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Cerebellar pilocytic astrocytoma

MedGen UID:
91158
Concept ID:
C0349620
Neoplastic Process
Synonyms: Cerebellar Pilocytic Astrocytoma; cerebellar pilocytic astrocytoma; cerebellum pilocytic astrocytoma; Pilocytic astrocytoma of cerebellum; Pilocytic Astrocytoma of Cerebellum; pilocytic astrocytoma of cerebellum; Pilocytic Astrocytoma of the Cerebellum; pilocytic astrocytoma of the cerebellum
SNOMED CT: Pilocytic astrocytoma of cerebellum (277507004)
 
Monarch Initiative: MONDO:0003168

Definition

A WHO Grade 1 astrocytoma which arises in the cerebellum. The tumor is composed of spindle shaped cells with numerous collections of reddish astrocytic fibers called Rosenthal fibers. Over 80% or the cerebellar astrocytomas of childhood are pilocytic. Pilocytic astrocytomas may rarely occur in adults. They are usually treated by surgical resection and in most cases have a favorable prognosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCerebellar pilocytic astrocytoma

Professional guidelines

PubMed

Dirven CM, Mooij JJ, Molenaar WM
Childs Nerv Syst 1997 Jan;13(1):17-23. doi: 10.1007/s003810050033. PMID: 9083697

Recent clinical studies

Etiology

Kameda-Smith MM, Green K, Hutton DL, Jeelani NUO, Thompson DNP, Hargrave D, Aquilina K
J Neurosurg Pediatr 2024 Aug 1;34(2):169-175. Epub 2024 May 17 doi: 10.3171/2024.2.PEDS23236. PMID: 38759245
Vladoiu MC, El-Hamamy I, Donovan LK, Farooq H, Holgado BL, Sundaravadanam Y, Ramaswamy V, Hendrikse LD, Kumar S, Mack SC, Lee JJY, Fong V, Juraschka K, Przelicki D, Michealraj A, Skowron P, Luu B, Suzuki H, Morrissy AS, Cavalli FMG, Garzia L, Daniels C, Wu X, Qazi MA, Singh SK, Chan JA, Marra MA, Malkin D, Dirks P, Heisler L, Pugh T, Ng K, Notta F, Thompson EM, Kleinman CL, Joyner AL, Jabado N, Stein L, Taylor MD
Nature 2019 Aug;572(7767):67-73. Epub 2019 May 1 doi: 10.1038/s41586-019-1158-7. PMID: 31043743Free PMC Article
McAuley E, Brophy H, Hayden J, Pettorini B, Parks C, Avula S, Mallucci C, Pizer B
Childs Nerv Syst 2019 May;35(5):801-805. Epub 2019 Feb 15 doi: 10.1007/s00381-019-04078-3. PMID: 30770993
Alford R, Gargan L, Bowers DC, Klesse LJ, Weprin B, Koral K
J Neurooncol 2016 Oct;130(1):149-154. Epub 2016 Aug 9 doi: 10.1007/s11060-016-2222-x. PMID: 27502785
Dirven CM, Mooij JJ, Molenaar WM
Childs Nerv Syst 1997 Jan;13(1):17-23. doi: 10.1007/s003810050033. PMID: 9083697

Diagnosis

Kameda-Smith MM, Green K, Hutton DL, Jeelani NUO, Thompson DNP, Hargrave D, Aquilina K
J Neurosurg Pediatr 2024 Aug 1;34(2):169-175. Epub 2024 May 17 doi: 10.3171/2024.2.PEDS23236. PMID: 38759245
Donofrio CA, Gagliardi F, Callea M, da Passano CF, Terreni MR, Cavalli A, Spina A, Acerno S, Bailo M, Elbabaa SK, Mortini P
Neurosurg Rev 2020 Feb;43(1):9-16. Epub 2018 Mar 22 doi: 10.1007/s10143-018-0969-6. PMID: 29569086
Brandão LA, Young Poussaint T
Neuroimaging Clin N Am 2017 Feb;27(1):1-37. doi: 10.1016/j.nic.2016.08.001. PMID: 27889018
Sasaki T, Saito R, Kumabe T, Kanamori M, Sonoda Y, Watanabe M, Tominaga T
Brain Tumor Pathol 2014 Apr;31(2):108-12. Epub 2013 Jul 25 doi: 10.1007/s10014-013-0154-0. PMID: 23884731
Redhu R, Nadkarni TD
J Clin Neurosci 2011 Oct;18(10):1412-4. Epub 2011 Jul 20 doi: 10.1016/j.jocn.2011.01.038. PMID: 21764319

