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Feeling of lump in throat

MedGen UID:: 9031
•Concept ID:: C0017650
•: Sign or Symptom

Synonyms:	Globus Hystericus; Globus Pharyngeus; Globus Sensation; Globus Sensations; Sensation, Globus
SNOMED CT:	Globus hystericus (267103008); Globus sensation (267103008); Globus pharyngeus (267103008); Feeling of lump in throat (267103008)

Definition

Persistent or intermittent non-painful sensation of a lump or foreign body in the throat occurring between meals in the absence of dysphagia, odynophagia, evidence of gastroesophageal acid reflux, or histopathogically based esophageal motility disorders. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVFeeling of lump in throat

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Mental disorder
      - Somatoform disorder
        Conversion disorder
        Feeling of lump in throat

Professional guidelines

PubMed

An update on current treatment strategies for laryngopharyngeal reflux symptoms.

Krause AJ, Walsh EH, Weissbrod PA, Taft TH, Yadlapati R
Ann N Y Acad Sci 2022 Apr;1510(1):5-17. Epub 2021 Dec 17 doi: 10.1111/nyas.14728. PMID: 34921412 Free PMC Article

Identification and Management of Chronic Laryngitis.

Zhukhovitskaya A, Verma SP
Otolaryngol Clin North Am 2019 Aug;52(4):607-616. Epub 2019 May 14 doi: 10.1016/j.otc.2019.03.004. PMID: 31101358

Gastroesophageal Reflux Disease: Pathophysiology, Diagnosis, and Treatment.

Chen J, Brady P
Gastroenterol Nurs 2019 Jan/Feb;42(1):20-28. doi: 10.1097/SGA.0000000000000359. PMID: 30688703

See all (25)

Recent clinical studies

Etiology

Persistence of somatic symptoms after COVID-19 in the Netherlands: an observational cohort study.

Ballering AV, van Zon SKR, Olde Hartman TC, Rosmalen JGM; Lifelines Corona Research Initiative
Lancet 2022 Aug 6;400(10350):452-461. doi: 10.1016/S0140-6736(22)01214-4. PMID: 35934007 Free PMC Article

The development and validation of the laryngopharyngeal measure of perceived sensation.

Melancon CC, Russell GB, Ruckart K, Persia S, Peterson M, Carter Wright S Jr,, Madden LL
Laryngoscope 2020 Dec;130(12):2767-2772. Epub 2019 Oct 23 doi: 10.1002/lary.28348. PMID: 31643076 Free PMC Article

Gastroesophageal Reflux Disease: Pathophysiology, Diagnosis, and Treatment.

Chen J, Brady P
Gastroenterol Nurs 2019 Jan/Feb;42(1):20-28. doi: 10.1097/SGA.0000000000000359. PMID: 30688703

Diabetes Mellitus: Management of Gastrointestinal Complications.

Careyva B, Stello B
Am Fam Physician 2016 Dec 15;94(12):980-986. PMID: 28075092

Nasolaryngoscopy.

Moser SE
Prim Care 2014 Mar;41(1):109-13. doi: 10.1016/j.pop.2013.10.009. PMID: 24439885

See all (195)

Diagnosis

An update on current treatment strategies for laryngopharyngeal reflux symptoms.

Krause AJ, Walsh EH, Weissbrod PA, Taft TH, Yadlapati R
Ann N Y Acad Sci 2022 Apr;1510(1):5-17. Epub 2021 Dec 17 doi: 10.1111/nyas.14728. PMID: 34921412 Free PMC Article

A lump in the throat: laryngopharyngeal reflux.

Hamilton NJI, Wilcock J, Hannan SA
BMJ 2020 Nov 2;371:m4091. doi: 10.1136/bmj.m4091. PMID: 33139245

Identification and Management of Chronic Laryngitis.

Zhukhovitskaya A, Verma SP
Otolaryngol Clin North Am 2019 Aug;52(4):607-616. Epub 2019 May 14 doi: 10.1016/j.otc.2019.03.004. PMID: 31101358

Gastroesophageal Reflux Disease: Pathophysiology, Diagnosis, and Treatment.

Chen J, Brady P
Gastroenterol Nurs 2019 Jan/Feb;42(1):20-28. doi: 10.1097/SGA.0000000000000359. PMID: 30688703

Nasolaryngoscopy.

Moser SE
Prim Care 2014 Mar;41(1):109-13. doi: 10.1016/j.pop.2013.10.009. PMID: 24439885

See all (258)

Therapy

An update on current treatment strategies for laryngopharyngeal reflux symptoms.

Krause AJ, Walsh EH, Weissbrod PA, Taft TH, Yadlapati R
Ann N Y Acad Sci 2022 Apr;1510(1):5-17. Epub 2021 Dec 17 doi: 10.1111/nyas.14728. PMID: 34921412 Free PMC Article

A lump in the throat: laryngopharyngeal reflux.

Hamilton NJI, Wilcock J, Hannan SA
BMJ 2020 Nov 2;371:m4091. doi: 10.1136/bmj.m4091. PMID: 33139245

Laryngeal Contact Ulcer.

Barrena BG, Miller TM, Nelson BL
Head Neck Pathol 2020 Dec;14(4):1032-1035. Epub 2020 May 7 doi: 10.1007/s12105-020-01167-7. PMID: 32383044 Free PMC Article

Gastroesophageal Reflux Disease: Pathophysiology, Diagnosis, and Treatment.

