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Hyperfibrinolysis

MedGen UID:
882781
•Concept ID:
C3805089
•
Disease or Syndrome
SNOMED CT: Hyperfibrinolysis (1177171004)
 
HPO: HP:0040236

Definition

Increased degradation of fibrin, associated with clot instability and bleeding [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHyperfibrinolysis

Professional guidelines

PubMed

Mechanisms and management of the coagulopathy of trauma and sepsis: trauma-induced coagulopathy, sepsis-induced coagulopathy, and disseminated intravascular coagulation.
Iba T, Helms J, Neal MD, Levy JH
J Thromb Haemost 2023 Dec;21(12):3360-3370. Epub 2023 Sep 16 doi: 10.1016/j.jtha.2023.05.028. PMID: 37722532Free PMC Article
Definition and Treatment of Hyperfibrinolysis During Liver Transplantation: Are All Viscoelastic Tests Created Equal?
Abuelkasem E, Mazzeffi MA, Tanaka KA
Anesth Analg 2023 Jun 1;136(6):e33-e35. Epub 2023 May 19 doi: 10.1213/ANE.0000000000006432. PMID: 37205817
On hyperfibrinolysis and its treatment.
Marx R, Meisner A
Angiologica 1968;5(2):105-18. PMID: 4232513

Recent clinical studies

Etiology

Tranexamic acid in pediatric hemorrhagic trauma.
Borgman MA, Nishijima DK
J Trauma Acute Care Surg 2023 Jan 1;94(1S Suppl 1):S36-S40. Epub 2022 Aug 31 doi: 10.1097/TA.0000000000003775. PMID: 36044459
Role of Fibrinogen in Trauma-Induced Coagulopathy.
Meizoso JP, Moore EE, Pieracci FM, Saberi RA, Ghasabyan A, Chandler J, Namias N, Sauaia A
J Am Coll Surg 2022 Apr 1;234(4):465-473. doi: 10.1097/XCS.0000000000000078. PMID: 35290265
Prevention and treatment of postpartum hemorrhage: focus on hematological aspects of management.
McLintock C
Hematology Am Soc Hematol Educ Program 2020 Dec 4;2020(1):542-546. doi: 10.1182/hematology.2020000139. PMID: 33275708Free PMC Article
Trauma-associated hyperfibrinolysis.
Schöchl H, Voelckel W, Maegele M, Solomon C
Hamostaseologie 2012;32(1):22-7. Epub 2011 Oct 19 doi: 10.5482/ha-1178. PMID: 22009115
Coagulation disorders in liver disease.
Amitrano L, Guardascione MA, Brancaccio V, Balzano A
Semin Liver Dis 2002 Feb;22(1):83-96. doi: 10.1055/s-2002-23205. PMID: 11928081

Diagnosis

How to manage coagulopathies in critically ill patients.
Helms J, Iba T, Connors JM, Gando S, Levi M, Meziani F, Levy JH
Intensive Care Med 2023 Mar;49(3):273-290. Epub 2023 Feb 17 doi: 10.1007/s00134-023-06980-6. PMID: 36808215
Disseminated Intravascular Coagulation: The Past, Present, and Future Considerations.
Iba T, Levi M, Thachil J, Levy JH
Semin Thromb Hemost 2022 Nov;48(8):978-987. Epub 2022 Sep 13 doi: 10.1055/s-0042-1756300. PMID: 36100234
Perioperative Coagulation Monitoring.
Fenger-Eriksen C
Anesthesiol Clin 2021 Sep;39(3):525-535. doi: 10.1016/j.anclin.2021.03.010. PMID: 34392883
Point-of-Care Testing in Neurosurgery.
Beynon C, Wessels L, Unterberg AW
Semin Thromb Hemost 2017 Jun;43(4):416-422. Epub 2017 Mar 27 doi: 10.1055/s-0037-1599159. PMID: 28346963
Coagulation disorders in liver disease.
Amitrano L, Guardascione MA, Brancaccio V, Balzano A
Semin Liver Dis 2002 Feb;22(1):83-96. doi: 10.1055/s-2002-23205. PMID: 11928081

Therapy

Tranexamic acid in pediatric hemorrhagic trauma.
Borgman MA, Nishijima DK
J Trauma Acute Care Surg 2023 Jan 1;94(1S Suppl 1):S36-S40. Epub 2022 Aug 31 doi: 10.1097/TA.0000000000003775. PMID: 36044459
Role of Fibrinogen in Trauma-Induced Coagulopathy.
Meizoso JP, Moore EE, Pieracci FM, Saberi RA, Ghasabyan A, Chandler J, Namias N, Sauaia A
J Am Coll Surg 2022 Apr 1;234(4):465-473. doi: 10.1097/XCS.0000000000000078. PMID: 35290265
Bleeding and Thrombotic Complications in the Use of Extracorporeal Membrane Oxygenation.
Thomas J, Kostousov V, Teruya J
Semin Thromb Hemost 2018 Feb;44(1):20-29. Epub 2017 Sep 12 doi: 10.1055/s-0037-1606179. PMID: 28898902
Point-of-Care Testing in Neurosurgery.
Beynon C, Wessels L, Unterberg AW
Semin Thromb Hemost 2017 Jun;43(4):416-422. Epub 2017 Mar 27 doi: 10.1055/s-0037-1599159. PMID: 28346963
Trauma-associated hyperfibrinolysis.
Schöchl H, Voelckel W, Maegele M, Solomon C
Hamostaseologie 2012;32(1):22-7. Epub 2011 Oct 19 doi: 10.5482/ha-1178. PMID: 22009115

