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Intermediate Soft Tissue Tumor of Uncertain Differentiation

MedGen UID:
888418
•Concept ID:
C4054705
•
Neoplastic Process
Synonym: Intermediate Soft Tissue Neoplasm of Uncertain Differentiation

Definition

A soft tissue neoplasm of uncertain differentiation which is locally aggressive but rarely metastasizes. [from NCI]

Professional guidelines

PubMed

Ossifying Fibromyxoid Tumor: A Review With Emphasis on Recent Molecular Advances and Differential Diagnosis.
Carter CS, Patel RM
Arch Pathol Lab Med 2019 Dec;143(12):1504-1512. doi: 10.5858/arpa.2019-0371-RA. PMID: 31765250
Ossifying fibromyxoid tumor: morphology, genetics, and differential diagnosis.
Schneider N, Fisher C, Thway K
Ann Diagn Pathol 2016 Feb;20:52-8. Epub 2015 Dec 2 doi: 10.1016/j.anndiagpath.2015.11.002. PMID: 26732302

Recent clinical studies

Etiology

Accuracy of histological grades from intraoperative frozen-section diagnoses of soft-tissue tumors.
Miwa S, Yamamoto N, Hayashi K, Takeuchi A, Igarashi K, Tada K, Higuchi T, Yonezawa H, Morinaga S, Araki Y, Asano Y, Ikeda H, Nojima T, Tsuchiya H
Int J Clin Oncol 2020 Dec;25(12):2158-2165. Epub 2020 Aug 10 doi: 10.1007/s10147-020-01762-2. PMID: 32779038
Novel recurrent PHF1-TFE3 fusions in ossifying fibromyxoid tumors.
Suurmeijer AJH, Song W, Sung YS, Zhang L, Swanson D, Fletcher CDM, Dickson BC, Antonescu CR
Genes Chromosomes Cancer 2019 Sep;58(9):643-649. Epub 2019 Apr 17 doi: 10.1002/gcc.22755. PMID: 30920708Free PMC Article
Angiomatoid fibrous histiocytoma: the current status of pathology and genetics.
Thway K, Fisher C
Arch Pathol Lab Med 2015 May;139(5):674-82. doi: 10.5858/arpa.2014-0234-RA. PMID: 25927151
Application of immunohistochemistry to soft tissue neoplasms.
Heim-Hall J, Yohe SL
Arch Pathol Lab Med 2008 Mar;132(3):476-89. doi: 10.5858/2008-132-476-AOITST. PMID: 18318588
Ossifying fibromyxoid tumor of soft parts: a clinicopathologic study of 70 cases with emphasis on atypical and malignant variants.
Folpe AL, Weiss SW
Am J Surg Pathol 2003 Apr;27(4):421-31. doi: 10.1097/00000478-200304000-00001. PMID: 12657926

Diagnosis

Pearls and Pitfalls in the Imaging of Soft-Tissue Masses in Children.
Navarro OM
Semin Ultrasound CT MR 2020 Oct;41(5):498-512. Epub 2020 May 28 doi: 10.1053/j.sult.2020.05.014. PMID: 32980096
Inflammatory Myofibroblastic Tumors: Current Update.
Surabhi VR, Chua S, Patel RP, Takahashi N, Lalwani N, Prasad SR
Radiol Clin North Am 2016 May;54(3):553-63. Epub 2016 Mar 12 doi: 10.1016/j.rcl.2015.12.005. PMID: 27153788
Ossifying fibromyxoid tumor: morphology, genetics, and differential diagnosis.
Schneider N, Fisher C, Thway K
Ann Diagn Pathol 2016 Feb;20:52-8. Epub 2015 Dec 2 doi: 10.1016/j.anndiagpath.2015.11.002. PMID: 26732302
Vascular tumors of bone.
Hart JL, Edgar MA, Gardner JM
Semin Diagn Pathol 2014 Jan;31(1):30-8. Epub 2014 Jan 7 doi: 10.1053/j.semdp.2014.01.003. PMID: 24680180
Vascular and perivascular lesions of skin and soft tissues in children and adolescents.
Bruder E, Alaggio R, Kozakewich HP, Jundt G, Dehner LP, Coffin CM
Pediatr Dev Pathol 2012;15(1 Suppl):26-61. doi: 10.2350/11-11-1119-PB.1. PMID: 22420724

Prognosis

Clinical and pathological analyses of 14 cases of angiomatoid fibrous histiocytoma.
Zeng Q, Li JZ, Li GP, Chen YP, Song FL, Gao F
Med Mol Morphol 2024 Dec;57(4):299-305. Epub 2024 Jul 30 doi: 10.1007/s00795-024-00400-4. PMID: 39078440
Primary intra-osseous myoepithelioma of phalanx mimicking an enchondroma.
Nambirajan A, Mridha AR, Sharma MC, Panda A, Palaniswamy A
Skeletal Radiol 2016 Oct;45(10):1453-8. Epub 2016 Aug 14 doi: 10.1007/s00256-016-2452-1. PMID: 27524490
Ossifying fibromyxoid tumor: morphology, genetics, and differential diagnosis.
Schneider N, Fisher C, Thway K
Ann Diagn Pathol 2016 Feb;20:52-8. Epub 2015 Dec 2 doi: 10.1016/j.anndiagpath.2015.11.002. PMID: 26732302
Vascular tumors of bone.
Hart JL, Edgar MA, Gardner JM
Semin Diagn Pathol 2014 Jan;31(1):30-8. Epub 2014 Jan 7 doi: 10.1053/j.semdp.2014.01.003. PMID: 24680180
Ossifying fibromyxoid tumor of soft parts: a clinicopathologic study of 70 cases with emphasis on atypical and malignant variants.
Folpe AL, Weiss SW
Am J Surg Pathol 2003 Apr;27(4):421-31. doi: 10.1097/00000478-200304000-00001. PMID: 12657926

Clinical prediction guides

Superficial malignant ossifying fibromyxoid tumors harboring the rare and recently described ZC3H7B-BCOR and PHF1-TFE3 fusions.
Linos K, Kerr DA, Baker M, Wong S, Henderson E, Sumegi J, Bridge JA
J Cutan Pathol 2020 Oct;47(10):934-945. Epub 2020 Jul 29 doi: 10.1111/cup.13728. PMID: 32352579
A rare case of malignant solitary fibrous tumor in prostate with review of the literature.
Ronchi A, La Mantia E, Gigantino V, Perdonà S, De Sio M, Facchini G, Franco R, De Chiara A
Diagn Pathol 2017 Jul 7;12(1):50. doi: 10.1186/s13000-017-0640-5. PMID: 28687087Free PMC Article
Ossifying fibromyxoid tumor: modified myoepithelial cell tumor? Report of three cases with immunohistochemical and electron microscopic studies.
Min KW, Seo IS, Pitha J
Ultrastruct Pathol 2005 Nov-Dec;29(6):535-48. doi: 10.1080/01913120500323605. PMID: 16316954

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