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Insulin coma

MedGen UID:
9496
•Concept ID:
C0021645
•
Disease or Syndrome
Synonyms: Coma, Insulin; Insulin Coma
SNOMED CT: Insulin coma (111558006)

Definition

A hypoglycemia-induced comatose state resulting from a large dose of exogenous insulin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInsulin coma

Professional guidelines

PubMed

The menstrual cycle and insulin coma treatment in schizophrenia.
MERLIS S, MICHAEL ST
J Nerv Ment Dis 1954 Jun;119(6):512-6. doi: 10.1097/00005053-195406000-00005. PMID: 13201962
Novaldin and serum albumin in the treatment of irreversible insulin coma.
SIKES ZS
Dis Nerv Syst 1952 Jan;13(1):20-1. PMID: 14906165
The treatment and theory of prolonged insulin coma with a case presentation.
KALICHMAN N
Psychiatr Q 1948 Apr;22(2):213-30. PMID: 18874311

Recent clinical studies

Etiology

Improving Current Treatments for Schizophrenia.
Maric NP, Jovicic MJ, Mihaljevic M, Miljevic C
Drug Dev Res 2016 Nov;77(7):357-367. Epub 2016 Sep 16 doi: 10.1002/ddr.21337. PMID: 27633376
Long-term follow-up of patients with a diagnosis of paranoid state and hospitalized, 1913 to 1940.
Stephens JH, Richard P, McHugh PR
J Nerv Ment Dis 2000 Apr;188(4):202-8. doi: 10.1097/00005053-200004000-00002. PMID: 10789996
Lawrence Lecture. Hypoglycaemia and diabetes.
Frier BM
Diabet Med 1986 Nov-Dec;3(6):513-25. doi: 10.1111/j.1464-5491.1986.tb00807.x. PMID: 3030623
Factitious brittle diabetes mellitus.
Schade DS, Drumm DA, Eaton RP, Sterling WA
Am J Med 1985 May;78(5):777-84. doi: 10.1016/0002-9343(85)90283-9. PMID: 3922220
Insulin coma and group psychotherapy.
MORROW TF, LAUCKS SP, MCKNIGHT WK
AMA Arch Neurol Psychiatry 1952 Oct;68(4):491-7. doi: 10.1001/archneurpsyc.1952.02320220068007. PMID: 12975892

Diagnosis

Insulin-induced factitious hypoglycemic coma.
Price WA, Zimmer B, Conway R, Szekely B
Gen Hosp Psychiatry 1986 Jul;8(4):291-3. doi: 10.1016/0163-8343(86)90012-5. PMID: 3527869
Factitious brittle diabetes mellitus.
Schade DS, Drumm DA, Eaton RP, Sterling WA
Am J Med 1985 May;78(5):777-84. doi: 10.1016/0002-9343(85)90283-9. PMID: 3922220
Hypoglycemic and hyperglycemic coma.
Hurwitz D
Surg Clin North Am 1968 Apr;48(2):361-70. doi: 10.1016/s0039-6109(16)38490-0. PMID: 4966948
ELECTROENCEPHALOGRAMS DURING COMA.
LOEB C
Acta Neurochir (Wien) 1964;12:270-81. doi: 10.1007/BF01402098. PMID: 14293381
Therapeutic response in insulin coma therapy; a study of vital signs and sensitivity.
SCHEFLEN AE, REINER ER, COWITZ B
J Clin Exp Psychopathol 1953 Jan-Mar;14(1):57-67. PMID: 13061599

Therapy

Improving Current Treatments for Schizophrenia.
Maric NP, Jovicic MJ, Mihaljevic M, Miljevic C
Drug Dev Res 2016 Nov;77(7):357-367. Epub 2016 Sep 16 doi: 10.1002/ddr.21337. PMID: 27633376
Hypoglycemic neuropathy.
Mohseni S
Acta Neuropathol 2001 Nov;102(5):413-21. doi: 10.1007/s004010100459. PMID: 11699552
Insulin coma therapy in schizophrenia.
Jones K
J R Soc Med 2000 Mar;93(3):147-9. doi: 10.1177/014107680009300313. PMID: 10741319Free PMC Article
Hypoglycaemia.
Gale E
Clin Endocrinol Metab 1980 Nov;9(3):461-75. PMID: 6260399
Diabetic and insulin coma.
NABARRO JD
Br Med J 1955 Apr 9;1(4918):902-4. doi: 10.1136/bmj.1.4918.902. PMID: 14363747Free PMC Article

Prognosis

Factitious brittle diabetes mellitus.
Schade DS, Drumm DA, Eaton RP, Sterling WA
Am J Med 1985 May;78(5):777-84. doi: 10.1016/0002-9343(85)90283-9. PMID: 3922220
ELECTRIC AND INSULIN SHOCK THERAPY DURING PREGNANCY.
IMPASTATO DJ, GABRIEL AR, LARDARO HH
Dis Nerv Syst 1964 Sep;25:542-6. PMID: 14215244
The effect of insulin coma and E.C.T. on the three-year prognosis of schizophrenia.
LEIBERMAN DM, HOENIG J, AUERBACH I
J Neurol Neurosurg Psychiatry 1957 May;20(2):108-13. doi: 10.1136/jnnp.20.2.108. PMID: 13429378Free PMC Article
The effect of insulin coma and E.C.T. on the short-term prognosis of schizophrenia.
HOENIG J, LEIBERMAN DM, AUERBACH I
J Neurol Neurosurg Psychiatry 1956 May;19(2):130-6. doi: 10.1136/jnnp.19.2.130. PMID: 13346386Free PMC Article
Observations on the relation between insulin coma dosage and prognosis in schizophrenia.
FREUDENBERG RK
J Ment Sci 1952 Jul;98(412):441-9. doi: 10.1192/bjp.98.412.441. PMID: 14938888

Clinical prediction guides

Hypoglycemic neuropathy.
Mohseni S
Acta Neuropathol 2001 Nov;102(5):413-21. doi: 10.1007/s004010100459. PMID: 11699552
Long-term follow-up of patients with a diagnosis of paranoid state and hospitalized, 1913 to 1940.
Stephens JH, Richard P, McHugh PR
J Nerv Ment Dis 2000 Apr;188(4):202-8. doi: 10.1097/00005053-200004000-00002. PMID: 10789996
Reversible decerebrate posturing after profound and prolonged hypoglycemia.
Kirk MM, Hoogwerf BJ, Stoller JK
Cleve Clin J Med 1991 Jul-Aug;58(4):361-3. doi: 10.3949/ccjm.58.4.361. PMID: 1889117
Observations on organic brain damage and clinical improvement following protracted insulin coma.
REVITCH E
Psychiatr Q 1954 Jan;28(1):72-92. doi: 10.1007/BF01567038. PMID: 13155690
Observations on the relation between insulin coma dosage and prognosis in schizophrenia.
FREUDENBERG RK
J Ment Sci 1952 Jul;98(412):441-9. doi: 10.1192/bjp.98.412.441. PMID: 14938888

Recent systematic reviews

Electroconvulsive therapy for schizophrenia.
Tharyan P
Cochrane Database Syst Rev 2000;(2):CD000076. doi: 10.1002/14651858.CD000076. PMID: 10796292

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