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Nocturnal paroxysmal dystonia

MedGen UID:
95991
•Concept ID:
C0393777
•
Disease or Syndrome
Synonyms: Dystonia, Hypnogenic Paroxysmal; Dystonia, Nocturnal Paroxysmal; Dystonia, Nocturnal, Paroxysmal; Dystonia, Sleep-Related; Dystonias, Hypnogenic Paroxysmal; Dystonias, Nocturnal Paroxysmal; Dystonias, Sleep-Related; Hypnogenic Paroxysmal Dystonia; Hypnogenic Paroxysmal Dystonias; Nocturnal Paroxysmal Dystonia; Nocturnal Paroxysmal Dystonias; Paroxysmal Dystonia, Hypnogenic; Paroxysmal Dystonia, Nocturnal; Paroxysmal Dystonias, Hypnogenic; Paroxysmal Dystonias, Nocturnal; Sleep Related Dystonia; Sleep-Related Dystonia; Sleep-Related Dystonias
SNOMED CT: Sleep-related dystonia (230500006)
 
Monarch Initiative: MONDO:0043969

Definition

A parasomnia characterized by paroxysmal episodes of choreoathetotic, ballistic, dystonic movements, and semipurposeful activity. The episodes occur during non-rapid eye movement sleep and typically recur several times per night. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNocturnal paroxysmal dystonia

Professional guidelines

PubMed

Parasomnias and nocturnal frontal lobe epilepsy (NFLE): lights and shadows--controversial points in the differential diagnosis.
Bisulli F, Vignatelli L, Provini F, Leta C, Lugaresi E, Tinuper P
Sleep Med 2011 Dec;12 Suppl 2:S27-32. doi: 10.1016/j.sleep.2011.10.008. PMID: 22136895

Recent clinical studies

Etiology

Nocturnal motor events in epilepsy: Is there a defined physiological network?
Woolfe M, Prime D, Tjoa L, O'Keefe S, Rowlands D, Dionisio S
Clin Neurophysiol 2019 Sep;130(9):1531-1538. Epub 2019 Jul 2 doi: 10.1016/j.clinph.2019.05.033. PMID: 31299588
Nocturnal paroxysmal events in an 8-year-old girl.
DelRosso LM, Wang L, Hoque R
J Clin Sleep Med 2013 Feb 1;9(2):178-80. doi: 10.5664/jcsm.2424. PMID: 23372474Free PMC Article
Oxcarbazepine in children with nocturnal frontal-lobe epilepsy.
Raju GP, Sarco DP, Poduri A, Riviello JJ, Bergin AM, Takeoka M
Pediatr Neurol 2007 Nov;37(5):345-9. doi: 10.1016/j.pediatrneurol.2007.06.013. PMID: 17950420
Treatment of periodic leg movements with a dopaminergic agonist in subjects with total spinal cord lesions.
de Mello MT, Poyares DL, Tufik S
Spinal Cord 1999 Sep;37(9):634-7. doi: 10.1038/sj.sc.3100909. PMID: 10490854
Is nocturnal paroxysmal dystonia a form of frontal lobe epilepsy?
Meierkord H, Fish DR, Smith SJ, Scott CA, Shorvon SD, Marsden CD
Mov Disord 1992;7(1):38-42. doi: 10.1002/mds.870070107. PMID: 1557065

Diagnosis

Nocturnal paroxysmal dystonia to sleep-related hypermotor epilepsy: A critical review.
Fotedar N, Lüders HO
Epilepsia 2024 Sep;65(9):2506-2518. Epub 2024 Jul 24 doi: 10.1111/epi.18067. PMID: 39046177
Paroxysmal hypnogenic dyskinesia.
Almeida L, Dure LS
Neurology 2014 May 27;82(21):1935. doi: 10.1212/WNL.0000000000000451. PMID: 24862895
Epilepsy and sleep.
Meierkord H
Curr Opin Neurol 1994 Apr;7(2):107-12. doi: 10.1097/00019052-199404000-00006. PMID: 7912613
Nocturnal paroxysmal dystonia.
Lugaresi E, Cirignotta F, Montagna P
Epilepsy Res Suppl 1991;2:137-40. PMID: 1760084
Nocturnal paroxysmal dystonia.
Lugaresi E, Cirignotta F, Montagna P
J Neurol Neurosurg Psychiatry 1986 Apr;49(4):375-80. doi: 10.1136/jnnp.49.4.375. PMID: 2939199Free PMC Article

