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Reduced plasminogen activator inhibitor 1 antigen

MedGen UID:
897922
•Concept ID:
C4280699
•
Finding
HPO: HP:0040249

Definition

Reduced level of plasminogen activator inhibitor 1 antigen. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced plasminogen activator inhibitor 1 antigen

Professional guidelines

PubMed

Oral contraceptive pill (OCP) treatment alters the gene expression of intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) in polycystic ovary syndrome (PCOS) women compared to drug-naive PCOS women.
Yousuf SD, Ganie MA, Urwat U, Andrabi SM, Zargar MA, Dar MA, Manzoor-Ul-Rehman M, Mudassar S, Rashid F
BMC Womens Health 2023 Feb 15;23(1):68. doi: 10.1186/s12905-023-02187-5. PMID: 36793022Free PMC Article
Long-term treatment with growth hormone decreases plasminogen activator inhibitor-1 and tissue plasminogen activator in growth hormone-deficient adults.
Johansson JO, Landin K, Johannsson G, Tengborn L, Bengtsson BA
Thromb Haemost 1996 Sep;76(3):422-8. PMID: 8883281
Insulin treatment improves microalbuminuria and other cardiovascular risk factors in patients with type 2 diabetes mellitus.
Lindström T, Olsson AG, von Schenck H, Wallentin L, Arnqvist HJ
J Intern Med 1994 Mar;235(3):253-61. doi: 10.1111/j.1365-2796.1994.tb01069.x. PMID: 8120522

Recent clinical studies

Etiology

Oral contraceptive pill (OCP) treatment alters the gene expression of intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) in polycystic ovary syndrome (PCOS) women compared to drug-naive PCOS women.
Yousuf SD, Ganie MA, Urwat U, Andrabi SM, Zargar MA, Dar MA, Manzoor-Ul-Rehman M, Mudassar S, Rashid F
BMC Womens Health 2023 Feb 15;23(1):68. doi: 10.1186/s12905-023-02187-5. PMID: 36793022Free PMC Article
Oligofructose decreases serum lipopolysaccharide and plasminogen activator inhibitor-1 in adults with overweight/obesity.
Parnell JA, Klancic T, Reimer RA
Obesity (Silver Spring) 2017 Mar;25(3):510-513. doi: 10.1002/oby.21763. PMID: 28229548
Prognostic and predictive factors in early-stage breast cancer.
Cianfrocca M, Goldstein LJ
Oncologist 2004;9(6):606-16. doi: 10.1634/theoncologist.9-6-606. PMID: 15561805
Obesity and impaired fibrinolysis: role of adipose production of plasminogen activator inhibitor-1.
Skurk T, Hauner H
Int J Obes Relat Metab Disord 2004 Nov;28(11):1357-64. doi: 10.1038/sj.ijo.0802778. PMID: 15356668
Inflammation, the endothelium, and the acute coronary syndromes.
Kinlay S, Selwyn AP, Libby P, Ganz P
J Cardiovasc Pharmacol 1998;32 Suppl 3:S62-6. PMID: 9883750

Diagnosis

Measuring Fibrinolysis.
Longstaff C
Hamostaseologie 2021 Feb;41(1):69-75. Epub 2021 Feb 15 doi: 10.1055/a-1325-0268. PMID: 33588458
Plasminogen activator inhibitor type 1 deficiency.
Mehta R, Shapiro AD
Haemophilia 2008 Nov;14(6):1255-60. doi: 10.1111/j.1365-2516.2008.01834.x. PMID: 19141166
Simvastatin reduces circulating plasminogen activator inhibitor 1 activity in volunteers with the metabolic syndrome.
Wang L, Rockwood J, Zak D, Devaraj S, Jialal I
Metab Syndr Relat Disord 2008 Jun;6(2):149-52. doi: 10.1089/met.2008.0012. PMID: 18484901Free PMC Article
Plasminogen activator inhibitor-1 as a predictor of postoperative atrial fibrillation after cardiopulmonary bypass.
Pretorius M, Donahue BS, Yu C, Greelish JP, Roden DM, Brown NJ
Circulation 2007 Sep 11;116(11 Suppl):I1-7. doi: 10.1161/CIRCULATIONAHA.106.677906. PMID: 17846288
Neisseria meningitidis lipopolysaccharides in human pathology.
Brandtzaeg P, Bjerre A, Øvstebø R, Brusletto B, Joø GB, Kierulf P
J Endotoxin Res 2001;7(6):401-20. PMID: 11753210

