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Cerebellopontine angle tumor

MedGen UID:
99181
•Concept ID:
C0474740
•
Neoplastic Process
Synonyms: Angle Tumor; Angle Tumor, Cerebellopontine; Angle Tumors; Angle Tumors, Cerebellopontine; Cerebellopontine Angle Tumor; Cerebellopontine Angle Tumors; Tumor, Angle; Tumor, Cerebellopontine Angle; Tumors, Angle; Tumors, Cerebellopontine Angle
SNOMED CT: Cerebellopontine angle tumor (126947009)
 
Monarch Initiative: MONDO:0002553

Definition

A neoplasm that affects the cerebellopontine angle. Representative examples include vestibular schwannoma and meningioma. [from NCI]

Professional guidelines

PubMed

Imaging of the Vestibular Schwannoma: Diagnosis, Monitoring, and Treatment Planning.
Connor SEJ
Neuroimaging Clin N Am 2021 Nov;31(4):451-471. doi: 10.1016/j.nic.2021.05.006. PMID: 34689927
EAONO Position Statement on Vestibular Schwannoma: Imaging Assessment. What are the Indications for Performing a Screening MRI Scan for a Potential Vestibular Schwannoma?
Waterval J, Kania R, Somers T
J Int Adv Otol 2018 Apr;14(1):95-99. doi: 10.5152/iao.2018.5364. PMID: 29764782Free PMC Article
The Management and Imaging of Vestibular Schwannomas.
Lin EP, Crane BT
AJNR Am J Neuroradiol 2017 Nov;38(11):2034-2043. Epub 2017 May 25 doi: 10.3174/ajnr.A5213. PMID: 28546250Free PMC Article

Recent clinical studies

Etiology

Evaluation of balance after surgery for cerebellopontine angle tumor.
Canbaz N, Atılgan E, Tarakcı E, Papaker MG
J Back Musculoskelet Rehabil 2019;32(1):93-99. doi: 10.3233/BMR-181198. PMID: 30248037
The relation between flocculus volume and tinnitus after cerebellopontine angle tumor surgery.
Mennink LM, Van Dijk JMC, Van Der Laan BFAM, Metzemaekers JDM, Van Laar PJ, Van Dijk P
Hear Res 2018 Apr;361:113-120. Epub 2018 Jan 31 doi: 10.1016/j.heares.2018.01.009. PMID: 29398141
Gliosarcoma in the Cerebellopontine Angle with Rapid Tumor Growth and Intratumoral Hemorrhage.
Duan H, Kitazawa K, Yako T, Ichinose S, Kobayashi S, Sudo M
World Neurosurg 2016 Aug;92:580.e17-580.e21. Epub 2016 Jun 23 doi: 10.1016/j.wneu.2016.06.053. PMID: 27338213
Audiologic evaluation of vestibular schwannoma and other cerebellopontine angle tumors.
Kim SH, Lee SH, Choi SK, Lim YJ, Na SY, Yeo SG
Acta Otolaryngol 2016;136(2):149-53. Epub 2015 Oct 19 doi: 10.3109/00016489.2015.1100326. PMID: 26479426
Cerebellopontine angle tumors in infants and children.
Tomita T, Grahovac G
Childs Nerv Syst 2015 Oct;31(10):1739-50. Epub 2015 Sep 9 doi: 10.1007/s00381-015-2747-x. PMID: 26351227Free PMC Article

