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Mesangiolysis

MedGen UID:
883506
Concept ID:
C4054531
Pathologic Function
HPO: HP:0030762

Definition

Partial or complete dissolution of the mesangial matrix, identified by reduced staining on a periodic acid-Schiff (PAS) or silver stain. [from HPO]

Professional guidelines

PubMed

Suyama K, Kawasaki Y, Miyazaki K, Kanno S, Ono A, Ohara S, Sato M, Hosoya M
Nephrol Dial Transplant 2015 Jun;30(6):969-77. Epub 2015 Feb 17 doi: 10.1093/ndt/gfv004. PMID: 25694534

Recent clinical studies

Etiology

Furuichi K, Shimizu M, Yamanouchi M, Hoshino J, Sakai N, Iwata Y, Toyama T, Kitajima S, Hara A, Yuzawa Y, Kitamura H, Suzuki Y, Sato H, Uesugi N, Ueda Y, Nishi S, Nishino T, Samejima K, Kohagura K, Shibagaki Y, Makino H, Matsuo S, Ubara Y, Yokoyama H, Wada T
BMJ Open Diabetes Res Care 2020 Jun;8(1) doi: 10.1136/bmjdrc-2019-001157. PMID: 32503809Free PMC Article
Ravindran A, Go RS, Fervenza FC, Sethi S
Kidney Int 2017 Mar;91(3):691-698. Epub 2016 Dec 18 doi: 10.1016/j.kint.2016.09.045. PMID: 27998645
El Karoui K, Vuiblet V, Dion D, Izzedine H, Guitard J, Frimat L, Delahousse M, Remy P, Boffa JJ, Pillebout E, Galicier L, Noël LH, Daugas E
Nephrol Dial Transplant 2011 Feb;26(2):599-609. Epub 2010 Jul 23 doi: 10.1093/ndt/gfq427. PMID: 20656751
Shigematsu H
Pathol Int 1997 Apr;47(4):194-202. doi: 10.1111/j.1440-1827.1997.tb04480.x. PMID: 9103209
Antignac C, Gubler MC, Leverger G, Broyer M, Habib R
Kidney Int 1989 Jun;35(6):1336-44. doi: 10.1038/ki.1989.132. PMID: 2671466

Diagnosis

Furuichi K, Shimizu M, Yamanouchi M, Hoshino J, Sakai N, Iwata Y, Toyama T, Kitajima S, Hara A, Yuzawa Y, Kitamura H, Suzuki Y, Sato H, Uesugi N, Ueda Y, Nishi S, Nishino T, Samejima K, Kohagura K, Shibagaki Y, Makino H, Matsuo S, Ubara Y, Yokoyama H, Wada T
BMJ Open Diabetes Res Care 2020 Jun;8(1) doi: 10.1136/bmjdrc-2019-001157. PMID: 32503809Free PMC Article
Ravindran A, Go RS, Fervenza FC, Sethi S
Kidney Int 2017 Mar;91(3):691-698. Epub 2016 Dec 18 doi: 10.1016/j.kint.2016.09.045. PMID: 27998645
Takahashi T, Harris RC
J Diabetes Res 2014;2014:590541. Epub 2014 Oct 13 doi: 10.1155/2014/590541. PMID: 25371905Free PMC Article
Wada T, Shimizu M, Yokoyama H, Iwata Y, Sakai Y, Kaneko S, Furuichi K
Clin Exp Nephrol 2013 Feb;17(1):3-9. Epub 2012 Oct 26 doi: 10.1007/s10157-012-0711-6. PMID: 23100177
Najafian B, Alpers CE, Fogo AB
Contrib Nephrol 2011;170:36-47. Epub 2011 Jun 9 doi: 10.1159/000324942. PMID: 21659756

