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Multiple digital exostoses

MedGen UID:
870708
•Concept ID:
C4025162
•
Neoplastic Process
HPO: HP:0005655

Definition

Multiple exostoses originating in the fingers and toes. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMultiple digital exostoses

Conditions with this feature

Metachondromatosis
MedGen UID:
98377
•Concept ID:
C0410530
•
Disease or Syndrome
Metachondromatosis is characterized by exostoses (osteochondromas), commonly of the hands and feet, and enchondromas of long bone metaphyses and iliac crests (summary by Sobreira et al., 2010).
See: Condition Record
Metachondromatosis

Recent clinical studies

Etiology

Multiple long bone cysts revealed by MRI in trichorhinophalangeal syndrome type II predisposing to pathological fractures.
Konala P, Kiely N, Noakes C, Blair E, Cassar-Pullicino VN
Pediatr Radiol 2017 Jul;47(8):1016-1021. Epub 2017 May 10 doi: 10.1007/s00247-017-3839-4. PMID: 28493010
Successful operative management of an asymptomatic chest lesion in hereditary multiple exostosis.
Pelc HJ, Walker J, Davies G
J Pediatr Orthop B 2013 Sep;22(5):505-8. doi: 10.1097/BPB.0b013e32835875d2. PMID: 23907180
An unusual complication of pubic exostosis.
Mnif H, Zrig M, Koubaa M, Zammel N, Abid A
Orthop Traumatol Surg Res 2009 Apr;95(2):151-3. Epub 2009 Mar 24 doi: 10.1016/j.otsr.2009.02.003. PMID: 19321394
Hereditary spinal osteochondromas in diaphyseal aclasia.
Robbins SE, Laitt RD, Lewis T
Neuroradiology 1996 Jan;38(1):59-61. doi: 10.1007/BF00593223. PMID: 8773280
Chondrosarcoma arising in osteochondroma.
Garrison RC, Unni KK, McLeod RA, Pritchard DJ, Dahlin DC
Cancer 1982 May 1;49(9):1890-7. doi: 10.1002/1097-0142(19820501)49:9<1890::aid-cncr2820490923>3.0.co;2-u. PMID: 7074587

Diagnosis

Surgical Management of Thoracic Multiple Exostoses.
Kanthasamy S, Aresu G, Peryt A, Coonar AS
Ann Thorac Surg 2020 May;109(5):e361-e362. Epub 2019 Oct 4 doi: 10.1016/j.athoracsur.2019.08.088. PMID: 31589851
Spontaneous Haemothorax Secondary to Rib Exostosis.
Lin CY, Chang CC, Chuang MT
Heart Lung Circ 2017 Aug;26(8):e62-e63. Epub 2017 Mar 11 doi: 10.1016/j.hlc.2017.02.005. PMID: 28343950
Multiple Hereditary Exostoses.
DuBose CO
Radiol Technol 2016 Jan-Feb;87(3):305-21. quiz 322-5. PMID: 26721841
Exostoses and vascular complications in the lower limbs: two case reports and review of the literature.
Nasr B, Albert B, David CH, Marques da Fonseca P, Badra A, Gouny P
Ann Vasc Surg 2015 Aug;29(6):1315.e7-1315.e14. Epub 2015 May 29 doi: 10.1016/j.avsg.2015.02.020. PMID: 26028464
Sarcomatous transformation in diaphyseal aclasis.
Shah ZK, Peh WC, Wong Y, Shek TW, Davies AM
Australas Radiol 2007 Apr;51(2):110-9. doi: 10.1111/j.1440-1673.2007.01679.x. PMID: 17419854

