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Leukoplakia of Lip

MedGen UID:
98317
•Concept ID:
C0399602
•
Neoplastic Process
Synonyms: Leucokeratosis of lip; Leukokeratosis of lip; Leukoplakia of lips
SNOMED CT: Leukokeratosis of lip (17531008); Leucokeratosis of lip (17531008); Leukoplakia of lips (17531008)

Definition

A clinical term that indicates the presence of a white patch on the surface of the lip which cannot be characterized as any other disease. It may be a precancerous condition and in most cases histologic examination reveals keratosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLeukoplakia of Lip

Professional guidelines

PubMed

Low prevalence of high risk genotypes of human papilloma virus in normal oral mucosa, oral leukoplakia and verrucous carcinoma.
Saghravanian N, Ghazvini K, Babakoohi S, Firooz A, Mohtasham N
Acta Odontol Scand 2011 Nov;69(6):406-9. Epub 2011 Apr 5 doi: 10.3109/00016357.2011.572560. PMID: 21466259
Oral cancer detection. The importance of routine screening for prolongation of survival.
Chiodo GT, Eigner T, Rosenstein DI
Postgrad Med 1986 Aug;80(2):231-6. doi: 10.1080/00325481.1986.11699497. PMID: 3526308
Evaluation of 5-fluorouracil in the treatment of actinic keratosis of the lip.
Warnock GR, Fuller RP Jr, Pelleu GB Jr
Oral Surg Oral Med Oral Pathol 1981 Nov;52(5):501-5. doi: 10.1016/0030-4220(81)90362-5. PMID: 6946379

Recent clinical studies

Etiology

Oral potentially malignant disorders: A consensus report from an international seminar on nomenclature and classification, convened by the WHO Collaborating Centre for Oral Cancer.
Warnakulasuriya S, Kujan O, Aguirre-Urizar JM, Bagan JV, González-Moles MÁ, Kerr AR, Lodi G, Mello FW, Monteiro L, Ogden GR, Sloan P, Johnson NW
Oral Dis 2021 Nov;27(8):1862-1880. Epub 2020 Nov 26 doi: 10.1111/odi.13704. PMID: 33128420
Characterization of dendritic cells in lip and oral cavity squamous cell carcinoma.
Costa NL, Gonçalves AS, Martins AF, Arantes DA, Silva TA, Batista AC
J Oral Pathol Med 2016 Jul;45(6):418-24. Epub 2015 Oct 30 doi: 10.1111/jop.12380. PMID: 26514660
Differential infiltration of CD8+ and NK cells in lip and oral cavity squamous cell carcinoma.
Zancope E, Costa NL, Junqueira-Kipnis AP, Valadares MC, Silva TA, Leles CR, Mendonça EF, Batista AC
J Oral Pathol Med 2010 Feb;39(2):162-7. Epub 2009 Sep 14 doi: 10.1111/j.1600-0714.2009.00792.x. PMID: 19754647
Oral lesions in organ transplant patients.
Seymour RA, Thomason JM, Nolan A
J Oral Pathol Med 1997 Aug;26(7):297-304. doi: 10.1111/j.1600-0714.1997.tb00219.x. PMID: 9250928
Carcinoma of the lip.
Wurman LH, Adams GL, Meyerhoff WL
Am J Surg 1975 Oct;130(4):470-4. doi: 10.1016/0002-9610(75)90486-9. PMID: 1101725

