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Bile duct adenoma

MedGen UID:
918
•Concept ID:
C0008309
•
Neoplastic Process
Synonyms: Adenoma, Bile Duct; Adenomas, Bile Duct; Bile Duct Adenoma; Bile Duct Adenomas; Cholangioma; Cholangiomas
SNOMED CT: Cholangioadenoma (424091006); Bile duct adenoma (39471001); Cholangioma (39471001)
 
Monarch Initiative: MONDO:0006108

Definition

A benign, well-demarcated polypoid neoplasm arising from the bile duct epithelium. According to the growth pattern, it is classified as tubular, papillary, or tubulopapillary. Adenomas arising from the extrahepatic bile ducts usually produce symptoms related to biliary obstruction. [from NCI]

Professional guidelines

PubMed

Cholangiocarcinoma: A position paper by the Italian Society of Gastroenterology (SIGE), the Italian Association of Hospital Gastroenterology (AIGO), the Italian Association of Medical Oncology (AIOM) and the Italian Association of Oncological Radiotherapy (AIRO).
Alvaro D, Cannizzaro R, Labianca R, Valvo F, Farinati F; Italian Society of Gastroenterology (SIGE); Italian Association of Hospital Gastroenterology (AIGO); Italian Association of Medical Oncology (AIOM); Italian Association of Oncological Radiotherapy (AIRO)
Dig Liver Dis 2010 Dec;42(12):831-8. Epub 2010 Aug 11 doi: 10.1016/j.dld.2010.06.005. PMID: 20702152

Recent clinical studies

Etiology

Cholangiocarcinoma: Classification, Histopathology and Molecular Carcinogenesis.
Lendvai G, Szekerczés T, Illyés I, Dóra R, Kontsek E, Gógl A, Kiss A, Werling K, Kovalszky I, Schaff Z, Borka K
Pathol Oncol Res 2020 Jan;26(1):3-15. Epub 2018 Nov 17 doi: 10.1007/s12253-018-0491-8. PMID: 30448973
Imaging features of bile duct adenoma: case series and review of literature.
Chuy JA, Garg I, Graham RP, VanBuren WM, Venkatesh SK
Diagn Interv Radiol 2018 Sep;24(5):249-254. doi: 10.5152/dir.2018.18036. PMID: 30211677Free PMC Article
Benign hepatic tumours.
Biecker E, Fischer HP, Strunk H, Sauerbruch T
Z Gastroenterol 2003 Feb;41(2):191-200. doi: 10.1055/s-2003-37316. PMID: 12650132
Cholangiocarcinoma complicating primary sclerosing cholangitis.
Rosen CB, Nagorney DM
Semin Liver Dis 1991 Feb;11(1):26-30. doi: 10.1055/s-2008-1040419. PMID: 1646485
Obstructive jaundice. Causes and surgical interventions.
Fry DE
Postgrad Med 1988 Oct;84(5):217-22, 227, 230. doi: 10.1080/00325481.1988.11700446. PMID: 2845377

Diagnosis

Common bile duct adenomas: A diagnostic and therapeutic challenge.
Ochoa Segarra F, Sánchez Velázquez P, Grande Posa L, Burdio F, Ielpo B
Cir Esp (Engl Ed) 2022 Nov;100(11):738-741. Epub 2022 Jul 16 doi: 10.1016/j.cireng.2022.07.004. PMID: 35850475
Malignant liver tumors.
Ros PR, Rasmussen JF
Curr Probl Diagn Radiol 1989 May-Jun;18(3):95-124. doi: 10.1016/0363-0188(89)90026-1. PMID: 2544348
Klatskin tumours.
Burcharth F
Acta Chir Scand Suppl 1988;541:63-9. PMID: 2455407
Hepatomegaly.
Kaude JV, DeLand F
Med Clin North Am 1975 Jan;59(1):145-67. doi: 10.1016/s0025-7125(16)32059-4. PMID: 162803
Cholangiocarcinoma.
Kaude J, Rian R
Radiology 1971 Sep;100(3):573-80. doi: 10.1148/100.3.573. PMID: 4327847

