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Metastatic Malignant Neoplasm in the Choroid

MedGen UID:
87569
•Concept ID:
C0347021
•
Neoplastic Process
Synonyms: Cancer metastatic to choroid; Metastasis to choroid; Metastatic malignant neoplasm of choroid; Metastatic malignant neoplasm to choroid; Metastatic Malignant Neoplasm to the Choroid; Metastatic Neoplasm to the Choroid; Metastatic Tumor to the Choroid; Secondary choroidal tumor; Secondary malignant neoplasm of choroid
SNOMED CT: Secondary choroidal tumor (94254004); Metastasis to choroid (94254004); Secondary malignant neoplasm of choroid (94254004); Metastatic malignant neoplasm to choroid (94254004); Cancer metastatic to choroid (94254004); Metastatic malignant neoplasm of choroid (94254004)

Definition

A malignant neoplasm that has spread to the choroid from another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Choroid

Professional guidelines

PubMed

Management of Uveal Melanoma: Updated Cancer Care Alberta Clinical Practice Guideline.
Weis E, Surgeoner B, Salopek TG, Cheng T, Hyrcza M, Kostaras X, Larocque M, McKinnon G, McWhae J, Menon G, Monzon J, Murtha AD, Walker J, Temple-Oberle C
Curr Oncol 2023 Dec 20;31(1):24-41. doi: 10.3390/curroncol31010002. PMID: 38275828Free PMC Article
Metastatic disease from uveal melanoma: treatment options and future prospects.
Carvajal RD, Schwartz GK, Tezel T, Marr B, Francis JH, Nathan PD
Br J Ophthalmol 2017 Jan;101(1):38-44. Epub 2016 Aug 29 doi: 10.1136/bjophthalmol-2016-309034. PMID: 27574175Free PMC Article
Uveal melanoma: From diagnosis to treatment and the science in between.
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article

Recent clinical studies

Etiology

Management of Uveal Melanoma: Updated Cancer Care Alberta Clinical Practice Guideline.
Weis E, Surgeoner B, Salopek TG, Cheng T, Hyrcza M, Kostaras X, Larocque M, McKinnon G, McWhae J, Menon G, Monzon J, Murtha AD, Walker J, Temple-Oberle C
Curr Oncol 2023 Dec 20;31(1):24-41. doi: 10.3390/curroncol31010002. PMID: 38275828Free PMC Article
Uveal melanoma: From diagnosis to treatment and the science in between.
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article
Choroidal metastases of choriocarcinoma.
Hazan A, Katz MS, Leder H, Blace N, Szlechter M
Retin Cases Brief Rep 2014 Spring;8(2):95-6. doi: 10.1097/ICB.0000000000000012. PMID: 25372318
Orbital melanoma.
Furdova A, Chynoransky M, Krajcova P
Bratisl Lek Listy 2011;112(8):466-8. PMID: 21863619
Ocular melanoma.
Laver NV, McLaughlin ME, Duker JS
Arch Pathol Lab Med 2010 Dec;134(12):1778-84. doi: 10.5858/2009-0441-RAR.1. PMID: 21128775

Diagnosis

Intraocular Metastases--A Review.
Konstantinidis L, Damato B
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):208-214. doi: 10.22608/APO.201712. PMID: 28399345
Choroidal osteoma.
Kadrmas EF, Weiter JJ
Int Ophthalmol Clin 1997 Fall;37(4):171-82. doi: 10.1097/00004397-199703740-00015. PMID: 9429940
Metastatic tumors to the uvea.
Shields JA
Int Ophthalmol Clin 1993 Summer;33(3):155-61. doi: 10.1097/00004397-199303330-00022. PMID: 8407181
Choroidal osteoma.
Shields CL, Shields JA, Augsburger JJ
Surv Ophthalmol 1988 Jul-Aug;33(1):17-27. doi: 10.1016/0039-6257(88)90069-0. PMID: 3051466
Metastatic carcinoma of the eye and ocular adnexa.
Ferry AP
Int Ophthalmol Clin 1967 Fall;7(3):615-58. PMID: 5602374

Therapy

Abemaciclib and Fulvestrant for Bilateral Choroidal Metastasis From Breast Carcinoma.
Barke MR, Agrawal KU, Shields CL
JAMA Ophthalmol 2022 Oct 1;140(10):1026-1028. doi: 10.1001/jamaophthalmol.2022.3453. PMID: 36074499
Generalized morphea in the setting of pembrolizumab.
Cheng MW, Hisaw LD, Bernet L
Int J Dermatol 2019 Jun;58(6):736-738. Epub 2018 Jun 22 doi: 10.1111/ijd.14097. PMID: 29931792
Breast cancer (metastatic).
Stebbing J, Ngan S
BMJ Clin Evid 2010 Sep 8;2010 PMID: 21418674Free PMC Article
Metastatic choroidal choriocarcinoma.
Flam F, Kock E
Acta Obstet Gynecol Scand 1996 Aug;75(7):688-9. doi: 10.3109/00016349609054702. PMID: 8822670
Metastatic carcinoma of the eye and ocular adnexa.
Ferry AP
Int Ophthalmol Clin 1967 Fall;7(3):615-58. PMID: 5602374

