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Impaired neutrophil killing of staphylococci

MedGen UID:
870734
•Concept ID:
C4025188
•
Finding
HPO: HP:0005512

Definition

A reduction in the ability of neutrophils to kill the gram-positive bacteria, staphylococcus, which is commonly known as staph. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImpaired neutrophil killing of staphylococci

Recent clinical studies

Etiology

Host defence to bacterial infection in the neonate.
Fleer A, Gerards LJ, Verhoef J
J Hosp Infect 1988 Feb;11 Suppl A:320-7. doi: 10.1016/0195-6701(88)90206-x. PMID: 2896728
Blocking of antibody complement-dependent effector functions by streptococcal IgG Fc-receptor and staphylococcal protein A.
Schalén C, Truedsson L, Christensen KK, Christensen P
Acta Pathol Microbiol Immunol Scand B 1985 Dec;93(6):395-400. doi: 10.1111/j.1699-0463.1985.tb02908.x. PMID: 3914819

Therapy

Bactericidal activity against coagulase-negative staphylococci is impaired in infants receiving long-term parenteral nutrition.
Okada Y, Klein NJ, van Saene HK, Webb G, Holzel H, Pierro A
Ann Surg 2000 Feb;231(2):276-81. doi: 10.1097/00000658-200002000-00018. PMID: 10674621Free PMC Article
Peter Paul Rickham Prize--1998. Neutrophil dysfunction the cellular mechanism of impaired immunity during total parenteral nutrition in infancy.
Okada Y, Klein NJ, Pierro A
J Pediatr Surg 1999 Feb;34(2):242-5. doi: 10.1016/s0022-3468(99)90182-3. PMID: 10052796

Prognosis

Enhanced killing of penicillin-treated gram-positive cocci by human granulocytes: role of bacterial autolysins, catalase, and granulocyte oxidative pathways.
Isturiz R, Metcalf JA, Root RK
Yale J Biol Med 1985 Mar-Apr;58(2):133-43. PMID: 4036175Free PMC Article

Clinical prediction guides

Biomaterial-neutrophil interactions: dysregulation of oxidative functions of fresh neutrophils induced by prior neutrophil-biomaterial interaction.
Kaplan SS, Basford RE, Jeong MH, Simmons RL
J Biomed Mater Res 1996 Jan;30(1):67-75. doi: 10.1002/(SICI)1097-4636(199601)30:1<67::AID-JBM9>3.0.CO;2-P. PMID: 8788107
Enhanced killing of penicillin-treated gram-positive cocci by human granulocytes: role of bacterial autolysins, catalase, and granulocyte oxidative pathways.
Isturiz R, Metcalf JA, Root RK
Yale J Biol Med 1985 Mar-Apr;58(2):133-43. PMID: 4036175Free PMC Article
Trypan blue inhibits complement-mediated phagocytosis by human polymorphonuclear leukocytes.
Guckian JC, Christensen WD, Fine DP
J Immunol 1978 May;120(5):1580-6. PMID: 659863

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