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Adrenocortical abnormality

MedGen UID:: 871332
•Concept ID:: C4025820
•: Anatomical Abnormality

HPO:	HP:0000849

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAdrenocortical abnormality

Phenotypic abnormality
- Abnormality of the endocrine system
  - Abnormal endocrine morphology
    - Abnormal adrenal morphology
      - Adrenocortical abnormality
        Adrenocortical hyperplasia
        Adrenocortical hypoplasia
        Pigmented micronodular adrenocortical disease

Professional guidelines

PubMed

Mild autonomous cortisol secretion: pathophysiology, comorbidities and management approaches.

Prete A, Bancos I
Nat Rev Endocrinol 2024 Aug;20(8):460-473. Epub 2024 Apr 22 doi: 10.1038/s41574-024-00984-y. PMID: 38649778

Management challenges and therapeutic advances in congenital adrenal hyperplasia.

Mallappa A, Merke DP
Nat Rev Endocrinol 2022 Jun;18(6):337-352. Epub 2022 Apr 11 doi: 10.1038/s41574-022-00655-w. PMID: 35411073 Free PMC Article

Modern Management of Mild Autonomous Cortisol Secretion.

Delivanis DA, Athimulam S, Bancos I
Clin Pharmacol Ther 2019 Dec;106(6):1209-1221. Epub 2019 Aug 6 doi: 10.1002/cpt.1551. PMID: 31206616

Recent clinical studies

Etiology

21-Hydroxylase-deficient nonclassic adrenal hyperplasia is a progressive disorder: a multicenter study.

Moran C, Azziz R, Carmina E, Dewailly D, Fruzzetti F, Ibañez L, Knochenhauer ES, Marcondes JA, Mendonca BB, Pignatelli D, Pugeat M, Rohmer V, Speiser PW, Witchel SF
Am J Obstet Gynecol 2000 Dec;183(6):1468-74. doi: 10.1067/mob.2000.108020. PMID: 11120512

Steroid hormones in the adrenal venous effluents in idiopathic hirsutism under basal and stimulated conditions.

Valenta LJ, Elias AN
Horm Metab Res 1986 Oct;18(10):710-2. doi: 10.1055/s-2007-1012413. PMID: 3023220

Diagnosis

Autonomic dysfunction and adrenocortical unresponsiveness to ACTH.

Makari G, Hoffman WH, Carroll JE, Savage DR, Van der Zalm T
J Child Neurol 1988 Jul;3(3):174-6. doi: 10.1177/088307388800300304. PMID: 2850314

Therapy

Late onset adrenocortical hydroxylase deficiencies associated with menstrual dysfunction.

Birnbaum MD, Rose LI
Obstet Gynecol 1984 Apr;63(4):445-51. PMID: 6322077

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Clinical resources

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Consumer resources

MedlinePlus

Reviews

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