Therapy

Unresectable malignant biliary obstruction: treatment by self-expandable biliary endoprostheses.
Glättli A, Stain SC, Baer HU, Schweizer W, Triller J, Blumgart LH
HPB Surg 1993;6(3):175-84. doi: 10.1155/1993/78590. PMID: 7683908Free PMC Article
Cholangiocarcinoma.
Yeo CJ, Pitt HA, Cameron JL
Surg Clin North Am 1990 Dec;70(6):1429-47. doi: 10.1016/s0039-6109(16)45293-x. PMID: 2174191
Results of radiation therapy in carcinoma of the proximal bile duct (Klatskin tumor).
González González D, Gerard JP, Maners AW, De la Lande-Guyaux B, Van Dijk-Milatz A, Meerwaldt JH, Bosset JF, Van Dijk JD
Semin Liver Dis 1990 May;10(2):131-41. doi: 10.1055/s-2008-1040466. PMID: 2162565
Obstructive jaundice. Causes and surgical interventions.
Fry DE
Postgrad Med 1988 Oct;84(5):217-22, 227, 230. doi: 10.1080/00325481.1988.11700446. PMID: 2845377
Clinical liver transplantation.
Starzi TE, Brettschneider L, Penn I, Giles G, Picache R, Putnam CW
Transplant Rev 1969;2:3-68. doi: 10.1111/j.1600-065x.1969.tb00206.x. PMID: 4333563

Prognosis

Cholangiocarcinoma: Classification, Histopathology and Molecular Carcinogenesis.
Lendvai G, Szekerczés T, Illyés I, Dóra R, Kontsek E, Gógl A, Kiss A, Werling K, Kovalszky I, Schaff Z, Borka K
Pathol Oncol Res 2020 Jan;26(1):3-15. Epub 2018 Nov 17 doi: 10.1007/s12253-018-0491-8. PMID: 30448973
Endosonography in the clinical staging of Klatskin tumor.
Tio TL, Reeders JW, Sie LH, Wijers OB, Maas JJ, Colin EM, Tytgat GN
Endoscopy 1993 Jan;25(1):81-5. doi: 10.1055/s-2007-1009129. PMID: 8384104
Unresectable malignant biliary obstruction: treatment by self-expandable biliary endoprostheses.
Glättli A, Stain SC, Baer HU, Schweizer W, Triller J, Blumgart LH
HPB Surg 1993;6(3):175-84. doi: 10.1155/1993/78590. PMID: 7683908Free PMC Article
Palliative treatment of bile duct tumoral compression by an endoprosthesis: clinical results.
Sezeur A, Kracht M, Rey P, Leandri J, Fagniez PL, Farah A, Julien M, Malafosse M
ASAIO Trans 1990 Jul-Sep;36(3):M192-4. PMID: 1701317
Bile duct carcinoma. Diagnosis and treatment.
Gibby DG, Hanks JB, Wanebo HJ, Kaiser DL, Tegtmeyer CJ, Chandler JG, Jones RS
Ann Surg 1985 Aug;202(2):139-44. doi: 10.1097/00000658-198508000-00001. PMID: 2990361Free PMC Article

Clinical prediction guides

Biliary cystadenoma of the liver.
Kim K, Choi J, Park Y, Lee W, Kim B
J Hepatobiliary Pancreat Surg 1998;5(3):348-52. doi: 10.1007/s005340050058. PMID: 9880787
Endosonography in the clinical staging of Klatskin tumor.
Tio TL, Reeders JW, Sie LH, Wijers OB, Maas JJ, Colin EM, Tytgat GN
Endoscopy 1993 Jan;25(1):81-5. doi: 10.1055/s-2007-1009129. PMID: 8384104
Bile duct carcinoma. Diagnosis and treatment.
Gibby DG, Hanks JB, Wanebo HJ, Kaiser DL, Tegtmeyer CJ, Chandler JG, Jones RS
Ann Surg 1985 Aug;202(2):139-44. doi: 10.1097/00000658-198508000-00001. PMID: 2990361Free PMC Article
Cholangiocarcinoma in hepatolithiasis.
Chen PH, Lo HW, Wang CS, Tsai KR, Chen YC, Lin KY, Siauw CP, Hwang RR, Liu MH, Ko HC
J Clin Gastroenterol 1984 Dec;6(6):539-47. doi: 10.1097/00004836-198412000-00010. PMID: 6096441
The bile ducts.
Menuck L, Amberg J
Radiol Clin North Am 1976 Dec;14(3):499-525. PMID: 188068

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