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Cervical disk degenerative disorder

MedGen UID:
96081
•Concept ID:
C0410606
•
Disease or Syndrome
Synonym: Cervical disc degenerative disorder
 
Monarch Initiative: MONDO:0044343

Definition

Any degenerative disorder affecting one or more vertebral discs of the cervical spine. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervical disk degenerative disorder

Professional guidelines

PubMed

Management of the Patient with Cervical Cord Compression but no Evidence of Myelopathy: What Should We do?
Naito K, Yamagata T, Ohata K, Takami T
Neurosurg Clin N Am 2018 Jan;29(1):145-152. Epub 2017 Oct 27 doi: 10.1016/j.nec.2017.09.010. PMID: 29173427
Cervical radiculopathy: epidemiology, etiology, diagnosis, and treatment.
Woods BI, Hilibrand AS
J Spinal Disord Tech 2015 Jun;28(5):E251-9. doi: 10.1097/BSD.0000000000000284. PMID: 25985461
Defining the role of epidural steroid injections in the treatment of radicular pain from degenerative cervical disk disease.
Vasudeva V, Chi J
Neurosurgery 2015 Feb;76(2):N16-7. doi: 10.1227/01.neu.0000460595.01428.1c. PMID: 25594200

Recent clinical studies

Etiology

Increasing Cervical Kyphosis Correlates With Cervical Degenerative Disk Disease in Patients With Adolescent Idiopathic Scoliosis.
Lin A, Skaggs DL, Andras LM, Tolo V, Tamrazi B, Illingworth KD
Spine (Phila Pa 1976) 2024 Apr 1;49(7):486-491. Epub 2023 Sep 9 doi: 10.1097/BRS.0000000000004824. PMID: 37694562
Mid-term and Long-term Outcomes After Total Cervical Disk Arthroplasty Compared With Anterior Cervical Discectomy and Fusion: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Kim LJY, Mazur MD, Dailey AT
Clin Spine Surg 2023 Nov 1;36(9):339-355. Epub 2023 Sep 22 doi: 10.1097/BSD.0000000000001537. PMID: 37735768
Is Cervical Disk Arthroplasty a Suitable Alternative to Treat Degenerative Cervical Myelopathy?
Schupper AJ, Boylan AJ, Houten JK
Clin Spine Surg 2023 Nov 1;36(9):356-362. Epub 2023 Sep 8 doi: 10.1097/BSD.0000000000001528. PMID: 37684716
Management of the Patient with Cervical Cord Compression but no Evidence of Myelopathy: What Should We do?
Naito K, Yamagata T, Ohata K, Takami T
Neurosurg Clin N Am 2018 Jan;29(1):145-152. Epub 2017 Oct 27 doi: 10.1016/j.nec.2017.09.010. PMID: 29173427
Degenerative Cervical Myelopathy: A Spectrum of Related Disorders Affecting the Aging Spine.
Tetreault L, Goldstein CL, Arnold P, Harrop J, Hilibrand A, Nouri A, Fehlings MG
Neurosurgery 2015 Oct;77 Suppl 4:S51-67. doi: 10.1227/NEU.0000000000000951. PMID: 26378358

Diagnosis

Imaging of Degenerative and Infectious Conditions of the Spine.
Shah LM, Ross JS
Neurosurgery 2016 Sep;79(3):315-35. doi: 10.1227/NEU.0000000000001323. PMID: 27352276
Degenerative Cervical Myelopathy: A Spectrum of Related Disorders Affecting the Aging Spine.
Tetreault L, Goldstein CL, Arnold P, Harrop J, Hilibrand A, Nouri A, Fehlings MG
Neurosurgery 2015 Oct;77 Suppl 4:S51-67. doi: 10.1227/NEU.0000000000000951. PMID: 26378358
Cervical radiculopathy: epidemiology, etiology, diagnosis, and treatment.
Woods BI, Hilibrand AS
J Spinal Disord Tech 2015 Jun;28(5):E251-9. doi: 10.1097/BSD.0000000000000284. PMID: 25985461
Total disk arthroplasty.
Lin EL, Wang JC
J Am Acad Orthop Surg 2006 Dec;14(13):705-14. doi: 10.5435/00124635-200612000-00002. PMID: 17148618
Thoracic disk disease: diagnosis and treatment.
Vanichkachorn JS, Vaccaro AR
J Am Acad Orthop Surg 2000 May-Jun;8(3):159-69. doi: 10.5435/00124635-200005000-00003. PMID: 10874223

Therapy

Mid-term and Long-term Outcomes After Total Cervical Disk Arthroplasty Compared With Anterior Cervical Discectomy and Fusion: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Kim LJY, Mazur MD, Dailey AT
Clin Spine Surg 2023 Nov 1;36(9):339-355. Epub 2023 Sep 22 doi: 10.1097/BSD.0000000000001537. PMID: 37735768
Is Cervical Disk Arthroplasty a Suitable Alternative to Treat Degenerative Cervical Myelopathy?
Schupper AJ, Boylan AJ, Houten JK
Clin Spine Surg 2023 Nov 1;36(9):356-362. Epub 2023 Sep 8 doi: 10.1097/BSD.0000000000001528. PMID: 37684716
Cervical Disk Arthroplasty.
Koreckij TD, Gandhi SD, Park DK
J Am Acad Orthop Surg 2019 Feb 1;27(3):e96-e104. doi: 10.5435/JAAOS-D-17-00231. PMID: 30285984
Cervical radiculopathy: epidemiology, etiology, diagnosis, and treatment.
Woods BI, Hilibrand AS
J Spinal Disord Tech 2015 Jun;28(5):E251-9. doi: 10.1097/BSD.0000000000000284. PMID: 25985461
Defining the role of epidural steroid injections in the treatment of radicular pain from degenerative cervical disk disease.
Vasudeva V, Chi J
Neurosurgery 2015 Feb;76(2):N16-7. doi: 10.1227/01.neu.0000460595.01428.1c. PMID: 25594200

