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Infant Acute Biphenotypic Leukemia

MedGen UID:
926425
•Concept ID:
C4288893
•
Neoplastic Process

Definition

An acute biphenotypic leukemia that occurs in infancy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInfant Acute Biphenotypic Leukemia

Professional guidelines

PubMed

Acute lymphoblastic leukemia-like treatment regimen provides better response in mixed phenotype acute leukemia: a comparative study between adults and pediatric MPAL patients.
Rasekh EO, Osman R, Ibraheem D, Madney Y, Radwan E, Gameel A, Abdelhafiz A, Kamel A, Elfishawi S
Ann Hematol 2021 Mar;100(3):699-707. Epub 2020 Nov 23 doi: 10.1007/s00277-020-04354-2. PMID: 33230570
International cooperative study identifies treatment strategy in childhood ambiguous lineage leukemia.
Hrusak O, de Haas V, Stancikova J, Vakrmanova B, Janotova I, Mejstrikova E, Capek V, Trka J, Zaliova M, Luks A, Bleckmann K, Möricke A, Irving J, Konatkowska B, Alexander TB, Inaba H, Schmiegelow K, Stokley S, Zemanova Z, Moorman AV, Rossi JG, Felice MS, Dalla-Pozza L, Morales J, Dworzak M, Buldini B, Basso G, Campbell M, Cabrera ME, Marinov N, Elitzur S, Izraeli S, Luria D, Feuerstein T, Kolenova A, Svec P, Kreminska O, Rabin KR, Polychronopoulou S, da Costa E, Marquart HV, Kattamis A, Ratei R, Reinhardt D, Choi JK, Schrappe M, Stary J
Blood 2018 Jul 19;132(3):264-276. Epub 2018 May 2 doi: 10.1182/blood-2017-12-821363. PMID: 29720486
Diagnosis and management of neonatal leukaemia.
van der Linden MH, Creemers S, Pieters R
Semin Fetal Neonatal Med 2012 Aug;17(4):192-195. Epub 2012 Apr 15 doi: 10.1016/j.siny.2012.03.003. PMID: 22510298

Recent clinical studies

Etiology

Auer rod-positive acute leukemia with predominantly lymphoid immunophenotype: Report on 11 cases and review of literature.
Hrusak O, Stancikova J, Vodickova E, Podolska T, Möricke A, Attarbaschi A, Dworzak M, Sestakova Z, Svec P, Zaliova MK, Janotova I, Zapletal O, Mejstrikova E, Stary J
Pediatr Blood Cancer 2025 Jan;72(1):e31394. Epub 2024 Oct 16 doi: 10.1002/pbc.31394. PMID: 39415351
Effect of FOXP3 polymorphism on the clinical outcomes after allogeneic hematopoietic stem cell transplantation in pediatric acute leukemia patients.
Piao Z, Kim HJ, Choi JY, Hong CR, Lee JW, Kang HJ, Park KD, Shin HY
Int Immunopharmacol 2016 Feb;31:132-9. Epub 2015 Dec 29 doi: 10.1016/j.intimp.2015.12.022. PMID: 26735609
Clinical characteristics and outcome of children with biphenotypic acute leukemia.
Al-Seraihy AS, Owaidah TM, Ayas M, El-Solh H, Al-Mahr M, Al-Ahmari A, Belgaumi AF
Haematologica 2009 Dec;94(12):1682-90. Epub 2009 Aug 27 doi: 10.3324/haematol.2009.009282. PMID: 19713227Free PMC Article
Cytogenetics, molecular and ultrastructural characteristics of biphenotypic acute leukemia identified by the EGIL scoring system.
Owaidah TM, Al Beihany A, Iqbal MA, Elkum N, Roberts GT
Leukemia 2006 Apr;20(4):620-6. doi: 10.1038/sj.leu.2404128. PMID: 16437134
Definition of acute biphenotypic leukemia.
Matutes E, Morilla R, Farahat N, Carbonell F, Swansbury J, Dyer M, Catovsky D
Haematologica 1997 Jan-Feb;82(1):64-6. PMID: 9107085

Diagnosis

Effect of FOXP3 polymorphism on the clinical outcomes after allogeneic hematopoietic stem cell transplantation in pediatric acute leukemia patients.
Piao Z, Kim HJ, Choi JY, Hong CR, Lee JW, Kang HJ, Park KD, Shin HY
Int Immunopharmacol 2016 Feb;31:132-9. Epub 2015 Dec 29 doi: 10.1016/j.intimp.2015.12.022. PMID: 26735609
Diagnosis and management of neonatal leukaemia.
van der Linden MH, Creemers S, Pieters R
Semin Fetal Neonatal Med 2012 Aug;17(4):192-195. Epub 2012 Apr 15 doi: 10.1016/j.siny.2012.03.003. PMID: 22510298
Clinical characteristics and outcome of children with biphenotypic acute leukemia.
Al-Seraihy AS, Owaidah TM, Ayas M, El-Solh H, Al-Mahr M, Al-Ahmari A, Belgaumi AF
Haematologica 2009 Dec;94(12):1682-90. Epub 2009 Aug 27 doi: 10.3324/haematol.2009.009282. PMID: 19713227Free PMC Article
Cytogenetics, molecular and ultrastructural characteristics of biphenotypic acute leukemia identified by the EGIL scoring system.
Owaidah TM, Al Beihany A, Iqbal MA, Elkum N, Roberts GT
Leukemia 2006 Apr;20(4):620-6. doi: 10.1038/sj.leu.2404128. PMID: 16437134
Definition of acute biphenotypic leukemia.
Matutes E, Morilla R, Farahat N, Carbonell F, Swansbury J, Dyer M, Catovsky D
Haematologica 1997 Jan-Feb;82(1):64-6. PMID: 9107085