Diagnosis

Cerebellopontine angle tumor presenting as acute audiovestibular syndrome.
Jung T, Kim H, Jang M, Kim T, Lee DH, Shin JE, Kim CH
Acta Otolaryngol 2023 Nov-Dec;143(11-12):951-957. Epub 2024 Jan 26 doi: 10.1080/00016489.2023.2290202. PMID: 38108643
Imaging of the Vestibular Schwannoma: Diagnosis, Monitoring, and Treatment Planning.
Connor SEJ
Neuroimaging Clin N Am 2021 Nov;31(4):451-471. doi: 10.1016/j.nic.2021.05.006. PMID: 34689927
Neurosarcoidosis Presenting as Isolated Bilateral Cerebellopontine Angle Tumors: Case Report and Review of the Literature.
Crawford F, Alvi SA, Brahimaj B, Byrne R, Kocak M, Wiet RM
Ear Nose Throat J 2019 Sep;98(8):NP120-NP124. doi: 10.1177/0145561319860528. PMID: 31522556
Gliosarcoma in the Cerebellopontine Angle with Rapid Tumor Growth and Intratumoral Hemorrhage.
Duan H, Kitazawa K, Yako T, Ichinose S, Kobayashi S, Sudo M
World Neurosurg 2016 Aug;92:580.e17-580.e21. Epub 2016 Jun 23 doi: 10.1016/j.wneu.2016.06.053. PMID: 27338213
Cerebellopontine angle tumors in infants and children.
Tomita T, Grahovac G
Childs Nerv Syst 2015 Oct;31(10):1739-50. Epub 2015 Sep 9 doi: 10.1007/s00381-015-2747-x. PMID: 26351227Free PMC Article

Therapy

Salvage Microsurgery Following Failed Primary Radiosurgery in Sporadic Vestibular Schwannoma.
Marinelli JP, Herberg HA, Moore LS, Yancey KL, Kay-Rivest E, Casale GG, Durham A, Khandalavala KR, Lund-Johansen M, Kosaraju N, Lohse CM, Patel NS, Gurgel RK, Babu SC, Golfinos JG, Roland JT Jr, Hunter JB, Kutz JW Jr, Santa Maria PL, Link MJ, Tveiten ØV, Carlson ML
JAMA Otolaryngol Head Neck Surg 2024 Apr 1;150(4):287-294. doi: 10.1001/jamaoto.2023.4474. PMID: 38358763Free PMC Article
Petrous Apex Pneumatization: Influence on Postoperative Cerebellopontine Angle Tumor Cerebrospinal Fluid Fistula.
Shew M, Muelleman T, Harris M, Li M, Sykes K, Staecker H, Adunka OF, Lin J
Ann Otol Rhinol Laryngol 2018 Sep;127(9):604-607. Epub 2018 Jun 21 doi: 10.1177/0003489418781934. PMID: 29925246
The relation between flocculus volume and tinnitus after cerebellopontine angle tumor surgery.
Mennink LM, Van Dijk JMC, Van Der Laan BFAM, Metzemaekers JDM, Van Laar PJ, Van Dijk P
Hear Res 2018 Apr;361:113-120. Epub 2018 Jan 31 doi: 10.1016/j.heares.2018.01.009. PMID: 29398141
Effect of corticosteroids on facial function after cerebellopontine angle tumor removal: a double-blind study versus placebo.
Bozorg Grayeli A, Ferrary E, Tubach F, Bernat I, Deguine O, Darrouzet V, Robier A, Zaouche S, Dubreuil C, Marx M, Kalamarides M, Fraysse B, Sterkers O
Audiol Neurootol 2015;20(4):213-21. Epub 2015 Apr 28 doi: 10.1159/000370191. PMID: 25924803
Early complications and symptoms of cerebellopontine angle tumor surgery: a prospective analysis.
Lazard DS, Tosello M, Bozorg-Grayeli A, Vitte E, Bouccara D, Kalamarides M, Sterkers O
Eur Arch Otorhinolaryngol 2011 Nov;268(11):1575-82. Epub 2011 Mar 4 doi: 10.1007/s00405-011-1539-5. PMID: 21373897

