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Adrenal Cortical Mixed Cell Adenoma

MedGen UID:
87220
•Concept ID:
C0334336
•
Neoplastic Process
Synonyms: Adrenal Cortex Mixed Cell Adenoma; Adrenal cortical adenoma - mixed cell; Adrenal cortical adenoma, mixed cell; Adrenal Gland Mixed Cell Adenoma; Mixed Cell Adrenal Cortex Adenoma; Mixed Cell Adrenal Cortical Adenoma; Mixed Cell Adrenocortical Adenoma
SNOMED CT: Adrenal cortical adenoma - mixed cell (39720002); Adrenal cortical adenoma, mixed cell (39720002)

Definition

An adenoma of the adrenal cortex composed of a mixed neoplastic cellular population, including varying numbers of neoplastic clear and compact cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdrenal Cortical Mixed Cell Adenoma

Recent clinical studies

Etiology

Toxicology and carcinogenesis studies of 2,3',4,4',5-pentachlorobiphenyl (PCB 118) (CAS No. 31508-00-6) in female harlan Sprague-Dawley rats (gavage studies).
National Toxicology Program
Natl Toxicol Program Tech Rep Ser 2010 Nov;(559):1-174. PMID: 21383778
Toxicology and carcinogenesis studies of 3,3',4,4'-tetrachloroazobenzene (TCAB) (CAS No. 14047-09-7) in Harlan Sprague-Dawley rats and B6C3F1 mice (gavage studies).
National Toxicology Program
Natl Toxicol Program Tech Rep Ser 2010 Nov;(558):1-206. PMID: 21383777
Fine needle aspiration cytology of primary and metastatic lesions of the adrenal gland. A series of 188 biopsies with radiologic correlation.
Saboorian MH, Katz RL, Charnsangavej C
Acta Cytol 1995 Sep-Oct;39(5):843-51. PMID: 7571958
Adrenocortical factors in hypertension. I. Significance of 18-hydroxy-11-deoxycorticosterone.
Ulick S
Am J Cardiol 1976 Nov 23;38(6):814-24. doi: 10.1016/0002-9149(76)90360-x. PMID: 187051

Diagnosis

Mixed ganglioneuroma and cortical adenoma in adrenal gland: A case report.
Kang YN
Medicine (Baltimore) 2022 Nov 25;101(47):e31403. doi: 10.1097/MD.0000000000031403. PMID: 36451378Free PMC Article
Stemness regulation of the adrenal mixed corticomedullary tumorigenesis-a case-control study.
Chiou HC, Jiang HJ, Yang SF, Kuo KK, Lin PC, Hsiao PJ
Neoplasia 2020 Jul;22(7):263-271. Epub 2020 May 18 doi: 10.1016/j.neo.2020.04.003. PMID: 32438306Free PMC Article
Mixed corticomedullary carcinoma of the adrenal gland: a case report.
Turk AT, Asad H, Trapasso J, Perilli G, LiVolsi VA
Endocr Pract 2012 May-Jun;18(3):e37-42. doi: 10.4158/EP11222.CR. PMID: 22548942
Anti-CD10 (56C6) is expressed variably in adrenocortical tumors and cannot be used to discriminate clear cell renal cell carcinomas.
Mete O, Kapran Y, Güllüoğlu MG, Kiliçaslan I, Erbil Y, Senyürek YG, Dizdaroğlu F
Virchows Arch 2010 May;456(5):515-21. doi: 10.1007/s00428-010-0901-0. PMID: 20390424
Effects of spironolactone, canrenone and canrenoate-K on cytochrome P450, and 11beta- and 18-hydroxylation in bovine and human adrenal cortical mitochondria.
Cheng SC, Suzuki K, Sadee W, Harding BW
Endocrinology 1976 Oct;99(4):1097-106. doi: 10.1210/endo-99-4-1097. PMID: 976190

Prognosis

Toxicology and carcinogenesis studies of 2,3',4,4',5-pentachlorobiphenyl (PCB 118) (CAS No. 31508-00-6) in female harlan Sprague-Dawley rats (gavage studies).
National Toxicology Program
Natl Toxicol Program Tech Rep Ser 2010 Nov;(559):1-174. PMID: 21383778
Fine needle aspiration cytology of primary and metastatic lesions of the adrenal gland. A series of 188 biopsies with radiologic correlation.
Saboorian MH, Katz RL, Charnsangavej C
Acta Cytol 1995 Sep-Oct;39(5):843-51. PMID: 7571958

Clinical prediction guides

Toxicology and carcinogenesis studies of 2,3',4,4',5-pentachlorobiphenyl (PCB 118) (CAS No. 31508-00-6) in female harlan Sprague-Dawley rats (gavage studies).
National Toxicology Program
Natl Toxicol Program Tech Rep Ser 2010 Nov;(559):1-174. PMID: 21383778
Toxicology and carcinogenesis studies of 3,3',4,4'-tetrachloroazobenzene (TCAB) (CAS No. 14047-09-7) in Harlan Sprague-Dawley rats and B6C3F1 mice (gavage studies).
National Toxicology Program
Natl Toxicol Program Tech Rep Ser 2010 Nov;(558):1-206. PMID: 21383777
Regulation of aldosterone secretion by several aberrant receptors including for glucose-dependent insulinotropic peptide in a patient with an aldosteronoma.
Lampron A, Bourdeau I, Oble S, Godbout A, Schürch W, Arjane P, Hamet P, Lacroix A
J Clin Endocrinol Metab 2009 Mar;94(3):750-6. Epub 2008 Dec 9 doi: 10.1210/jc.2008-1340. PMID: 19066304
Multiple endocrine adenomatosis of mixed type.
Hansen OP, Hansen M, Hansen HH, Rose B
Acta Med Scand 1976;200(4):327-31. doi: 10.1111/j.0954-6820.1976.tb08240.x. PMID: 10717

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