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Insulin level above reference range

MedGen UID:
894826
•Concept ID:
C0852795
•
Finding
Synonyms: Hyperinsulinemia; Hyperinsulinism
SNOMED CT: Increased insulin level (131103005); Insulin level above reference range (131103005)

Definition

Abnormally high levels of insulin in the blood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInsulin level above reference range

Professional guidelines

PubMed

IGF-I assay methods and biologic variability: evaluation of acromegaly treatment response.
Clemmons DR, Bidlingmaier M
Eur J Endocrinol 2024 Jul 2;191(1):R1-R8. doi: 10.1093/ejendo/lvae065. PMID: 38916798
Association of Achieving Time in Range Clinical Targets With Treatment Modality Among Youths With Type 1 Diabetes.
Dovc K, Lanzinger S, Cardona-Hernandez R, Tauschmann M, Marigliano M, Cherubini V, Preikša R, Schierloh U, Clapin H, AlJaser F, Pelicand J, Shukla R, Biester T
JAMA Netw Open 2023 Feb 1;6(2):e230077. doi: 10.1001/jamanetworkopen.2023.0077. PMID: 36808243Free PMC Article
No clinical utility of common polymorphisms in IGF1, IRS1, GCKR, PPARG, GCK1 and KCTD1 genes previously associated with insulin resistance in overweight children from Romania and Moldova.
Chirita-Emandi A, Munteanu D, Andreescu N, Tutac P, Paul C, Velea IP, Pusztai AM, Hlistun V, Boiciuc C, Sacara V, Vudu L, Usurelu N, Puiu M
J Pediatr Endocrinol Metab 2019 Jan 28;32(1):33-39. doi: 10.1515/jpem-2018-0288. PMID: 30864372

Recent clinical studies

Etiology

Hair cortisol in polycystic ovary syndrome.
Gonzalez D, Maidana P, Ibar C, Jamardo J, Jacobsen D, Fritzler A, Fortuna F, Fernandez G, Lamas-Majek E, Mallea-Gil S, Ballarino C, Onetto C, Lopez M, Mesch V, Fabre B
Sci Rep 2022 Jun 20;12(1):10309. doi: 10.1038/s41598-022-14061-9. PMID: 35725989Free PMC Article
Novel modeling of reference values of cardiovascular risk factors in children aged 7 to 20 years.
Mellerio H, Alberti C, Druet C, Capelier F, Mercat I, Josserand E, Vol S, Tichet J, Lévy-Marchal C
Pediatrics 2012 Apr;129(4):e1020-9. Epub 2012 Mar 26 doi: 10.1542/peds.2011-0449. PMID: 22451707
Serum adipocyte fatty acid binding protein as a new biomarker predicting the development of type 2 diabetes: a 10-year prospective study in a Chinese cohort.
Tso AW, Xu A, Sham PC, Wat NM, Wang Y, Fong CH, Cheung BM, Janus ED, Lam KS
Diabetes Care 2007 Oct;30(10):2667-72. Epub 2007 Jul 9 doi: 10.2337/dc07-0413. PMID: 17620449
Gamma-knife surgery is effective in normalising plasma insulin-like growth factor I in patients with acromegaly.
Gutt B, Wowra B, Alexandrov R, Uhl E, Schaaf L, Stalla GK, Schopohl J
Exp Clin Endocrinol Diabetes 2005 Apr;113(4):219-24. doi: 10.1055/s-2005-837552. PMID: 15891958
Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation.
Alberti KG, Zimmet PZ
Diabet Med 1998 Jul;15(7):539-53. doi: 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S. PMID: 9686693

Diagnosis

Hair cortisol in polycystic ovary syndrome.
Gonzalez D, Maidana P, Ibar C, Jamardo J, Jacobsen D, Fritzler A, Fortuna F, Fernandez G, Lamas-Majek E, Mallea-Gil S, Ballarino C, Onetto C, Lopez M, Mesch V, Fabre B
Sci Rep 2022 Jun 20;12(1):10309. doi: 10.1038/s41598-022-14061-9. PMID: 35725989Free PMC Article
Subclinical hypothyroidism in childhood and adolescense.
Catli G, Abaci A, Büyükgebiz A, Bober E
J Pediatr Endocrinol Metab 2014 Nov;27(11-12):1049-57. doi: 10.1515/jpem-2014-0089. PMID: 25153584
Screening for Cushing's syndrome in obese patients.
Tiryakioglu O, Ugurlu S, Yalin S, Yirmibescik S, Caglar E, Yetkin DO, Kadioglu P
Clinics (Sao Paulo) 2010;65(1):9-13. doi: 10.1590/S1807-59322010000100003. PMID: 20126340Free PMC Article
Serum adipocyte fatty acid binding protein as a new biomarker predicting the development of type 2 diabetes: a 10-year prospective study in a Chinese cohort.
Tso AW, Xu A, Sham PC, Wat NM, Wang Y, Fong CH, Cheung BM, Janus ED, Lam KS
Diabetes Care 2007 Oct;30(10):2667-72. Epub 2007 Jul 9 doi: 10.2337/dc07-0413. PMID: 17620449
Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation.
Alberti KG, Zimmet PZ
Diabet Med 1998 Jul;15(7):539-53. doi: 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S. PMID: 9686693

