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Benign neoplasm of major salivary gland

MedGen UID:: 96923
•Concept ID:: C0496858
•: Neoplastic Process

Synonyms:	Benign Major Salivary Gland Neoplasm; benign Major salivary gland neoplasm; Benign Major Salivary Gland Tumor; benign Major salivary gland tumor; benign Major salivary gland tumour; Benign Neoplasm of Major Salivary Gland; benign neoplasm of major salivary gland; Benign neoplasm of major salivary glands; Benign Neoplasm of the Major Salivary Gland; benign neoplasm of the Major salivary gland; Benign tumor major salivary gland; Benign Tumor of Major Salivary Gland; benign tumor of Major salivary gland; Benign Tumor of the Major Salivary Gland; benign tumor of the Major salivary gland; benign tumour of Major salivary gland; benign tumour of the Major salivary gland; major salivary gland benign neoplasm
SNOMED CT:	Benign tumor major salivary gland (92205005); Benign neoplasm of major salivary glands (92205005); Benign neoplasm of major salivary gland (92205005)

Monarch Initiative:	MONDO:0021492

Definition

A neoplasm that arises from the major salivary glands and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include Warthin tumor, monomorphic adenoma, and pleomorphic adenoma. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVBenign neoplasm of major salivary gland

Disease
- Neoplasm
  - Neoplasm by Special Category
    - Benign neoplasm
      - Benign Head and Neck Neoplasm
        Benign neoplasm of salivary gland
        Benign neoplasm of major salivary gland
        Benign neoplasm of parotid gland
        Parotid Gland Hemangioma
        Parotid Gland Lipoma
        Parotid Gland Lymphangioma
        Parotid Gland Monomorphic Adenoma
        Parotid Gland Nodular Fasciitis
        Parotid Gland Pleomorphic Adenoma
        Parotid Gland Sebaceous Lymphadenoma
        Parotid Gland Sialolipoma
        Parotid Gland Warthin Tumor
        Benign neoplasm of sublingual gland
        Benign neoplasm of submandibular gland

Professional guidelines

PubMed

Current opinions on diagnosis and treatment of adenoid cystic carcinoma.

Fang Y, Peng Z, Wang Y, Gao K, Liu Y, Fan R, Zhang H, Xie Z, Jiang W
Oral Oncol 2022 Jul;130:105945. Epub 2022 Jun 2 doi: 10.1016/j.oraloncology.2022.105945. PMID: 35662026

Guidelines for Clinical Target Volume Definition for Perineural Spread of Major Salivary Gland Cancers.

Armstrong K, Ward J, Hughes NM, Mihai A, Blayney A, Mascott C, Kileen R, Armstrong J
Clin Oncol (R Coll Radiol) 2018 Dec;30(12):773-779. Epub 2018 Sep 14 doi: 10.1016/j.clon.2018.08.018. PMID: 30224202

Surgical treatment of salivary malignant tumors.

Lombardi D, McGurk M, Vander Poorten V, Guzzo M, Accorona R, Rampinelli V, Nicolai P
Oral Oncol 2017 Feb;65:102-113. Epub 2016 Dec 22 doi: 10.1016/j.oraloncology.2016.12.007. PMID: 28017651

See all (125)

Recent clinical studies

Etiology

Adenoid cystic carcinoma. An indolent but aggressive tumour. Part A: from aetiopathogenesis to diagnosis.

Cantù G
Acta Otorhinolaryngol Ital 2021 Jun;41(3):206-214. doi: 10.14639/0392-100X-N1379. PMID: 34264913 Free PMC Article

Major and minor salivary gland tumours.

Gatta G, Guzzo M, Locati LD, McGurk M, Prott FJ
Crit Rev Oncol Hematol 2020 Aug;152:102959. Epub 2020 May 18 doi: 10.1016/j.critrevonc.2020.102959. PMID: 32485526

Guidelines for Clinical Target Volume Definition for Perineural Spread of Major Salivary Gland Cancers.

Management of salivary gland carcinomas - a review.

Wang X, Luo Y, Li M, Yan H, Sun M, Fan T
Oncotarget 2017 Jan 17;8(3):3946-3956. doi: 10.18632/oncotarget.13952. PMID: 27992367 Free PMC Article

Cancers of major salivary glands.

