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Obesity, Metabolically Benign

MedGen UID:
875725
•Concept ID:
C4042861
•
Sign or Symptom
Synonyms: Benign Obesity, Metabolically; Healthy Obesity, Metabolically; Metabolically Benign Obesity; Metabolically Healthy Obesity; Obesity, Metabolically Healthy

Definition

A sub-PHENOTYPE of obese individuals who have a risk for CARDIOVASCULAR DISEASES between that of healthy individuals with normal weight and unhealthy individuals with obesity. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVObesity, Metabolically Benign

Professional guidelines

PubMed

Metabolically Healthy Obesity: Criteria, Epidemiology, Controversies, and Consequences.
Tsatsoulis A, Paschou SA
Curr Obes Rep 2020 Jun;9(2):109-120. doi: 10.1007/s13679-020-00375-0. PMID: 32301039
The Prevalence of Metabolically Healthy and Unhealthy Obesity according to Different Criteria.
Liu C, Wang C, Guan S, Liu H, Wu X, Zhang Z, Gu X, Zhang Y, Zhao Y, Tse LA, Fang X
Obes Facts 2019;12(1):78-90. Epub 2019 Feb 27 doi: 10.1159/000495852. PMID: 30814477Free PMC Article
New obesity classification criteria as a tool for bariatric surgery indication.
De Lorenzo A, Soldati L, Sarlo F, Calvani M, Di Lorenzo N, Di Renzo L
World J Gastroenterol 2016 Jan 14;22(2):681-703. doi: 10.3748/wjg.v22.i2.681. PMID: 26811617Free PMC Article

Recent clinical studies

Etiology

Obesity, metabolic syndrome, and primary hypertension.
Litwin M, Kułaga Z
Pediatr Nephrol 2021 Apr;36(4):825-837. Epub 2020 May 9 doi: 10.1007/s00467-020-04579-3. PMID: 32388582Free PMC Article
Metabolically Healthy Obesity: Criteria, Epidemiology, Controversies, and Consequences.
Tsatsoulis A, Paschou SA
Curr Obes Rep 2020 Jun;9(2):109-120. doi: 10.1007/s13679-020-00375-0. PMID: 32301039
Metabolically Healthy Obesity.
Blüher M
Endocr Rev 2020 May 1;41(3) doi: 10.1210/endrev/bnaa004. PMID: 32128581Free PMC Article
Metabolically healthy versus metabolically unhealthy obesity.
Iacobini C, Pugliese G, Blasetti Fantauzzi C, Federici M, Menini S
Metabolism 2019 Mar;92:51-60. Epub 2018 Nov 17 doi: 10.1016/j.metabol.2018.11.009. PMID: 30458177
Obesity and the Obesity Paradox in Heart Failure.
Horwich TB, Fonarow GC, Clark AL
Prog Cardiovasc Dis 2018 Jul-Aug;61(2):151-156. Epub 2018 May 28 doi: 10.1016/j.pcad.2018.05.005. PMID: 29852198

Diagnosis

Cardiometabolic characteristics of people with metabolically healthy and unhealthy obesity.
Petersen MC, Smith GI, Palacios HH, Farabi SS, Yoshino M, Yoshino J, Cho K, Davila-Roman VG, Shankaran M, Barve RA, Yu J, Stern JH, Patterson BW, Hellerstein MK, Shulman GI, Patti GJ, Klein S
Cell Metab 2024 Apr 2;36(4):745-761.e5. doi: 10.1016/j.cmet.2024.03.002. PMID: 38569471Free PMC Article
Metabolically Healthy Obesity: Criteria, Epidemiology, Controversies, and Consequences.
Tsatsoulis A, Paschou SA
Curr Obes Rep 2020 Jun;9(2):109-120. doi: 10.1007/s13679-020-00375-0. PMID: 32301039
Metabolically Healthy Obesity.
Blüher M
Endocr Rev 2020 May 1;41(3) doi: 10.1210/endrev/bnaa004. PMID: 32128581Free PMC Article
An Overview and Update on Obesity and the Obesity Paradox in Cardiovascular Diseases.
Elagizi A, Kachur S, Lavie CJ, Carbone S, Pandey A, Ortega FB, Milani RV
Prog Cardiovasc Dis 2018 Jul-Aug;61(2):142-150. Epub 2018 Jul 5 doi: 10.1016/j.pcad.2018.07.003. PMID: 29981771
New obesity classification criteria as a tool for bariatric surgery indication.
De Lorenzo A, Soldati L, Sarlo F, Calvani M, Di Lorenzo N, Di Renzo L
World J Gastroenterol 2016 Jan 14;22(2):681-703. doi: 10.3748/wjg.v22.i2.681. PMID: 26811617Free PMC Article