Therapy

El Sheikh M, Fadelalla M, Kanodia AK, Kouli O, Peebles M, Hossain-Ibrahim K
Br J Neurosurg 2023 Aug;37(4):892-895. Epub 2020 Jan 8 doi: 10.1080/02688697.2019.1710824. PMID: 31913712
Bonomo G, Rubiu E, Iess G, Bonomo R, Amato A, Restelli F, Falco J, Mazzapicchi E, Locatelli M, Rampini P, Carrabba GG
Pediatr Neurosurg 2022;57(5):358-364. Epub 2022 Aug 19 doi: 10.1159/000526645. PMID: 35988537
Panagopoulos D, Antoniades E, Karydakis P, Giakoumettis D, Themistocleous M
Am J Case Rep 2020 Mar 12;21:e920213. doi: 10.12659/AJCR.920213. PMID: 32161253Free PMC Article
Strazzer S, Zucca C, Fiocchi I, Genitori L, Castelli E
J Child Neurol 2006 Sep;21(9):817-20. doi: 10.1177/08830738060210091701. PMID: 16970895
Aarsen FK, Van Dongen HR, Paquier PF, Van Mourik M, Catsman-Berrevoets CE
Neurology 2004 Apr 27;62(8):1311-6. doi: 10.1212/01.wnl.0000120549.77188.36. PMID: 15111667

Prognosis

Kameda-Smith MM, Green K, Hutton DL, Jeelani NUO, Thompson DNP, Hargrave D, Aquilina K
J Neurosurg Pediatr 2024 Aug 1;34(2):169-175. Epub 2024 May 17 doi: 10.3171/2024.2.PEDS23236. PMID: 38759245
Donofrio CA, Gagliardi F, Callea M, da Passano CF, Terreni MR, Cavalli A, Spina A, Acerno S, Bailo M, Elbabaa SK, Mortini P
Neurosurg Rev 2020 Feb;43(1):9-16. Epub 2018 Mar 22 doi: 10.1007/s10143-018-0969-6. PMID: 29569086
Vladoiu MC, El-Hamamy I, Donovan LK, Farooq H, Holgado BL, Sundaravadanam Y, Ramaswamy V, Hendrikse LD, Kumar S, Mack SC, Lee JJY, Fong V, Juraschka K, Przelicki D, Michealraj A, Skowron P, Luu B, Suzuki H, Morrissy AS, Cavalli FMG, Garzia L, Daniels C, Wu X, Qazi MA, Singh SK, Chan JA, Marra MA, Malkin D, Dirks P, Heisler L, Pugh T, Ng K, Notta F, Thompson EM, Kleinman CL, Joyner AL, Jabado N, Stein L, Taylor MD
Nature 2019 Aug;572(7767):67-73. Epub 2019 May 1 doi: 10.1038/s41586-019-1158-7. PMID: 31043743Free PMC Article
Fiset PO, Fontebasso AM, De Jay N, Gayden T, Nikbakht H, Majewski J, Jabado N, Albrecht S
Pediatr Blood Cancer 2017 Feb;64(2):275-278. Epub 2016 Oct 8 doi: 10.1002/pbc.26215. PMID: 27718322
Alford R, Gargan L, Bowers DC, Klesse LJ, Weprin B, Koral K
J Neurooncol 2016 Oct;130(1):149-154. Epub 2016 Aug 9 doi: 10.1007/s11060-016-2222-x. PMID: 27502785

Clinical prediction guides

Grin K, Azizi A, Haberler C, Peyrl A, Kasprian G, Czech T, Rössler K, Gojo J, Dorfer C
Childs Nerv Syst 2024 Dec 28;41(1):73. doi: 10.1007/s00381-024-06733-w. PMID: 39733051Free PMC Article
Tanaka T, Teshigawara A, Takei J, Tochigi S, Hasegawa Y, Murayama Y, Yokoo H
World Neurosurg 2020 Oct;142:441-449. Epub 2020 Jul 4 doi: 10.1016/j.wneu.2020.06.173. PMID: 32634636
Ait Khelifa-Gallois N, Laroussinie F, Puget S, Sainte-Rose C, Dellatolas G
Brain Inj 2015;29(3):366-73. Epub 2014 Nov 10 doi: 10.3109/02699052.2014.975281. PMID: 25383654
Shibao S, Kimura T, Sasaki H, Fujiwara H, Akiyama T, Ueno M, Shidoh S, Yoshida K
Brain Tumor Pathol 2012 Apr;29(2):96-102. Epub 2011 Oct 19 doi: 10.1007/s10014-011-0068-7. PMID: 22009025
O'Dorisio MS, Khanna G, Bushnell D
Cancer Metastasis Rev 2008 Dec;27(4):665-77. doi: 10.1007/s10555-008-9153-8. PMID: 18581060

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