U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Oropharyngeal Poorly Differentiated Carcinoma

MedGen UID:
926082
•Concept ID:
C4288550
•
Neoplastic Process

Definition

A high-grade carcinoma that arises from the oropharynx. It is characterized by the presence of malignant cells which bear minimal resemblance to the cells from which they arose. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOropharyngeal Poorly Differentiated Carcinoma

Professional guidelines

PubMed

Clinicopathological features, management and outcome of patients with poorly-differentiated oral and oropharyngeal squamous cell carcinoma.
Feng Z, Xu QS, Wang C, Li B, Li JZ, Mao MH, Li H, Qin LZ, Han Z
J Craniomaxillofac Surg 2017 Sep;45(9):1478-1485. Epub 2017 Jul 4 doi: 10.1016/j.jcms.2017.06.013. PMID: 28743604
Treatment results and prognostic factors for advanced squamous cell carcinoma of the head and neck treated with salvage surgery after concurrent chemoradiotherapy.
Taguchi T, Nishimura G, Takahashi M, Shiono O, Komatsu M, Sano D, Yabuki KI, Arai Y, Yamashita Y, Yamamoto K, Sakuma Y, Oridate N
Int J Clin Oncol 2016 Oct;21(5):869-874. Epub 2016 Feb 23 doi: 10.1007/s10147-016-0964-2. PMID: 26908193
The management of extrapulmonary poorly differentiated (high-grade) neuroendocrine carcinomas.
Smith J, Reidy-Lagunes D
Semin Oncol 2013 Feb;40(1):100-8. doi: 10.1053/j.seminoncol.2012.11.011. PMID: 23391117

Recent clinical studies

Etiology

Oral and oropharyngeal NUT carcinoma: a multicentre screening study of poorly differentiated oral cancer.
Liang Z, Tang Y, Li C, Xie G, Chen M, Zhou P, Li M, Wang Y, Yu X, Tang Y, Wang J, Bao J, Jiang L, Wang W
Histopathology 2024 Dec;85(6):868-878. Epub 2024 Jun 20 doi: 10.1111/his.15245. PMID: 39031601
Clinicopathological and genomic features in patients with head and neck neuroendocrine carcinoma.
Ohmoto A, Sato Y, Asaka R, Fukuda N, Wang X, Urasaki T, Hayashi N, Sato Y, Nakano K, Yunokawa M, Ono M, Tomomatsu J, Toshiyasu T, Mitani H, Takeuchi K, Mori S, Takahashi S
Mod Pathol 2021 Nov;34(11):1979-1989. Epub 2021 Jul 10 doi: 10.1038/s41379-021-00869-9. PMID: 34247193Free PMC Article
Poorly differentiated neuroendocrine carcinoma of the head and neck: human papillomavirus tumour status/p16 status and impact on overall survival.
Benzerdjeb N, Traverse-Glehen A, Philouze P, Bishop J, Devouassoux-Shisheboran M
Histopathology 2020 Mar;76(4):581-591. Epub 2020 Jan 24 doi: 10.1111/his.13982. PMID: 31463946
The management of extrapulmonary poorly differentiated (high-grade) neuroendocrine carcinomas.
Smith J, Reidy-Lagunes D
Semin Oncol 2013 Feb;40(1):100-8. doi: 10.1053/j.seminoncol.2012.11.011. PMID: 23391117
Heavy water delays growth of human carcinoma in nude mice.
Altermatt HJ, Gebbers JO, Laissue JA
Cancer 1988 Aug 1;62(3):462-6. PMID: 2839279

Diagnosis

Oral and oropharyngeal NUT carcinoma: a multicentre screening study of poorly differentiated oral cancer.
Liang Z, Tang Y, Li C, Xie G, Chen M, Zhou P, Li M, Wang Y, Yu X, Tang Y, Wang J, Bao J, Jiang L, Wang W
Histopathology 2024 Dec;85(6):868-878. Epub 2024 Jun 20 doi: 10.1111/his.15245. PMID: 39031601
Oral and Maxillofacial Neuroendocrine Carcinoma: A Systematic Review.
Schuch LF, Schmidt TR, de Oliveira Zigmundo G, Kirschnick LB, Silveira FM, Martins MAT, Carlos R, Dos Santos JN, Fonseca FP, Vargas PA, Wagner VP, Martins MD
Head Neck Pathol 2022 Jun;16(2):525-537. Epub 2021 Dec 6 doi: 10.1007/s12105-021-01398-2. PMID: 34870796Free PMC Article
The management of extrapulmonary poorly differentiated (high-grade) neuroendocrine carcinomas.
Smith J, Reidy-Lagunes D
Semin Oncol 2013 Feb;40(1):100-8. doi: 10.1053/j.seminoncol.2012.11.011. PMID: 23391117
Endobronchial actinomycosis after airway stenting.
Godfrey AM, Diaz-Mendoza J, Ray C, Simoff MJ
J Bronchology Interv Pulmonol 2012 Oct;19(4):315-8. doi: 10.1097/LBR.0b013e31826a3aed. PMID: 23207533
Human papillomavirus-associated oropharyngeal cancer: a new clinical entity.
Nguyen NP, Chi A, Nguyen LM, Ly BH, Karlsson U, Vinh-Hung V
QJM 2010 Apr;103(4):229-36. Epub 2009 Dec 16 doi: 10.1093/qjmed/hcp176. PMID: 20015950