Chen J, Brady P
Gastroenterol Nurs 2019 Jan/Feb;42(1):20-28. doi: 10.1097/SGA.0000000000000359. PMID: 30688703

The problem of bilateral lesions in stereotaxic surgery.

Dierssen G, Obrador S
Confin Neurol 1967;29(2):181-5. doi: 10.1159/000103703. PMID: 4872056

See all (109)

Prognosis

Validation of the Spanish version of DYsphagia in MUltiple Sclerosis questionnaire (DYMUS).

Renom M, Galán I, Vidal X, Aldevert M, Curto G, Feliu P, García I, Gonzalo L, Sibera X, Anglada E, Meza R, García M, Najas V, Mongay-Ochoa N, Arévalo MJ, Vidal-Jordana Á, Tintoré M, Bascuñana H, Montalban X, Terré R, Sastre-Garriga J
Mult Scler Relat Disord 2023 Jun;74:104724. Epub 2023 Apr 17 doi: 10.1016/j.msard.2023.104724. PMID: 37086636

Sensitivity, Specificity, and Predictive Values of Laryngopharyngeal Reflux Symptoms and Signs in Clinical Practice.

Lechien JR
Otolaryngol Head Neck Surg 2023 Jul;169(1):97-104. Epub 2023 Jan 29 doi: 10.1177/01945998221121822. PMID: 36040820

ESNM/ANMS Review. Diagnosis and management of globus sensation: A clinical challenge.

Zerbib F, Rommel N, Pandolfino J, Gyawali CP
Neurogastroenterol Motil 2020 Sep;32(9):e13850. Epub 2020 Apr 23 doi: 10.1111/nmo.13850. PMID: 32329203

Globus pharyngeus: a review of etiology, diagnostics, and treatment.

Järvenpää P, Arkkila P, Aaltonen LM
Eur Arch Otorhinolaryngol 2018 Aug;275(8):1945-1953. Epub 2018 Jun 25 doi: 10.1007/s00405-018-5041-1. PMID: 29943257

Diabetes Mellitus: Management of Gastrointestinal Complications.

Careyva B, Stello B
Am Fam Physician 2016 Dec 15;94(12):980-986. PMID: 28075092

See all (83)

Clinical prediction guides

Translation and validation of the Korean Version of the Reflux Symptom Score.

Min HK, Jeon SY, Lechien JR, Park JM, Park H, Yu JW, Kim S, Jeong SJ, Kang JW, Su Il K, Young Chan L, Eun YG, Ko SG
J Voice 2024 Mar;38(2):545.e1-545.e8. Epub 2021 Oct 13 doi: 10.1016/j.jvoice.2021.08.026. PMID: 34656394

Persistence of somatic symptoms after COVID-19 in the Netherlands: an observational cohort study.

The development and validation of the laryngopharyngeal measure of perceived sensation.

Gastric inlet patches: symptomatic or silent?

Cock C, Hamarneh Z
Curr Opin Otolaryngol Head Neck Surg 2019 Dec;27(6):453-462. doi: 10.1097/MOO.0000000000000581. PMID: 31567494

Diabetes Mellitus: Management of Gastrointestinal Complications.

Careyva B, Stello B
Am Fam Physician 2016 Dec 15;94(12):980-986. PMID: 28075092

See all (139)

Recent systematic reviews

Does surgical management still play a role in the management of ectopic lingual thyroid: Institutional experience and systematic review of the literature.

Sauer AB, Dowling EM, Bauman MMJ, Moore EJ, Carlson ML, Van Abel KM
Am J Otolaryngol 2022 May-Jun;43(3):103461. Epub 2022 Apr 8 doi: 10.1016/j.amjoto.2022.103461. PMID: 35427937

Esophageal Lipoma and Liposarcoma: A Systematic Review.

Ferrari D, Bernardi D, Siboni S, Lazzari V, Asti E, Bonavina L
World J Surg 2021 Jan;45(1):225-234. Epub 2020 Oct 7 doi: 10.1007/s00268-020-05789-4. PMID: 33026474 Free PMC Article

A Systematic Review and Activation Likelihood Estimation Meta-Analysis of fMRI Studies on Sweet Taste in Humans.

Roberts CA, Giesbrecht T, Fallon N, Thomas A, Mela DJ, Kirkham TC
J Nutr 2020 Jun 1;150(6):1619-1630. doi: 10.1093/jn/nxaa071. PMID: 32271923 Free PMC Article

Effects of antidepressants in patients with functional esophageal disorders or gastroesophageal reflux disease: a systematic review.

Weijenborg PW, de Schepper HS, Smout AJ, Bredenoord AJ
Clin Gastroenterol Hepatol 2015 Feb;13(2):251-259.e1. Epub 2014 Jul 3 doi: 10.1016/j.cgh.2014.06.025. PMID: 24997325

Effects and side-effects of surgery for snoring and obstructive sleep apnea--a systematic review.

Franklin KA, Anttila H, Axelsson S, Gislason T, Maasilta P, Myhre KI, Rehnqvist N
Sleep 2009 Jan;32(1):27-36. PMID: 19189776 Free PMC Article

See all (8)

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Feeling of lump in throat

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

Recent activity