U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Exanthem

MedGen UID:
8732
•Concept ID:
C0015230
•
Finding; Sign or Symptom
Synonyms: Exanthema; Rash; Rash, Skin; Skin Rash
 
HPO: HP:4000054
Monarch Initiative: MONDO:0006547

Definition

A widespread rash. [from HPO]

Professional guidelines

PubMed

Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms. Part II diagnosis and management.
Wei BM, Fox LP, Kaffenberger BH, Korman AM, Micheletti RG, Mostaghimi A, Noe MH, Rosenbach M, Shinkai K, Kwah JH, Phillips EJ, Bolognia JL, Damsky W, Nelson CA
J Am Acad Dermatol 2024 May;90(5):911-926. Epub 2023 Jul 28 doi: 10.1016/j.jaad.2023.02.073. PMID: 37516356
Recognition and treatment of devastating vasculopathic systemic disorders: Coronavirus disease 2019 and rickettsioses.
Mittal A, Elias ML, Schwartz RA, Kapila R
Dermatol Ther 2021 Jul;34(4):e14984. Epub 2021 May 29 doi: 10.1111/dth.14984. PMID: 34003557Free PMC Article
Pathogenesis, diagnosis, and treatment of acute disseminated encephalomyelitis.
Stüve O, Zamvil SS
Curr Opin Neurol 1999 Aug;12(4):395-401. doi: 10.1097/00019052-199908000-00005. PMID: 10555827

Recent clinical studies

Etiology

Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms. Part I. Epidemiology, pathogenesis, clinicopathological features, and prognosis.
Wei BM, Fox LP, Kaffenberger BH, Korman AM, Micheletti RG, Mostaghimi A, Noe MH, Rosenbach M, Shinkai K, Kwah JH, Phillips EJ, Bolognia JL, Damsky W, Nelson CA
J Am Acad Dermatol 2024 May;90(5):885-908. Epub 2023 Jul 27 doi: 10.1016/j.jaad.2023.02.072. PMID: 37516359
Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms. Part II diagnosis and management.
Wei BM, Fox LP, Kaffenberger BH, Korman AM, Micheletti RG, Mostaghimi A, Noe MH, Rosenbach M, Shinkai K, Kwah JH, Phillips EJ, Bolognia JL, Damsky W, Nelson CA
J Am Acad Dermatol 2024 May;90(5):911-926. Epub 2023 Jul 28 doi: 10.1016/j.jaad.2023.02.073. PMID: 37516356
Hand, Foot, and Mouth Disease: A Narrative Review.
Leung AKC, Lam JM, Barankin B, Leong KF, Hon KL
Recent Adv Inflamm Allergy Drug Discov 2022;16(2):77-95. doi: 10.2174/1570180820666221024095837. PMID: 36284392
Paraviral exanthems.
Fölster-Holst R, Zawar VP, Chuh A
Expert Rev Anti Infect Ther 2016 Jun;14(6):601-11. doi: 10.1080/14787210.2016.1184084. PMID: 27144956
Pityriasis rosea.
Stulberg DL, Wolfrey J
Am Fam Physician 2004 Jan 1;69(1):87-91. PMID: 14727822

Diagnosis

Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms. Part II diagnosis and management.
Wei BM, Fox LP, Kaffenberger BH, Korman AM, Micheletti RG, Mostaghimi A, Noe MH, Rosenbach M, Shinkai K, Kwah JH, Phillips EJ, Bolognia JL, Damsky W, Nelson CA
J Am Acad Dermatol 2024 May;90(5):911-926. Epub 2023 Jul 28 doi: 10.1016/j.jaad.2023.02.073. PMID: 37516356
Roseola Infantum: An Updated Review.
Leung AK, Lam JM, Barankin B, Leong KF, Hon KL
Curr Pediatr Rev 2024;20(2):119-128. doi: 10.2174/1573396319666221118123844. PMID: 36411550
Monkeypox Virus Infections in Humans.
Elsayed S, Bondy L, Hanage WP
Clin Microbiol Rev 2022 Dec 21;35(4):e0009222. Epub 2022 Nov 14 doi: 10.1128/cmr.00092-22. PMID: 36374082Free PMC Article
Hand, Foot, and Mouth Disease: A Narrative Review.
Leung AKC, Lam JM, Barankin B, Leong KF, Hon KL
Recent Adv Inflamm Allergy Drug Discov 2022;16(2):77-95. doi: 10.2174/1570180820666221024095837. PMID: 36284392
Coccidioidomycosis.
DiCaudo DJ
Semin Cutan Med Surg 2014 Sep;33(3):140-5. doi: 10.12788/j.sder.0111. PMID: 25577855

