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Impaired platelet adhesion

MedGen UID:
870256
•Concept ID:
C4024694
•
Finding
Synonym: Impaired thrombocytes adhesion
 
HPO: HP:0008352

Definition

An abnormality of adhesion of thrombocytes. Normally, platelets adhere to collagen in the vascular subendothelium within seconds of injury via a receptor made up of glycoprotein Ia and IIa and GPVI and to vWF via receptor GPIb/IX/V. The adherent platelets then release granules that lead to platelet activation and aggregation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImpaired platelet adhesion

Conditions with this feature

Athrombia, essential
MedGen UID:
349197
•Concept ID:
C1859595
•
Disease or Syndrome
See: Condition Record
Athrombia, essential

Professional guidelines

PubMed

Coagulation Factor XIIIA (F13A1): Novel Perspectives in Treatment and Pharmacogenetics.
Gemmati D, Vigliano M, Burini F, Mari R, El Mohsein HH, Parmeggiani F, Serino ML
Curr Pharm Des 2016;22(11):1449-59. doi: 10.2174/1381612822666151210122954. PMID: 26654441
Congenital platelet disorders: overview of their mechanisms, diagnostic evaluation and treatment.
Hayward CP, Rao AK, Cattaneo M
Haemophilia 2006 Jul;12 Suppl 3:128-36. doi: 10.1111/j.1365-2516.2006.01270.x. PMID: 16684008
Congenital and acquired platelet disorders: current dilemmas and treatment strategies.
White GC 2nd
Semin Hematol 2006 Jan;43(1 Suppl 1):S37-41. doi: 10.1053/j.seminhematol.2005.11.011. PMID: 16427384

Recent clinical studies

Etiology

Perioperative Management of Coagulation Disorders in Ophthalmic Surgery.
Sucker C, Zeitz O, Feltgen N
Klin Monbl Augenheilkd 2024 Aug;241(8):944-951. Epub 2024 Aug 15 doi: 10.1055/a-2315-2206. PMID: 39146577
Emicizumab improves thrombus formation of type 2A von willebrand disease under high shear condition.
Yaoi H, Shida Y, Kitazawa T, Shima M, Nogami K
Haemophilia 2021 Mar;27(2):e194-e203. Epub 2021 Feb 8 doi: 10.1111/hae.14272. PMID: 33555083
Autoantibody-mediated desialylation impairs human thrombopoiesis and platelet lifespan.
Marini I, Zlamal J, Faul C, Holzer U, Hammer S, Pelzl L, Bethge W, Althaus K, Bakchoul T
Haematologica 2021 Jan 1;106(1):196-207. doi: 10.3324/haematol.2019.236117. [Epub ahead of print] PMID: 31857361Free PMC Article
Outcomes associated with dual antiplatelet therapy after myocardial infarction in patients with aortic stenosis.
Martinsson A, Li X, Torp-Pedersen C, Zöller B, Andell P, Andreasen C, Gislason G, Køber L, Sundquist K, Smith JG, Andersson C
Int J Cardiol 2019 Apr 15;281:140-145. Epub 2019 Jan 19 doi: 10.1016/j.ijcard.2019.01.063. PMID: 30722957Free PMC Article
Von Willebrand Factor-GP1bα Interactions in Venoarterial Extracorporeal Membrane Oxygenation Patients.
Mazzeffi M, Hasan S, Abuelkasem E, Meyer M, Deatrick K, Taylor B, Kon Z, Herr D, Tanaka K
J Cardiothorac Vasc Anesth 2019 Aug;33(8):2125-2132. Epub 2018 Nov 22 doi: 10.1053/j.jvca.2018.11.031. PMID: 30595484

Diagnosis

Perioperative Management of Coagulation Disorders in Ophthalmic Surgery.
Sucker C, Zeitz O, Feltgen N
Klin Monbl Augenheilkd 2024 Aug;241(8):944-951. Epub 2024 Aug 15 doi: 10.1055/a-2315-2206. PMID: 39146577
Defective calcium signalling in uraemic platelets and its amelioration with long-term erythropoietin therapy.
Zhou XJ, Vaziri ND
Nephrol Dial Transplant 2002 Jun;17(6):992-7. doi: 10.1093/ndt/17.6.992. PMID: 12032187

