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Reduced euglobulin clot lysis time

MedGen UID:
908297
•Concept ID:
C4280701
•
Finding
HPO: HP:0040247

Definition

Abnormally decreased length of time required for an in vitro clot to dissolve in the absence of the normal plasmin inhibitors. This test is a clinical assay used to measure fibrinolysis. The euglobulin fraction of plasma is precipitated and used to form clot by addition of thrombin; after clot forms the rate of clot breakdown (fibrinolysis) can be monitored. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced euglobulin clot lysis time

Professional guidelines

PubMed

Viscoelastic haemostatic point-of-care assays in the management of postpartum haemorrhage: a narrative review.
Dias JD, Butwick AJ, Hartmann J, Waters JH
Anaesthesia 2022 Jun;77(6):700-711. Epub 2022 Feb 22 doi: 10.1111/anae.15662. PMID: 35194779
Hemostasis and Fibrinolysis following Aneurysmal Subarachnoid Hemorrhage: A Systematic Review on Additional Knowledge from Dynamic Assays and Potential Treatment Targets.
Hvas CL, Hvas AM
Semin Thromb Hemost 2022 Apr;48(3):356-381. Epub 2021 Jul 14 doi: 10.1055/s-0041-1730346. PMID: 34261149
Endogenous fibrinolysis-Relevance to clinical thrombosis risk assessment.
Kanji R, Kubica J, Navarese EP, Gorog DA
Eur J Clin Invest 2021 Apr;51(4):e13471. Epub 2020 Dec 16 doi: 10.1111/eci.13471. PMID: 33296082

Recent clinical studies

Etiology

Viscoelastic haemostatic point-of-care assays in the management of postpartum haemorrhage: a narrative review.
Dias JD, Butwick AJ, Hartmann J, Waters JH
Anaesthesia 2022 Jun;77(6):700-711. Epub 2022 Feb 22 doi: 10.1111/anae.15662. PMID: 35194779
Anabolic-Androgenic Steroid Abuse Impairs Fibrin Clot Lysis.
Sidelmann JJ, Gram JB, Rasmussen JJ, Kistorp C
Semin Thromb Hemost 2021 Feb;47(1):11-17. Epub 2020 Oct 5 doi: 10.1055/s-0040-1714398. PMID: 33017849
Altered fibrin clot properties and fibrinolysis in patients with atrial fibrillation: practical implications.
Undas A
Europace 2020 Feb 1;22(2):185-194. doi: 10.1093/europace/euz271. PMID: 31625555
Measuring fibrinolysis: from research to routine diagnostic assays.
Longstaff C
J Thromb Haemost 2018 Apr;16(4):652-662. Epub 2018 Feb 17 doi: 10.1111/jth.13957. PMID: 29363269Free PMC Article
Prolonged clot lysis time increases the risk of a first but not recurrent venous thrombosis.
Karasu A, Baglin TP, Luddington R, Baglin CA, van Hylckama Vlieg A
Br J Haematol 2016 Mar;172(6):947-53. Epub 2016 Jan 15 doi: 10.1111/bjh.13911. PMID: 26773756

Diagnosis

Impaired fibrinolysis and increased clot strength are potential risk factors for thrombosis in lymphoma.
Bønløkke ST, Fenger-Eriksen C, Ommen HB, Hvas AM
Blood Adv 2023 Nov 28;7(22):7056-7066. doi: 10.1182/bloodadvances.2023011379. PMID: 37756519Free PMC Article
Viscoelastic haemostatic point-of-care assays in the management of postpartum haemorrhage: a narrative review.
Dias JD, Butwick AJ, Hartmann J, Waters JH
Anaesthesia 2022 Jun;77(6):700-711. Epub 2022 Feb 22 doi: 10.1111/anae.15662. PMID: 35194779
Altered fibrin clot properties and fibrinolysis in patients with atrial fibrillation: practical implications.
Undas A
Europace 2020 Feb 1;22(2):185-194. doi: 10.1093/europace/euz271. PMID: 31625555
Measuring fibrinolysis: from research to routine diagnostic assays.
Longstaff C
J Thromb Haemost 2018 Apr;16(4):652-662. Epub 2018 Feb 17 doi: 10.1111/jth.13957. PMID: 29363269Free PMC Article
Fibrinogen and platelet contributions to clot formation: implications for trauma resuscitation and thromboprophylaxis.
Kornblith LZ, Kutcher ME, Redick BJ, Calfee CS, Vilardi RF, Cohen MJ
J Trauma Acute Care Surg 2014 Feb;76(2):255-6; discussion 262-3. doi: 10.1097/TA.0000000000000108. PMID: 24458031Free PMC Article

