, Huang B, Wu A, Gao J, Liu X, Cao W, Ma T, Kuang Y, Guo J, Wu Q, Shao B, Guan Q, Yao H, Zhang X, Wang H; Chinese Radiation Intestinal Injury Research Group
Gastroenterology 2023 Dec;165(6):1430-1442.e14. Epub 2023 Aug 23 doi: 10.1053/j.gastro.2023.08.022. PMID: 37625498
The importance of MRI for rectal cancer evaluation.
Fernandes MC, Gollub MJ, Brown G
Surg Oncol 2022 Aug;43:101739. Epub 2022 Mar 18 doi: 10.1016/j.suronc.2022.101739. PMID: 35339339Free PMC Article
Management of the adenocarcinoma of the upper rectum: a reappraisal.
Pechlivanides G, Gourtsoyianni S, Gouvas N, Sougklakos J, Xynos E
Updates Surg 2021 Apr;73(2):513-526. Epub 2020 Oct 27 doi: 10.1007/s13304-020-00903-6. PMID: 33108641
The Intestinal Microbiota in Colorectal Cancer.
Tilg H, Adolph TE, Gerner RR, Moschen AR
Cancer Cell 2018 Jun 11;33(6):954-964. Epub 2018 Apr 12 doi: 10.1016/j.ccell.2018.03.004. PMID: 29657127
The mesorectum in rectal cancer surgery--the clue to pelvic recurrence?
Heald RJ, Husband EM, Ryall RD
Br J Surg 1982 Oct;69(10):613-6. doi: 10.1002/bjs.1800691019. PMID: 6751457

Diagnosis

Development and Validation of a Post-Radiotherapy Prediction Model for Bowel Dysfunction After Rectal Cancer Resection.
Qin Q, Huang B, Wu A, Gao J, Liu X, Cao W, Ma T, Kuang Y, Guo J, Wu Q, Shao B, Guan Q, Yao H, Zhang X, Wang H; Chinese Radiation Intestinal Injury Research Group
Gastroenterology 2023 Dec;165(6):1430-1442.e14. Epub 2023 Aug 23 doi: 10.1053/j.gastro.2023.08.022. PMID: 37625498
Serrated polyps of the colon and rectum: Remove or not?
Sano W, Hirata D, Teramoto A, Iwatate M, Hattori S, Fujita M, Sano Y
World J Gastroenterol 2020 May 21;26(19):2276-2285. doi: 10.3748/wjg.v26.i19.2276. PMID: 32476792Free PMC Article
MRI of Rectal Cancer: Tumor Staging, Imaging Techniques, and Management.
Horvat N, Carlos Tavares Rocha C, Clemente Oliveira B, Petkovska I, Gollub MJ
Radiographics 2019 Mar-Apr;39(2):367-387. Epub 2019 Feb 15 doi: 10.1148/rg.2019180114. PMID: 30768361Free PMC Article
Retrorectal tumors.
Bullard Dunn K
Surg Clin North Am 2010 Feb;90(1):163-71, Table of Contents. doi: 10.1016/j.suc.2009.09.009. PMID: 20109640
Rectal cancer staging.
Torricelli P
Surg Oncol 2007 Dec;16 Suppl 1:S49-50. Epub 2007 Nov 26 doi: 10.1016/j.suronc.2007.10.037. PMID: 18032027