Therapy

A systematic description of MLL fusion gene formation.
Wright RL, Vaughan AT
Crit Rev Oncol Hematol 2014 Sep;91(3):283-91. Epub 2014 Apr 8 doi: 10.1016/j.critrevonc.2014.03.004. PMID: 24787275
Diagnosis and management of neonatal leukaemia.
van der Linden MH, Creemers S, Pieters R
Semin Fetal Neonatal Med 2012 Aug;17(4):192-195. Epub 2012 Apr 15 doi: 10.1016/j.siny.2012.03.003. PMID: 22510298
Clinical characteristics and outcome of children with biphenotypic acute leukemia.
Al-Seraihy AS, Owaidah TM, Ayas M, El-Solh H, Al-Mahr M, Al-Ahmari A, Belgaumi AF
Haematologica 2009 Dec;94(12):1682-90. Epub 2009 Aug 27 doi: 10.3324/haematol.2009.009282. PMID: 19713227Free PMC Article
An uncommon case of childhood biphenotypic precursor-B/T acute lymphoblastic leukemia.
Costa ES, Thiago LS, Otazu IB, Ornellas MH, Land MG, Orfao A
Pediatr Blood Cancer 2008 Apr;50(4):941-2. doi: 10.1002/pbc.21290. PMID: 17610263
Chromosomal translocations involving the MLL gene: molecular mechanisms.
Aplan PD
DNA Repair (Amst) 2006 Sep 8;5(9-10):1265-72. Epub 2006 Jun 21 doi: 10.1016/j.dnarep.2006.05.034. PMID: 16797254Free PMC Article

Prognosis

Effect of FOXP3 polymorphism on the clinical outcomes after allogeneic hematopoietic stem cell transplantation in pediatric acute leukemia patients.
Piao Z, Kim HJ, Choi JY, Hong CR, Lee JW, Kang HJ, Park KD, Shin HY
Int Immunopharmacol 2016 Feb;31:132-9. Epub 2015 Dec 29 doi: 10.1016/j.intimp.2015.12.022. PMID: 26735609
Diagnosis and management of neonatal leukaemia.
van der Linden MH, Creemers S, Pieters R
Semin Fetal Neonatal Med 2012 Aug;17(4):192-195. Epub 2012 Apr 15 doi: 10.1016/j.siny.2012.03.003. PMID: 22510298
Clinical characteristics and outcome of children with biphenotypic acute leukemia.
Al-Seraihy AS, Owaidah TM, Ayas M, El-Solh H, Al-Mahr M, Al-Ahmari A, Belgaumi AF
Haematologica 2009 Dec;94(12):1682-90. Epub 2009 Aug 27 doi: 10.3324/haematol.2009.009282. PMID: 19713227Free PMC Article
The biological and clinical significance of MLL abnormalities in haematological malignancies.
Mitterbauer-Hohendanner G, Mannhalter C
Eur J Clin Invest 2004 Aug;34 Suppl 2:12-24. doi: 10.1111/j.0960-135X.2004.01366.x. PMID: 15291802
Definition of acute biphenotypic leukemia.
Matutes E, Morilla R, Farahat N, Carbonell F, Swansbury J, Dyer M, Catovsky D
Haematologica 1997 Jan-Feb;82(1):64-6. PMID: 9107085

Clinical prediction guides

Effect of FOXP3 polymorphism on the clinical outcomes after allogeneic hematopoietic stem cell transplantation in pediatric acute leukemia patients.
Piao Z, Kim HJ, Choi JY, Hong CR, Lee JW, Kang HJ, Park KD, Shin HY
Int Immunopharmacol 2016 Feb;31:132-9. Epub 2015 Dec 29 doi: 10.1016/j.intimp.2015.12.022. PMID: 26735609
Diagnosis and management of neonatal leukaemia.
van der Linden MH, Creemers S, Pieters R
Semin Fetal Neonatal Med 2012 Aug;17(4):192-195. Epub 2012 Apr 15 doi: 10.1016/j.siny.2012.03.003. PMID: 22510298
Clinical characteristics and outcome of children with biphenotypic acute leukemia.
Al-Seraihy AS, Owaidah TM, Ayas M, El-Solh H, Al-Mahr M, Al-Ahmari A, Belgaumi AF
Haematologica 2009 Dec;94(12):1682-90. Epub 2009 Aug 27 doi: 10.3324/haematol.2009.009282. PMID: 19713227Free PMC Article
The biological and clinical significance of MLL abnormalities in haematological malignancies.
Mitterbauer-Hohendanner G, Mannhalter C
Eur J Clin Invest 2004 Aug;34 Suppl 2:12-24. doi: 10.1111/j.0960-135X.2004.01366.x. PMID: 15291802
Definition of acute biphenotypic leukemia.
Matutes E, Morilla R, Farahat N, Carbonell F, Swansbury J, Dyer M, Catovsky D
Haematologica 1997 Jan-Feb;82(1):64-6. PMID: 9107085

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