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Synovium neoplasm

MedGen UID:
99197
•Concept ID:
C0476203
•
Neoplastic Process
Synonyms: neoplasm of synovial membrane of synovial joint; Neoplasm of Synovium; neoplasm of synovium; Neoplasm of the Synovium; neoplasm of the synovium; synovial membrane of synovial joint neoplasm; synovial membrane of synovial joint neoplasm (disease); synovial membrane of synovial joint tumor; synovial membrane of synovial joint tumour; Synovial Neoplasm; synovial neoplasm; synovial neoplasm (morphologic abnormality); synovial neoplasm NOS (morphologic abnormality); Synovial Tumor; synovial tumor; synovial tumour; synovium neoplasm; tumor of synovial membrane of synovial joint; Tumor of Synovium; tumor of synovium; Tumor of the Synovium; tumor of the synovium; tumour of synovial membrane of synovial joint; tumour of synovium; tumour of the synovium
 
Monarch Initiative: MONDO:0002528

Definition

A benign or malignant soft tissue neoplasm arising exclusively from the synovial membrane. Examples include the diffuse giant cell tumor of tendon sheath, localized giant cell tumor of tendon sheath, and malignant giant cell tumor of tendon sheath. [from NCI]

Professional guidelines

PubMed

Updates on the Treatment of Tenosynovial Giant Cell Tumor.
Chan AS, Katiyar V, Dy P, Singh V
Hematol Oncol Stem Cell Ther 2023 May 23;16(4):307-315. doi: 10.56875/2589-0646.1032. PMID: 37363972
Diffuse-type tenosynovial giant cell tumour: Current treatment concepts and future perspectives.
Staals EL, Ferrari S, Donati DM, Palmerini E
Eur J Cancer 2016 Aug;63:34-40. Epub 2016 Jun 5 doi: 10.1016/j.ejca.2016.04.022. PMID: 27267143
Anterior knee pain in the young athlete: diagnosis and treatment.
Kodali P, Islam A, Andrish J
Sports Med Arthrosc Rev 2011 Mar;19(1):27-33. doi: 10.1097/JSA.0b013e3182045aa1. PMID: 21293235

Recent clinical studies

Etiology

Tenosynovial giant cell tumor.
Kager M, Kager R, Fałek P, Fałek A, Szczypiór G, Niemunis-Sawicka J, Rzepecka-Wejs L, Starosławska E, Burdan F
Folia Med Cracov 2022;62(2):93-107. doi: 10.24425/fmc.2022.141702. PMID: 36256897
Musculoskeletal Manifestations of Amyloidosis: A Focused Review.
Nguyen TX, Naqvi A, Thompson TL, Wilson RH
J Surg Orthop Adv 2018 Spring;27(1):1-5. PMID: 29762107
Dosimetry perspectives in radiation synovectomy.
Ahmad I, Nisar H
Phys Med 2018 Mar;47:64-72. Epub 2018 Feb 28 doi: 10.1016/j.ejmp.2018.02.015. PMID: 29609820
Pigmented villonodular synovitis.
Ofluoglu O
Orthop Clin North Am 2006 Jan;37(1):23-33. doi: 10.1016/j.ocl.2005.08.002. PMID: 16311109
Synovial neoformations and tumours.
Szendrói M, Deodhar A
Baillieres Best Pract Res Clin Rheumatol 2000 Jun;14(2):363-83. doi: 10.1053/berh.1999.0070. PMID: 10925750

Diagnosis

Tenosynovial giant cell tumor.
Kager M, Kager R, Fałek P, Fałek A, Szczypiór G, Niemunis-Sawicka J, Rzepecka-Wejs L, Starosławska E, Burdan F
Folia Med Cracov 2022;62(2):93-107. doi: 10.24425/fmc.2022.141702. PMID: 36256897
Synovial Tumors and Proliferative Diseases.
Levine BD, Motamedi K, Seeger LL
Rheum Dis Clin North Am 2016 Nov;42(4):753-768. Epub 2016 Sep 7 doi: 10.1016/j.rdc.2016.07.008. PMID: 27742025
Lipoma arborescens.
Sanamandra SK, Ong KO
Singapore Med J 2014 Jan;55(1):5-10; quiz 11. doi: 10.11622/smedj.2014003. PMID: 24452971Free PMC Article
Benign synovial disorders.
Adelani MA, Wupperman RM, Holt GE
J Am Acad Orthop Surg 2008 May;16(5):268-75. doi: 10.5435/00124635-200805000-00005. PMID: 18460687
Synovial sarcoma.
Fisher C
Ann Diagn Pathol 1998 Dec;2(6):401-21. doi: 10.1016/s1092-9134(98)80042-7. PMID: 9930576

Therapy

Tenosynovial giant cell tumor.
Kager M, Kager R, Fałek P, Fałek A, Szczypiór G, Niemunis-Sawicka J, Rzepecka-Wejs L, Starosławska E, Burdan F
Folia Med Cracov 2022;62(2):93-107. doi: 10.24425/fmc.2022.141702. PMID: 36256897
Guizhi-Shaoyao-Zhimu decoction possesses anti-arthritic effects on type II collagen-induced arthritis in rats via suppression of inflammatory reactions, inhibition of invasion & migration and induction of apoptosis in synovial fibroblasts.
Zhang Q, Peng W, Wei S, Wei D, Li R, Liu J, Peng L, Yang S, Gao Y, Wu C, Pu X
Biomed Pharmacother 2019 Oct;118:109367. Epub 2019 Aug 21 doi: 10.1016/j.biopha.2019.109367. PMID: 31545276
Pigmented villonodular synovitis.
Fałek A, Niemunis-Sawicka J, Wrona K, Szczypiór G, Rzepecka-Wejs L, Cięszczyk K, Burdan M, Puderecki M, Burzec P, Marzec-Kotarska B, Szumiło J, Burdan F
Folia Med Cracov 2018;58(4):93-104. PMID: 30745604
CSF-1R Inhibitor Development: Current Clinical Status.
Peyraud F, Cousin S, Italiano A
Curr Oncol Rep 2017 Sep 5;19(11):70. doi: 10.1007/s11912-017-0634-1. PMID: 28875266
Pathology of the synovium.
O'Connell JX
Am J Clin Pathol 2000 Nov;114(5):773-84. doi: 10.1309/LWW3-5XK0-FKG9-HDRK. PMID: 11068553