Panwar A, Kozel JA, Lydiatt WM
Surg Oncol Clin N Am 2015 Jul;24(3):615-33. doi: 10.1016/j.soc.2015.03.011. PMID: 25979403

See all (1018)

Diagnosis

Current opinions on diagnosis and treatment of adenoid cystic carcinoma.

Fang Y, Peng Z, Wang Y, Gao K, Liu Y, Fan R, Zhang H, Xie Z, Jiang W
Oral Oncol 2022 Jul;130:105945. Epub 2022 Jun 2 doi: 10.1016/j.oraloncology.2022.105945. PMID: 35662026

Adenoid cystic carcinoma. An indolent but aggressive tumour. Part A: from aetiopathogenesis to diagnosis.

Cantù G
Acta Otorhinolaryngol Ital 2021 Jun;41(3):206-214. doi: 10.14639/0392-100X-N1379. PMID: 34264913 Free PMC Article

Major and minor salivary gland tumours.

Gatta G, Guzzo M, Locati LD, McGurk M, Prott FJ
Crit Rev Oncol Hematol 2020 Aug;152:102959. Epub 2020 May 18 doi: 10.1016/j.critrevonc.2020.102959. PMID: 32485526

Salivary Gland Malignancies.

Carlson ER, Schlieve T
Oral Maxillofac Surg Clin North Am 2019 Feb;31(1):125-144. doi: 10.1016/j.coms.2018.08.007. PMID: 30449524

CT and MR imaging findings of palatal tumors.

Kato H, Kanematsu M, Makita H, Kato K, Hatakeyama D, Shibata T, Mizuta K, Aoki M
Eur J Radiol 2014 Mar;83(3):e137-46. Epub 2013 Dec 12 doi: 10.1016/j.ejrad.2013.11.028. PMID: 24377674

See all (1140)

Therapy

Extensive preclinical evaluation of lutetium-177-labeled PSMA-specific tracers for prostate cancer radionuclide therapy.

Ruigrok EAM, van Vliet N, Dalm SU, de Blois E, van Gent DC, Haeck J, de Ridder C, Stuurman D, Konijnenberg MW, van Weerden WM, de Jong M, Nonnekens J
Eur J Nucl Med Mol Imaging 2021 May;48(5):1339-1350. Epub 2020 Oct 23 doi: 10.1007/s00259-020-05057-6. PMID: 33094433 Free PMC Article

Current State of Knowledge on Salivary Gland Cancers.

Lin HH, Limesand KH, Ann DK
Crit Rev Oncog 2018;23(3-4):139-151. doi: 10.1615/CritRevOncog.2018027598. PMID: 30311570 Free PMC Article

Advances in salivary gland gene therapy - oral and systemic implications.

Baum BJ, Alevizos I, Chiorini JA, Cotrim AP, Zheng C
Expert Opin Biol Ther 2015;15(10):1443-54. Epub 2015 Jul 6 doi: 10.1517/14712598.2015.1064894. PMID: 26149284 Free PMC Article

Major and minor salivary gland tumors.

Guzzo M, Locati LD, Prott FJ, Gatta G, McGurk M, Licitra L
Crit Rev Oncol Hematol 2010 May;74(2):134-48. Epub 2009 Nov 24 doi: 10.1016/j.critrevonc.2009.10.004. PMID: 19939701

Graft-vs.-host disease.

Woo SB, Lee SJ, Schubert MM
Crit Rev Oral Biol Med 1997;8(2):201-16. doi: 10.1177/10454411970080020701. PMID: 9167093

See all (294)

Prognosis

Adenoid cystic carcinoma. An indolent but aggressive tumour. Part A: from aetiopathogenesis to diagnosis.

Cantù G
Acta Otorhinolaryngol Ital 2021 Jun;41(3):206-214. doi: 10.14639/0392-100X-N1379. PMID: 34264913 Free PMC Article

Major and minor salivary gland tumours.

Gatta G, Guzzo M, Locati LD, McGurk M, Prott FJ
Crit Rev Oncol Hematol 2020 Aug;152:102959. Epub 2020 May 18 doi: 10.1016/j.critrevonc.2020.102959. PMID: 32485526

Guidelines for Clinical Target Volume Definition for Perineural Spread of Major Salivary Gland Cancers.