Prognosis

The imaging of cervical spondylotic myeloradiculopathy.
Hesni S, Baxter D, Saifuddin A
Skeletal Radiol 2023 Dec;52(12):2341-2365. Epub 2023 Apr 18 doi: 10.1007/s00256-023-04329-0. PMID: 37071191
Management of the Patient with Cervical Cord Compression but no Evidence of Myelopathy: What Should We do?
Naito K, Yamagata T, Ohata K, Takami T
Neurosurg Clin N Am 2018 Jan;29(1):145-152. Epub 2017 Oct 27 doi: 10.1016/j.nec.2017.09.010. PMID: 29173427
Is Total Disk Replacement a Cost-effective Treatment for Cervical Degenerative Disk Disease?
Wiedenhöfer B, Nacke J, Stephan M, Richter W, Carstens C, Eichler M
Clin Spine Surg 2017 Jun;30(5):E530-E534. doi: 10.1097/BSD.0000000000000189. PMID: 28525473
Predictors of Motor Weakness and Delayed Recovery in Cervical Disk Herniation.
Nam TW, Lee HS, Goh TS, Lee JS
J Spinal Disord Tech 2015 Aug;28(7):E405-9. doi: 10.1097/BSD.0b013e31829f5a1f. PMID: 26213841
Neck pain, cervical radiculopathy, and cervical myelopathy: pathophysiology, natural history, and clinical evaluation.
Rao R
Instr Course Lect 2003;52:479-88. PMID: 12690874

Clinical prediction guides

Mid-term and Long-term Outcomes After Total Cervical Disk Arthroplasty Compared With Anterior Cervical Discectomy and Fusion: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Kim LJY, Mazur MD, Dailey AT
Clin Spine Surg 2023 Nov 1;36(9):339-355. Epub 2023 Sep 22 doi: 10.1097/BSD.0000000000001537. PMID: 37735768
Is Cervical Disk Arthroplasty a Suitable Alternative to Treat Degenerative Cervical Myelopathy?
Schupper AJ, Boylan AJ, Houten JK
Clin Spine Surg 2023 Nov 1;36(9):356-362. Epub 2023 Sep 8 doi: 10.1097/BSD.0000000000001528. PMID: 37684716
The imaging of cervical spondylotic myeloradiculopathy.
Hesni S, Baxter D, Saifuddin A
Skeletal Radiol 2023 Dec;52(12):2341-2365. Epub 2023 Apr 18 doi: 10.1007/s00256-023-04329-0. PMID: 37071191
Safety and Effectiveness of the Flexible Cervical Implant: Preliminary Short-Term Clinical Results.
Alvarez CE, Saal-Zapata G, Rodríguez-Varela R, Ginocchio F, Pacussich C
World Neurosurg 2022 Feb;158:e122-e127. Epub 2021 Oct 20 doi: 10.1016/j.wneu.2021.10.122. PMID: 34687929
Spinal Perineural Cysts among European Patients.
Kozłowski P, Kalinowski P, Kozłowska M, Jankiewicz M, Budny A, Starosławska E, Burdan F
J Neurol Surg A Cent Eur Neurosurg 2021 Sep;82(5):463-467. Epub 2021 Apr 1 doi: 10.1055/s-0040-1722194. PMID: 33822351

Recent systematic reviews

Long-Term Clinical and Radiographic Outcomes After Bryan Cervical Disk Arthroplasty: A Systematic Literature Review.
Perna A, Velluto C, Smakaj A, Caredda M, Proietti L, Santagada DA, Candura D, Meluzio MC, Tamburrelli FC, Genitiempo M
Acta Neurochir Suppl 2023;135:321-329. doi: 10.1007/978-3-031-36084-8_49. PMID: 38153488
Mid-term and Long-term Outcomes After Total Cervical Disk Arthroplasty Compared With Anterior Cervical Discectomy and Fusion: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Kim LJY, Mazur MD, Dailey AT
Clin Spine Surg 2023 Nov 1;36(9):339-355. Epub 2023 Sep 22 doi: 10.1097/BSD.0000000000001537. PMID: 37735768
Is Cervical Disk Arthroplasty a Suitable Alternative to Treat Degenerative Cervical Myelopathy?
Schupper AJ, Boylan AJ, Houten JK
Clin Spine Surg 2023 Nov 1;36(9):356-362. Epub 2023 Sep 8 doi: 10.1097/BSD.0000000000001528. PMID: 37684716
Cost-effectiveness of anterior surgical decompression surgery for cervical degenerative disk disease: a systematic review of economic evaluations.
Schuermans VNE, Smeets AYJM, Boselie AFM, Zarrouk O, Hermans SMM, Droeghaag R, Curfs I, Evers SMAA, van Santbrink H
Eur Spine J 2022 May;31(5):1206-1218. Epub 2022 Feb 28 doi: 10.1007/s00586-022-07137-7. PMID: 35224672
Cervical Disk Arthroplasty Versus Anterior Cervical Decompression and Fusion for the Treatment of 2-Level Cervical Spondylopathy: A Systematic Review and Meta-analysis.
Kuang L, Chen Y, Wang B, Li L, Lü G
Clin Spine Surg 2016 Nov;29(9):372-382. doi: 10.1097/BSD.0000000000000395. PMID: 27295435

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