Therapy

Perioperative Management of Coagulation Disorders in Ophthalmic Surgery.
Sucker C, Zeitz O, Feltgen N
Klin Monbl Augenheilkd 2024 Aug;241(8):944-951. Epub 2024 Aug 15 doi: 10.1055/a-2315-2206. PMID: 39146577
Outcomes associated with dual antiplatelet therapy after myocardial infarction in patients with aortic stenosis.
Martinsson A, Li X, Torp-Pedersen C, Zöller B, Andell P, Andreasen C, Gislason G, Køber L, Sundquist K, Smith JG, Andersson C
Int J Cardiol 2019 Apr 15;281:140-145. Epub 2019 Jan 19 doi: 10.1016/j.ijcard.2019.01.063. PMID: 30722957Free PMC Article
Von Willebrand Factor-GP1bα Interactions in Venoarterial Extracorporeal Membrane Oxygenation Patients.
Mazzeffi M, Hasan S, Abuelkasem E, Meyer M, Deatrick K, Taylor B, Kon Z, Herr D, Tanaka K
J Cardiothorac Vasc Anesth 2019 Aug;33(8):2125-2132. Epub 2018 Nov 22 doi: 10.1053/j.jvca.2018.11.031. PMID: 30595484
Platelet hyperreactivity explains the bleeding abnormality and macrothrombocytopenia in a murine model of sitosterolemia.
Kanaji T, Kanaji S, Montgomery RR, Patel SB, Newman PJ
Blood 2013 Oct 10;122(15):2732-42. Epub 2013 Aug 7 doi: 10.1182/blood-2013-06-510461. PMID: 23926302Free PMC Article
Platelet adhesion defect in type I Gaucher Disease is associated with a risk of mucosal bleeding.
Spectre G, Roth B, Ronen G, Rosengarten D, Elstein D, Zimran A, Varon D, Revel-Vilk S
Br J Haematol 2011 May;153(3):372-8. Epub 2011 Mar 9 doi: 10.1111/j.1365-2141.2011.08613.x. PMID: 21401572

Prognosis

Outcomes associated with dual antiplatelet therapy after myocardial infarction in patients with aortic stenosis.
Martinsson A, Li X, Torp-Pedersen C, Zöller B, Andell P, Andreasen C, Gislason G, Køber L, Sundquist K, Smith JG, Andersson C
Int J Cardiol 2019 Apr 15;281:140-145. Epub 2019 Jan 19 doi: 10.1016/j.ijcard.2019.01.063. PMID: 30722957Free PMC Article

Clinical prediction guides

Von Willebrand Factor-GP1bα Interactions in Venoarterial Extracorporeal Membrane Oxygenation Patients.
Mazzeffi M, Hasan S, Abuelkasem E, Meyer M, Deatrick K, Taylor B, Kon Z, Herr D, Tanaka K
J Cardiothorac Vasc Anesth 2019 Aug;33(8):2125-2132. Epub 2018 Nov 22 doi: 10.1053/j.jvca.2018.11.031. PMID: 30595484
Effects of human recombinant, plasma-derived and porcine von Willebrand factor in pigs with severe von Willebrand disease.
Roussi J, Turecek PL, André P, Bonneau M, Pignaud G, Bal dit Sollier C, Schlokat U, Dorner F, Schwarz HP, Drouet L
Blood Coagul Fibrinolysis 1998 Jun;9(4):361-72. doi: 10.1097/00001721-199806000-00009. PMID: 9690808
Platelet adhesion and thrombus formation on subendothelium in platelets deficient in glycoproteins IIb-IIIa, Ib, and storage granules.
Weiss HJ, Turitto VT, Baumgartner HR
Blood 1986 Feb;67(2):322-30. PMID: 2935207

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