Prognosis

Gender is associated with long-term mortality after cerebellopontine angle tumor resection.
Farooqi AS, Detchou DK, Glauser G, Strouz K, McClintock SD, Malhotra NR
Clin Neurol Neurosurg 2021 Feb;201:106452. Epub 2020 Dec 30 doi: 10.1016/j.clineuro.2020.106452. PMID: 33422925
Gliosarcoma in the Cerebellopontine Angle with Rapid Tumor Growth and Intratumoral Hemorrhage.
Duan H, Kitazawa K, Yako T, Ichinose S, Kobayashi S, Sudo M
World Neurosurg 2016 Aug;92:580.e17-580.e21. Epub 2016 Jun 23 doi: 10.1016/j.wneu.2016.06.053. PMID: 27338213
Epidermoid cysts of the cerebellopontine angle: Clinical features and treatment outcomes.
Czernicki T, Kunert P, Nowak A, Wojciechowski J, Marchel A
Neurol Neurochir Pol 2016;50(2):75-82. Epub 2015 Dec 11 doi: 10.1016/j.pjnns.2015.11.008. PMID: 26969562
Audiologic evaluation of vestibular schwannoma and other cerebellopontine angle tumors.
Kim SH, Lee SH, Choi SK, Lim YJ, Na SY, Yeo SG
Acta Otolaryngol 2016;136(2):149-53. Epub 2015 Oct 19 doi: 10.3109/00016489.2015.1100326. PMID: 26479426
Gamma Knife radiosurgery following subtotal resection of vestibular schwannoma.
Brokinkel B, Sauerland C, Holling M, Ewelt C, Horstmann G, van Eck AT, Stummer W
J Clin Neurosci 2014 Dec;21(12):2077-82. Epub 2014 Jul 22 doi: 10.1016/j.jocn.2014.03.037. PMID: 25065850

Clinical prediction guides

Intraoperative transcranial facial motor evoked potential monitoring in surgery of cerebellopontine angle tumors predicts early and late postoperative facial nerve function.
Hiruta R, Sato T, Itakura T, Fujii M, Sakuma J, Bakhit M, Kojima T, Ichikawa M, Iwatate K, Saito K
Clin Neurophysiol 2021 Apr;132(4):864-871. Epub 2021 Feb 3 doi: 10.1016/j.clinph.2020.12.025. PMID: 33636603
Gender is associated with long-term mortality after cerebellopontine angle tumor resection.
Farooqi AS, Detchou DK, Glauser G, Strouz K, McClintock SD, Malhotra NR
Clin Neurol Neurosurg 2021 Feb;201:106452. Epub 2020 Dec 30 doi: 10.1016/j.clineuro.2020.106452. PMID: 33422925
Glioneuronal Heterotopia Presenting as Cerebellopontine Angle Tumor of Cranial Nerve VIII.
Peris-Celda M, Giannini C, Diehn FE, Eckel LJ, Neff BA, Van Gompel JJ
World Neurosurg 2018 Jun;114:289-292. Epub 2018 Apr 3 doi: 10.1016/j.wneu.2018.03.185. PMID: 29625310
The Management and Imaging of Vestibular Schwannomas.
Lin EP, Crane BT
AJNR Am J Neuroradiol 2017 Nov;38(11):2034-2043. Epub 2017 May 25 doi: 10.3174/ajnr.A5213. PMID: 28546250Free PMC Article
Early complications and symptoms of cerebellopontine angle tumor surgery: a prospective analysis.
Lazard DS, Tosello M, Bozorg-Grayeli A, Vitte E, Bouccara D, Kalamarides M, Sterkers O
Eur Arch Otorhinolaryngol 2011 Nov;268(11):1575-82. Epub 2011 Mar 4 doi: 10.1007/s00405-011-1539-5. PMID: 21373897

Recent systematic reviews

The predictive value of intraoperative facial motor evoked potentials in cerebellopontine angle tumor surgery.
Pan SY, Holdefer RN, Wu HL, Li CR, Guo L
Clin Neurophysiol 2024 Oct;166:176-190. Epub 2024 Aug 6 doi: 10.1016/j.clinph.2024.07.021. PMID: 39178552
Utility and Prognostic Value of Intraoperative Blink Reflex in Trigeminal or Facial Nerve Monitoring in Skull Base Surgeries: A Systematic Review.
Prado MB, Kubota Y
World Neurosurg 2024 Jul;187:e759-e768. Epub 2024 May 3 doi: 10.1016/j.wneu.2024.04.164. PMID: 38705267
Preoperative diffusion tensor imaging-fiber tracking for facial nerve identification in vestibular schwannoma: a systematic review on its evolution and current status with a pooled data analysis of surgical concordance rates.
Savardekar AR, Patra DP, Thakur JD, Narayan V, Mohammed N, Bollam P, Nanda A
Neurosurg Focus 2018 Mar;44(3):E5. doi: 10.3171/2017.12.FOCUS17672. PMID: 29490547

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