Prognosis

Intraocular Metastases--A Review.
Konstantinidis L, Damato B
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):208-214. doi: 10.22608/APO.201712. PMID: 28399345
Metastatic disease from uveal melanoma: treatment options and future prospects.
Carvajal RD, Schwartz GK, Tezel T, Marr B, Francis JH, Nathan PD
Br J Ophthalmol 2017 Jan;101(1):38-44. Epub 2016 Aug 29 doi: 10.1136/bjophthalmol-2016-309034. PMID: 27574175Free PMC Article
Choroidal metastases of choriocarcinoma.
Hazan A, Katz MS, Leder H, Blace N, Szlechter M
Retin Cases Brief Rep 2014 Spring;8(2):95-6. doi: 10.1097/ICB.0000000000000012. PMID: 25372318
Ocular melanoma.
Laver NV, McLaughlin ME, Duker JS
Arch Pathol Lab Med 2010 Dec;134(12):1778-84. doi: 10.5858/2009-0441-RAR.1. PMID: 21128775
Choroidal osteoma.
Shields CL, Shields JA, Augsburger JJ
Surv Ophthalmol 1988 Jul-Aug;33(1):17-27. doi: 10.1016/0039-6257(88)90069-0. PMID: 3051466

Clinical prediction guides

Preclinical and pilot clinical evaluation of a small-molecule carbonic anhydrase IX targeting PET tracer in clear cell renal cell carcinoma.
Zhu W, Li X, Zheng G, Bai C, Ji Z, Zhang H, Xing H, Zhang Y, Huo L
Eur J Nucl Med Mol Imaging 2023 Aug;50(10):3116-3125. Epub 2023 May 29 doi: 10.1007/s00259-023-06248-7. PMID: 37246998
Cancers of the eye.
Maheshwari A, Finger PT
Cancer Metastasis Rev 2018 Dec;37(4):677-690. doi: 10.1007/s10555-018-9762-9. PMID: 30203109
Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis.
Boire A, Zou Y, Shieh J, Macalinao DG, Pentsova E, Massagué J
Cell 2017 Mar 9;168(6):1101-1113.e13. doi: 10.1016/j.cell.2017.02.025. PMID: 28283064Free PMC Article
Breast cancer (metastatic).
Stebbing J, Ngan S
BMJ Clin Evid 2010 Sep 8;2010 PMID: 21418674Free PMC Article
Breast cancer (metastatic).
Stebbing J, Slater S, Slevin M
BMJ Clin Evid 2007 Feb 1;2007 PMID: 19454050Free PMC Article

Recent systematic reviews

Choroidal nevi and melanoma doubling times and implications for delays in treatment: A systematic review and meta-analysis.
Stålhammar G, Hagström A, Ermedahl Conradi M, Williams PA
Surv Ophthalmol 2025 Jan-Feb;70(1):38-46. Epub 2024 Sep 28 doi: 10.1016/j.survophthal.2024.09.004. PMID: 39343315
TTF-1 immunohistochemistry in primary CNS tumors: A systematic review.
Das S, Ahlawat S, Sarangi J, Panda AK, Jain P, Gupta RK, Vaishya S, Patir R
Clin Neuropathol 2024 Sept./Oct. & Nov./Dec.;43(5 & 6):138-146. doi: 10.5414/NP301642. PMID: 39445381
Vitreoretinal Surgery in the Prevention and Treatment of Toxic Tumour Syndrome in Uveal Melanoma: A Systematic Review.
Romano MR, Catania F, Confalonieri F, Zollet P, Allegrini D, Sergenti J, Lanza FB, Ferrara M, Angi M
Int J Mol Sci 2021 Sep 17;22(18) doi: 10.3390/ijms221810066. PMID: 34576231Free PMC Article
Breast cancer (metastatic).
Stebbing J, Ngan S
BMJ Clin Evid 2010 Sep 8;2010 PMID: 21418674Free PMC Article
Breast cancer (metastatic).
Stebbing J, Slater S, Slevin M
BMJ Clin Evid 2007 Feb 1;2007 PMID: 19454050Free PMC Article

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