Therapy

Neoadjuvant radiotherapy for rectal cancer management.
Feeney G, Sehgal R, Sheehan M, Hogan A, Regan M, Joyce M, Kerin M
World J Gastroenterol 2019 Sep 7;25(33):4850-4869. doi: 10.3748/wjg.v25.i33.4850. PMID: 31543678Free PMC Article
Long-course preoperative chemoradiation versus 5 × 5 Gy and consolidation chemotherapy for clinical T4 and fixed clinical T3 rectal cancer: long-term results of the randomized Polish II study.
Ciseł B, Pietrzak L, Michalski W, Wyrwicz L, Rutkowski A, Kosakowska E, Cencelewicz A, Spałek M, Polkowski W, Jankiewicz M, Styliński R, Bębenek M, Kapturkiewicz B, Maciejczyk A, Sadowski J, Zygulska J, Zegarski W, Jankowski M, Las-Jankowska M, Toczko Z, Żelazowska-Omiotek U, Kępka L, Socha J, Wasilewska-Tesluk E, Markiewicz W, Kładny J, Majewski A, Kapuściński W, Suwiński R, Bujko K; Polish Colorectal Study Group
Ann Oncol 2019 Aug 1;30(8):1298-1303. doi: 10.1093/annonc/mdz186. PMID: 31192355
Recent advances in multidisciplinary approach for rectal cancer.
Oki E, Ando K, Kasagi Y, Zaitsu Y, Sugiyama M, Nakashima Y, Sonoda H, Ohgaki K, Saeki H, Maehara Y
Int J Clin Oncol 2015 Aug;20(4):641-9. Epub 2015 Jun 23 doi: 10.1007/s10147-015-0858-8. PMID: 26100273
Robotic surgery: colon and rectum.
Baek SK, Carmichael JC, Pigazzi A
Cancer J 2013 Mar-Apr;19(2):140-6. doi: 10.1097/PPO.0b013e31828ba0fd. PMID: 23528722
Symptomatic hemorrhoids.
Gearhart SL
Adv Surg 2004;38:167-82. PMID: 15515618

Prognosis

The importance of MRI for rectal cancer evaluation.
Fernandes MC, Gollub MJ, Brown G
Surg Oncol 2022 Aug;43:101739. Epub 2022 Mar 18 doi: 10.1016/j.suronc.2022.101739. PMID: 35339339Free PMC Article
Imaging and Management of Rectal Cancer.
Arya S, Sen S, Engineer R, Saklani A, Pandey T
Semin Ultrasound CT MR 2020 Apr;41(2):183-206. Epub 2020 Jan 24 doi: 10.1053/j.sult.2020.01.001. PMID: 32446431
Long-course preoperative chemoradiation versus 5 × 5 Gy and consolidation chemotherapy for clinical T4 and fixed clinical T3 rectal cancer: long-term results of the randomized Polish II study.
Ciseł B, Pietrzak L, Michalski W, Wyrwicz L, Rutkowski A, Kosakowska E, Cencelewicz A, Spałek M, Polkowski W, Jankiewicz M, Styliński R, Bębenek M, Kapturkiewicz B, Maciejczyk A, Sadowski J, Zygulska J, Zegarski W, Jankowski M, Las-Jankowska M, Toczko Z, Żelazowska-Omiotek U, Kępka L, Socha J, Wasilewska-Tesluk E, Markiewicz W, Kładny J, Majewski A, Kapuściński W, Suwiński R, Bujko K; Polish Colorectal Study Group
Ann Oncol 2019 Aug 1;30(8):1298-1303. doi: 10.1093/annonc/mdz186. PMID: 31192355
Rectal Cancer in 2018: A Primer for the Gastroenterologist.
Goldenberg BA, Holliday EB, Helewa RM, Singh H
Am J Gastroenterol 2018 Dec;113(12):1763-1771. doi: 10.1038/s41395-018-0180-y. PMID: 30008472Free PMC Article
The mesorectum in rectal cancer surgery--the clue to pelvic recurrence?
Heald RJ, Husband EM, Ryall RD
Br J Surg 1982 Oct;69(10):613-6. doi: 10.1002/bjs.1800691019. PMID: 6751457