Therapy

Metabolic Risk Profile and Graft Function Deterioration 2 Years After Kidney Transplant.
Yan J, Yang X, Wang J, Cai H, Che X, Ying L, Zhang T, Chen Q, Xia J, Gu L, Yuan X, Chen R, Li D, Liu Z, Dong K, He L, Zhang M, Mou S
JAMA Netw Open 2023 Dec 1;6(12):e2349538. doi: 10.1001/jamanetworkopen.2023.49538. PMID: 38150251Free PMC Article
Myocardial Tissue-Level Characteristics of Adults With Metabolically Healthy Obesity.
Zhao H, Huang R, Jiang M, Wang W, Chai Y, Liu Q, Zhang W, Han Y, Yan F, Lu Q, Tao Z, Wu Q, Yue J, Ma J, Pu J
JACC Cardiovasc Imaging 2023 Jul;16(7):889-901. Epub 2023 Apr 12 doi: 10.1016/j.jcmg.2023.01.022. PMID: 37052557
The association between metabolically healthy obesity and risk of cancer: A systematic review and meta-analysis of prospective cohort studies.
Lin CJ, Chang YC, Cheng TY, Lo K, Liu SJ, Yeh TL
Obes Rev 2020 Oct;21(10):e13049. Epub 2020 Jun 1 doi: 10.1111/obr.13049. PMID: 32476278
New obesity classification criteria as a tool for bariatric surgery indication.
De Lorenzo A, Soldati L, Sarlo F, Calvani M, Di Lorenzo N, Di Renzo L
World J Gastroenterol 2016 Jan 14;22(2):681-703. doi: 10.3748/wjg.v22.i2.681. PMID: 26811617Free PMC Article
Metabolically healthy obesity and cardiovascular events: A systematic review and meta-analysis.
Eckel N, Meidtner K, Kalle-Uhlmann T, Stefan N, Schulze MB
Eur J Prev Cardiol 2016 Jun;23(9):956-66. Epub 2015 Dec 23 doi: 10.1177/2047487315623884. PMID: 26701871

Prognosis

Metabolically Healthy Obesity: Criteria, Epidemiology, Controversies, and Consequences.
Tsatsoulis A, Paschou SA
Curr Obes Rep 2020 Jun;9(2):109-120. doi: 10.1007/s13679-020-00375-0. PMID: 32301039
Metabolically healthy obesity: facts and fantasies.
Smith GI, Mittendorfer B, Klein S
J Clin Invest 2019 Oct 1;129(10):3978-3989. doi: 10.1172/JCI129186. PMID: 31524630Free PMC Article
Metabolically healthy versus metabolically unhealthy obesity.
Iacobini C, Pugliese G, Blasetti Fantauzzi C, Federici M, Menini S
Metabolism 2019 Mar;92:51-60. Epub 2018 Nov 17 doi: 10.1016/j.metabol.2018.11.009. PMID: 30458177
An Overview and Update on Obesity and the Obesity Paradox in Cardiovascular Diseases.
Elagizi A, Kachur S, Lavie CJ, Carbone S, Pandey A, Ortega FB, Milani RV
Prog Cardiovasc Dis 2018 Jul-Aug;61(2):142-150. Epub 2018 Jul 5 doi: 10.1016/j.pcad.2018.07.003. PMID: 29981771
Obesity and the Obesity Paradox in Heart Failure.
Horwich TB, Fonarow GC, Clark AL
Prog Cardiovasc Dis 2018 Jul-Aug;61(2):151-156. Epub 2018 May 28 doi: 10.1016/j.pcad.2018.05.005. PMID: 29852198

