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Clear cell squamous cell skin carcinoma

MedGen UID:
91064
Concept ID:
C0345978
Neoplastic Process
Synonyms: Clear cell squamous cell carcinoma of skin; Clear Cell Squamous Cell Carcinoma of Skin; clear cell squamous cell carcinoma of skin; Clear Cell Squamous Cell Carcinoma of the Skin; clear cell squamous cell carcinoma of the skin; Clear Cell Squamous Cell Skin Carcinoma; clear cell squamous cell skin carcinoma; SCC - Clear cell squamous cell carcinoma of skin; Skin Clear Cell Squamous Cell Carcinoma
SNOMED CT: SCC - Clear cell squamous cell carcinoma of skin (254652000); Clear cell squamous cell carcinoma of skin (254652000)
 
Monarch Initiative: MONDO:0004523

Definition

A squamous cell carcinoma of the skin with a prominent clear cell component. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVClear cell squamous cell skin carcinoma

Professional guidelines

PubMed

Firnhaber JM
Am Fam Physician 2020 Sep 15;102(6):339-346. PMID: 32931212
Arenberger P, Arenbergerova M
J Eur Acad Dermatol Venereol 2017 Sep;31 Suppl 5:13-17. doi: 10.1111/jdv.14375. PMID: 28805940
Goldenberg G
J Eur Acad Dermatol Venereol 2017 Mar;31 Suppl 2:12-16. doi: 10.1111/jdv.14152. PMID: 28263018

Recent clinical studies

Etiology

Cassalia F, Danese A, Tudurachi I, Federico S, Zambello A, Guidotti A, Franceschin L, Bolzon A, Naldi L, Belloni Fortina A
Int J Mol Sci 2024 Jan 27;25(3) doi: 10.3390/ijms25031582. PMID: 38338862Free PMC Article
Firnhaber JM
Am Fam Physician 2020 Sep 15;102(6):339-346. PMID: 32931212
Santana AL, Felsen D, Carucci JA
Dermatol Clin 2017 Jan;35(1):73-84. doi: 10.1016/j.det.2016.07.003. PMID: 27890239Free PMC Article
Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM
Eur Urol 2016 Jul;70(1):93-105. Epub 2016 Feb 28 doi: 10.1016/j.eururo.2016.02.029. PMID: 26935559
Brash DE, Pontén J
Cancer Surv 1998;32:69-113. PMID: 10489624

Diagnosis

Cassalia F, Danese A, Tudurachi I, Federico S, Zambello A, Guidotti A, Franceschin L, Bolzon A, Naldi L, Belloni Fortina A
Int J Mol Sci 2024 Jan 27;25(3) doi: 10.3390/ijms25031582. PMID: 38338862Free PMC Article
Firnhaber JM
Am Fam Physician 2020 Sep 15;102(6):339-346. PMID: 32931212
Paulson KG, Lahman MC, Chapuis AG, Brownell I
Int Immunol 2019 Jul 13;31(7):465-475. doi: 10.1093/intimm/dxz012. PMID: 30753483Free PMC Article
Santana AL, Felsen D, Carucci JA
Dermatol Clin 2017 Jan;35(1):73-84. doi: 10.1016/j.det.2016.07.003. PMID: 27890239Free PMC Article
Rashid RM, Cutlan JE
Dermatol Online J 2010 Mar 15;16(3):12. PMID: 20233569

Therapy

Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article
Harwood CA, Toland AE, Proby CM, Euvrard S, Hofbauer GFL, Tommasino M, Bouwes Bavinck JN; KeraCon Consortium
Br J Dermatol 2017 Nov;177(5):1217-1224. Epub 2017 Oct 30 doi: 10.1111/bjd.15956. PMID: 29086420
Santana AL, Felsen D, Carucci JA
Dermatol Clin 2017 Jan;35(1):73-84. doi: 10.1016/j.det.2016.07.003. PMID: 27890239Free PMC Article
Sánchez G, Nova J, Rodriguez-Hernandez AE, Medina RD, Solorzano-Restrepo C, Gonzalez J, Olmos M, Godfrey K, Arevalo-Rodriguez I
Cochrane Database Syst Rev 2016 Jul 25;7(7):CD011161. doi: 10.1002/14651858.CD011161.pub2. PMID: 27455163Free PMC Article
Madan V, Lear JT, Szeimies RM
Lancet 2010 Feb 20;375(9715):673-85. doi: 10.1016/S0140-6736(09)61196-X. PMID: 20171403

Prognosis

Cassalia F, Danese A, Tudurachi I, Federico S, Zambello A, Guidotti A, Franceschin L, Bolzon A, Naldi L, Belloni Fortina A
Int J Mol Sci 2024 Jan 27;25(3) doi: 10.3390/ijms25031582. PMID: 38338862Free PMC Article
Newman JG, Hall MA, Kurley SJ, Cook RW, Farberg AS, Geiger JL, Koyfman SA
Head Neck 2021 Sep;43(9):2822-2843. Epub 2021 Jun 7 doi: 10.1002/hed.26767. PMID: 34096664Free PMC Article
Cheng X, Wang X, Nie K, Cheng L, Zhang Z, Hu Y, Peng W
Front Immunol 2021;12:646523. Epub 2021 Feb 17 doi: 10.3389/fimmu.2021.646523. PMID: 33679809Free PMC Article
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article
Navarrete-Dechent C, Veness MJ, Droppelmann N, Uribe P
G Ital Dermatol Venereol 2018 Jun;153(3):403-418. Epub 2018 Feb 26 doi: 10.23736/S0392-0488.18.05936-9. PMID: 29485258

Clinical prediction guides

Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article
Navarrete-Dechent C, Veness MJ, Droppelmann N, Uribe P
G Ital Dermatol Venereol 2018 Jun;153(3):403-418. Epub 2018 Feb 26 doi: 10.23736/S0392-0488.18.05936-9. PMID: 29485258
Goldenberg G
J Eur Acad Dermatol Venereol 2017 Mar;31 Suppl 2:12-16. doi: 10.1111/jdv.14152. PMID: 28263018
Brash DE, Pontén J
Cancer Surv 1998;32:69-113. PMID: 10489624

Recent systematic reviews

Zhang J, Wang Y, Wijaya WA, Liang Z, Chen J
J Eur Acad Dermatol Venereol 2021 Sep;35(9):1777-1787. Epub 2021 May 27 doi: 10.1111/jdv.17330. PMID: 33930213
Krausz AE, Ji-Xu A, Smile T, Koyfman S, Schmults CD, Ruiz ES
Dermatol Surg 2021 May 1;47(5):587-592. doi: 10.1097/DSS.0000000000002965. PMID: 33577212
Sánchez G, Nova J, Rodriguez-Hernandez AE, Medina RD, Solorzano-Restrepo C, Gonzalez J, Olmos M, Godfrey K, Arevalo-Rodriguez I
Cochrane Database Syst Rev 2016 Jul 25;7(7):CD011161. doi: 10.1002/14651858.CD011161.pub2. PMID: 27455163Free PMC Article
Savage JA, Maize JC Sr
Am J Dermatopathol 2014 May;36(5):422-9. doi: 10.1097/DAD.0000000000000031. PMID: 24366198
Lansbury L, Leonardi-Bee J, Perkins W, Goodacre T, Tweed JA, Bath-Hextall FJ
Cochrane Database Syst Rev 2010 Apr 14;2010(4):CD007869. doi: 10.1002/14651858.CD007869.pub2. PMID: 20393962Free PMC Article

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