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Imbalanced hemoglobin synthesis

MedGen UID:
870723
•Concept ID:
C4025177
•
Finding
Synonyms: Imbalanced haemoglobin synthesis; Imbalanced Hb synthesis
 
HPO: HP:0005560

Definition

Normal hemoglobin synthesis is characterized by production of equal amounts of alpha and beta globins. This term refers to a deviation from this pattern and is the main characteristic of the various forms of thalassemia. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImbalanced hemoglobin synthesis

Conditions with this feature

HEMOGLOBIN NYU
MedGen UID:
855075
•Concept ID:
C3889376
•
Finding
See: Condition Record
HEMOGLOBIN NYU

Recent clinical studies

Etiology

The Effects of Spirulina Supplementation on Cardiometabolic Risk Factors: A Narrative Review.
Sokary S, Bawadi H, Zakaria ZZ, Al-Asmakh M
J Diet Suppl 2024;21(4):527-542. Epub 2024 Jan 22 doi: 10.1080/19390211.2023.2301366. PMID: 38251049
Long-term safety and efficacy of alogliptin, a DPP-4 inhibitor, in patients with type 2 diabetes: a 3-year prospective, controlled, observational study (J-BRAND Registry).
Ueki K, Tanizawa Y, Nakamura J, Yamada Y, Inagaki N, Watada H, Shimomura I, Nishimura R, Miyoshi H, Abiko A, Katagiri H, Hayashi M, Shimada A, Naruse K, Fujimoto S, Fujiwara M, Shikata K, Okada Y, Araki E, Yamazaki T, Kadowaki T; J-BRAND Registry Group
BMJ Open Diabetes Res Care 2021 Jan;9(1) doi: 10.1136/bmjdrc-2020-001787. PMID: 33441417Free PMC Article
SIV infection aggravates malaria in a Chinese rhesus monkey coinfection model.
Liu G, Li Y, Qin L, Yan Y, Ye Y, Chen Y, Huang C, Zhao S, Yao Y, Su Z, Chen X
BMC Infect Dis 2019 Nov 12;19(1):965. doi: 10.1186/s12879-019-4465-6. PMID: 31718574Free PMC Article
Analysis of serum and urinal copper and zinc in Chinese northeast population with the prediabetes or diabetes with and without complications.
Xu J, Zhou Q, Liu G, Tan Y, Cai L
Oxid Med Cell Longev 2013;2013:635214. Epub 2013 Sep 22 doi: 10.1155/2013/635214. PMID: 24175012Free PMC Article
Hemoglobin Bart's in Northern Algeria.
Henni T, Bachir D, Tabone P, Jurdic P, Godet J, Colonna P
Acta Haematol 1981;65(4):240-6. doi: 10.1159/000207187. PMID: 6789587

Diagnosis

The Effects of Spirulina Supplementation on Cardiometabolic Risk Factors: A Narrative Review.
Sokary S, Bawadi H, Zakaria ZZ, Al-Asmakh M
J Diet Suppl 2024;21(4):527-542. Epub 2024 Jan 22 doi: 10.1080/19390211.2023.2301366. PMID: 38251049
Red blood cells free α-haemoglobin pool: a biomarker to monitor the β-thalassemia intermedia variability. The ALPHAPOOL study.
Vasseur C, Domingues-Hamdi E, Ledudal K, Le Corvoisier P, Barau C, Ghaleh B, Rialland A, Pissard S, Galactéros F, Baudin-Creuza V
Br J Haematol 2017 Oct;179(1):142-153. Epub 2017 Jun 23 doi: 10.1111/bjh.14800. PMID: 28643346
The imbalanced profile and clinical significance of T helper associated cytokines in bone marrow microenvironment of the patients with acute myeloid leukemia.
Sun YX, Kong HL, Liu CF, Yu S, Tian T, Ma DX, Ji CY
Hum Immunol 2014 Feb;75(2):113-8. Epub 2013 Nov 20 doi: 10.1016/j.humimm.2013.11.014. PMID: 24269703
Molecular analysis of globin gene expression in different thalassaemia disorders: individual variation of β(E) pre-mRNA splicing determine disease severity.
Tubsuwan A, Munkongdee T, Jearawiriyapaisarn N, Boonchoy C, Winichagoon P, Fucharoen S, Svasti S
Br J Haematol 2011 Sep;154(5):635-43. Epub 2011 Jul 7 doi: 10.1111/j.1365-2141.2011.08770.x. PMID: 21732929
Embryonic erythroid differentiation in the human leukemic cell line K562.
Rutherford T, Clegg JB, Higgs DR, Jones RW, Thompson J, Weatherall DJ
Proc Natl Acad Sci U S A 1981 Jan;78(1):348-52. doi: 10.1073/pnas.78.1.348. PMID: 6264439Free PMC Article

