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Abnormal tubulointerstitial morphology

MedGen UID:
892966
•Concept ID:
C4025732
•
Anatomical Abnormality
Synonym: Tubulointerstitial abnormalities
 
HPO: HP:0001969

Definition

An abnormality that involves the tubules and interstitial tissue of the kidney. [from HPO]

Conditions with this feature

Nephropathy, progressive tubulointerstitial, with cholestatic liver disease
MedGen UID:
355562
•Concept ID:
C1865831
•
Disease or Syndrome
See: Condition Record
Nephropathy, progressive tubulointerstitial, with cholestatic liver disease

Professional guidelines

PubMed

Classification Criteria for Tubulointerstitial Nephritis With Uveitis Syndrome.
Standardization of Uveitis Nomenclature (SUN) Working Group
Am J Ophthalmol 2021 Aug;228:255-261. Epub 2021 May 11 doi: 10.1016/j.ajo.2021.03.041. PMID: 33845023Free PMC Article
Proposal for diagnostic criteria for IgG4-related kidney disease.
Kawano M, Saeki T, Nakashima H, Nishi S, Yamaguchi Y, Hisano S, Yamanaka N, Inoue D, Yamamoto M, Takahashi H, Nomura H, Taguchi T, Umehara H, Makino H, Saito T
Clin Exp Nephrol 2011 Oct;15(5):615-626. Epub 2011 Sep 7 doi: 10.1007/s10157-011-0521-2. PMID: 21898030
Curable renal parenchymatous hypertension: current diagnosis and management.
Lüscher TF, Wanner C, Hauri D, Siegenthaler W, Vetter W
Cardiology 1985;72 Suppl 1:33-45. doi: 10.1159/000173942. PMID: 3902229

Recent clinical studies

Etiology

The genetic landscape and clinical spectrum of nephronophthisis and related ciliopathies.
Petzold F, Billot K, Chen X, Henry C, Filhol E, Martin Y, Avramescu M, Douillet M, Morinière V, Krug P, Jeanpierre C, Tory K, Boyer O, Burgun A, Servais A, Salomon R, Benmerah A, Heidet L, Garcelon N, Antignac C, Zaidan M, Saunier S; INSERM–Necker Hospital NPH collaborative group
Kidney Int 2023 Aug;104(2):378-387. Epub 2023 May 23 doi: 10.1016/j.kint.2023.05.007. PMID: 37230223
Aristolochic Acid Induces Renal Fibrosis and Senescence in Mice.
Urate S, Wakui H, Azushima K, Yamaji T, Suzuki T, Abe E, Tanaka S, Taguchi S, Tsukamoto S, Kinguchi S, Uneda K, Kanaoka T, Atobe Y, Funakoshi K, Yamashita A, Tamura K
Int J Mol Sci 2021 Nov 18;22(22) doi: 10.3390/ijms222212432. PMID: 34830314Free PMC Article
A Rare Kidney Disease To Cure Them All? Towards Mechanism-Based Therapies for Proteinopathies.
Dvela-Levitt M, Shaw JL, Greka A
Trends Mol Med 2021 Apr;27(4):394-409. Epub 2020 Dec 16 doi: 10.1016/j.molmed.2020.11.008. PMID: 33341352
De novo glomerular diseases after renal transplantation.
Ponticelli C, Moroni G, Glassock RJ
Clin J Am Soc Nephrol 2014 Aug 7;9(8):1479-87. Epub 2014 Apr 3 doi: 10.2215/CJN.12571213. PMID: 24700797Free PMC Article
Tubulointerstitial diseases.
Lombardo JV, Terlinsky A, Chester AC, Preuss HG
Am Fam Physician 1980 Jan;21(1):128-35. PMID: 7350733

Diagnosis

The genetic landscape and clinical spectrum of nephronophthisis and related ciliopathies.
Petzold F, Billot K, Chen X, Henry C, Filhol E, Martin Y, Avramescu M, Douillet M, Morinière V, Krug P, Jeanpierre C, Tory K, Boyer O, Burgun A, Servais A, Salomon R, Benmerah A, Heidet L, Garcelon N, Antignac C, Zaidan M, Saunier S; INSERM–Necker Hospital NPH collaborative group
Kidney Int 2023 Aug;104(2):378-387. Epub 2023 May 23 doi: 10.1016/j.kint.2023.05.007. PMID: 37230223
The causes and consequences of paediatric kidney disease on adult nephrology care.
Pepper RJ, Trompeter RS
Pediatr Nephrol 2022 Jun;37(6):1245-1261. Epub 2021 Aug 13 doi: 10.1007/s00467-021-05182-w. PMID: 34389906
Infections and the kidney: a tale from the tropics.
Kamath N, Iyengar A
Pediatr Nephrol 2018 Aug;33(8):1317-1326. Epub 2017 Sep 6 doi: 10.1007/s00467-017-3785-2. PMID: 28879600
De novo glomerular diseases after renal transplantation.
Ponticelli C, Moroni G, Glassock RJ
Clin J Am Soc Nephrol 2014 Aug 7;9(8):1479-87. Epub 2014 Apr 3 doi: 10.2215/CJN.12571213. PMID: 24700797Free PMC Article
Tubulointerstitial diseases.
Lombardo JV, Terlinsky A, Chester AC, Preuss HG
Am Fam Physician 1980 Jan;21(1):128-35. PMID: 7350733