Therapy

Glycemic control and diabetes complications across health status categories in older adults treated with insulin or insulin secretagogues: The Diabetes & Aging Study.
Lipska KJ, Huang ES, Liu JY, Parker MM, Laiteerapong N, Grant RW, Moffet HH, Karter AJ
J Am Geriatr Soc 2023 Dec;71(12):3692-3700. Epub 2023 Aug 28 doi: 10.1111/jgs.18565. PMID: 37638777Free PMC Article
Complete nutrition drink with retrograded starch is low glycemic, and the individual glucose response to the low glycemic complete nutrition drink depends on fasting insulin levels and HOMA-IR in a randomized cross-over control trial.
Wongniyomkaset W, Rungraung N, Muangpracha N, Winuprasith T, Trachootham D
J Nutr Sci 2022;11:e25. Epub 2022 Apr 1 doi: 10.1017/jns.2022.23. PMID: 35462880Free PMC Article
Screening for Cushing's syndrome in obese patients.
Tiryakioglu O, Ugurlu S, Yalin S, Yirmibescik S, Caglar E, Yetkin DO, Kadioglu P
Clinics (Sao Paulo) 2010;65(1):9-13. doi: 10.1590/S1807-59322010000100003. PMID: 20126340Free PMC Article
Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults.
Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA
J Clin Endocrinol Metab 2006 Mar;91(3):799-805. Epub 2005 Dec 13 doi: 10.1210/jc.2005-1536. PMID: 16352683
Determinants of circulating insulin-like growth factor-I.
Hall K, Hilding A, Thorén M
J Endocrinol Invest 1999;22(5 Suppl):48-57. PMID: 10442571

Prognosis

Complete nutrition drink with retrograded starch is low glycemic, and the individual glucose response to the low glycemic complete nutrition drink depends on fasting insulin levels and HOMA-IR in a randomized cross-over control trial.
Wongniyomkaset W, Rungraung N, Muangpracha N, Winuprasith T, Trachootham D
J Nutr Sci 2022;11:e25. Epub 2022 Apr 1 doi: 10.1017/jns.2022.23. PMID: 35462880Free PMC Article
Serum adipocyte fatty acid binding protein as a new biomarker predicting the development of type 2 diabetes: a 10-year prospective study in a Chinese cohort.
Tso AW, Xu A, Sham PC, Wat NM, Wang Y, Fong CH, Cheung BM, Janus ED, Lam KS
Diabetes Care 2007 Oct;30(10):2667-72. Epub 2007 Jul 9 doi: 10.2337/dc07-0413. PMID: 17620449
Gamma-knife surgery is effective in normalising plasma insulin-like growth factor I in patients with acromegaly.
Gutt B, Wowra B, Alexandrov R, Uhl E, Schaaf L, Stalla GK, Schopohl J
Exp Clin Endocrinol Diabetes 2005 Apr;113(4):219-24. doi: 10.1055/s-2005-837552. PMID: 15891958
Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation.
Alberti KG, Zimmet PZ
Diabet Med 1998 Jul;15(7):539-53. doi: 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S. PMID: 9686693
Insulin resistance and insulin secretion are determinants of oral glucose tolerance in normal individuals.
Reaven GM, Brand RJ, Chen YD, Mathur AK, Goldfine I
Diabetes 1993 Sep;42(9):1324-32. doi: 10.2337/diab.42.9.1324. PMID: 8349044

Clinical prediction guides

IGF-I assay methods and biologic variability: evaluation of acromegaly treatment response.
Clemmons DR, Bidlingmaier M
Eur J Endocrinol 2024 Jul 2;191(1):R1-R8. doi: 10.1093/ejendo/lvae065. PMID: 38916798
Rectangular multivariate normal prediction regions for setting reference regions in laboratory medicine.
Lucagbo MD, Mathew T, Young DS
J Biopharm Stat 2023 Mar;33(2):191-209. Epub 2022 Aug 9 doi: 10.1080/10543406.2022.2105347. PMID: 35943354
Hair cortisol in polycystic ovary syndrome.
Gonzalez D, Maidana P, Ibar C, Jamardo J, Jacobsen D, Fritzler A, Fortuna F, Fernandez G, Lamas-Majek E, Mallea-Gil S, Ballarino C, Onetto C, Lopez M, Mesch V, Fabre B
Sci Rep 2022 Jun 20;12(1):10309. doi: 10.1038/s41598-022-14061-9. PMID: 35725989Free PMC Article
Serum adipocyte fatty acid binding protein as a new biomarker predicting the development of type 2 diabetes: a 10-year prospective study in a Chinese cohort.
Tso AW, Xu A, Sham PC, Wat NM, Wang Y, Fong CH, Cheung BM, Janus ED, Lam KS
Diabetes Care 2007 Oct;30(10):2667-72. Epub 2007 Jul 9 doi: 10.2337/dc07-0413. PMID: 17620449
Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation.
Alberti KG, Zimmet PZ
Diabet Med 1998 Jul;15(7):539-53. doi: 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S. PMID: 9686693

Recent systematic reviews

Time in Range for Multiple Technologies in Type 1 Diabetes: A Systematic Review and Network Meta-analysis.
Pease A, Lo C, Earnest A, Kiriakova V, Liew D, Zoungas S
Diabetes Care 2020 Aug;43(8):1967-1975. doi: 10.2337/dc19-1785. PMID: 32669412

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