Diagnosis

Oral potentially malignant disorders: A consensus report from an international seminar on nomenclature and classification, convened by the WHO Collaborating Centre for Oral Cancer.
Warnakulasuriya S, Kujan O, Aguirre-Urizar JM, Bagan JV, González-Moles MÁ, Kerr AR, Lodi G, Mello FW, Monteiro L, Ogden GR, Sloan P, Johnson NW
Oral Dis 2021 Nov;27(8):1862-1880. Epub 2020 Nov 26 doi: 10.1111/odi.13704. PMID: 33128420
Oral leukoplakia-epidemiological survey and histochemical analysis of 107 cases in Brazil.
Dogenski LC, de Figueiredo Ribeiro S, Gambin DJ, Maso PC, Linden MSS, Trentin MS, Zoehler B, Crivelini MM, De Carli JP
Clin Oral Investig 2021 Apr;25(4):1859-1867. Epub 2020 Aug 6 doi: 10.1007/s00784-020-03488-x. PMID: 32761445
Oral Biopsy Techniques.
Shanti RM, Tanaka T, Stanton DC
Dermatol Clin 2020 Oct;38(4):421-427. Epub 2020 Aug 10 doi: 10.1016/j.det.2020.05.003. PMID: 32892851
Oral Verruciform Xanthoma: A Series of 212 Cases and Review of the Literature.
Belknap AN, Islam MN, Bhattacharyya I, Cohen DM, Fitzpatrick SG
Head Neck Pathol 2020 Sep;14(3):742-748. Epub 2020 Jan 2 doi: 10.1007/s12105-019-01123-0. PMID: 31898056Free PMC Article
Characterization of dendritic cells in lip and oral cavity squamous cell carcinoma.
Costa NL, Gonçalves AS, Martins AF, Arantes DA, Silva TA, Batista AC
J Oral Pathol Med 2016 Jul;45(6):418-24. Epub 2015 Oct 30 doi: 10.1111/jop.12380. PMID: 26514660

Therapy

Oral leukoplakia-epidemiological survey and histochemical analysis of 107 cases in Brazil.
Dogenski LC, de Figueiredo Ribeiro S, Gambin DJ, Maso PC, Linden MSS, Trentin MS, Zoehler B, Crivelini MM, De Carli JP
Clin Oral Investig 2021 Apr;25(4):1859-1867. Epub 2020 Aug 6 doi: 10.1007/s00784-020-03488-x. PMID: 32761445
Oral field cancerization: current evidence and future perspectives.
Angadi PV, Savitha JK, Rao SS, Sivaranjini Y
Oral Maxillofac Surg 2012 Jun;16(2):171-80. Epub 2012 Feb 22 doi: 10.1007/s10006-012-0317-x. PMID: 22354325
Oral lesions in organ transplant patients.
Seymour RA, Thomason JM, Nolan A
J Oral Pathol Med 1997 Aug;26(7):297-304. doi: 10.1111/j.1600-0714.1997.tb00219.x. PMID: 9250928
Carcinoma of the lip.
Wurman LH, Adams GL, Meyerhoff WL
Am J Surg 1975 Oct;130(4):470-4. doi: 10.1016/0002-9610(75)90486-9. PMID: 1101725
Oral lesions.
Hinds EC, Kent JN
Am J Gastroenterol 1971 Mar;55(3):225-36. PMID: 4931041

Prognosis

Oral lichen planus and related lesions. What should we accept based on the available evidence?
González-Moles MÁ, Ramos-García P
Oral Dis 2023 Oct;29(7):2624-2637. Epub 2022 Dec 8 doi: 10.1111/odi.14438. PMID: 36371653
Oral leukoplakia-epidemiological survey and histochemical analysis of 107 cases in Brazil.
Dogenski LC, de Figueiredo Ribeiro S, Gambin DJ, Maso PC, Linden MSS, Trentin MS, Zoehler B, Crivelini MM, De Carli JP
Clin Oral Investig 2021 Apr;25(4):1859-1867. Epub 2020 Aug 6 doi: 10.1007/s00784-020-03488-x. PMID: 32761445
Characterization of dendritic cells in lip and oral cavity squamous cell carcinoma.
Costa NL, Gonçalves AS, Martins AF, Arantes DA, Silva TA, Batista AC
J Oral Pathol Med 2016 Jul;45(6):418-24. Epub 2015 Oct 30 doi: 10.1111/jop.12380. PMID: 26514660
Oral field cancerization: current evidence and future perspectives.
Angadi PV, Savitha JK, Rao SS, Sivaranjini Y
Oral Maxillofac Surg 2012 Jun;16(2):171-80. Epub 2012 Feb 22 doi: 10.1007/s10006-012-0317-x. PMID: 22354325
Differential infiltration of CD8+ and NK cells in lip and oral cavity squamous cell carcinoma.
Zancope E, Costa NL, Junqueira-Kipnis AP, Valadares MC, Silva TA, Leles CR, Mendonça EF, Batista AC
J Oral Pathol Med 2010 Feb;39(2):162-7. Epub 2009 Sep 14 doi: 10.1111/j.1600-0714.2009.00792.x. PMID: 19754647