Therapy

Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms. Part I. Epidemiology, pathogenesis, clinicopathological features, and prognosis.
Wei BM, Fox LP, Kaffenberger BH, Korman AM, Micheletti RG, Mostaghimi A, Noe MH, Rosenbach M, Shinkai K, Kwah JH, Phillips EJ, Bolognia JL, Damsky W, Nelson CA
J Am Acad Dermatol 2024 May;90(5):885-908. Epub 2023 Jul 27 doi: 10.1016/j.jaad.2023.02.072. PMID: 37516359
Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms. Part II diagnosis and management.
Wei BM, Fox LP, Kaffenberger BH, Korman AM, Micheletti RG, Mostaghimi A, Noe MH, Rosenbach M, Shinkai K, Kwah JH, Phillips EJ, Bolognia JL, Damsky W, Nelson CA
J Am Acad Dermatol 2024 May;90(5):911-926. Epub 2023 Jul 28 doi: 10.1016/j.jaad.2023.02.073. PMID: 37516356
Paraviral exanthems.
Fölster-Holst R, Zawar VP, Chuh A
Expert Rev Anti Infect Ther 2016 Jun;14(6):601-11. doi: 10.1080/14787210.2016.1184084. PMID: 27144956
Viral Skin Diseases.
Ramdass P, Mullick S, Farber HF
Prim Care 2015 Dec;42(4):517-67. doi: 10.1016/j.pop.2015.08.006. PMID: 26612372
Pityriasis rosea.
Stulberg DL, Wolfrey J
Am Fam Physician 2004 Jan 1;69(1):87-91. PMID: 14727822

Prognosis

Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms. Part I. Epidemiology, pathogenesis, clinicopathological features, and prognosis.
Wei BM, Fox LP, Kaffenberger BH, Korman AM, Micheletti RG, Mostaghimi A, Noe MH, Rosenbach M, Shinkai K, Kwah JH, Phillips EJ, Bolognia JL, Damsky W, Nelson CA
J Am Acad Dermatol 2024 May;90(5):885-908. Epub 2023 Jul 27 doi: 10.1016/j.jaad.2023.02.072. PMID: 37516359
Cutaneous manifestations of COVID-19.
Wang CJ, Worswick S
Dermatol Online J 2021 Jan 15;27(1) PMID: 33560783
Paraviral exanthems.
Fölster-Holst R, Zawar VP, Chuh A
Expert Rev Anti Infect Ther 2016 Jun;14(6):601-11. doi: 10.1080/14787210.2016.1184084. PMID: 27144956
Erythema infectiosum.
Vafaie J, Schwartz RA
J Cutan Med Surg 2005 Aug;9(4):159-61. doi: 10.1007/s10227-005-0101-8. PMID: 16502203
Pityriasis rosea.
Stulberg DL, Wolfrey J
Am Fam Physician 2004 Jan 1;69(1):87-91. PMID: 14727822

Clinical prediction guides

Roseola Infantum: An Updated Review.
Leung AK, Lam JM, Barankin B, Leong KF, Hon KL
Curr Pediatr Rev 2024;20(2):119-128. doi: 10.2174/1573396319666221118123844. PMID: 36411550
Hand, Foot, and Mouth Disease: A Narrative Review.
Leung AKC, Lam JM, Barankin B, Leong KF, Hon KL
Recent Adv Inflamm Allergy Drug Discov 2022;16(2):77-95. doi: 10.2174/1570180820666221024095837. PMID: 36284392
Clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain: a prospective observational cohort study.
Tarín-Vicente EJ, Alemany A, Agud-Dios M, Ubals M, Suñer C, Antón A, Arando M, Arroyo-Andrés J, Calderón-Lozano L, Casañ C, Cabrera JM, Coll P, Descalzo V, Folgueira MD, García-Pérez JN, Gil-Cruz E, González-Rodríguez B, Gutiérrez-Collar C, Hernández-Rodríguez Á, López-Roa P, de Los Ángeles Meléndez M, Montero-Menárguez J, Muñoz-Gallego I, Palencia-Pérez SI, Paredes R, Pérez-Rivilla A, Piñana M, Prat N, Ramirez A, Rivero Á, Rubio-Muñiz CA, Vall M, Acosta-Velásquez KS, Wang A, Galván-Casas C, Marks M, Ortiz-Romero PL, Mitjà O
Lancet 2022 Aug 27;400(10353):661-669. Epub 2022 Aug 8 doi: 10.1016/S0140-6736(22)01436-2. PMID: 35952705Free PMC Article
Drug hypersensitivity.
Bircher AJ
Chem Immunol Allergy 2014;100:120-31. Epub 2014 May 22 doi: 10.1159/000358617. PMID: 24925392
Mercury exanthem.
Vena GA, Foti C, Grandolfo M, Angelini G
Contact Dermatitis 1994 Oct;31(4):214-6. doi: 10.1111/j.1600-0536.1994.tb01990.x. PMID: 7842674

Recent systematic reviews

Otolaryngologic manifestations among MPOX patients: A systematic review and meta-analysis.
Shah J, Saak TM, Desai AN, Gudis DA, Cheema HA, Abuelazm M, Preciado D, Zucker J, Overdevest JB
Am J Otolaryngol 2023 Nov-Dec;44(6):103991. Epub 2023 Jul 11 doi: 10.1016/j.amjoto.2023.103991. PMID: 37487464
Dermatologic manifestations of COVID-19: a comprehensive systematic review.
Mirza FN, Malik AA, Omer SB, Sethi A
Int J Dermatol 2021 Apr;60(4):418-450. Epub 2020 Nov 3 doi: 10.1111/ijd.15168. PMID: 33141443
The trend of cutaneous lesions during COVID-19 pandemic: lessons from a meta-analysis and systematic review.
Rajan M B, Kumar-M P, Bhardwaj A
Int J Dermatol 2020 Nov;59(11):1358-1370. Epub 2020 Sep 16 doi: 10.1111/ijd.15154. PMID: 32936462
Rates of cutaneous reactions to drugs.
Bigby M
Arch Dermatol 2001 Jun;137(6):765-70. PMID: 11405768

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...