Prognosis

Role of Fibrinogen in Trauma-Induced Coagulopathy.
Meizoso JP, Moore EE, Pieracci FM, Saberi RA, Ghasabyan A, Chandler J, Namias N, Sauaia A
J Am Coll Surg 2022 Apr 1;234(4):465-473. doi: 10.1097/XCS.0000000000000078. PMID: 35290265
Measuring Fibrinolysis.
Longstaff C
Hamostaseologie 2021 Feb;41(1):69-75. Epub 2021 Feb 15 doi: 10.1055/a-1325-0268. PMID: 33588458
Blood management in enhanced recovery after hip and knee replacement.
Dao P, Massin P
Orthop Traumatol Surg Res 2020 Feb;106(1S):S1-S5. Epub 2019 Dec 10 doi: 10.1016/j.otsr.2019.05.022. PMID: 31836497
The role of fibrinogen in trauma-induced coagulopathy.
Schlimp CJ, Schöchl H
Hamostaseologie 2014;34(1):29-39. Epub 2013 Oct 30 doi: 10.5482/HAMO-13-07-0038. PMID: 24172764
Trauma-associated hyperfibrinolysis.
Schöchl H, Voelckel W, Maegele M, Solomon C
Hamostaseologie 2012;32(1):22-7. Epub 2011 Oct 19 doi: 10.5482/ha-1178. PMID: 22009115

Clinical prediction guides

Tranexamic acid in pediatric hemorrhagic trauma.
Borgman MA, Nishijima DK
J Trauma Acute Care Surg 2023 Jan 1;94(1S Suppl 1):S36-S40. Epub 2022 Aug 31 doi: 10.1097/TA.0000000000003775. PMID: 36044459
Role of Fibrinogen in Trauma-Induced Coagulopathy.
Meizoso JP, Moore EE, Pieracci FM, Saberi RA, Ghasabyan A, Chandler J, Namias N, Sauaia A
J Am Coll Surg 2022 Apr 1;234(4):465-473. doi: 10.1097/XCS.0000000000000078. PMID: 35290265
Measuring Fibrinolysis.
Longstaff C
Hamostaseologie 2021 Feb;41(1):69-75. Epub 2021 Feb 15 doi: 10.1055/a-1325-0268. PMID: 33588458
Blood management in enhanced recovery after hip and knee replacement.
Dao P, Massin P
Orthop Traumatol Surg Res 2020 Feb;106(1S):S1-S5. Epub 2019 Dec 10 doi: 10.1016/j.otsr.2019.05.022. PMID: 31836497
Effect of thromboelastography (TEG®) and rotational thromboelastometry (ROTEM®) on diagnosis of coagulopathy, transfusion guidance and mortality in trauma: descriptive systematic review.
Da Luz LT, Nascimento B, Shankarakutty AK, Rizoli S, Adhikari NK
Crit Care 2014 Sep 27;18(5):518. doi: 10.1186/s13054-014-0518-9. PMID: 25261079Free PMC Article

Recent systematic reviews

Altered Fibrinolysis in Hematological Malignances.
Bønløkke ST, Ommen HB, Hvas AM
Semin Thromb Hemost 2021 Jul;47(5):569-580. Epub 2021 May 31 doi: 10.1055/s-0041-1725099. PMID: 34058766
Time Course of Hemostatic Disruptions After Traumatic Brain Injury: A Systematic Review of the Literature.
Fletcher-Sandersjöö A, Thelin EP, Maegele M, Svensson M, Bellander BM
Neurocrit Care 2021 Apr;34(2):635-656. doi: 10.1007/s12028-020-01037-8. PMID: 32607969Free PMC Article
Tranexamic Acid Use in Prehospital Uncontrolled Hemorrhage.
Huebner BR, Dorlac WC, Cribari C
Wilderness Environ Med 2017 Jun;28(2S):S50-S60. doi: 10.1016/j.wem.2016.12.006. PMID: 28601210Free PMC Article
Effect of thromboelastography (TEG®) and rotational thromboelastometry (ROTEM®) on diagnosis of coagulopathy, transfusion guidance and mortality in trauma: descriptive systematic review.
Da Luz LT, Nascimento B, Shankarakutty AK, Rizoli S, Adhikari NK
Crit Care 2014 Sep 27;18(5):518. doi: 10.1186/s13054-014-0518-9. PMID: 25261079Free PMC Article
A systematic review of antifibrinolytics and massive injury.
Faraoni D, Van Der Linden P
Minerva Anestesiol 2014 Oct;80(10):1115-22. Epub 2013 Nov 28 PMID: 24287671

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