Clinical prediction guides

Oral squamous cell carcinomas and oral potentially malignant disorders: A Latin American study.
Gilligan G, Panico R, Lazos J, Morelatto R, Belardinelli P, Criscuolo MI, Bolesina N, Molina Ávila I, Pimentel Solá JM, Rivarola E, Morgante MJ, Ingrassia Tonelli ME, Gimenez J, Doratti P, Werner LC, Prado-Ribeiro AC, Brandão TB, Vechiato-Filho AJ, Cuzzullin MC, Saldivia-Siracusa C, Lopes MA, Agostini M, Romañach MJ, Abrahão AC, Fonsêca TC, Kaminagakura E, Anbinder AL, Santos Alves K, de Almeida Lança ML, Sacsaquispe-Contreras S, Rodriguez Ibazetta K, Gerber-Mora R, Aranda Romo S, Tejeda Nava FJ, Cordero-Torres K, Moreno Silva R, Gonzalez-Arriagada W, Toro R, Silveira FM, Gonzalez N, Vargas PA, Santos-Silva AR, Bologna-Molina R, Villarroel-Dorrego M, Martinez B, Piemonte E
Oral Dis 2024 Jul;30(5):2965-2984. Epub 2023 Oct 25 doi: 10.1111/odi.14778. PMID: 37877476
Oral leukoplakia-epidemiological survey and histochemical analysis of 107 cases in Brazil.
Dogenski LC, de Figueiredo Ribeiro S, Gambin DJ, Maso PC, Linden MSS, Trentin MS, Zoehler B, Crivelini MM, De Carli JP
Clin Oral Investig 2021 Apr;25(4):1859-1867. Epub 2020 Aug 6 doi: 10.1007/s00784-020-03488-x. PMID: 32761445
Orofacial diseases in solid organ and hematopoietic stem cell transplant recipients.
Petti S, Polimeni A, Berloco PB, Scully C
Oral Dis 2013 Jan;19(1):18-36. Epub 2012 Mar 28 doi: 10.1111/j.1601-0825.2012.01925.x. PMID: 22458357
Distinct expression of perforin and granzyme B in lip and oral cavity squamous cell carcinoma.
Costa NL, Gonçalves AS, Souza-Lima NC, Jaime-Paiva LG, Junqueira-Kipnis AP, Silva TA, Mendonça EF, Batista AC
J Oral Pathol Med 2011 May;40(5):380-4. Epub 2011 Feb 22 doi: 10.1111/j.1600-0714.2011.01014.x. PMID: 21342273
Occurrence of epithelial dysplasia in oral leukoplakia. Analysis and follow-up study of 12 cases.
Bánóczy J, Csiba A
Oral Surg Oral Med Oral Pathol 1976 Dec;42(6):766-74. doi: 10.1016/0030-4220(76)90099-2. PMID: 1069220

Recent systematic reviews

Prevalence of human papillomavirus (HPV) in oral mucosal lesions in Iran: A systematic review and meta-analysis.
Aghaeipour F, Salehiniya H, Abbaszadeh H
J Med Virol 2021 Nov;93(11):6089-6099. Epub 2021 Jul 6 doi: 10.1002/jmv.27161. PMID: 34180541

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