Therapy

Viscoelastic haemostatic point-of-care assays in the management of postpartum haemorrhage: a narrative review.
Dias JD, Butwick AJ, Hartmann J, Waters JH
Anaesthesia 2022 Jun;77(6):700-711. Epub 2022 Feb 22 doi: 10.1111/anae.15662. PMID: 35194779
Enhanced clot lysis by a single point mutation in a reteplase variant.
Chen S, Chen D, Liu Y, Xu Y, Lin H, Cheng Y, Li J, Meng C, Liang M, Yuan C, Huang M
Br J Haematol 2022 Feb;196(4):1076-1085. Epub 2021 Nov 16 doi: 10.1111/bjh.17942. PMID: 34783361
Anabolic-Androgenic Steroid Abuse Impairs Fibrin Clot Lysis.
Sidelmann JJ, Gram JB, Rasmussen JJ, Kistorp C
Semin Thromb Hemost 2021 Feb;47(1):11-17. Epub 2020 Oct 5 doi: 10.1055/s-0040-1714398. PMID: 33017849
Clearing bloody cerebrospinal fluid: clot lysis, neuroendoscopy and lumbar drainage.
Staykov D, Schwab S
Curr Opin Crit Care 2013 Apr;19(2):92-100. doi: 10.1097/MCC.0b013e32835cae5e. PMID: 23337912
Role of fibrin sealants in liver surgery.
de Boer MT, Boonstra EA, Lisman T, Porte RJ
Dig Surg 2012;29(1):54-61. Epub 2012 Mar 15 doi: 10.1159/000335735. PMID: 22441621

Prognosis

Viscoelastic haemostatic point-of-care assays in the management of postpartum haemorrhage: a narrative review.
Dias JD, Butwick AJ, Hartmann J, Waters JH
Anaesthesia 2022 Jun;77(6):700-711. Epub 2022 Feb 22 doi: 10.1111/anae.15662. PMID: 35194779
Endogenous fibrinolysis-Relevance to clinical thrombosis risk assessment.
Kanji R, Kubica J, Navarese EP, Gorog DA
Eur J Clin Invest 2021 Apr;51(4):e13471. Epub 2020 Dec 16 doi: 10.1111/eci.13471. PMID: 33296082
Altered clot formation and lysis are associated with increased fibrinolytic activity in ascites in patients with advanced cirrhosis.
Gitto S, Romanelli RG, Cellai AP, Lami D, Vizzutti F, Abbate R, Margheri F, Fibbi G, Del Rosso M, Laffi G
Intern Emerg Med 2021 Mar;16(2):339-347. Epub 2020 May 22 doi: 10.1007/s11739-020-02375-3. PMID: 32445164
Altered fibrin clot properties and fibrinolysis in patients with atrial fibrillation: practical implications.
Undas A
Europace 2020 Feb 1;22(2):185-194. doi: 10.1093/europace/euz271. PMID: 31625555
Measuring fibrinolysis: from research to routine diagnostic assays.
Longstaff C
J Thromb Haemost 2018 Apr;16(4):652-662. Epub 2018 Feb 17 doi: 10.1111/jth.13957. PMID: 29363269Free PMC Article

Clinical prediction guides

Endogenous fibrinolysis-Relevance to clinical thrombosis risk assessment.
Kanji R, Kubica J, Navarese EP, Gorog DA
Eur J Clin Invest 2021 Apr;51(4):e13471. Epub 2020 Dec 16 doi: 10.1111/eci.13471. PMID: 33296082
Anabolic-Androgenic Steroid Abuse Impairs Fibrin Clot Lysis.
Sidelmann JJ, Gram JB, Rasmussen JJ, Kistorp C
Semin Thromb Hemost 2021 Feb;47(1):11-17. Epub 2020 Oct 5 doi: 10.1055/s-0040-1714398. PMID: 33017849
Altered fibrin clot properties and fibrinolysis in patients with atrial fibrillation: practical implications.
Undas A
Europace 2020 Feb 1;22(2):185-194. doi: 10.1093/europace/euz271. PMID: 31625555
Measuring fibrinolysis: from research to routine diagnostic assays.
Longstaff C
J Thromb Haemost 2018 Apr;16(4):652-662. Epub 2018 Feb 17 doi: 10.1111/jth.13957. PMID: 29363269Free PMC Article
Prolonged clot lysis time increases the risk of a first but not recurrent venous thrombosis.
Karasu A, Baglin TP, Luddington R, Baglin CA, van Hylckama Vlieg A
Br J Haematol 2016 Mar;172(6):947-53. Epub 2016 Jan 15 doi: 10.1111/bjh.13911. PMID: 26773756

Recent systematic reviews

Hemostasis and Fibrinolysis following Aneurysmal Subarachnoid Hemorrhage: A Systematic Review on Additional Knowledge from Dynamic Assays and Potential Treatment Targets.
Hvas CL, Hvas AM
Semin Thromb Hemost 2022 Apr;48(3):356-381. Epub 2021 Jul 14 doi: 10.1055/s-0041-1730346. PMID: 34261149

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