Therapy

The Effects of Spirulina Supplementation on Cardiometabolic Risk Factors: A Narrative Review.
Sokary S, Bawadi H, Zakaria ZZ, Al-Asmakh M
J Diet Suppl 2024;21(4):527-542. Epub 2024 Jan 22 doi: 10.1080/19390211.2023.2301366. PMID: 38251049
Oral ferroportin inhibitor vamifeport for improving iron homeostasis and erythropoiesis in β-thalassemia: current evidence and future clinical development.
Porter J, Taher A, Viprakasit V, Kattamis A, Coates TD, Garbowski M, Dürrenberger F, Manolova V, Richard F, Cappellini MD
Expert Rev Hematol 2021 Jul;14(7):633-644. Epub 2021 Jul 29 doi: 10.1080/17474086.2021.1935854. PMID: 34324404
Long-term safety and efficacy of alogliptin, a DPP-4 inhibitor, in patients with type 2 diabetes: a 3-year prospective, controlled, observational study (J-BRAND Registry).
Ueki K, Tanizawa Y, Nakamura J, Yamada Y, Inagaki N, Watada H, Shimomura I, Nishimura R, Miyoshi H, Abiko A, Katagiri H, Hayashi M, Shimada A, Naruse K, Fujimoto S, Fujiwara M, Shikata K, Okada Y, Araki E, Yamazaki T, Kadowaki T; J-BRAND Registry Group
BMJ Open Diabetes Res Care 2021 Jan;9(1) doi: 10.1136/bmjdrc-2020-001787. PMID: 33441417Free PMC Article
SIV infection aggravates malaria in a Chinese rhesus monkey coinfection model.
Liu G, Li Y, Qin L, Yan Y, Ye Y, Chen Y, Huang C, Zhao S, Yao Y, Su Z, Chen X
BMC Infect Dis 2019 Nov 12;19(1):965. doi: 10.1186/s12879-019-4465-6. PMID: 31718574Free PMC Article
Analysis of serum and urinal copper and zinc in Chinese northeast population with the prediabetes or diabetes with and without complications.
Xu J, Zhou Q, Liu G, Tan Y, Cai L
Oxid Med Cell Longev 2013;2013:635214. Epub 2013 Sep 22 doi: 10.1155/2013/635214. PMID: 24175012Free PMC Article

Prognosis

Blood oxygenation state in COVID-19 patients: Unexplored role of 2,3-bisphosphoglycerate.
Bertilacchi MS, Piccarducci R, Celi A, Germelli L, Romei C, Bartholmai BJ, Barbieri G, Giacomelli C, Martini C
Biomed J 2024 Dec;47(6):100723. Epub 2024 Apr 6 doi: 10.1016/j.bj.2024.100723. PMID: 38583585Free PMC Article
SIV infection aggravates malaria in a Chinese rhesus monkey coinfection model.
Liu G, Li Y, Qin L, Yan Y, Ye Y, Chen Y, Huang C, Zhao S, Yao Y, Su Z, Chen X
BMC Infect Dis 2019 Nov 12;19(1):965. doi: 10.1186/s12879-019-4465-6. PMID: 31718574Free PMC Article
Molecular analysis of globin gene expression in different thalassaemia disorders: individual variation of β(E) pre-mRNA splicing determine disease severity.
Tubsuwan A, Munkongdee T, Jearawiriyapaisarn N, Boonchoy C, Winichagoon P, Fucharoen S, Svasti S
Br J Haematol 2011 Sep;154(5):635-43. Epub 2011 Jul 7 doi: 10.1111/j.1365-2141.2011.08770.x. PMID: 21732929
Care of patients with haemoglobin abnormalities: history and biology.
Khattab AD, Rawlings B, Ali IS
Br J Nurs 2006 Oct 12-25;15(18):994-8. doi: 10.12968/bjon.2006.15.18.22024. PMID: 17077770
Hemoglobin Bart's in Northern Algeria.
Henni T, Bachir D, Tabone P, Jurdic P, Godet J, Colonna P
Acta Haematol 1981;65(4):240-6. doi: 10.1159/000207187. PMID: 6789587

Clinical prediction guides

The Effects of Spirulina Supplementation on Cardiometabolic Risk Factors: A Narrative Review.
Sokary S, Bawadi H, Zakaria ZZ, Al-Asmakh M
J Diet Suppl 2024;21(4):527-542. Epub 2024 Jan 22 doi: 10.1080/19390211.2023.2301366. PMID: 38251049
Oral ferroportin inhibitor vamifeport for improving iron homeostasis and erythropoiesis in β-thalassemia: current evidence and future clinical development.
Porter J, Taher A, Viprakasit V, Kattamis A, Coates TD, Garbowski M, Dürrenberger F, Manolova V, Richard F, Cappellini MD
Expert Rev Hematol 2021 Jul;14(7):633-644. Epub 2021 Jul 29 doi: 10.1080/17474086.2021.1935854. PMID: 34324404
Long-term safety and efficacy of alogliptin, a DPP-4 inhibitor, in patients with type 2 diabetes: a 3-year prospective, controlled, observational study (J-BRAND Registry).
Ueki K, Tanizawa Y, Nakamura J, Yamada Y, Inagaki N, Watada H, Shimomura I, Nishimura R, Miyoshi H, Abiko A, Katagiri H, Hayashi M, Shimada A, Naruse K, Fujimoto S, Fujiwara M, Shikata K, Okada Y, Araki E, Yamazaki T, Kadowaki T; J-BRAND Registry Group
BMJ Open Diabetes Res Care 2021 Jan;9(1) doi: 10.1136/bmjdrc-2020-001787. PMID: 33441417Free PMC Article
Pathophysiology of beta thalassemia--a guide to molecular therapies.
Thein SL
Hematology Am Soc Hematol Educ Program 2005:31-7. doi: 10.1182/asheducation-2005.1.31. PMID: 16304356
Beta-thalassemia unlinked to the beta-globin gene in an English family.
Thein SL, Wood WG, Wickramasinghe SN, Galvin MC
Blood 1993 Aug 1;82(3):961-7. PMID: 8101733

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