Therapy

Paroxysmal hypnogenic dyskinesia.
Almeida L, Dure LS
Neurology 2014 May 27;82(21):1935. doi: 10.1212/WNL.0000000000000451. PMID: 24862895
A patient with epilepsy and new onset of nocturnal symptoms.
Liebman RF, Rodriguez AJ
Rev Neurol Dis 2009 Winter;6(1):40-4. PMID: 19367225
Seeing the good and bad in aplastic anemia: is autoimmunity in AA dysregulated or antineoplastic?
Nissen C, Schubert J
Hematol J 2002;3(4):169-75. doi: 10.1038/sj.thj.6200179. PMID: 12189561
Treatment of periodic leg movements with a dopaminergic agonist in subjects with total spinal cord lesions.
de Mello MT, Poyares DL, Tufik S
Spinal Cord 1999 Sep;37(9):634-7. doi: 10.1038/sj.sc.3100909. PMID: 10490854
Nocturnal paroxysmal dystonia.
Lugaresi E, Cirignotta F, Montagna P
J Neurol Neurosurg Psychiatry 1986 Apr;49(4):375-80. doi: 10.1136/jnnp.49.4.375. PMID: 2939199Free PMC Article

Prognosis

Effects of antiepileptic treatment on sleep and seizures in nocturnal frontal lobe epilepsy.
De Paolis F, Colizzi E, Milioli G, Grassi A, Riccardi S, Puligheddu M, Terzano MG, Marrosu F, Parrino L
Sleep Med 2013 Jul;14(7):597-604. Epub 2013 Jun 7 doi: 10.1016/j.sleep.2013.02.014. PMID: 23746822
Oxcarbazepine in children with nocturnal frontal-lobe epilepsy.
Raju GP, Sarco DP, Poduri A, Riviello JJ, Bergin AM, Takeoka M
Pediatr Neurol 2007 Nov;37(5):345-9. doi: 10.1016/j.pediatrneurol.2007.06.013. PMID: 17950420
Clinical identification of the simple sleep-related movement disorders.
Walters AS
Chest 2007 Apr;131(4):1260-6. doi: 10.1378/chest.06-1602. PMID: 17426241
Autosomal dominant nocturnal frontal lobe epilepsy: an electroclinical study of a Norwegian family with ten affected members.
Nakken KO, Magnusson A, Steinlein OK
Epilepsia 1999 Jan;40(1):88-92. doi: 10.1111/j.1528-1157.1999.tb01993.x. PMID: 9924907

Clinical prediction guides

A clinical efficacy experience of Lacosamide on sleep quality in patients with Nocturnal Frontal Lobe Epilepsy (NFLE).
Mangiardi M, Alfano G
Acta Biomed 2018 Oct 8;89(3):397-399. doi: 10.23750/abm.v89i3.6956. PMID: 30333465Free PMC Article
Reduced striatal D1 receptor binding in autosomal dominant nocturnal frontal lobe epilepsy.
Fedi M, Berkovic SF, Scheffer IE, O'Keefe G, Marini C, Mulligan R, Gong S, Tochon-Danguy H, Reutens DC
Neurology 2008 Sep 9;71(11):795-8. Epub 2008 Aug 6 doi: 10.1212/01.wnl.0000316192.52731.77. PMID: 18685138
Coupling of minor motor events and epileptiform discharges with arousal fluctuations in NFLE.
Terzaghi M, Sartori I, Mai R, Tassi L, Francione S, Cardinale F, Castana L, Cossu M, LoRusso G, Manni R, Nobili L
Epilepsia 2008 Apr;49(4):670-6. Epub 2007 Nov 19 doi: 10.1111/j.1528-1167.2007.01419.x. PMID: 18028403
Seeing the good and bad in aplastic anemia: is autoimmunity in AA dysregulated or antineoplastic?
Nissen C, Schubert J
Hematol J 2002;3(4):169-75. doi: 10.1038/sj.thj.6200179. PMID: 12189561
Nocturnal paroxysmal dystonia.
Lugaresi E, Cirignotta F, Montagna P
J Neurol Neurosurg Psychiatry 1986 Apr;49(4):375-80. doi: 10.1136/jnnp.49.4.375. PMID: 2939199Free PMC Article

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