Therapy

Spontaneous absorption of osteophytic calcification associated with chronic dural tear and ventral spinal CSF leak.
Rohatgi VK, Robbins MS, Schievink WI, Chazen JL
Neuroradiol J 2024 Apr;37(2):257-260. Epub 2023 Jun 30 doi: 10.1177/19714009231187360. PMID: 37387398Free PMC Article
A Novel Cause of Acute Coronary Syndrome Due to Dynamic Extrinsic Coronary Artery Compression by a Rib Exostosis: Multimodality Imaging Diagnosis.
Rodrigues JC, Mathias HC, Lyen SM, Mcalindon E, Bucciarelli-Ducci C, Batchelor TJ, Hamilton MC, Manghat NE
Can J Cardiol 2015 Oct;31(10):1303.e9-1303.e11. Epub 2015 May 16 doi: 10.1016/j.cjca.2015.05.008. PMID: 26255213
Selective computed tomography-guided perisciatic injection as a diagnostic tool in multiple hereditary exostoses.
Tenenbaum S, Arzi H, Shabshin N, Liberman B, Caspi I
Orthopedics 2012 Sep;35(9):e1446-8. doi: 10.3928/01477447-20120822-38. PMID: 22955418
Prevalence and severity of external auditory exostoses in breath-hold divers.
Sheard PW, Doherty M
J Laryngol Otol 2008 Nov;122(11):1162-7. Epub 2008 Mar 18 doi: 10.1017/S0022215108001850. PMID: 18346299
Spinal cord compression in a patient with multiple hereditary exostoses caused by breast adenocarcinoma metastatic to osteochondromas of the spine: case report.
Pandya NK, Auerbach JD, Baldwin K, Lackman RD, Chin KR
Spine (Phila Pa 1976) 2006 Nov 15;31(24):E920-4. doi: 10.1097/01.brs.0000245926.30594.bf. PMID: 17108823

Prognosis

Successful operative management of an asymptomatic chest lesion in hereditary multiple exostosis.
Pelc HJ, Walker J, Davies G
J Pediatr Orthop B 2013 Sep;22(5):505-8. doi: 10.1097/BPB.0b013e32835875d2. PMID: 23907180
An unusual complication of pubic exostosis.
Mnif H, Zrig M, Koubaa M, Zammel N, Abid A
Orthop Traumatol Surg Res 2009 Apr;95(2):151-3. Epub 2009 Mar 24 doi: 10.1016/j.otsr.2009.02.003. PMID: 19321394
Dedifferentiated chondrosarcoma in patients with multiple osteochondromatosis: report of a case and review of the literature.
Kilpatrick SE, Pike EJ, Ward WG, Pope TL
Skeletal Radiol 1997 Jun;26(6):370-4. doi: 10.1007/s002560050250. PMID: 9229421
Malignant transformation of a multiple cartilaginous exostosis--a case report.
Willms R, Hartwig CH, Böhm P, Sell S
Int Orthop 1997;21(2):133-6. doi: 10.1007/s002640050136. PMID: 9195270Free PMC Article
Hereditary spinal osteochondromas in diaphyseal aclasia.
Robbins SE, Laitt RD, Lewis T
Neuroradiology 1996 Jan;38(1):59-61. doi: 10.1007/BF00593223. PMID: 8773280

Clinical prediction guides

Multiple unexpected lesions of metachondromatosis detected by technetium-99m methylene diphosphonate SPECT/CT: A case report.
Wang Z, Zou Y, Chen Y, Chen Y
Medicine (Baltimore) 2018 Apr;97(17):e0512. doi: 10.1097/MD.0000000000010512. PMID: 29703018Free PMC Article
Multiple long bone cysts revealed by MRI in trichorhinophalangeal syndrome type II predisposing to pathological fractures.
Konala P, Kiely N, Noakes C, Blair E, Cassar-Pullicino VN
Pediatr Radiol 2017 Jul;47(8):1016-1021. Epub 2017 May 10 doi: 10.1007/s00247-017-3839-4. PMID: 28493010
Positive identification by a skull with multiple epigenetic traits and abnormal structure of the neurocranium, viscerocranium, and the skeleton.
Kuharić J, Kovacic N, Marusic P, Marusic A, Petrovecki V
J Forensic Sci 2011 May;56(3):788-93. Epub 2011 Mar 1 doi: 10.1111/j.1556-4029.2011.01718.x. PMID: 21361944
Prevalence and severity of external auditory exostoses in breath-hold divers.
Sheard PW, Doherty M
J Laryngol Otol 2008 Nov;122(11):1162-7. Epub 2008 Mar 18 doi: 10.1017/S0022215108001850. PMID: 18346299
Secondary chondrosarcoma in osteochondroma: report of 107 patients.
Ahmed AR, Tan TS, Unni KK, Collins MS, Wenger DE, Sim FH
Clin Orthop Relat Res 2003 Jun;(411):193-206. doi: 10.1097/01.blo.0000069888.31220.2b. PMID: 12782876

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