Clinical prediction guides

Association between metabolic healthy obesity and female infertility: the national health and nutrition examination survey, 2013-2020.
Tang J, Xu Y, Wang Z, Ji X, Qiu Q, Mai Z, Huang J, Ouyang N, Chen H
BMC Public Health 2023 Aug 10;23(1):1524. doi: 10.1186/s12889-023-16397-x. PMID: 37563562Free PMC Article
Trends in the Prevalence of Metabolically Healthy Obesity Among US Adults, 1999-2018.
Wang JS, Xia PF, Ma MN, Li Y, Geng TT, Zhang YB, Tu ZZ, Jiang L, Zhou LR, Zhang BF, Tong WW, Shan Z, Liu G, Yang K, Pan A
JAMA Netw Open 2023 Mar 1;6(3):e232145. doi: 10.1001/jamanetworkopen.2023.2145. PMID: 36892842Free PMC Article
Obesity, metabolic syndrome, and primary hypertension.
Litwin M, Kułaga Z
Pediatr Nephrol 2021 Apr;36(4):825-837. Epub 2020 May 9 doi: 10.1007/s00467-020-04579-3. PMID: 32388582Free PMC Article
Metabolically Healthy Obesity.
Blüher M
Endocr Rev 2020 May 1;41(3) doi: 10.1210/endrev/bnaa004. PMID: 32128581Free PMC Article
New obesity classification criteria as a tool for bariatric surgery indication.
De Lorenzo A, Soldati L, Sarlo F, Calvani M, Di Lorenzo N, Di Renzo L
World J Gastroenterol 2016 Jan 14;22(2):681-703. doi: 10.3748/wjg.v22.i2.681. PMID: 26811617Free PMC Article

Recent systematic reviews

Metabolically healthy overweight/obesity are associated with increased risk of cardiovascular disease in adults, even in the absence of metabolic risk factors: A systematic review and meta-analysis of prospective cohort studies.
Opio J, Croker E, Odongo GS, Attia J, Wynne K, McEvoy M
Obes Rev 2020 Dec;21(12):e13127. Epub 2020 Sep 1 doi: 10.1111/obr.13127. PMID: 32869512
The association between metabolically healthy obesity and risk of cancer: A systematic review and meta-analysis of prospective cohort studies.
Lin CJ, Chang YC, Cheng TY, Lo K, Liu SJ, Yeh TL
Obes Rev 2020 Oct;21(10):e13049. Epub 2020 Jun 1 doi: 10.1111/obr.13049. PMID: 32476278
Role of Physical Activity and Fitness in the Characterization and Prognosis of the Metabolically Healthy Obesity Phenotype: A Systematic Review and Meta-analysis.
Ortega FB, Cadenas-Sanchez C, Migueles JH, Labayen I, Ruiz JR, Sui X, Blair SN, Martínez-Vizcaino V, Lavie CJ
Prog Cardiovasc Dis 2018 Jul-Aug;61(2):190-205. Epub 2018 Jul 6 doi: 10.1016/j.pcad.2018.07.008. PMID: 30122522
The prevalence, metabolic risk and effects of lifestyle intervention for metabolically healthy obesity: a systematic review and meta-analysis: A PRISMA-compliant article.
Lin H, Zhang L, Zheng R, Zheng Y
Medicine (Baltimore) 2017 Nov;96(47):e8838. doi: 10.1097/MD.0000000000008838. PMID: 29381992Free PMC Article
Metabolically healthy obesity and cardiovascular events: A systematic review and meta-analysis.
Eckel N, Meidtner K, Kalle-Uhlmann T, Stefan N, Schulze MB
Eur J Prev Cardiol 2016 Jun;23(9):956-66. Epub 2015 Dec 23 doi: 10.1177/2047487315623884. PMID: 26701871

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