Primary Salivary Gland Type Tumors of the Thymus.

Kalhor N, Weissferdt A, Moran CA
Adv Anat Pathol 2017 Jan;24(1):15-23. doi: 10.1097/PAP.0000000000000132. PMID: 27941539

Cancers of major salivary glands.

Panwar A, Kozel JA, Lydiatt WM
Surg Oncol Clin N Am 2015 Jul;24(3):615-33. doi: 10.1016/j.soc.2015.03.011. PMID: 25979403

See all (854)

Clinical prediction guides

Margins for Benign Salivary Gland Neoplasms of the Head and Neck.

Carlson ER, McCoy JM
Oral Maxillofac Surg Clin North Am 2017 Aug;29(3):325-340. doi: 10.1016/j.coms.2017.03.009. PMID: 28709532

Recurrent Benign Salivary Gland Neoplasms.

Witt RL, Nicolai P
Adv Otorhinolaryngol 2016;78:63-70. Epub 2016 Apr 12 doi: 10.1159/000442126. PMID: 27093568

Advances in salivary gland gene therapy - oral and systemic implications.

Baum BJ, Alevizos I, Chiorini JA, Cotrim AP, Zheng C
Expert Opin Biol Ther 2015;15(10):1443-54. Epub 2015 Jul 6 doi: 10.1517/14712598.2015.1064894. PMID: 26149284 Free PMC Article

Salivary gland malignancies in children.

Yoshida EJ, García J, Eisele DW, Chen AM
Int J Pediatr Otorhinolaryngol 2014 Feb;78(2):174-8. Epub 2013 Nov 19 doi: 10.1016/j.ijporl.2013.11.001. PMID: 24332197

Pitfalls in the staging of cancer of the major salivary gland neoplasms.

Friedman ER, Saindane AM
Neuroimaging Clin N Am 2013 Feb;23(1):107-22. doi: 10.1016/j.nic.2012.08.009. PMID: 23199664

See all (602)

Recent systematic reviews

Clinicopathological study and survival outcomes of sialoblastoma: A systematic review.

Cruz VMS, Pérez-de-Oliveira ME, Dos Santos Leite ÉG, Louredo BVR, Bezerra HKF, Lopes MA, Vargas PA, Santos-Silva AR, Kowalski LP, da Cruz Perez DE
Head Neck 2023 Aug;45(8):2136-2148. Epub 2023 Jun 26 doi: 10.1002/hed.27440. PMID: 37357912

Surgical treatment of pleomorphic adenoma of parotid gland in children: a systematic review.

Galluzzi F, Garavello W
Auris Nasus Larynx 2022 Aug;49(4):547-553. Epub 2022 Jan 31 doi: 10.1016/j.anl.2022.01.013. PMID: 35101285

Impact of tumor site on the prognosis of salivary gland neoplasms: A systematic review and meta-analysis.

Dos Santos ES, Rodrigues-Fernandes CI, Speight PM, Khurram SA, Alsanie I, Costa Normando AG, Prado-Ribeiro AC, Brandão TB, Kowalski LP, Silva Guerra EN, Lopes MA, Vargas PA, Santos-Silva AR, Leme AFP
Crit Rev Oncol Hematol 2021 Jun;162:103352. Epub 2021 May 12 doi: 10.1016/j.critrevonc.2021.103352. PMID: 33991662

Clinicopathological analysis of oral and maxillofacial acinic cell carcinoma: A systematic review.

Kirschnick LB, Silveira FM, Schuch LF, Fonseca FP, Martins MAT, Lopes MA, Santos-Silva AR, Carrard VC, Dos Santos JN, Vargas PA, Wagner VP, Martins MD
J Oral Pathol Med 2021 Sep;50(8):741-749. Epub 2021 Feb 18 doi: 10.1111/jop.13159. PMID: 33455041

Histopathologic classification of parapharyngeal space tumors: a case series and review of the literature.

Locketz GD, Horowitz G, Abu-Ghanem S, Wasserzug O, Abergel A, Yehuda M, Fliss DM
Eur Arch Otorhinolaryngol 2016 Mar;273(3):727-34. Epub 2015 Feb 24 doi: 10.1007/s00405-015-3545-5. PMID: 25708410

See all (22)

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Benign neoplasm of major salivary gland

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

Related information

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