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Adrenal Cortical Compact Cell Adenoma

MedGen UID:
90764
•Concept ID:
C0334332
•
Neoplastic Process
Synonyms: Adrenal Cortex Compact Cell Adenoma; Adrenal cortical adenoma - compact cell; Adrenal cortical adenoma, compact cell; Adrenal Gland Compact Cell Adenoma; Compact Cell Adrenal Cortex Adenoma; Compact Cell Adrenal Cortical Adenoma; Compact Cell Adrenocortical Adenoma
SNOMED CT: Adrenal cortical adenoma, compact cell (63687009); Adrenal cortical adenoma - compact cell (63687009)

Definition

An adenoma of the adrenal cortex composed of neoplastic compact cells with eosinophilic cytoplasm. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdrenal Cortical Compact Cell Adenoma

Professional guidelines

PubMed

Phenotype-genotype correlation in aldosterone-producing adenomas characterized by intracellular cholesterol metabolism.
Harashima S, Yamazaki Y, Motomura N, Ono Y, Omata K, Tezuka Y, Morimoto R, Nakamura Y, Satoh F, Suzuki H, Kwon GE, Choi MH, Sasano H
J Steroid Biochem Mol Biol 2022 Jul;221:106116. Epub 2022 May 6 doi: 10.1016/j.jsbmb.2022.106116. PMID: 35533918
Intratumoral heterogeneity of the tumor cells based on in situ cortisol excess in cortisol-producing adenomas; ∼An association among morphometry, genotype and cellular senescence∼.
Gao X, Yamazaki Y, Tezuka Y, Pieroni J, Ishii K, Atsumi N, Ono Y, Omata K, Morimoto R, Nakamura Y, Satoh F, Sasano H
J Steroid Biochem Mol Biol 2020 Nov;204:105764. Epub 2020 Sep 28 doi: 10.1016/j.jsbmb.2020.105764. PMID: 33002589

Recent clinical studies

Etiology

Characteristics of benign adrenocortical adenomas with 18F-FDG PET accumulation.
Ishiwata K, Suzuki S, Igarashi K, Ruike Y, Naito K, Ishida A, Deguchi-Horiuchi H, Fujimoto M, Koide H, Imamura Y, Sakamoto S, Ichikawa T, Ikeda JI, Yokote K
Eur J Endocrinol 2021 Jun 5;185(1):155-165. doi: 10.1530/EJE-20-1459. PMID: 33960957
Uptake of 18F-FDG in Adrenal Adenomas Is Associated With Unenhanced CT Value and Constituent Cells.
Murayama R, Nishie A, Hida T, Baba S, Inokuchi J, Oda Y, Honda H
Clin Nucl Med 2019 Dec;44(12):943-948. doi: 10.1097/RLU.0000000000002759. PMID: 31490313
Adrenocortical adenoma with rhabdoid features.
Dundr P, Povýsil C, Zelinka T, Tvrdík D, Ciprová V, Novák K
Pathol Res Pract 2006;202(3):177-81. Epub 2006 Jan 31 doi: 10.1016/j.prp.2005.01.011. PMID: 16448785
Relationship between clear cell/compact cell ratio and computed tomographic attenuation number in adrenocortical adenoma.
Ichiyanagi O, Sasagawa I, Izumi T, Ohji H, Suzuki H, Nakada T, Sugai Y, Yamaguchi K
Int Urol Nephrol 1999;31(5):585-90. doi: 10.1023/a:1007144118399. PMID: 10755348
Variable expression of the V1 vasopressin receptor modulates the phenotypic response of steroid-secreting adrenocortical tumors.
Arnaldi G, Gasc JM, de Keyzer Y, Raffin-Sanson ML, Perraudin V, Kuhn JM, Raux-Demay MC, Luton JP, Clauser E, Bertagna X
J Clin Endocrinol Metab 1998 Jun;83(6):2029-35. doi: 10.1210/jcem.83.6.4873. PMID: 9626135