Prognosis

Tenosynovial giant cell tumor.
Kager M, Kager R, Fałek P, Fałek A, Szczypiór G, Niemunis-Sawicka J, Rzepecka-Wejs L, Starosławska E, Burdan F
Folia Med Cracov 2022;62(2):93-107. doi: 10.24425/fmc.2022.141702. PMID: 36256897
MRI of synovitis and joint fluid.
Burke CJ, Alizai H, Beltran LS, Regatte RR
J Magn Reson Imaging 2019 Jun;49(6):1512-1527. Epub 2019 Jan 8 doi: 10.1002/jmri.26618. PMID: 30618151Free PMC Article
Lipoma arborescens.
Sanamandra SK, Ong KO
Singapore Med J 2014 Jan;55(1):5-10; quiz 11. doi: 10.11622/smedj.2014003. PMID: 24452971Free PMC Article
Pigmented villonodular synovitis.
Tyler WK, Vidal AF, Williams RJ, Healey JH
J Am Acad Orthop Surg 2006 Jun;14(6):376-85. doi: 10.5435/00124635-200606000-00007. PMID: 16757677
Synovial sarcoma.
Fisher C
Ann Diagn Pathol 1998 Dec;2(6):401-21. doi: 10.1016/s1092-9134(98)80042-7. PMID: 9930576

Clinical prediction guides

Clinical, Radiographic, and Ultrasound Findings Between Simple and Complicated Baker's Cysts.
Park GY, Kwon DR, Kwon DG
Am J Phys Med Rehabil 2020 Jan;99(1):7-12. doi: 10.1097/PHM.0000000000001263. PMID: 31335340
Guizhi-Shaoyao-Zhimu decoction possesses anti-arthritic effects on type II collagen-induced arthritis in rats via suppression of inflammatory reactions, inhibition of invasion & migration and induction of apoptosis in synovial fibroblasts.
Zhang Q, Peng W, Wei S, Wei D, Li R, Liu J, Peng L, Yang S, Gao Y, Wu C, Pu X
Biomed Pharmacother 2019 Oct;118:109367. Epub 2019 Aug 21 doi: 10.1016/j.biopha.2019.109367. PMID: 31545276
Unusual Findings in Synovial Fluid Analysis: A Review.
Oliviero F, Galozzi P, Ramonda R, de Oliveira FL, Schiavon F, Scanu A, Punzi L
Ann Clin Lab Sci 2017 May;47(3):253-259. PMID: 28667024
Cyclooxygenase-2 in human pathological disease.
Koki A, Khan NK, Woerner BM, Dannenberg AJ, Olson L, Seibert K, Edwards D, Hardy M, Isakson P, Masferrer JL
Adv Exp Med Biol 2002;507:177-84. doi: 10.1007/978-1-4615-0193-0_28. PMID: 12664583
Silicone breast implants: pathology.
Raso DS, Greene WB
Ultrastruct Pathol 1997 May-Jun;21(3):263-71. doi: 10.3109/01913129709021922. PMID: 9183827

Recent systematic reviews

Surgical management of upper limb lipoma arborescens: a systematic review.
Kalifis G, Maffulli N, Migliorini F, Marín Fermín T, Hovsepian JM, Stefanou N, Hantes M
J Orthop Surg Res 2022 Mar 4;17(1):138. doi: 10.1186/s13018-022-02997-7. PMID: 35246183Free PMC Article
Treatment, recurrence rates and follow-up of Tenosynovial Giant Cell Tumor (TGCT) of the foot and ankle-A systematic review and meta-analysis.
Siegel M, Bode L, Südkamp N, Kühle J, Zwingmann J, Schmal H, Herget GW
PLoS One 2021;16(12):e0260795. Epub 2021 Dec 2 doi: 10.1371/journal.pone.0260795. PMID: 34855875Free PMC Article
Synovial Sarcoma of the Nerve-Clinical and Pathological Features: Case Series and Systematic Review.
Burks SS, Puffer RC, Cajigas I, Valdivia D, Rosenberg AE, Spinner RJ, Levi AD
Neurosurgery 2019 Dec 1;85(6):E975-E991. doi: 10.1093/neuros/nyz321. PMID: 31435657Free PMC Article
Pigmented Villonodular Synovitis of the Hip: A Systematic Review.
Levy DM, Haughom BD, Nho SJ, Gitelis S
Am J Orthop (Belle Mead NJ) 2016 Jan;45(1):23-8. PMID: 26761914
A multidisciplinary approach to giant cell tumors of tendon sheath and synovium--a critical appraisal of literature and treatment proposal.
van der Heijden L, Gibbons CL, Hassan AB, Kroep JR, Gelderblom H, van Rijswijk CS, Nout RA, Bradley KM, Athanasou NA, Dijkstra PD, Hogendoorn PC, van de Sande MA
J Surg Oncol 2013 Mar;107(4):433-45. Epub 2012 Jul 17 doi: 10.1002/jso.23220. PMID: 22806927

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