Therapy

Fisetin ameliorates fibrotic kidney disease in mice via inhibiting ACSL4-mediated tubular ferroptosis.
Wang B, Yang LN, Yang LT, Liang Y, Guo F, Fu P, Ma L
Acta Pharmacol Sin 2024 Jan;45(1):150-165. Epub 2023 Sep 11 doi: 10.1038/s41401-023-01156-w. PMID: 37696989Free PMC Article
Infections and the kidney: a tale from the tropics.
Kamath N, Iyengar A
Pediatr Nephrol 2018 Aug;33(8):1317-1326. Epub 2017 Sep 6 doi: 10.1007/s00467-017-3785-2. PMID: 28879600
De novo glomerular diseases after renal transplantation.
Ponticelli C, Moroni G, Glassock RJ
Clin J Am Soc Nephrol 2014 Aug 7;9(8):1479-87. Epub 2014 Apr 3 doi: 10.2215/CJN.12571213. PMID: 24700797Free PMC Article
IgG4-related kidney disease.
Saeki T, Kawano M
Kidney Int 2014 Feb;85(2):251-7. Epub 2013 Oct 9 doi: 10.1038/ki.2013.393. PMID: 24107849
Tubulointerstitial diseases.
Lombardo JV, Terlinsky A, Chester AC, Preuss HG
Am Fam Physician 1980 Jan;21(1):128-35. PMID: 7350733

Prognosis

Active flare of IgA nephropathy during long-term therapy with anti-tumor necrosis factor-α antibody drugs for Crohn's disease: three case reports and literature review.
Shimizu A, Tsuboi N, Haruhara K, Shirai I, Ogawa K, Miura A, Oshiro K, Ueda H, Yokote S, Okabe M, Sasaki T, Ikeda M, Yokoo T
CEN Case Rep 2024 Aug;13(4):249-257. Epub 2023 Nov 30 doi: 10.1007/s13730-023-00836-0. PMID: 38032436Free PMC Article
KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease.
Mori Y, Ajay AK, Chang JH, Mou S, Zhao H, Kishi S, Li J, Brooks CR, Xiao S, Woo HM, Sabbisetti VS, Palmer SC, Galichon P, Li L, Henderson JM, Kuchroo VK, Hawkins J, Ichimura T, Bonventre JV
Cell Metab 2021 May 4;33(5):1042-1061.e7. doi: 10.1016/j.cmet.2021.04.004. PMID: 33951465Free PMC Article
De novo glomerular diseases after renal transplantation.
Ponticelli C, Moroni G, Glassock RJ
Clin J Am Soc Nephrol 2014 Aug 7;9(8):1479-87. Epub 2014 Apr 3 doi: 10.2215/CJN.12571213. PMID: 24700797Free PMC Article
IgG4-related kidney disease.
Saeki T, Kawano M
Kidney Int 2014 Feb;85(2):251-7. Epub 2013 Oct 9 doi: 10.1038/ki.2013.393. PMID: 24107849
Tubulointerstitial diseases.
Lombardo JV, Terlinsky A, Chester AC, Preuss HG
Am Fam Physician 1980 Jan;21(1):128-35. PMID: 7350733

Clinical prediction guides

KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease.
Mori Y, Ajay AK, Chang JH, Mou S, Zhao H, Kishi S, Li J, Brooks CR, Xiao S, Woo HM, Sabbisetti VS, Palmer SC, Galichon P, Li L, Henderson JM, Kuchroo VK, Hawkins J, Ichimura T, Bonventre JV
Cell Metab 2021 May 4;33(5):1042-1061.e7. doi: 10.1016/j.cmet.2021.04.004. PMID: 33951465Free PMC Article
IgG4-related kidney disease.
Saeki T, Kawano M
Kidney Int 2014 Feb;85(2):251-7. Epub 2013 Oct 9 doi: 10.1038/ki.2013.393. PMID: 24107849
Nephronophthisis.
Salomon R, Saunier S, Niaudet P
Pediatr Nephrol 2009 Dec;24(12):2333-44. Epub 2008 Jul 8 doi: 10.1007/s00467-008-0840-z. PMID: 18607645Free PMC Article
Glomerulonephritis.
Remuzzi G, Zoja C, Bertani T
Curr Opin Nephrol Hypertens 1993 May;2(3):465-74. doi: 10.1097/00041552-199305000-00015. PMID: 7922207
Renal involvement in visceral leishmaniasis.
Dutra M, Martinelli R, de Carvalho EM, Rodrigues LE, Brito E, Rocha H
Am J Kidney Dis 1985 Jul;6(1):22-7. doi: 10.1016/s0272-6386(85)80034-2. PMID: 4025325

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