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Abnormal circulating insulin concentration

MedGen UID:
893016
•Concept ID:
C4073160
•
Finding
Synonym: Abnormal insulin level
 
HPO: HP:0040214

Definition

An abnormal concentration of insulin in the body. [from HPO]

Professional guidelines

PubMed

Circulating Levels of Nesfatin-1 and Spexin in Children with Prader-Willi Syndrome during Growth Hormone Treatment and Dietary Intervention.
Gajewska J, Szamotulska K, Klemarczyk W, Chełchowska M, Strucińska M, Ambroszkiewicz J
Nutrients 2023 Mar 1;15(5) doi: 10.3390/nu15051240. PMID: 36904239Free PMC Article
Circulating IGF-I, IGFBP-3 and the IGF-I/IGFBP-3 Molar Ratio Concentration and Height Outcome in Prepubertal Short Children on rhGH Treatment over Two Years of Therapy.
Ballerini MG, Braslavsky D, Scaglia PA, Keselman A, Rodríguez ME, Martínez A, Freire AV, Domené HM, Jasper HG, Bergadá I, Ropelato MG
Horm Res Paediatr 2017;88(5):354-363. Epub 2017 Sep 19 doi: 10.1159/000479691. PMID: 28926833
Quantitative measurement of IGF-I and its use in diagnosing and monitoring treatment of disorders of growth hormone secretion.
Clemmons DR
Endocr Dev 2005;9:55-65. doi: 10.1159/000085756. PMID: 15879688

Recent clinical studies

Etiology

PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis.
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
Stress Cardiac Biomarkers, Cardiovascular and Renal Outcomes, and Response to Canagliflozin.
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
Circulating Bile Acid Profiles: A Need for Further Examination.
Qi L, Tian Y, Chen Y
J Clin Endocrinol Metab 2021 Oct 21;106(11):3093-3112. doi: 10.1210/clinem/dgab531. PMID: 34279029
Cholecystectomy and risk of metabolic syndrome.
Di Ciaula A, Garruti G, Wang DQ, Portincasa P
Eur J Intern Med 2018 Jul;53:3-11. Epub 2018 Apr 26 doi: 10.1016/j.ejim.2018.04.019. PMID: 29706426Free PMC Article
Measurement of Gastrointestinal Hormones.
Albrechtsen NJW
Dan Med J 2017 Nov;64(11) PMID: 29115211

Diagnosis

PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis.
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
Stress Cardiac Biomarkers, Cardiovascular and Renal Outcomes, and Response to Canagliflozin.
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
Exercise and Regulation of Carbohydrate Metabolism.
Mul JD, Stanford KI, Hirshman MF, Goodyear LJ
Prog Mol Biol Transl Sci 2015;135:17-37. Epub 2015 Aug 20 doi: 10.1016/bs.pmbts.2015.07.020. PMID: 26477909Free PMC Article
Control of glycaemia.
Gerich JE
Baillieres Clin Endocrinol Metab 1993 Jul;7(3):551-86. doi: 10.1016/s0950-351x(05)80207-1. PMID: 8379904
Mutant insulin syndromes.
Vinik A, Bell G
Horm Metab Res 1988 Jan;20(1):1-10. doi: 10.1055/s-2007-1010736. PMID: 3286444

Therapy

PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis.
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
Stress Cardiac Biomarkers, Cardiovascular and Renal Outcomes, and Response to Canagliflozin.
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
Metabolic changes after cardiac surgery.
Jakob SM, Ensinger H, Takala J
Curr Opin Clin Nutr Metab Care 2001 Mar;4(2):149-55. doi: 10.1097/00075197-200103000-00012. PMID: 11224661
Dichloroacetate.
Stacpoole PW, Greene YJ
Diabetes Care 1992 Jun;15(6):785-91. doi: 10.2337/diacare.15.6.785. PMID: 1600837
Diabetes and exercise.
Zinman B, Vranic M
Med Clin North Am 1985 Jan;69(1):145-57. doi: 10.1016/s0025-7125(16)31062-8. PMID: 3883072

Prognosis

PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis.
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
Stress Cardiac Biomarkers, Cardiovascular and Renal Outcomes, and Response to Canagliflozin.
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
Circulating Bile Acid Profiles: A Need for Further Examination.
Qi L, Tian Y, Chen Y
J Clin Endocrinol Metab 2021 Oct 21;106(11):3093-3112. doi: 10.1210/clinem/dgab531. PMID: 34279029
Role of endothelial dysfunction and insulin resistance in angina pectoris and normal coronary angiogram.
Monti LD, Piatti PM
Herz 2005 Feb;30(1):48-54. doi: 10.1007/s00059-005-2638-0. PMID: 15754155
Clinical aspects of leptin.
Sinha MK, Caro JF
Vitam Horm 1998;54:1-30. doi: 10.1016/s0083-6729(08)60919-x. PMID: 9529971

Clinical prediction guides

SERCA2 regulates proinsulin processing and processing enzyme maturation in pancreatic beta cells.
Iida H, Kono T, Lee CC, Krishnan P, Arvin MC, Weaver SA, Jarvela TS, Branco RCS, McLaughlin MR, Bone RN, Tong X, Arvan P, Lindberg I, Evans-Molina C
Diabetologia 2023 Nov;66(11):2042-2061. Epub 2023 Aug 4 doi: 10.1007/s00125-023-05979-4. PMID: 37537395Free PMC Article
Stress Cardiac Biomarkers, Cardiovascular and Renal Outcomes, and Response to Canagliflozin.
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
Circulating Bile Acid Profiles: A Need for Further Examination.
Qi L, Tian Y, Chen Y
J Clin Endocrinol Metab 2021 Oct 21;106(11):3093-3112. doi: 10.1210/clinem/dgab531. PMID: 34279029
Pycnodysostosis: clinical, radiologic, and endocrine evaluation and linear growth after growth hormone therapy.
Soliman AT, Ramadan MA, Sherif A, Aziz Bedair ES, Rizk MM
Metabolism 2001 Aug;50(8):905-11. doi: 10.1053/meta.2001.24924. PMID: 11474477
Clinical aspects of leptin.
Sinha MK, Caro JF
Vitam Horm 1998;54:1-30. doi: 10.1016/s0083-6729(08)60919-x. PMID: 9529971

Recent systematic reviews

Association between female circulating heavy metal concentration and abortion: a systematic review and meta-analysis.
Ren M, Wang L, Wen L, Chen J, Quan S, Shi X
Front Endocrinol (Lausanne) 2023;14:1216507. Epub 2023 Aug 29 doi: 10.3389/fendo.2023.1216507. PMID: 37711903Free PMC Article
PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis.
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
The biology of human overfeeding: A systematic review.
Bray GA, Bouchard C
Obes Rev 2020 Sep;21(9):e13040. Epub 2020 Jun 8 doi: 10.1111/obr.13040. PMID: 32515127

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