Clinical prediction guides

Development and Validation of a Post-Radiotherapy Prediction Model for Bowel Dysfunction After Rectal Cancer Resection.
Qin Q, Huang B, Wu A, Gao J, Liu X, Cao W, Ma T, Kuang Y, Guo J, Wu Q, Shao B, Guan Q, Yao H, Zhang X, Wang H; Chinese Radiation Intestinal Injury Research Group
Gastroenterology 2023 Dec;165(6):1430-1442.e14. Epub 2023 Aug 23 doi: 10.1053/j.gastro.2023.08.022. PMID: 37625498
The importance of MRI for rectal cancer evaluation.
Fernandes MC, Gollub MJ, Brown G
Surg Oncol 2022 Aug;43:101739. Epub 2022 Mar 18 doi: 10.1016/j.suronc.2022.101739. PMID: 35339339Free PMC Article
ESTRO ACROP consensus guideline on CT- and MRI-based target volume delineation for primary radiation therapy of localized prostate cancer.
Salembier C, Villeirs G, De Bari B, Hoskin P, Pieters BR, Van Vulpen M, Khoo V, Henry A, Bossi A, De Meerleer G, Fonteyne V
Radiother Oncol 2018 Apr;127(1):49-61. doi: 10.1016/j.radonc.2018.01.014. PMID: 29496279
Clinical Significance and Prognostic Relevance of Microsatellite Instability in Sporadic Colorectal Cancer Patients.
Copija A, Waniczek D, Witkoś A, Walkiewicz K, Nowakowska-Zajdel E
Int J Mol Sci 2017 Jan 6;18(1) doi: 10.3390/ijms18010107. PMID: 28067827Free PMC Article
What influences preneoplastic colorectal lesion recurrence?
De Maio G, Zama E, Rengucci C, Calistri D
Oncotarget 2017 Feb 14;8(7):12406-12416. doi: 10.18632/oncotarget.13628. PMID: 27902488Free PMC Article

Recent systematic reviews

Hyperbaric oxygen therapy for late radiation tissue injury.
Lin ZC, Bennett MH, Hawkins GC, Azzopardi CP, Feldmeier J, Smee R, Milross C
Cochrane Database Syst Rev 2023 Aug 15;8(8):CD005005. doi: 10.1002/14651858.CD005005.pub5. PMID: 37585677Free PMC Article
Non-occupational physical activity and risk of cardiovascular disease, cancer and mortality outcomes: a dose-response meta-analysis of large prospective studies.
Garcia L, Pearce M, Abbas A, Mok A, Strain T, Ali S, Crippa A, Dempsey PC, Golubic R, Kelly P, Laird Y, McNamara E, Moore S, de Sa TH, Smith AD, Wijndaele K, Woodcock J, Brage S
Br J Sports Med 2023 Aug;57(15):979-989. Epub 2023 Feb 28 doi: 10.1136/bjsports-2022-105669. PMID: 36854652Free PMC Article
Delta radiomics: a systematic review.
Nardone V, Reginelli A, Grassi R, Boldrini L, Vacca G, D'Ippolito E, Annunziata S, Farchione A, Belfiore MP, Desideri I, Cappabianca S
Radiol Med 2021 Dec;126(12):1571-1583. Epub 2021 Dec 4 doi: 10.1007/s11547-021-01436-7. PMID: 34865190
Total Neoadjuvant Therapy (TNT) versus Standard Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer: A Systematic Review and Meta-Analysis.
Liu S, Jiang T, Xiao L, Yang S, Liu Q, Gao Y, Chen G, Xiao W
Oncologist 2021 Sep;26(9):e1555-e1566. Epub 2021 Jun 7 doi: 10.1002/onco.13824. PMID: 33987952Free PMC Article
Mortality due to cancer treatment delay: systematic review and meta-analysis.
Hanna TP, King WD, Thibodeau S, Jalink M, Paulin GA, Harvey-Jones E, O'Sullivan DE, Booth CM, Sullivan R, Aggarwal A
BMJ 2020 Nov 4;371:m4087. doi: 10.1136/bmj.m4087. PMID: 33148535Free PMC Article

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