Diagnosis

Different cell compositions and a novel somatic KCNJ5 variant found in a patient with bilateral adrenocortical adenomas secreting aldosterone and cortisol.
Zhao L, Wan J, Wang Y, Yang W, Liang Q, Wang J, Jin P
Front Endocrinol (Lausanne) 2023;14:1068335. Epub 2023 Mar 7 doi: 10.3389/fendo.2023.1068335. PMID: 36960396Free PMC Article
Uptake of 18F-FDG in Adrenal Adenomas Is Associated With Unenhanced CT Value and Constituent Cells.
Murayama R, Nishie A, Hida T, Baba S, Inokuchi J, Oda Y, Honda H
Clin Nucl Med 2019 Dec;44(12):943-948. doi: 10.1097/RLU.0000000000002759. PMID: 31490313
Black adrenal adenoma: distinction from PPNAD.
Kamalanathan S, Mahesh DM, Muruganandham K, Basu D
BMJ Case Rep 2012 Jul 3;2012 doi: 10.1136/bcr.03.2012.6076. PMID: 22761223Free PMC Article
A functioning black adenoma of the adrenal gland.
Ueda Y, Tanaka H, Murakami H, Ninomiya T, Yamashita Y, Ichikawa M, Kondoh T, Chiba T
Intern Med 1997 Jun;36(6):398-402. doi: 10.2169/internalmedicine.36.398. PMID: 9213185
A compound adrenal medullary tumor (pheochromocytoma and ganglioneuroma) and a cortical adenoma in the ipsilateral adrenal gland. A case report with enzyme histochemical and immunohistochemical studies.
Aiba M, Hirayama A, Ito Y, Fujimoto Y, Nakagami Y, Demura H, Shizume K
Am J Surg Pathol 1988 Jul;12(7):559-66. doi: 10.1097/00000478-198807000-00008. PMID: 3389453

Therapy

Cushing's syndrome due to bilateral adrenocortical adenomas with different pathological features.
Tamura H, Sugihara H, Minami S, Emoto N, Shibasaki T, Shuto Y, Shimizu K, Gomi Y, Sasano H, Wakabayashi I
Intern Med 1997 Nov;36(11):804-9. doi: 10.2169/internalmedicine.36.804. PMID: 9392354

Prognosis

Post-mortem histopathology of pituitary and adrenals of COVID-19 patients.
Fitzek A, Gerling M, Püschel K, Saeger W
Leg Med (Tokyo) 2022 Jul;57:102045. Epub 2022 Feb 25 doi: 10.1016/j.legalmed.2022.102045. PMID: 35334433Free PMC Article
Adrenocortical adenoma with rhabdoid features.
Dundr P, Povýsil C, Zelinka T, Tvrdík D, Ciprová V, Novák K
Pathol Res Pract 2006;202(3):177-81. Epub 2006 Jan 31 doi: 10.1016/j.prp.2005.01.011. PMID: 16448785
Adrenocortical oncocytoma. A true nonfunctioning adrenocortical tumor.
Sasano H, Suzuki T, Sano T, Kameya T, Sasano N, Nagura H
Am J Surg Pathol 1991 Oct;15(10):949-56. doi: 10.1097/00000478-199110000-00005. PMID: 1928551

Clinical prediction guides

Different cell compositions and a novel somatic KCNJ5 variant found in a patient with bilateral adrenocortical adenomas secreting aldosterone and cortisol.
Zhao L, Wan J, Wang Y, Yang W, Liang Q, Wang J, Jin P
Front Endocrinol (Lausanne) 2023;14:1068335. Epub 2023 Mar 7 doi: 10.3389/fendo.2023.1068335. PMID: 36960396Free PMC Article
Uptake of 18F-FDG in Adrenal Adenomas Is Associated With Unenhanced CT Value and Constituent Cells.
Murayama R, Nishie A, Hida T, Baba S, Inokuchi J, Oda Y, Honda H
Clin Nucl Med 2019 Dec;44(12):943-948. doi: 10.1097/RLU.0000000000002759. PMID: 31490313
Increased expression of (pro)renin receptor in aldosterone-producing adenomas.
Yamamoto H, Kaneko K, Ohba K, Morimoto R, Hirose T, Satoh F, Totsune K, Takahashi K
Peptides 2013 Nov;49:68-73. Epub 2013 Sep 8 doi: 10.1016/j.peptides.2013.08.022. PMID: 24025599
Aldosterone-producing adrenal cortical cancer: a case report and analysis of steroidogenic enzymes in the tumor.
Morioka M, Furukawa Y, Kobayashi T, Tanaka H, Ohashi Y, Jin TX
Endocr J 1997 Aug;44(4):547-52. doi: 10.1507/endocrj.44.547. PMID: 9447288
Ultrastructural types of cell in adrenal cortical adenoma with primary aldosteronism.
Eto T, Kumamoto K, Kawasaki T, Omae T, Masaki Z, Yamamoto T
J Pathol 1979 May;128(1):1-6. doi: 10.1002/path.1711280102. PMID: 469647

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