Therapy

Delsante M, Monroy-Trujillo JM, Carter-Monroe N, Ball DW, Rosenberg AZ
Virchows Arch 2022 Feb;480(2):467-473. Epub 2021 May 6 doi: 10.1007/s00428-021-03114-5. PMID: 33959820
Ravindran A, Go RS, Fervenza FC, Sethi S
Kidney Int 2017 Mar;91(3):691-698. Epub 2016 Dec 18 doi: 10.1016/j.kint.2016.09.045. PMID: 27998645
Boor P, van Roeyen CR, Kunter U, Villa L, Bücher E, Hohenstein B, Hugo CP, Eriksson U, Satchell SC, Mathieson PW, Eitner F, Floege J, Ostendorf T
Am J Pathol 2010 Jul;177(1):58-69. Epub 2010 May 20 doi: 10.2353/ajpath.2010.091008. PMID: 20489153Free PMC Article
Sitprija V
Nephrology (Carlton) 2006 Oct;11(5):442-8. doi: 10.1111/j.1440-1797.2006.00599.x. PMID: 17014559
Cohen EP, Robbins ME
Semin Nephrol 2003 Sep;23(5):486-99. doi: 10.1016/s0270-9295(03)00093-7. PMID: 13680538

Prognosis

Sun L, Duan T, Zhao Q, Xu L, Han Y, Xi Y, Zhu X, He L, Tang C, Fu X, Sun L
J Clin Endocrinol Metab 2022 Sep 28;107(10):2758-2768. doi: 10.1210/clinem/dgac416. PMID: 35914281
Hu YF, Tan Y, Yu XJ, Wang H, Wang SX, Yu F, Zhao MH
Am J Nephrol 2020;51(9):752-760. Epub 2020 Aug 28 doi: 10.1159/000510141. PMID: 32862175
Mizuno H, Sekine A, Oguro M, Oshima Y, Kawada M, Sumida K, Yamanouchi M, Hayami N, Suwabe T, Hiramatsu R, Hasegawa E, Hoshino J, Sawa N, Fujii T, Takaichi K, Ohashi K, Ubara Y
Hum Pathol 2018 Dec;82:258-263. Epub 2018 Apr 4 doi: 10.1016/j.humpath.2018.03.021. PMID: 29626596
Najafian B, Alpers CE, Fogo AB
Contrib Nephrol 2011;170:36-47. Epub 2011 Jun 9 doi: 10.1159/000324942. PMID: 21659756
Nishi H, Tomida C, Gotoh M, Yamagata K, Akiyama H, Shimokama T
Ren Fail 2006;28(6):519-22. doi: 10.1080/08860220600781393. PMID: 16928623

Clinical prediction guides

Suto Y, Oguchi H, Tochigi N, Mikami T, Shinoda K, Honda K, Kounoue N, Hashimoto J, Muramatsu M, Itabashi Y, Sakai K
Nephron 2023;147 Suppl 1:14-21. Epub 2023 Jun 15 doi: 10.1159/000531573. PMID: 37321180
Chen FF, Yu XJ, Wang H, Zhang X, Tan Y, Qu Z, Wang SX, Yu F, Chen M, Zhao MH
Ren Fail 2023 Dec;45(1):2161396. doi: 10.1080/0886022X.2022.2161396. PMID: 36648027Free PMC Article
Furuichi K, Shimizu M, Yamanouchi M, Hoshino J, Sakai N, Iwata Y, Toyama T, Kitajima S, Hara A, Yuzawa Y, Kitamura H, Suzuki Y, Sato H, Uesugi N, Ueda Y, Nishi S, Nishino T, Samejima K, Kohagura K, Shibagaki Y, Makino H, Matsuo S, Ubara Y, Yokoyama H, Wada T
BMJ Open Diabetes Res Care 2020 Jun;8(1) doi: 10.1136/bmjdrc-2019-001157. PMID: 32503809Free PMC Article
Nakagawa T, Tanabe K, Croker BP, Johnson RJ, Grant MB, Kosugi T, Li Q
Nat Rev Nephrol 2011 Jan;7(1):36-44. Epub 2010 Nov 2 doi: 10.1038/nrneph.2010.152. PMID: 21045790Free PMC Article
El Karoui K, Vuiblet V, Dion D, Izzedine H, Guitard J, Frimat L, Delahousse M, Remy P, Boffa JJ, Pillebout E, Galicier L, Noël LH, Daugas E
Nephrol Dial Transplant 2011 Feb;26(2):599-609. Epub 2010 Jul 23 doi: 10.1093/ndt/gfq427. PMID: 20656751

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