Therapy

Oral contraceptive pill (OCP) treatment alters the gene expression of intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) in polycystic ovary syndrome (PCOS) women compared to drug-naive PCOS women.
Yousuf SD, Ganie MA, Urwat U, Andrabi SM, Zargar MA, Dar MA, Manzoor-Ul-Rehman M, Mudassar S, Rashid F
BMC Womens Health 2023 Feb 15;23(1):68. doi: 10.1186/s12905-023-02187-5. PMID: 36793022Free PMC Article
Oligofructose decreases serum lipopolysaccharide and plasminogen activator inhibitor-1 in adults with overweight/obesity.
Parnell JA, Klancic T, Reimer RA
Obesity (Silver Spring) 2017 Mar;25(3):510-513. doi: 10.1002/oby.21763. PMID: 28229548
Interferon γ and plasminogen activator inhibitor 1 regulate adhesion formation after partial hepatectomy.
Ohashi K, Yoshimoto T, Kosaka H, Hirano T, Iimuro Y, Nakanishi K, Fujimoto J
Br J Surg 2014 Mar;101(4):398-407. doi: 10.1002/bjs.9405. PMID: 24536011
Plasminogen activator inhibitor type 1 deficiency.
Mehta R, Shapiro AD
Haemophilia 2008 Nov;14(6):1255-60. doi: 10.1111/j.1365-2516.2008.01834.x. PMID: 19141166
Obesity and impaired fibrinolysis: role of adipose production of plasminogen activator inhibitor-1.
Skurk T, Hauner H
Int J Obes Relat Metab Disord 2004 Nov;28(11):1357-64. doi: 10.1038/sj.ijo.0802778. PMID: 15356668

Prognosis

Hypoxia Promotes a Mixed Inflammatory-Fibrotic Macrophages Phenotype in Active Sarcoidosis.
Jeny F, Bernaudin JF, Valeyre D, Kambouchner M, Pretolani M, Nunes H, Planès C, Besnard V
Front Immunol 2021;12:719009. Epub 2021 Aug 11 doi: 10.3389/fimmu.2021.719009. PMID: 34456926Free PMC Article
Measuring Fibrinolysis.
Longstaff C
Hamostaseologie 2021 Feb;41(1):69-75. Epub 2021 Feb 15 doi: 10.1055/a-1325-0268. PMID: 33588458
Niacin affects cell adhesion molecules and plasminogen activator inhibitor-1 in HepG2 cells.
Tavintharan S, Sivakumar M, Lim SC, Sum CF
Clin Chim Acta 2007 Feb;376(1-2):41-4. Epub 2006 Jul 14 doi: 10.1016/j.cca.2006.07.009. PMID: 16916501
Prognostic and predictive factors in early-stage breast cancer.
Cianfrocca M, Goldstein LJ
Oncologist 2004;9(6):606-16. doi: 10.1634/theoncologist.9-6-606. PMID: 15561805
Dyslipidemias and fibrinolysis.
Puccetti L, Bruni F, Pasqui AL, Pastorelli M, Bova G, Cercignani M, Palazzuoli A, Auteri A
Ital Heart J 2002 Oct;3(10):579-86. PMID: 12478815

Clinical prediction guides

Sourdough Bread with Different Fermentation Times: A Randomized Clinical Trial in Subjects with Metabolic Syndrome.
Pérez-Vega KA, Sanllorente A, Zomeño MD, Quindós A, Muñoz-Martínez J, Malcampo M, Aldea-Perona A, Hernáez Á, Lluansí A, Llirós M, Elias I, Elias-Masiques N, Aldeguer X, Muñoz D, Gaixas S, Blanchart G, Schröder H, Hernando-Redondo J, Carrón N, González-Torres P, Konstantinidou V, Fitó M, Castañer O
Nutrients 2024 Jul 23;16(15) doi: 10.3390/nu16152380. PMID: 39125261Free PMC Article
Measuring Fibrinolysis.
Longstaff C
Hamostaseologie 2021 Feb;41(1):69-75. Epub 2021 Feb 15 doi: 10.1055/a-1325-0268. PMID: 33588458
Plasminogen activator inhibitor-1 in cigarette smoke exposure and influenza A virus infection-induced lung injury.
Bhandary YP, Shetty SK, Marudamuthu AS, Midde KK, Ji HL, Shams H, Subramaniam R, Fu J, Idell S, Shetty S
PLoS One 2015;10(5):e0123187. Epub 2015 May 1 doi: 10.1371/journal.pone.0123187. PMID: 25932922Free PMC Article
Interferon γ and plasminogen activator inhibitor 1 regulate adhesion formation after partial hepatectomy.
Ohashi K, Yoshimoto T, Kosaka H, Hirano T, Iimuro Y, Nakanishi K, Fujimoto J
Br J Surg 2014 Mar;101(4):398-407. doi: 10.1002/bjs.9405. PMID: 24536011
Prognostic and predictive factors in early-stage breast cancer.
Cianfrocca M, Goldstein LJ
Oncologist 2004;9(6):606-16. doi: 10.1634/theoncologist.9-6-606. PMID: 15561805

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