Therapy

When dizziness becomes sinister: oropharyngeal carcinoma presenting as a paraneoplastic neurological disorder.
Yong L, Asimakopoulos P, Mumford C, Fragkandrea Nixon I
BMJ Case Rep 2017 Jan 19;2017 doi: 10.1136/bcr-2016-216151. PMID: 28104720Free PMC Article
New insights into human papillomavirus-associated head and neck squamous cell carcinoma.
Boscolo-Rizzo P, Del Mistro A, Bussu F, Lupato V, Baboci L, Almadori G, DA Mosto MC, Paludetti G
Acta Otorhinolaryngol Ital 2013 Apr;33(2):77-87. PMID: 23853396Free PMC Article
Endobronchial actinomycosis after airway stenting.
Godfrey AM, Diaz-Mendoza J, Ray C, Simoff MJ
J Bronchology Interv Pulmonol 2012 Oct;19(4):315-8. doi: 10.1097/LBR.0b013e31826a3aed. PMID: 23207533
The role of human papillomavirus infection in head and neck cancers.
Syrjänen S
Ann Oncol 2010 Oct;21 Suppl 7:vii243-5. doi: 10.1093/annonc/mdq454. PMID: 20943622
Heavy water delays growth of human carcinoma in nude mice.
Altermatt HJ, Gebbers JO, Laissue JA
Cancer 1988 Aug 1;62(3):462-6. PMID: 2839279

Prognosis

Tumor Histological Grade and Immunotherapy Response in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma.
Alkhatib HH, Maroun CA, Amin N, Zhu G, Guller M, Herberg ME, Wu ES, Seiwert TY, Rooper LM, Eisele DW, Fakhry C, Pardoll D, Mandal R
JAMA Otolaryngol Head Neck Surg 2022 Jun 1;148(6):540-546. doi: 10.1001/jamaoto.2022.0640. PMID: 35482301Free PMC Article
Oral and Maxillofacial Neuroendocrine Carcinoma: A Systematic Review.
Schuch LF, Schmidt TR, de Oliveira Zigmundo G, Kirschnick LB, Silveira FM, Martins MAT, Carlos R, Dos Santos JN, Fonseca FP, Vargas PA, Wagner VP, Martins MD
Head Neck Pathol 2022 Jun;16(2):525-537. Epub 2021 Dec 6 doi: 10.1007/s12105-021-01398-2. PMID: 34870796Free PMC Article
Prevalence and prognosis of synchronous distant metastatic tonsil squamous cell carcinomas.
Li Y, Hu C
Int J Med Sci 2021;18(2):528-533. Epub 2021 Jan 1 doi: 10.7150/ijms.50966. PMID: 33390822Free PMC Article
Poorly differentiated neuroendocrine carcinoma of the head and neck: human papillomavirus tumour status/p16 status and impact on overall survival.
Benzerdjeb N, Traverse-Glehen A, Philouze P, Bishop J, Devouassoux-Shisheboran M
Histopathology 2020 Mar;76(4):581-591. Epub 2020 Jan 24 doi: 10.1111/his.13982. PMID: 31463946
Clinicopathological features, management and outcome of patients with poorly-differentiated oral and oropharyngeal squamous cell carcinoma.
Feng Z, Xu QS, Wang C, Li B, Li JZ, Mao MH, Li H, Qin LZ, Han Z
J Craniomaxillofac Surg 2017 Sep;45(9):1478-1485. Epub 2017 Jul 4 doi: 10.1016/j.jcms.2017.06.013. PMID: 28743604

Clinical prediction guides

Oral and oropharyngeal NUT carcinoma: a multicentre screening study of poorly differentiated oral cancer.
Liang Z, Tang Y, Li C, Xie G, Chen M, Zhou P, Li M, Wang Y, Yu X, Tang Y, Wang J, Bao J, Jiang L, Wang W
Histopathology 2024 Dec;85(6):868-878. Epub 2024 Jun 20 doi: 10.1111/his.15245. PMID: 39031601
Tumor Histological Grade and Immunotherapy Response in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma.
Alkhatib HH, Maroun CA, Amin N, Zhu G, Guller M, Herberg ME, Wu ES, Seiwert TY, Rooper LM, Eisele DW, Fakhry C, Pardoll D, Mandal R
JAMA Otolaryngol Head Neck Surg 2022 Jun 1;148(6):540-546. doi: 10.1001/jamaoto.2022.0640. PMID: 35482301Free PMC Article
Poorly differentiated neuroendocrine carcinoma of the head and neck: human papillomavirus tumour status/p16 status and impact on overall survival.
Benzerdjeb N, Traverse-Glehen A, Philouze P, Bishop J, Devouassoux-Shisheboran M
Histopathology 2020 Mar;76(4):581-591. Epub 2020 Jan 24 doi: 10.1111/his.13982. PMID: 31463946
Clinicopathological features, management and outcome of patients with poorly-differentiated oral and oropharyngeal squamous cell carcinoma.
Feng Z, Xu QS, Wang C, Li B, Li JZ, Mao MH, Li H, Qin LZ, Han Z
J Craniomaxillofac Surg 2017 Sep;45(9):1478-1485. Epub 2017 Jul 4 doi: 10.1016/j.jcms.2017.06.013. PMID: 28743604
Cytologic evaluation of cervical lymph node metastases from cancers of unknown primary origin.
Pusztaszeri MP, Faquin WC
Semin Diagn Pathol 2015 Jan;32(1):32-41. Epub 2014 Dec 20 doi: 10.1053/j.semdp.2014.12.002. PMID: 25618223

Recent systematic reviews

Oral and Maxillofacial Neuroendocrine Carcinoma: A Systematic Review.
Schuch LF, Schmidt TR, de Oliveira Zigmundo G, Kirschnick LB, Silveira FM, Martins MAT, Carlos R, Dos Santos JN, Fonseca FP, Vargas PA, Wagner VP, Martins MD
Head Neck Pathol 2022 Jun;16(2):525-537. Epub 2021 Dec 6 doi: 10.1007/s12105-021-01398-2. PMID: 34870796Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...